• Tuberculosis and Respiratory Diseases
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• v.44 no.6
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• pp.1245-1255
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• 1997

Background : Rifampicin(RFP) is a key component of the antituberculous short-course chemotherapy and the RFP resistance is a marker of multi-drug resistant(MDR) tuberculosis. RPoB gene encodes the $\beta$-subunit of RNA polymerase of M. tuberculosis which is the target of RFP. And rpoB gene mutations are the cause of RFP resistance of M. tuberculosis. Although several reports showed that PCR-SSCP would be a rapid diagnostic method for identifying the RFP resistance, there were few reports Performed using direct, clinical specimens. So we Performed PCR-SSCP analysis of rpoB gene of M. tuberculosis in direct, clinical specimens. Methods : 75 clinical specimens were collected from patients at Asan Medical Center from June to August 1996. After PCR of IS 6110 fragments, 43 both AFB smear-positive and IS6110 fragment PCR-positive specimens were evaluated. The RFP susceptibility test was referred to the referral laboratory of the Korean Tuberculosis Institute. DNA was extracted by bead beater method. And heminested PCR was done using 0.1ul(1uCi) [$\alpha-^{32}P$]-dCTP. SSCP analysis was done using non-denaturating MDE gel electrophoresis. Results : The results of PCR of IS6110 fragments of M. tuberculosis were positive in 55(73%) cases of 75 AFB smear-positive clinical specimens. Of the 55 specimens, RFP susceptibility was confirmed in only 43 specimens. Of the 43 AFB smear-positive and IS6110 fragment-positive specimens, 29 were RFP susceptible and 14 were RFP resistant. All the RFP susceptible 29 strains showed the same mobility compared with that of RFP sensitive H37Rv in SSCP analysis of ropB gene. And all the other RFP resistant 13 strains showed the different mobility. In other words they showed 100% identical results between PCR-SSCP analysis and traditional susceptibility test. Conclusion : The PCR-sseP analysis of rpoB gene in direct clinical specimens could be used as a rapid diagnostic method for detecting RFP resistant M. tuberculosis.

• Tuberculosis and Respiratory Diseases
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• v.49 no.6
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• pp.676-683
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• 2000

Background : Surgery may have a role when medical treatment alone is not successful in patients with multidrug resistant (MDR) pulmonary tuberculosis (PTB). To document the role of resection in MDR PTB, we analyzed 4 years of our experience. Methods : A retrospective review was performed on thirteen patients that underwent pulmonary resection for MDR PTB between May 1996 and February 2000. All patients had organisms resistant to many of the first-line drugs including isoniazid (INH) and rifampicin (RFP). Results : The thirteen patients were $37.5{\pm}12.4$ years old (mean${\pm}$S.D.)(M : F=5:8), and their sputum was culture positive even with adequate medication for prolonged periods ($109.7{\pm}132.0$ months), resistant to 2-8 drugs including isoniazid and rifampin. All patients had localized lesion(s) and most (92.3%) had cavities. At least 3 sensitive anti-TB medications were started before surgery in all patients according to the drug sensitivity test. The preoperative $FEV_1$ was $2.37{\pm}0.83$ L. Lobectomy was performed in 11 patients and pleuropneumonectomy in two. Postoperative mortality did not occur, but pneumonia occurred as a complication in one (7.7%). After $41.5{\pm}58.9$ days (range 1~150 days) follow up, negative conversion of sputum culture was achieved in all patients within 5 months. Only one patient (7.7%) recurred 32 months after lung resection. Conclusion : When medical treatment alone is not successful, surgical resection can be a good treatment option in patients with localized MDR PTB.

