• Clinical and Experimental Pediatrics
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• v.46 no.12
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• pp.1260-1265
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• 2003

Purpose : In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs. one DI phase for intermediate risk patients. Methods : One hundred and thirty nine children with ALL who were treated at the Department of Pediatrics of Wonju Christian Hospital and Yonsei University Medical Center between March, 1990 and July, 2002 were analysed retrospectively. Results : Thirty-eight patients were treated with a DI phase, and 101 patients were treated without a DI phase. Among the DI patients, seven patients were treated with a double DI phase. Five-year overall survival(OS) in the low, intermediate, and high risk groups were 68%, 66% and 58%, respectively. 5-year OS in DDI, DI, and control were 95%, 86% and 40%, respectively. In the low risk group, 5-year event free survival(EFS) in DI, and control were 94% and 58%, respectively. Conclusion : Delayed intensification improved EFS on childhood ALL in all risk groups.

• 산림경영
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• s.188
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• pp.42-45
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• 2008

시간이 갈수록 환경과 먹을거리가 오염되고 있는 현실을 감안할 때, 우리 몸은 독소로부터 무방비 상태에 놓여 있다고 해도 과언이 아니다. 인체에 유해한 독소를 빼냄으로써 자연치유력을 강화시킨다는 해독(Detox)요법이 새롭게 각광받는 이유다. 해독 요법에 대한 모든 궁금증을 풀어본다.

• The Monthly Diabetes
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• s.38
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• pp.48-52
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• 1993

• The Monthly Diabetes
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• s.196
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• pp.28-32
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• 2006

• Proceedings of the Korean Society of Dyers and Finishers Conference
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• 2012.03a
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• pp.96-96
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• 2012

최근 주 5일제 근무 실행과 사회복지의 확산, 여가 선용에 대한 욕구와 더불어 건강증진에 대한 싸이클이 주목을 받고 있음. 싸이클웨어(Cycle Wear)에 요구되는 개발요소는 경기력 향상을 위한 기능적 요소와 패션성을 부여하는 심미적 요소로 크게 구분 가능하며 해외에서는 기능성과 패션성이 적절하게 조화를 이룬 제품을 계속 출시되고 있음. 본 연구에서는 운동 시 발생하는 열을 흡한속건 기능으로 효과적으로 발산하고 동절기에는 보온 기능을 갖는 세섬도 하이멀티 OY형 이형단면사 및 잠재권축사를 이용한 고신축 환편 및 경편물 개발하고, 극한환경에서도 고견뢰도를 유지할 수 있는 섬유의 염색법 및 기능성 발현 가공법의 적용, 내마모성과 필링이 우수한 아라미드+나일론 복합가공사 신축직물 제직 및 염색가공 공정 개발을 통해 기능성을 발현할 수 있는 싸이클 웨어 원단을 개발하였음. 또한 종래 Compression Wear에만 적용하던 테이핑 요법을 응용한 근력강화형 싸이클웨어 패턴과 디자인 개발을 통해 다양한 형태의 근력강화형 싸이클웨어를 개발하였으며, 무산소파워, 유산소파워, 젖산분석, EMG 분석 및 에너지 대사분석 등의 운동능력 성능평가를 통해 테이핑 요법이 적용된 싸이클웨어의 근력강화 효과를 확인하였음. 이와 같이 개발된 싸이클웨어는 무산소파워, 유산소파워, EMG 분석에서 각각 근력강화 효과를 보였으며, 피로물질인 젖산의 경우는 발생의 정도가 낮게 나타났음. 또한 여성에 비해 남성의 근력강화 효과가 크게 나타나는 경향을 보였음.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.1
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• pp.71-75
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• 2001

