• Proceedings of the Korean Society of Applied Pharmacology
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• 1992.05a
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• pp.57-57
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• 1992

Teicoplanin은 actinoplanes teicomyceticus의 발효산물로서 vancomycin과 같은 glycopeptide 계열의 항균제이며, 그 작용기전은 세포벽 합성과정중 peptidoglycan의 중합을 억제하는 것으로 vancomycin과 유사하나 vancomycin과 달리 근육에 주사할 수 있으며 "red man's syndrome"이 생기지 않고 vancomycin보다 반감기가 길다. 그람양성균 감염증에 대한 teicoplanin의 효능 및 안전성을 조사하기 위하여, 그람양성균에 의한 감염증 또는 그람양성균과 그람음성균에 의한 혼합감염증이 확인되거나 의심되었던 환자 46명을 대상으로 teicoplanin과 vancomycin을 투여하였다. 투약 환자중 임상적인 반응을 평가할 수 있는 환자의 수는 vancomycin의 경우 투약환자 22명중 21명, teicoplanin의 경우 24명중 19명이였다. Vancomycin군중 임상적 반응의 평가에서 제외된 1명은 수술 후 흉막강에 MRSA 에 의한 농양으로 투약 29일째에 뇌출혈로 사망하였던 예로, 추적-배양검사에서는 MRSA가 제거 되었다. Teicoplanin군에서는 항균제 투여 중 간경변증에 의한 식도출혈 1예, 수술후 위장관 출혈 1예, 뇌 색전중 1예가 사망하였고, 1예는 Teicoplanin에 의한 심한 피부발진으로, 다른 1예는 봉와직염의 임상진단이 조직검사결과 악성종양의 근육침범으로 밝혀져 투약을 중단하였다.

• Journal of the Korean Child Neurology Society
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• v.26 no.4
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• pp.221-226
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• 2018

Purpose: Febrile seizures (FSs) are the most common type of seizure in the first 5 years of life and are frequently associated with viral infections. Influenza infection is associated with a variety of neurological conditions, including FSs. The purpose of this study was to evaluate the clinical implications of influenza infection in FSs. Methods: In total, 388 children with FS were divided into two groups: FS with influenza infection (n=75) and FSs without influenza infection (n=313). Their medical records, including seizure type, frequency, duration, and familial history of FSs or epilepsy, were retrospectively reviewed and the clinical characteristics of the two groups were compared. Results: In total, 75 of the 388 children (19.3%) had FSs associated with influenza infection; such children were significantly older than those with FSs without influenza infection ($34.9{\pm}22.3$ months vs. $24.4{\pm}14.2$ months; P<0.001). The children who had more than two febrile seizures episodes were more prevalent in children with FS with influenza infection [40/75 (53.3%) vs. 92/313 (29.4%); P<0.01]. Children older than 60 months were more likely to have influenza infection compared to those aged less than 60 months [11/22 (50%) vs. 64/366 (17.5%); P=0.001]. Conclusion: Influenza infection may be associated with FSs in older children, and with recurrence of FSs. Its role in the development of afebrile seizures or subsequent epilepsy requires further investigation with long-term follow-up.

• Pediatric Infection and Vaccine
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• v.16 no.1
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• pp.73-79
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• 2009

Purpose : We undertook this study to improve our understanding of the epidemiologic and clinical features of nonpolioenterovirus (NPEV) infections, especially enterovirus 71 (EV71) infections, in Korean children. Methods : Between April and June 2000, NPEVs were detected by RT-PCR and cultures of specimens obtained from patients with aseptic meningitis, acute respiratory disease, and acute gastroenteritis which were associated with enteroviral exanthem and vesicular pharyngeal enanthem, such as herpangina, and hand, foot, and mouth disease (HFMD). EV71 was identified by sequencing the VP1 gene. The clinical and epidemiologic data were analyzed retrospectively after all 87 NPEV-positive patients were divided into 4 groups, according to the clinical manifestations. Sixteen patients who mainly had symptoms of acute gastroenteritis were in group A, 21 patients with symptoms and signs of lower respiratory tract infections were in group B, 42 patients with a HFMD rash only were in group C with or without fever, and 8 patients with aseptic meningitis or paralysis were in group D. For the 11 EV71-positive patients, 1 was in group A, 2 were group B, 7 were in group C, and 1 was in group D. Results : There were 87 NPEV infections, including 11 EV71 infections. The mean age of the patients was 2 years and 11 months, ranging from 1 day to 15 years. There were no fatal cases among a total of 87 NPEV infections and no significant differences in clinical severity between the EV71 and other NPEV infections. Conclusion : NPEV infections in children were common during the 3 months in the spring of 2000. Unlike in southeast Asia, where fatal EV71 infection outbreaks have occurred since 1997, the clinical features of EV71 infection in Korean children are mild.

• The Monthly Diabetes
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• s.199
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• pp.14-19
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• 2006

혈당조절이 잘되지 않는 당뇨병환자에서 폐결핵이 발병할 경우 치료에 잘 반응하지 않아 폐결핵 유병기간이 길어지고 임상경과도 심각한 경우가 많다. 폐결핵이 있는 당뇨병환자는 인슐린 저항성이 더 높아지며 이로 인해 더 많은 양의 인슐린을 필요로 하고 혈당조절에 실패하는 경우가 많다.