• Korean Journal of Agricultural and Forest Meteorology
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• v.16 no.1
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• pp.39-50
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• 2014

This paper reviews the results of recent observations in the Yeonsuri valley of Mt. Youngmun during springtime (March to May) in 2012. Automated weather stations were installed at twelve sites in the valley to measure temperature and 2, 3 dimensional wind. We examined temporal and spatial characteristics of temperatures and wind data. The Yeonsuri valley springtime average temperature lapse rate between the top and bottom of the entire period is $-0.44^{\circ}C/100$ m. It can be changed by the synoptic weather conditions, the lapse rates is greatest in order of clear days ($-0.48^{\circ}C/100$ m), rainy ($-0.41^{\circ}C/100$ m) and cloudy days ($-0.40^{\circ}C/100$ m). In the night, the temperature inversion layer (thermal belt) and the cold pool are formed within the valley. In addition, we measured temperature and wind distribution from the bottom to 3.5 m, the cold layers existed up to 1.5 m, which were affected by ground mixed layer. The results will provide useful guidance on agricultural practices as well as model simulations.

• Journal of the Korean association of regional geographers
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• v.4 no.1
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• pp.43-56
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• 1998

The purpose of this study is to identify distributional characteristics of climatic elements and to analyze synoptic characteristics on the pressure fields for spring droughts in Korea. In the distributions of minimum temperature during the spring droughts, positive anomalies and negative anomalies are mixed up, but in March the negative anomaly areas are widely distributed in Korea. It implies that the droughts of March have more frequent occurrences of the west-high, east-low pressure patterns. In the maximum air temperatures, the positive anomalies appear in Korea. It indicates that the spring droughts have rain days, cloud amount and humidities less than normal. As a result, the amount of evaporation is increased in Korea. In the pressure anomaly of surface pressure fields, the positive anomalies appear in the west, negative anomalies in the east in March, but in May the positive anomalies appeared zonally around the Korean peninsula. It indicates that March droughts have more frequent occurrences of the west-high. east-low patterns, but in May the Korean Peninsula has more frequent recurrences of the migratory anticyclone patterns. The height anomaly patterns of 500hPa pressure surface in spring droughts are similarly shown to those of surface fields. In March droughts, the positive height anomalies appear in the west, the negative height anomalies in the east, but in April the negative height anomaly areas are extended to the west part. In May the positive anomalies appear zonally around the Korean Peninsula, and strong positive height anomalies appear around the Kamchatka Peninsula and the sea of Okhotsk. These are the result of circulations that inhibit the eastward movement of westerlies and that has persistent anticyclone circulation patterns around the Korean Peninsula. As a result, the zonal indices of westerlies during March and April droughts are lower than normal, but higher in May. These data indicate that early spring droughts are associated with weak zonal flow, but the late spring droughts are obviously related with strong zonal flow. In addition, during early spring droughts the abnormally deep trough over the west coast of the North Pacific Ocean that accompanied the anticyclone was associated with frequent advection of air from the dry regions in the Central Asia into the Korean Peninsula. The atmospheric circulation patterns at the height of the 500hPa pressure surface in May was quite different from March and April circulation patterns. Instead of the abnormal ridge in the west and trough in the east, the circulation pattern in May was characterized by a much stronger than normal anticyclone over the Korean Peninsula. Also, the zonal indices of westerlies in May are higher than normal. The occurrences of drought in early spring, therefore, have mechanism different from those of late spring.

• Journal of the Korean Society of Radiology
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• v.4 no.1
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• pp.5-9
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• 2010

In recent, a digital x-ray detector attracted worldwide attention and there are many studies to commercialize. There are two methods in digital x-ray detector. This method is an Indirect method and Direct method. This study is to see the differences between the digital x-ray detector based on a-Se used in the existing indirect conversion method and an x-ray conversion material that has better SNR(Signal-to-noise ratio) and property than the a-Se. To solve the problem that is difficult to make a large area film using Screen-Print method, we used a Screen-Print method. In this study, we used a polyclystal $HgI_2$ as x-ray conversion material and a sample thickness is $150{\mu}m$ and an area is $3cm{\times}3cm$. ITO(Indium-Tin-Oxide) electrode was used as top electrode using a Magnetron Sputtering System and each area is $3cm{\times}3cm$, $2cm{\times}2cm$ and $1cm{\times}1cm$ and then we evaluated darkcurrent, sensitivity and SNR of the $HgI_2$ film are measured, then we evaluated the electrical properties. And we used a current integration mode when I-V test. This experiment shows that the sensitivity increases in accordance with the area of the electrode but the SNR is decreased because of the high darkcurrent. Through fabricating of various thicknesses and optimal electrodes, we will optimize SNR in the future work.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.5
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• pp.787-795
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• 2001