백혈병은 조혈계통의 악성 증식성 질환으로서 현재까지 주로 화학약물요법에 의존하고 있는 실정이다. 화학약물요법은 백혈병 세포를 소멸시킬 수 있지만 또한 인체에 여러 가지 독성 반응 및 부작용을 일으키기도 한다. 따라서 중서의결합으로 백혈병 치료에 접근하는 것은 중요한 의미를 갖는다. 중의학에서 소아 백혈병을 치료하는 경우 청열해독법(淸熱解毒法), 부정보허법(扶正補虛法), 활혈화어법(活血化瘀法)을 주로 사용한다. 청열해독법은 백혈병의 조기치료에 주로 활용되는데, 인체의 저항력을 증강시켜 화학약물요법을 실시하는 동안 흔히 나타날 수 있는 감염증상을 예방하는 효과를 얻을 수 있다. 부정보허법(扶正補虛法)은 주로 화학약물요법의 유도 완화기 및 치료효과의 유지를 위하여 활용되는데, 이는 인체의 면역력을 향상시켜 화학약물요법이 인체에 미치는 손상을 경감시킬 수 있다. 활혈화어법(活血化瘀法)은 미세순환을 개선시키는 작용을 하며 골수의 조혈기능을 촉진하고 면역기능을 조절하며 또한 일부 활혈화어제(活血化瘀劑)는 백혈병 세포에 직접적인 억제효과를 보인다. 소아백혈병에 대하여 화학약물요법을 진행하는 동안 중약을 같이 병행하는 경우 다음과 같은 과정으로 나누어 실시할 수 있다. 1. 유도완화치료(화학요법)단계: 이와 같은 치료과정은 대개 화학약물요법으로 인한 극심한 독성반응이나 주작용을 나타내게 되는데, 이 과정에서 중약치료를 병행하면 신속하게 증상을 개선시킬 수 있다. 만약 구토나 설사와 같은 소화계 부작용이 나타나면 화위강역법(和胃降逆法)을 활용하고, 감염 증상이 나타나면 부정(扶正)과 거사법(祛邪法)을 병행할 수 있다. 화학약물요법을 진행한 후 신체가 극도로 허약해지고 골수의 기능이 심하게 억제되는 경우는 주로 부정(扶正)시키는 중약을 사용하면서 익기양혈제(益氣養血劑)를 곁들이고 보조적으로 단삼(丹蔘), 당귀(當歸), 천궁(川芎), 계혈등(鷄血藤) 등과 같은 활혈화어제(活血化瘀劑)를 사용하여 골수의 조혈기능을 회복시킨다. 2. 치료효과의 유지단계: 본 과정에서는 중약치료에 있어서 부정(扶正)과 거사법(祛邪法)을 병행한다. 화학약물요법을 실시하는 동시에 거사제(祛邪劑)를 중용(重用)함으로써 화학약물요법의 효과를 강화시킨다. 화학약물요법이 끝난 뒤 부정(扶正)시키는 약물을 중용(重用)하여 인체의 면역기능을 증강시키고 백혈병세포를 억제시킨다. 3. 치료효과의 유지 및 강화단계: 치료효과의 유지단계에서는 변증논치(辨證論治)의 원칙에 입각하여 항암효과가 있는 중약을 활용할 수 있는데, 예를 들어 백화사설초(白花蛇舌草), 산자고(山慈?), 청대(靑黛), 용규(龍葵) 등을 사용할 수 있고, 육신환(六神丸)을 장기적으로 복용하여도 된다. 소아백혈병 치료에 있어서 중서의결합의 치료법을 활용하는 경우 다음과 같은 내용에 주안점을 둘 수 있다. 화학약물요법을 진행하는 과정에서 중약을 병행하여 투여하는 경우 사진합삼(四診合參)을 근간으로 종합적인 분석을 통하여 병인(病因)을 살피어 치료에 임하도록 한다. 약물의 선택과 처방의 구성은 반드시 변증논치(辨證論治)의 원칙하에 이루어져야 한다. 화학약물요법과 중약치료를 병행하는 과정에서 변증(辨證)과 변병(辨病)이 서로 결합되고 부정(扶正)과 거사법(祛邪法)을 병행하여 활용한다. 정체관(整體觀)에서 출발하여 환자를 관찰하는 동시에 특징적인 증후(證候)에 대한 변증논치(辨證論治)도 중요하며, 또한 백혈병 환자의 유형(類型)이나 임상 혈액검사 소견, 골수의 양상, 화학요법의 진행단계 및 환자의 연령과 체질 등을 충분히 가만하여 종합적인 분석을 토대로 치료법을 선택하여야 중약요법과 화학약물요법의 협동적인 효과를 증폭시키고 백혈병치료에 새로운 전기를 마련할 수 있을 것이다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.05a
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• pp.730-732
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• 2017

While the short term effect of diet and exercise therapy has been proven, there has still been a problem of its long term effect. So, researchers has utilized behaviour modification therapy. It is expected to lead to natural weight loss by modifying wrong dietary life patterns and practices. However, this approach has turned out to be a more effective method for weight maintenance than loss of weight. In spite of its strength, as a matter of fact, persistent and continuous effort for weight management has not worked properly. This study proposes an artificial intelligence approach with the advantages of behaviour modification therapy, overcoming current approaches which is goal-driven and too uniform. For this, we plan to develop a health management program in which users get the messages that are customized for themselves according to different situations so that it can promotes persistent effort for exercise. Here, customized messages are handled by AI techniques, which eventually promotes soft persuasion, encouragement, and motivation.

