• Journal of Radiation Protection and Research
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• v.33 no.2
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• pp.53-59
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• 2008

We observed DNA damages as a function of mean absorbed dose to identify the indirect effect of high-energy radiation such as x-ray. Monolayer films of lyophilized pGEM-3Zf(-) plasmid DNA deposited on tantalum foils were exposed to Al $K{\alpha}$ X-ray (1.5 keV) for 0, 3, 7 and 10 min, respectively, in a condition of ultrahigh vacuum state. We compared DNA damages by X-ray irradiation with those by 3 eV electron irradiation. X-ray photons produced low-energy electrons (mainly below 20 eV) from the tantalum foils and DNA damage was induced chiefly by these electrons. For electron beam irradiation, DNA damage was directly caused by 3 eV electrons. Irradiated DNA was analyzed by agarose gel electrophoresis and quantified by ImagaQuant program. The quantities of remained supercoiled DNA after irradiation were linearly decreased as a function of mean absorbed dose. On the other hand, the yields of nicked circular (single strand break, SSB) and interduplex crosslinked form 1 DNA were linearly increased as a function of mean absorbed dose. From this study, it was confirmed that DNA damage was also induced by low energy electrons ($0{\sim}10\;eV$) even below threshold energies for the ionization of DNA.

• Korean Journal of Bronchoesophagology
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• v.2 no.1
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• pp.19-28
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• 1996

이상에서 고찰한 위식도역류의 병태를 간략히 요약하면 다음과 같다. 위액에는 염산, 펩신, 담즙산과 췌효소등을 포함하고 있어 역류된 위액은 상부 기관식도관에 자극을 주거나 손상을 줄 수 있으며 개개인의 점막 상피의 저항도와 적절한 타액의 분비는 위액에 의한 손상의 정도를 결정하는 중요한 요소로 알려져 있다. 위식도역류로 인한 많은 증상이나 소견은 두가지의 기전으로 나타나서 첫째, 역류된 위액이 직접 조직에 영향을 주거나 둘째, 간접적으로 식도 하부에 분포된 미주신경에 의한 연관자극에 의해 일어나는데 위식도역류의 증상 중 두부, 경부, 심장 및 폐장의 증상은 이들 장기에 미주신경의 일부가 같이 분포하여 일어나는 간접적인 기전이다. 하부식도괄약근(lower esophageal sphincter)의 기능은 역류를 막는 가장 중요한 요소로 알려져 있어 간헐적으로 하부식도 괄약근의 압력이 떨어지면 역류가 일어나게 된다. 정상적인 식도의 연동운동은 식도에 역류된 위내용물을 위로 제거되는데 중요하며 위식도역류 환자에서 흔히 연동운동이 저하되거나 비정상적인 연동운동을 관찰할 수 있다. 또한 위내용물이 소장으로 비워지는 시간이 연장되어 위내용물이 위내에 축적되는 것도 위식도역류의 원인의 하나로 생각된다. 이러한 위식도역류의 병태를 연구하는 것은 이 질환의 이해에 도움을 줄 것으로 생각된다.

• Journal of Korean Orthopaedic Sports Medicine
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• v.4 no.2
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• pp.95-99
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• 2005

Acromioclavicula. joint injuries occur as a result of force applied directly to the shoulder or indirectly through the humerus. Even though the main cause of injuries are direct trauma, indirect injury due to repetitive stress on the joint also could occur to the throwing athletes. The extent of injury to the ligaments responsible for acromioclavicular joint stability along with trapezius and deltoid muscle attachments determines the direction and degree of injury. Correct classification of injury based on clear understanding of anatomy and mechanism of injury can assist in tailoring a treatment to a throwing athletes.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2D
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• pp.243-248
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• 2008

Moisture damage of asphalt pavements can usually occur because of the loss of adhesion and cohesion between the asphalt binder and aggregate in the asphalt mixture due to presence of water. And this is one of the causes that is effect on the main distress of asphalt pavement. The objective of this study is to find out moisture damage characteristics of asphalt pavement. Effects of this study changes of the material properties and resistance characteristics of moisture damage on the asphalt mixtures under various temperatures and repeated immersion using indirect tensile test and modify Lottman test were evaluated during this study. The asphalt mixtures were produced using straight asphalt binder, SBS modified asphalt binder and aggregates. The material properties (resilient modulus, indirect tensile strength, failure energy and $DCSE_f$) of the asphalt mixtures were generally decreased with increasing to moisture damage caused by the number of repeated immersion. The decrease ratios of material properties by repeated immersion on SBS modified asphalt mixtures were lower than those of straight asphalt mixtures at all three test temperatures. As a conclusion, current criterion for evaluation moisture damage of asphalt mixtures is difficult for using distinction standard because of the limited evaluation criterion with one time immersion and single material property. Based on this research, to evaluate long term moisture damage on asphalt mixtures, material property tests of various kinds with repeated immersion test are considered.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.3
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• pp.101-107
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• 2014

Damage location and extent of structure could be detected by the inverse analysis on dynamic response properties such as frequencies and mode shapes. The dynamic response of building structures has many noise and affected by nonstructural members and, above all, the behavior of building structure is more complex than civil structure and this makes the damage detection difficult. In recent researches the damage is detected by the indirect index such as sensitivity or assumed values. However, for the more reasonable damage detection, it needs to use the damage index directly induced from dynamic equation. The purpose of this study is to provide the damage detection method on shear building structures by the damage index directly induced from dynamic equation. The provided damage index could be estimated from measured mode shape of undamaged structure and frequency difference between undamaged and damaged structure. The damage detection method is applied to numerical analysis model such as MATLAB and MIDAS GENw for the verification. The damage index at damaged story represents (-) sign and 15 times than other undamaged sories.

