• Journal of Pharmaceutical Investigation
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• v.9 no.4
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• pp.8-12
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• 1979

A study on the effects of the root components of Angelica koreana Max. on voluntary activity in mice has confirmed that: 1. MeOH soluble Ex., MeOH insoluble Ex., oxypucedanine and isoimperatorin were antagonized against the voluntary activity in mice pretreated with a dose of C.N.B. 30mg/kg. 2. MeOH insoluble Ex. showed higher depressant effect than MeOH soluble Ex.. 3. the depressant activity of oxypucedanine was significantly more effective than that of isoimperatorin.

• Environmental Analysis Health and Toxicology
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• v.20 no.2 s.49
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• pp.161-165
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• 2005

The present study was carried out to find the possible protective effects of Angelica koreana water extract on biochemical parameters in benzo(a)pyrene (B(a)P)-induced liver injury in rats. B(a)P treatment (0.1 mg/kg, 1.p.) caused a liver damages, which led to biochemical alterations in serum and liver enzyme activities and serum lipid levels. The activities of liver marker enzymes, especially, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were markedly changed in B(a)P treatment. Oral administration of Angelica koreana (50 mg/kg) recovered these biochemical Parameters to near normal levels. Therefore, the present results have revealed that Angelica koreana water extract might have the antihepatotoxic effect and consequently ameliorate liver damage associated with B(a)P in rats.

• The Hankook-Saengyark Bo
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• no.265
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• pp.1-8
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• 2006

고품질 약재 생산관리체계 구축 약용작물 자조금조성사업 추진/GAP는 국산약재 차별화 방안/2007년부터 국산한약재도 정밀검사 실시/완도군, '약산 생약초 테마파크' 조성/잔류농약허용기준 37종 추가 신설/당귀 강활등 국산약재 생산량 감소로 상보합세 유통실명제 영향 산지에서 국산 '가수요' 늘어/중국약재 시장동향/집중분석-약용작물 GAP 문제점과 과제//GAP 약용작물 취급 판매하려면 반드시 생산이력추적관리 등록해야/우수농산물 인증 및 관리절차/천연물 의약품 시장 무궁한 발전 가능성 분야/전북농기원 오미자 음료 개발/국내 자생식물 '매초향' 에서 동맥경화 억제 천연물질 개발/신령버섯 봉지재배법 나왔다/무성번식 삽목법으로 우량품종 대량증식 보급/협회장 동정/'인삼.약초대전' 이모저모/약초이야기/국산한약재-소매시세표

• Korean Journal of Pharmacognosy
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• v.7 no.1
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• pp.25-33
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• 1976

Ostericum praeteritum $K_{ITAGAWA}(=Angelica\;koreana\;M_{AXIM}.)$ has been regarded as the original plant of Korean Qianghuo. The morphological and anatomical examination were made on Korean Qianghuo (crude drug fruits, purchased at markets and cultivated), and compared with Gangwhal $(O.\;praeteritum\;K_{ITAG}.)$. It was found that 3 species $A.\; polymorpha\;M_{AXIM}.,O.\;grosseserratum\;K_{ITAG}.,\;and\;O.\;sieboldi \;N_{AKAI}$. were different from Gangwhal. The original plant of Korean Qianghuo was identified as $A.\;polymorpha\;M_{AXIM}$, through this study.

• Korean Journal of Pharmacognosy
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• v.51 no.3
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• pp.158-162
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• 2020

Three coumarins, one chromone, and a phytosterol were isolated from the stem of Ostericum koreanum. Basis on the spectral data, we determined to be the structures of isolated compounds as bergapten, xanthotoxin, auraptenol, hamaudol, and mixture of phytosterols. Auraptenol was isolated for the first time from this plant.

• Korean Journal of Pharmacognosy
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• v.22 no.3
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• pp.156-161
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• 1991

Four furocoumarins and two dihydrofuranocoumarin glycosides have been isolated from the benzene-soluble and butanol-soluble portions of the roots of Ostericum koreanum Kitagawa, respectively. Four furocoumarins have been determined as imperatorin, isoimperatorin, oxypeucedanin and oxypeucedanin hydrate, and two dihydrofuranocoumarin glycosides determined as marmesinin and $4'-O-{\beta}-D-glucopyranosyl-3'-hydroxymarmesin$ on the basis of spectral data and physico-chemical evidence.

