• 한국임상수의학회지
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• 제23권3호
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• pp.223-229
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• 2006

세계적으로 canine parvovirus(CPV) 고역가 백신이 사용된 후 CPV 감염이 효과적으로 관리되고 있지만 국내에서는 아직도 CPV 장염의 발생이 계속되고 있다. 본 연구에서는 2003년 6월부터 2005년 5월까지 CPV 장염으로 확진된 140두를 대상으로 CPV 장염의 역학적 조사와 CPV 장염에 이환된 환축의 생존에 영향을 미치는 역학적 요인들에 대하여 조사하였다. CPV 장염은 6-18주령의 예방접종을 실시하지 않았거나 불완전하게 실시한 개체에서 주로 발생하였다. CPV 장염에 이환된 개 중 암컷의 생존율이 숫컷보다 높았으며, 나이가 많을수록 생존율이 높았다(p<0.05). 그리고 HI 항체가가 낮을수록 폐사율이 높게 나타났다(p<0.05). 주요 임상증상으로 설사, 구토, 기면과 탈수증상이 대부분의 환축에서 나타났다. 최근 국내에서 발생하는 CPV 장염은 CPV에 대한 예방접종의 실패와 CPV 백신에 대한 면역반응이 부적당한 것에 기인하는 것으로 생각되므로 면역이 완전히 형성되기 전의 어린 개들은 CPV에 오염된 환경에 노출되지 않도록 예방관리 하는 것이 중요하다.

• 대한수의학회지
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• 제34권3호
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• pp.537-547
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• 1994

Ninety seven cases of histopathologically diagnosed spontaneous canine parvovirus enteritis(CPE) were studied gross pathologically, histopathologically, immunohistochemically, to investigate histopathological types of small intestinal lesions, and antigen distributions in each pattern related to the infected age. And also, reliability of histopathological method in diagnosis of CPE was inspected with immunohistochemistry. The results were as follows : 1. Age-related occurring ratio in histopathologically diagnosed CPE was 53.6% in 4-8 weeks, 26.8% in 9-15 weeks, 8.25 in 16-19 weeks and 11.3% in 20-45 weeks of the clog age. 2. In histopathologic classification based on patterns of villi/crypts lesions of small intestine(jejunum), the ratio of A type (initial phase of necrosis of crypt epithelia, desquamated epithelial cells in the dilated lumen of the crypt) was 20.6%; the ratio of B type(middle phase of atrophy and fission of the villi, collapse of the mucosa, loss of normal crypt structure) was 62.9%, and C type(regenerative phase of the crypt architecture) was 16.5%. 3. The ratio of A, B, C type in 4-8 weeks old, respectively, was 23.5%, 61.5%, 15.4%; in 9-15 weeks old was 19.2%, 65.4%, 15.3% in 16-19 weeks old was 25.0%, 75.0%, 0.0%; and in 20-45 weeks old was 9.0%, 54.5%, 36.4%. 4. The antigen distribution in the nuclei of the crypt epithelial cells was higher than of the cytoplasm and numerous desquamated epithelial cells in dialated crypts in A type; The antigen cytoplasm and numerous desquamated epithelial cells in dialated crypts in A type; The antigen distribution in the nuclei of the collapsed crypt epithelial cells was not higher than that of the cytoplasm, crypts were lined by and filled with released viral antigens from the destructed epithelial cells in B type; and its distribution was also higher than in the epithelial cells adjacent to the tips of the villi, but it was not reacted in the regenerative crypt epithelial cells in C type. 5. Immunohistochemically detected antigen ratio in the small intestine of histopathologically diagnosed CPE was 94.6%, and this result indicates that histopathological diagnosis is very reliable method in diagnosis of CPE.