For the developing natural fisheries flavoring substances using crustacea, the flavor constituents of enzyme hydrolysates from shore swimming crab (crab) and spotted shrimp (shrimp) were investigated. In taste-active compounds of both enzyme hydrolysates, total free amino acid contents of crab and shrimp enzyme hydrolysates were 5,226.7 mg% and 8,757.3 mg%, respectively. The major amino acids were taurine, glutamic acid, proline, asparagine, glycine, alanine, valine, leucine, lysine anserine and arginine. As for ATP related compounds, AMP was the principal component and small amounts of IMP was detected in both enzyme hydrolysates. In the quarternary ammonium bases, betaine was the principal component (593.8mg%), and contents of TMAO and betaine in both samples were 60.7 mg% and 850.0 mg%, 124.1 mg% and 755.9 mg%, respectively. The major components were Na, K, P and Cl in inorganic ions. The major fatty acids of both sample were 14 : 0, 16 : 0, 16 : 1n7, 18 : 1n9, 20 : 5n3 and 22 : 6n3, and composition ration of n3 polyunsaturated fatty acids of were 27.8% and 28.5%, respectively. Total 99~109 volatile compounds were detected as a cooked odor of crab and shrimp enzyme hydrolysates by SDE apparatus/gas chromatography/mass spectrometry. The volatile flavor compounds identified from cooked crab enzyme hydrolysate were composed of 6 acids, 10 alcohols, 7 aldehydes, 11 ketones, 1 ester, 5 phenols, 4 benzenes, 22 hydrocarbons, 1 furan, 21 nitrogen containing compounds and 11 micellaneous compounds. And the volatile flavor compounds indentified from cooked shrimp enzyme hydrolysate were composed of 13 acids, 10 alcohols, 6 aldehydes, 10 ketones, 3 esters, 2 phenols, 5 benzenes, 36 hydrocarbons, 1 furan, 14 nitrogen containing compounds and 8 micellaneous compounds.

• Korean Journal of Agricultural and Forest Meteorology
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• v.21 no.2
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• pp.85-96
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• 2019

Solar radiation is an important variable for estimation of energy balance and water cycle in natural and agricultural ecosystems. A deep neural network (DNN) model has been developed in order to estimate the daily global solar radiation. Temperature and precipitation, which would have wider availability from weather stations than other variables such as sunshine duration, were used as inputs to the DNN model. Five-fold cross-validation was applied to train and test the DNN models. Meteorological data at 15 weather stations were collected for a long term period, e.g., > 30 years in Korea. The DNN model obtained from the cross-validation had relatively small value of RMSE ($3.75MJ\;m^{-2}\;d^{-1}$) for estimates of the daily solar radiation at the weather station in Suwon. The DNN model explained about 68% of variation in observed solar radiation at the Suwon weather station. It was found that the measurements of solar radiation in 1985 and 1998 were considerably low for a small period of time compared with sunshine duration. This suggested that assessment of the quality for the observation data for solar radiation would be needed in further studies. When data for those years were excluded from the data analysis, the DNN model had slightly greater degree of agreement statistics. For example, the values of $R^2$ and RMSE were 0.72 and $3.55MJ\;m^{-2}\;d^{-1}$, respectively. Our results indicate that a DNN would be useful for the development a solar radiation estimation model using temperature and precipitation, which are usually available for downscaled scenario data for future climate conditions. Thus, such a DNN model would be useful for the impact assessment of climate change on crop production where solar radiation is used as a required input variable to a crop model.

