• Journal of Veterinary Clinics
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• v.26 no.5
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• pp.429-432
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• 2009

Aberrant translocation of ${\beta}$-catenin can be induced by the dissociation of cadherin-catenin complex, which is mediated by the activation of receptor tyrosine kinases (RTKs). We examined the expression levels of MET/RON RTKs in tissue samples of canine cutaneous melanotic tumor. The activation of MET/RON RTKs was observed in 28% of the examined samples. Our results indicate the possibility that the activated MET/RON RTKs are implicated in the dissociation of cadherin-catenin complex in canine cutaneous melanotic tumor.

• Journal of Chest Surgery
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• v.31 no.11
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• pp.1106-1109
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• 1998

Primary malignant melanoma of the esophagus(PMME) is an uncommon neoplasm. And the world literature reports only about 200 cases. A case of primary malignant melanoma of the esophagus is presented, and followed by review of the literature. In our patient, the walnut-sized melanoma was located at the midportion of esophagus and there were two small satellite lesions at the esophagogastric junction. The main mass was diagnosed as primary malignant melanoma histologically and immunohistologically. The tumor was curatively resected by the transthoracic subtotal esophagectomy and the 2 fields node dissection. Post- operative immunotherapy was performed but the tumor recurred 7 months later at the stomach.

• Journal of Chest Surgery
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• v.39 no.1 s.258
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• pp.76-79
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• 2006

Primary malignant melanoma of the lung is extremely rare. A 46-year-old lady was admitted with two month history of dry cough and blood-tinged sputum. Chest CT showed 4.5 $\times$ 5.0 cm sized mass at the right lower lobe. Repeated bronchoscopic and percutaneous biopsies showed no definite diagnosis. Preoperative evaluations revealed no systemic metastais. So, we tried the surgical approach. Right lower lobectomy and lymph node dissection was done. The mass and lymph node were confirmed as primary malignant melanoma. The patient presented with right hemiparesis 40 days after operation. Brain MRI showed 1.5$\times$2.0 cm sized mass lesion on the left parietal lobe. Mass excision was done. However, she expired 8 months later.

• Journal of Veterinary Clinics
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• v.26 no.6
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• pp.612-615
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• 2009

A 10-year-old intact male mixed breed dog was presented with a three-month history of massive oral mass. Physical examination revealed extending mass from the right upper gingiva. No metastasis was found at the time of presentation. Histopathologic examination of biopsied tissue from the oral mass was consistent with a neuroendocrine tumor with generalized epithelioid cells and few spindle cells. There were highly mitoses and no visible melanin granules with H&E staining. Immunohistochemical staining for Melan A was performed on section of tumor and was strongly positive. Diagnosis was made as amelanotic malignant melanoma based on histopathology with Melan A immunohistochemistry. This case study indicates that the Melan A immunohistochemical staining may be valuable to diagnose amelanotic malignant melanoma in dogs.

• Journal of Veterinary Clinics
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• v.20 no.4
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• pp.489-492
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• 2003

A 12-year-old, intact male Labrador Retriever was admitted to the Veterinary Teaching Hospital of Konkuk University for the evaluation of bleeding mass in the oral cavity. The mass was first noted 2 years ago and has been growing up to a size of $5{\times}6$ cm. On complete blood count(CBC), leukocytosis and mild anemia were observed. Pulmonary metastasis was found in the thoracic radiographic examination. Blackish necrotic oral mass at the left mandibular area was diagnosed as a malignant melanoma based on the histopathological examination. Thus hemimadibulectomy and chemotherapy (carboplatin) were performed. The patient eventually died due to severe secondary infection 3 months after the last treatment.

• Korean Journal of Ichthyology
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• v.34 no.2
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• pp.138-143
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• 2022

Based on three specimens (50.6~67.7 mm SL) collected from the southern coastal waters of Jejudo Island, Oxycheilinus bimaculatus was described as the first record from Korea. They were characterized by having two small dark spots behind eye on head and body posterodorsally, a rhomboid caudal fin with elongated central rays and produced uppermost ray as a filament in terminal male, six predorsal scales, and two scale rows on cheek. We proposed a new Korean name, "Du-jeom-gin-ju-dung-i-nol-rae-gi", for the species referring to having two dark spots on head and body.

• Korean Journal Plant Pathology
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• v.12 no.2
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• pp.251-254
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• 1996

1995년 4월, 국내 백합과 채소작물 4개 재배지역에서 흑백썩음균핵병 발생을 조사하였다. 이 병은 마늘에서 최고 85%까지 가장 심하게 발생하였으며, 파에서는 매우 적게 발생하였다. 쪽파와 양파에서는 흑색썩음균핵병이 국내에서는 처음으로 발견되었으며, 발생율은 각각 최고 10%와 30%에 이르렀다. 이 병의 원인균은 배양적 및 형태적 특성에 E라 Sclerotium cepivorum Berk로 동정되었다. 병원성검정 결과, 이 균은 상기한 4종의 백합과 채소작물에 병원성을 나타냈다.