• YAKHAK HOEJI
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• v.12 no.3_4
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• pp.59-64
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• 1968

Silica gel column chromatography of the ether extract of the root of Angelica Koreana $M_{AXIMOWICZ}$ (Umbelliferae) gave five kinds of crystalline products of coumarin. The following kinds of furocoumarins were identified by UV, IR, NMR spectra and physico-chemical tests. iso-imperatorin m.p. 108-$109^{\circ}$ $C_{16}H_{14}O_{4}$ oxypeucedanin m.p. 142-$143^{\circ}$ $C_{16}H_{14}O_{5}$ prangolarine m.p. 104-$105^{\circ}$ $C_{16}H_{14}O_{5}$ imperatorin m.p. 100-$101^{\circ}$ $C_{16}H_{14}O_{4}$ These analyses also showed that white needles m.p. 129-$130^{\circ}$ were likely to be a furocoumarin. Besides, the methanol extract of the root was found to contain sucrose.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.5
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• pp.619-622
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• 2005

To evaluate the preventive effects of methanolic extract of Angelica koreana(MEAK), this extract was given to rats orally at various doses of 10, 50 and 100 mg/kg before hepatotoxicant, benzo$(\alpha)pyrene$ treatment The increased serum enzyme levels of aspartate aminotransferase (AST), alanine aminotransferase(ALT) and alkaline phosphatase(ALP) by benzo$(\alpha)pyrene$ induction were significantly lowered in a dose dependent manner after pretreatment with MEAK. Furthermore, MEAK also decreased the elevated lipid levels after benzo$(\alpha)pyrene$ administration. These results revealed that MEAK could afford a significant protective action in the alleviation of benzoBenzo$(\alpha)pyrene$ induced hepatocellular injury.

• Korean Journal of Medicinal Crop Science
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• v.4 no.2
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• pp.101-108
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• 1996

This study was conducted to investigate the effect of growth regulators and $GeO_2$ on the induction and proliferation of callus and the effect of $GeO_2$ and citric acid on the Ge content of callus from explants and plant, Angelica koreana Max. The results obtained were summarized as follows. The callus induction was most effective on MS (Murashige and Skoog) medium containing 1. 0ppm 2, 4 - D with petiolule. The proliferation of callus was most effective at 2. 0ppm 2, 4 - D on the medium, at 2. 5ppm $GeO_2$ on the medium containing 2. 0ppm 2, 4 - D, and at $0.\;1{\sim}1mM$citric acid on the medium at pH6 containing 2. 0ppm 2, 4 - D and 2. 5ppm $GeO_2.$ The more $GeO_2$ in MS medium up to 20ppm, the more Ge content in callus. Ge content in callus was highest when the medium was supplemented with 0. 1mM citric acid and the pH of medium was low. The Ge content in plant was high in order of leaf > root > stem. Application $GeO_2$ to the soil increased Ge content in plant and application of 1mM citric acid with $GeO_2$ resulted in increasing Ge content highest in plant, but application more than l0mM citric acid resulted in Ge content decreased. Application of $GeO_2$ increased Ge content in callus and plant but had a tendency to decrease some mineral content, on the other hand application of $0.\;1{\sim}1mM$ citric acid with $GeO_2$ had a tendency to increase mineral content.

• Korean Journal of Plant Tissue Culture
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• v.25 no.1
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• pp.51-56
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• 1998

This study was carried out in order to establish plant regeneration via somatic embryogenesis from leaf explant of Ostericum koreanum Kitagawa and to elucidate the effects of NAA and cytokinins (kinetin, BA) on the abnormalities of somatic embryo and the relationship between thecotyledon numberand germinability. Calli were formed on leaf explants cultured on MS agar medium supplemented with various concentrations (0, 0.1, 0.5, 1, 2 mg/L) of NAA and cytokinins. The calli were white, watery and soft, became browning during cultures. Somatic embryos were formed from pale yellowish calli derived browning calli. High frequency somatic embryos were observed on MS medium containing 1 mg/L NAA and 0.1 mg/L BA after 60 days of culture. The mature somatic embryos germinated into plantlets without subculture after 2 weeks. The frequency of normal somatic embryo with two cotyledons was 39.8%. On the other hand, cotyledonary abnormalities of somatic embryos were observed at considerable frequency: 33.6% of somatic embryo with one cotyledon, 15.3% cotyledons with three, 8.2% four cotyledons and 3.1% jar shaped cotyledon. Germination frequency of somatic embryos with two cotyledons was 97.4%, and that of the embryos with abnormal cotyledon was almost similar to that of embryos with two cotyledons, except jar shaped somatic embryos (33.3%).