• Journal of East-West Nursing Research
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• v.10 no.1
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• pp.53-60
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• 2004

The purpose of this study was to examine the effects of the short term education and reinforcement program to health promotion in women in mid-life. This study has been done between February and April, 2004 and the subjects of the study were 26 women in mid-life. The treatment intervention was applied during total 8 weeks as 5 days for the short term education and 7 weeks for reinforcement with 1 time per a week. The short term education included health education for menopause, effect of exercise, healthy diet, management of stress and management of chronic illness and stretching exercise and recreation. The collected data were processed using the SPSS Win(12.0) program and analyzed using Wilcoxon Signed Ranks Test. The result of this study are as follows : 1. The short term education and reinforcement program significantly effected on the total cholesterol, HDL-cholesterol, triglyceride. 2. The short term education and reinforcement program significantly effected on the anxiety, but not depression. 3. The short term education and reinforcement program non significantly effected on the sleep disturbance and self-efficacy of exercise. 4. The short term education and reinforcement program significantly effected on the practice of healthy life. In conclusion, the short term education and reinforcement program effected on the physical health index, anxiety and practice of healthy life.

• Journal of East-West Nursing Research
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• v.19 no.2
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• pp.63-70
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• 2013

Purpose: The purpose of this study was to determine the effects of the hand acupressure and lumbar strengthening exercise on young adult women with back pain. Methods: The study used a nonequivalent control group pretest-posttest design. The subjects consisted of 37 female young adults (19 persons in the experimental group and 18 persons in the control group). The hand acupressure and strengthening exercise for lower back were developed by the investigator and a hand acupressure expert. The experimental group was exposed to this program 5 days a week for 4 weeks. The visual analog scale, back muscle strength, flexibility, and quality of life were used as measurement instruments. The data were analyzed with frequency, t-test, and repeated measures ANOVA using SPSS 18.0. Results: In this study, the hand acupressure and strengthening exercise showed siginificant effects on the back muscle strength, flexibility, and quality of life in the experimental group compared to the control group. However, back pain score was not significantly decreased after the program. Conclusion: The study suggests that this program can be applied for the women with low back pain in order to enhance the back muscle strength, flexibility, and quality of life.

• Radiation Oncology Journal
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• v.19 no.3
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• pp.237-244
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• 2001

Purpose : To assess the tolerance, complete response rate, bladder preservation rate and survival rate in patients with muscle-invading bladder cancer treated with selective bladder preservation protocol. Method and Materials : From October 1990 to June 1998, twenty six patients with muscle-invading bladder cancer (clinical stage T2-4, N0-3, M0) were enrolled for the treatment protocol of bladder preservation. They were treated with maximal TURBT (transurethral resection of bladder tumor) and 2 cycles of MCV chemotherapy (methotrexate, crisplatin, and vinblastine) followed by $39.6\~45\;Gy$ pelvic irradiation with concomitant cisplatin. After complete urologic evaluation (biopsy or cytology), the patients who achieved complete response were planed for bladder preservation treatment and treated with consolidation cisplatin and radiotherapy (19.8 Gy). The patients who had incomplete response were planed to immediate radical cystectomy. If they refused radical cystectomy, they were treated either with TURBT followed by MCV or cisplatin chemotherapy and radiotherapy. The median follow-up duration is 49.5 months. Results : The Patients with stage T2-3a and T3b-4a underwent complete removal of tumor or gross tumor removal by TURBT, respectively. Twenty one out of 26 patients $(81\%)$ successfully completed the protocol of the planned chemo-radiotherapy. Seven patients had documented complete response. Six of them were treated with additional consolidation cisplatin and radiotherapy. One patient was treated with 2 cycles of MCV chemotherapy due to refusal of chemo-radiotherapy. Five of 7 complete responders had functioning tumor-free bladder. Fourteen patients of incomplete responders were further treated with one of the followings : radical cystectomy (1 patient), or TURBT and 2 cycles of MCV chemotherapy (3 patients), or cisplatin and radiotherapy (10 patients). Thirteen patients of them were not treated with planned radical cystectomy due to patients' refusal (9 patients) or underlying medical problems (4 patients). Among twenty one patients, 12 patients $(58\%)$ were alive with their preserved bladder, 8 patients died with the disease, 1 patient died of intercurrent disease. The 5 years actuarial survival rates according to CR and PR after MCV chemotherapy and cisplatin chemoradiotherapy were $80\%\;and\;14\%$, respectively (u=0.001). Conclusion : In selected patients with muscle-invading bladder cancer, the bladder preservation could be achieved by MCV chemotherapy and cisplatin chemo-radiotherapy. All patients tolerated well this bladder preservation protoco. The availability of complete TURBT and the responsibility of neoadjuvant chemotherapy and chemoradiotherapy were important predictors for bladder preservation and survival. The patients who had not achieved complete response after neoadjuvant chemotherapy and chemoradiotherapy should be immediate radical cystectomy. A randomized prospective trial might be essential to determine more accurate indications between cystectomy or bladder preservation.