• Korean Journal of Ichthyology
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• v.28 no.3
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• pp.164-174
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• 2016

Tanakius kitaharae and Glyptocephalus stelleri, belonging to the family Pleuronectidae, were very similar in external morphology not only during adult periods, but also during larval periods. In this study, we compared larval development and growth of the two pleuronectids species in detail. Fifty-eight specimens of T. kitaharae larvae and five specimens of G. stelleri larvae were collected from the East Sea, southern Korean Strait, and the adjacent waters of Jeju Island during 2014~2016, and were identified using morphological and molecular markers. Flexion larvae of T. kitaharae (10.23~16.77 mm total length, TL) and G. stelleri (14.33 mm TL) were similar in morphometrics, but can be distinguished by the melanophores in the fin membranes (present in the former vs. absent in the latter), and the melanophores at posterior margin of shoulder girdle (absent in the former vs. present in the latter). Postflexion larvae of T. kitaharae (17.12~24.92 mm TL) and G. stelleri (27.71~32.95 mm TL) differed in the number of melanophores on the mid-lateral caudal region (two in the former vs. five in the latter), and that on the dorsal and anal fin pterygiophores (five or six in the former vs. one row in the latter). Tanakius kitaharae and G. stelleri larvae differed in size at the beginning of metamorphosis. The left eye of T. kitaharae larvae between 23.13~24.92 mm TL reached the dorsal margin of the head while that of G. stelleri larvae between 38.66~42.67 mm TL did not reached yet.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.4
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• pp.307-313
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• 2008

Purpose: Vascular endothelial growth factor (VEGF) and its receptor, fetal liver kinase 1 (Flk-1), play an important role in vascular permeability and tumor angiogenesis. The aim of this study is to evaluate the therapeutic efficacy of $^{131}I$ labeled anti-Flk-1 monoclonal antibody (DC101) on the growth of melanoma tumor, which is known to be very aggressive in vivo. Materials and Methods: Balb/c nude mice were injected subcutaneously with melanoma cells in the right flank. Tumors were allowed to grow up to $200-250\;mm^3$ in volume. Gamma camera imaging and biodistribution studies were performed to identify an uptake of $^{131}I$-DC101 in various organs. Mice with tumor were randomly divided into five groups (10 mice per group) and injected intravenously; control PBS (group 1), $^{131}I$-DC101 $50\;{\mu}g/mouse$ (group 2), non-labeled DC101 $50\;{\mu}g/mouse$ (group 3), $^{131}I$-DC101 $30\;{\mu}g/mouse$ (group 4) and $15\;{\mu}g/mouse$ (group 5) every 3 or 4 days for 20 days. Tumor volume was measured with caliper twice a week. Results: In gamma camera images, the uptake of $^{131}I$-DC101 into tumor and thyroid was increased with time. Biodistribution results showed that the radioactivity of blood and other major organ was gradually decreased with time whereas tumor uptake was increased up to 48 hr and then decreased. After 4th injection of $^{131}I$-DC101, tumor volume of group 2 and 4 was significantly smaller than that group 1. After 5th injection, the tumor volume of group 5 also significantly reduced. Conclusion: These results indicated that delivery of $^{131}I$ to tumor using FlK-1 antibody, DC101, effectively blocks tumor growth in aggressive melanoma xenograft model.

• Korean Journal of Poultry Science
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• v.46 no.3
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• pp.193-204
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• 2019

This study aimed to investigate the changes in production performance of five strains of Korean native chickens (KNCs), which have been collected and established at the National Institute of Animal Science, Korea, since 1992. A total of 38,026 KNCs were tested and survival rate, body weight, age at first egg-laying, hen-housed egg production, and egg weight was analyzed. The mean survival rates of KNCs were $87.9{\pm}0.8%$, but no significant difference in survival rate between strains and in the annual survival rates of KNCs was observed. The average body weight of KNCs was $1,609.7{\pm}21.3g$ at 150 d. The average body weight of KNC-Black was the highest, whereas KNC-White had the lowest weight. A gradual increase in the annual weight change has been observed in almost all strains after 2004. The average age at first egg-laying was $146.9{\pm}1.1d$ in KNCs where KNC-White was the earliest and KNC-Black was the latest. The age at first egg-laying has increased after 2003, but has gradually decreased after 2008. The average hen-housed egg production at 270 d was $77.3{\pm}1.7$ in KNCs, wherein KNC-Yellowish brown was the highest and KNC-Black was the lowest. The average egg weight at 270 d was $51.2{\pm}0.3g$ in KNCs, indicating that KNC-Black was the heaviest, whereas KNC-White was the lightest. A significant increase in annual egg weight has been observed since 2008. To conclude, the appearance and feather colors of KNCs have improved uniformly, and the body weight has also improved slightly since 2002.