• Korea Journal of Hospital Management
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• v.27 no.2
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• pp.16-33
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• 2022

Purposes: Prompt evaluation of routes and contact tracing are very important for epidemiological investigations of coronavirus disease 2019 (COVID-19). To ensure better adoption of contact tracing apps, it is necessary to understand users' expectations, preferences, and concerns. This study aimed to identify main reasons why people use the apps, appropriate services, and basis for voluntary app services that can improve app participation rates and data sharing. Methodology/Approach: This study conducted an online survey from November 11 to December 6, 2020, and received a total of 1,048 survey responses. This study analyzed the questionnaire survey findings of 883 respondents in areas with many confirmed cases of COVID-19. This study used a multiple regression analysis. Findings: Respondents who had experience of using related apps showed a high intention to use contact-tracing apps. Participants wished for the contact tracking apps to be provided by the government or public health centers (74%) and preferred free apps (93.88%). The factors affecting the participants' intention to use these apps were their preventive value, performance expectancy, perceived risk, facilitative ability, and effort expectancy. The results highlighted the need to ensure voluntary participation to address participants' concerns regarding privacy protection and personal information exposure. Practical Implications: The results can be used to accurately identify user needs and appropriate services and thereby improve the development of contact tracking apps. The findings provide the basis for voluntary app that can enhance app participation rates and data sharing. The results will also serve as the basis for developing trusted apps that can facilitate epidemiological investigations.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.23 no.1
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• pp.25-30
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• 2023

Leigh syndrome is a rare progressive neurodegenerative mitochondrial disorder with clinical and genetic heterogeneity. Recently, balletic IARS2 variants have been identified in a number of patients presenting broad clinical phenotypes from Leigh and West syndrome to a rare syndrome CAGSSS characterized by cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia syndrome (OMIM#616007). We describe a child with Korean Leigh syndrome with urologic manifestations resulting from a compound heterozygote mutation in IARS2. A 5-year-old girl visited the emergency room with a complaint of abdominal pain accompanied by abdominal distension. Abdominal-pelvic CT showed a markedly distended urinary bladder without definite obstructive lesions. She was diagnosed with neurogenic bladder dysfunction based on a urodynamic study. She had global delayed development due to neurologic regression after 6 months of age and a history of bilateral cataract surgery at the age of 2 years. Her brain magnetic resonance imaging showed symmetrically increased signal intensities in the bilateral putamen and caudate nuclei with diffuse cerebral atrophy. No gene variants were identified through whole-mitochondrial genome analysis. Whole exome sequencing was performed for diagnosis, and compound heterozygous pathogenic variants were identified in IARS2: c.2446C>T (p. Arg816Ter) and c.2450G>A (p. Arg817His). To the best of our knowledge, this is the first case report of bladder dysfunction manifestation in a patient with IARS2-related Leigh syndrome. Thus, it broadens the clinical and genetic spectrum of IARS2-associated diseases.