• RED RIBBON
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• s.61
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• pp.30-31
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• 2004

1999년 7월부터 2003년 9월까지 4년 동안에 서울대학교 병원에 내원한 HIV 감염자 중에서 매독에 걸린 환자가 없었다. 그러나, 2002년 상반기부터 1기 및 2기 매독에 걸린 사람은 급증하였고, 2003년 하반기에는 연 100명 당 18명 꼴로 매독 환자가 급격히 증가하였다.

• The Monthly Diabetes
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• s.207
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• pp.14-15
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• 2007

당뇨병환자의 치과시술시 가장 문제가 되는 사항은 감염에 대한 위험성 증가와 창상치유 지연이다. 대부분의 치과치료는 출혈을 일으키고 창상을 남긴다. 만약 치과치료를 예정하고 있는 환자가 당뇨병환자라면 치과의사는 보다 적극적으로 감염 가능성을 예방하거나 줄이고 창상을 최소화하는 방향으로 치과 치료계획을 세울 것이다. 그러므로 당뇨병환자가 치과치료를 받을 때 가장 중요한 사항은 환자 본인의 당뇨 병력을 상세히 치과 진료진에게 알려주는 것이다. 물론 병력은 상세할수록 좋다.

• RED RIBBON
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• s.68
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• pp.8-9
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• 2006

우리는 흔히 에이즈와 HIV를, 감염인과 환자를 혼용해서 사용하고 있다. 엄밀히 얘기하면 에이즈와 HIV, 감염인과 환자는 전혀 다른 개념이다. 2006년 신년호부터는 에이즈에 대한 기본적 지식을 원하는 독자들의 요구에 부응하여 6회에 걸쳐 에이즈에 대한 상식을 게재할 예정이다.

• Pediatric Infection and Vaccine
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• v.24 no.2
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• pp.87-94
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• 2017

Purpose: The inappropriate prescription of antibiotics in children with upper respiratory tract infection (URTI) is common. This study evaluated the factors that influence antibiotics use in hospitalized children with viral URTI confirmed by reverse transcriptase-polymerase chain reaction (RTPCR) assay. Methods: The medical records of admitted patients who performed RT-PCR assay for respiratory virus pathogens from January 2013 to November 2014 were examined. The demographic and clinical features were compared between patients who were administered antibiotics at admission and those who were not. We also investigated differences between children who continued antibiotics and those who stopped antibiotics after a viral pathogen was identified. Results: In the total 393 inpatients, the median age was 23 months (interquartile range, 13 to 41.3 months). Antimicrobial agents were prescribed in 79 patients (20.1%) at admission. Patients with acute otitis media (AOM) had higher rates of antibiotics prescription than those without AOM (48.1% vs. 2.2%, P<0.001), with an adjusted odds ratio of 91.1 (95% confidence interval, 30.5 to 271.7). Level of high-sensitivity C-reactive protein and the proportion of acute rhinosinusitis were also significantly associated with antibiotics use (P<0.001). Among the 44 patients with viruses identified using the RT-PCR method during hospitalization, antibiotic use was continued in 28 patients (63.6%). AOM was statistically associated with continued antibiotic use in the patients (P=0.002). Conclusions: Although the respiratory virus responsible for URTI etiology is identified, clinicians might not discontinue antibiotics if AOM is accompanying. Therefore, careful diagnosis and management of AOM could be a strategy to reduce unjustified antibiotic prescriptions for children with URTI.

• The Journal of the Korea Contents Association
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• v.12 no.12
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• pp.304-312
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• 2012

In this study, for behavior clinical signs and blood tests when autumn sudden fevered disease, Tsutsugamushi Disease is Single infected with mixing hemorrhagic fever with renal syndrom.221 positive patients, who have antibody titer more than 1:80 in serologic examination of Tsutsugamushi Disease in a general hospital, Jeollanam-do province, were adopted as a Analysis. in respect of frequency. Single infection patients of Tsutsugamushi Disease were 183 and mixed infection patients with Hemorrhagic Fever with Renal Syndrome were 38. In respect of age, patients over the 70's were mostly infected. In respect of sex, male patients were 70(31.7%) and female patients were 151(66.8%) Women were more infected than men. In respect of outbreak time, the more than 70% disease occurrence of all was charged in October and November and it also occurred in spring. In the clinical signs, fever(p=0.028), urtication(p=0.000) and muscle pain(p=0.000) of mixed infection was more higher than single infection. And in the blood tests, AST(p=0.000), ALT(p=0.000), blood urea nitrogen(p=0.002), total bilirubin(p=0.000) value of mixed infection was more higher than single infection.

• Proceedings of the Korean Association for Survey Research Conference
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• 2001.11a
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• pp.67-76
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• 2001

최근 급격하게 늘어난 홍역환자에 대한 방역 대책으로 예방 접종의 범위를 어디까지 해야만 하며 몇 차례까지 해야만 하는가에 대하여 알아보기 위해 SRS로 추출된 초ㆍ충ㆍ고 생을 대상으로 설문조사를 실시하였다. 홍역환자를 줄이기 위해서는 홍역예방접종의 효과가 어느 정도인지를 알아야만 한다. 이에 본 논문에서는 홍역환자 수 추계를 위한 기초감염자 (R$_{0}$)가 2차 감염자 (R$_{1}$)를 얼마나 만들어 내는가를 알 수 있는 R(effective reproductive number)출 조사하여 그 값의 변화를 봄으로서 홍역환자의 증가 감소에 대한 예측과 그에 대한 환자 수를 추정하고 피에 대한 비용편익을 조사하였다.