• Korean Journal of Agricultural and Forest Meteorology
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• v.24 no.1
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• pp.13-34
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• 2022

Soil moisture data have been collected at 11 agrometeorological stations operated by The Korea Meteorological Administration (KMA). This study aimed to verify the accuracy of soil moisture data of KMA and develop a correction formula to be applied to improve their quality. The soil of the observation field was sampled to analyze its physical properties that affect soil water content. Soil texture was classified to be sandy loam and loamy sand at most sites. The bulk density of the soil samples was about 1.5 g/cm³ on average. The content of silt and clay was also closely related to bulk density and water holding capacity. The EnviroSCAN model, which was used as a reference sensor, was calibrated using the self-manufactured "reference soil moisture observation system". Comparison between the calibrated reference sensor and the field sensor of KMA was conducted at least three times at each of the 11 sites. Overall, the trend of fluctuations over time in the measured values of the two sensors appeared similar. Still, there were sites where the latter had relatively lower soil moisture values than the former. A linear correction formula was derived for each site and depth using the range and average of the observed data for the given period. This correction formula resulted in an improvement in agreement between sensor values at the Suwon site. In addition, the detailed approach was developed to estimate the correction value for the period in which a correction formula was not calculated. In summary, the correction of soil moisture data at a regular time interval, e.g., twice a year, would be recommended for all observation sites to improve the quality of soil moisture observation data.

• Journal of the Korean earth science society
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• v.43 no.5
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• pp.604-617
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• 2022

Sea surface temperature (SST) is a key variable that can be used to understand ocean-atmosphere phenomena and predict climate change. Satellite microwave remote sensing enables the measurement of SST despite the presence of clouds and precipitation in the sensor path. Therefore, considering the high utilization of microwave SST, it is necessary to continuously verify its accuracy and analyze its error characteristics. In this study, the validation of the microwave global precision measurement (GPM)/GPM microwave imager (GMI) SST around the Northwest Pacific and Korean Peninsula was conducted using surface drifter temperature data for approximately eight years from March 2014 to December 2021. The GMI SST showed a bias of 0.09K and an average root mean square error of 0.97K compared to the actual SST, which was slightly higher than that observed in previous studies. In addition, the error characteristics of the GMI SST were related to environmental factors, such as latitude, distance from the coast, sea wind, and water vapor volume. Errors tended to increase in areas close to coastal areas within 300 km of land and in high-latitude areas. In addition, relatively high errors were found in the range of weak wind speeds (<6 m s^-1) during the day and strong wind speeds (>10 m s^-1) at night. Atmospheric water vapor contributed to high SST differences in very low ranges of <30 mm and in very high ranges of >60 mm. These errors are consistent with those observed in previous studies, in which GMI data were less accurate at low SST and were estimated to be due to differences in land and ocean radiation, wind-induced changes in sea surface roughness, and absorption of water vapor into the microwave atmosphere. These results suggest that the characteristics of the GMI SST differences should be clarified for more extensive use of microwave satellite SST calculations in the seas around the Korean Peninsula, including a part of the Northwest Pacific.

• Korean Journal of Culture and Social Issue
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• v.22 no.4
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• pp.595-622
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• 2016

This study aims to understand the process of family reunion of the ex-offenders. To this end, Korea Rehabilitation Agency under Ministry of Justice and Healthy Family Support Center conducted intensive interviews with ex-offenders, their families and with 8 counselors who are in charge of ex-offenders and their families' residential, psychological, and educational support. The data collected through the interviews were analyzed by Consensus Qualitative Research(COR). The followings are the results: the counselors found out that most of ex-offenders had experienced unhappy childhood which was lack of healthy relationship with their parents. Secondly, counselors noticed a common feature among the families of ex-offenders. The common feature was that they keep the fact that one of their parents was imprisoned to their children as a secret. Thirdly, through the data analysis, counselors could understand various factors that affect reunion of ex-offenders' families: the factors that helped successful reunion were ex-offenders' sense of responsibility, open and healthy communication among family members, and mutual understanding of being a good family member, whereas, irresponsible dependance to other family members, denier and avoidance from the family members against ex-offenders, and lost sense of being a family member were the factors that discouraged the reunion. It turned out that the kinds of crime that ex-offenders committed also affected family reunion. The processes of reunion were easier for those who served their time with fraud, embezzlement, whereas, it was much more challenging for those who served their time with rape, violence, or murder. Fourthly, counselors learned that "relaxation" is the key factor in the process of reunion of ex-offenders' families. They also emphasized that there should be thorough monitoring process before the intervention in the reunion process. This study contributes in terms of finding healthy ways of intervention with ex-offenders' families and developing programs that help ex-offenders to recover their relationship with their family.