• Economic and Environmental Geology
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• v.46 no.1
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• pp.85-91
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• 2013

OECD(2008) gives the concepts of inaction costs on key environmental challenges including: direct financial costs; total financial costs; total use costs; and total social welfare costs. In analyzing the losses of environmental goods' various values conducted by domestic and foreign researchers, this study suggests the value-cost category of OECD(2008) and other studies; and the indirect use and non-use values of groundwater and other natural environment using the concepts of inaction costs. The studies on the damages and their relationships among human, property, and ecosystem are essential to monetary valuation on the qualitative or quantitative degradation of groundwater and other natural environment.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.46-46
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• 2010

최근 상압 저온 플라즈마에서 발생되는 UV와 화학적 활성종들을 이용한 체내 조직 분해 처리, 피부 및 혈관 표면 처리, 대기 및 액체 정화 처리 등의 생체 의료적 응용이 활발하게 연구되고 있다. 이러한 플라즈마에서는 처리 대상 외의 생체 조직의 손상을 최소화 할 수 있는 기술이 필요하며, 이 조건이 확보된 상태에서 처리 목표 대상에 따른 플라즈마 특성, 즉 선택적 생성종 제어와 플라즈마 온도를 안정적으로 관리할 수 있어야 한다. 인체 내부 조직에 대하여 유효 활성종 등의 직접적인 작용이 필요할 경우 밀리미터 크기 이하의 미세침습성 플라즈마를 활용하게 된다. 이 경우 방전 특성을 간접적으로만 관측 가능하여 주변 조직과 플라즈마 간의 상호 영향 등이 고려되어야 하므로 직접적인 관측이 가능한 인체 외부에서 발생된 플라즈마에 비해서 더욱 정교한 제어가 필요하다. 본 연구에서는 미세 침습성 플라즈마의 발생 메커니즘 및 특성 분석을 수행하여 척추 디스크 탈출 치료 시술에 활용하기 위한 연구를 수행하였다. 처리 대상 조직으로의 접근 시 주변 조직의 손상을 막기 위하여 수 밀리미터 이하의 미세한 전극을 이용하였으며 전기 전도성을 띄는 인체 내부에서 절연공간의 확보를 위해 전극 표면에서 기포를 발생시켜 플라즈마 방전이 가능한 조건을 확보하였다. 또한 플라즈마 방전이 중단되거나 혹은 갑작스런 열 플라즈마로의 천이로 인해 생체에 심각한 열 손상을 초래하는 현상을 방지하기 위하여 발생 플라즈마와 주변 디스크간의 상호 영향을 통한 플라즈마의 동적인 특성 변화 및 안정적인 플라즈마 발생을 위한 조건을 도출하였다. 이를 실제 임상 실험에 활용한 결과를 소개하고 아울러 차세대 의료용 플라즈마 발생 장치 개발을 위한 플라즈마 학계의 관심을 이끌어 보고자 한다.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.12 no.2
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• pp.149-159
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• 1999

본 연구에서는 고유진동수를 사용하여 균열의 위치와 크기를 발견하는 비파괴 균열발견모델을 유도하고 Euler-Bernoulli 보를 대상으로 이 모델의 적합성을 검증하였다. 먼저, 균열위치예측모델과 균열크기예측모델로 이루어진 균열발견체계를 제시하였는데, 균열위치예측모델은 모드민감도와 고유진동수 사이의 선형적인 관계로부터 간접적으로 유도되었으며 균열크기예측모델은 균열발생에 의한 변형에너지의 손실을 진동특성치의 변화와 비교하는 동적 파괴역학적 방법으로부터 유도되었다. 다음으로, 기존에 발표된 양단-자유보에 대한 진동모드 실험결과를 사용하여 균열위치와 균열크기를 예측하고 평가하므로 균열발견모델의 적합성과 적용성을 실험적으로 검토하였다. 대부분의 손상시나리오에서 균열위치와 균열크기 예측치는 실제값과 근사하게 일치하였다.

• International Journal of Highway Engineering
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• v.10 no.1
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• pp.75-85
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• 2008

Moisture damage of asphalt mixtures can occur because of a loss of bond between the asphalt binder and the fine and coarse aggregates. Therefore, moisture damage on asphalt pavements is the main cause of potholes, which is one of the main distress type of asphalt pavement. The purpose of this study is to evaluation effect moisture damage on material properties of asphalt mixtures through the laboratory performance test. The existing Modified Lottman test procedure was improved and the number of times that thermal cyclic conditioning can be added until the asphalt mixtures is damaged, was tested in order to exhibit the changes of the material properties because of moisture damage by immersion. Through the above experiments, it was found that the material properties of asphalt mixtures on room-temperature were rapidly decreased with loss of about 50% at initial stage of moisture damage caused by the amount of repeated immersion. Also, it was found that the property damage ratio using material properties of failure energy and $DCSE_f$ by test temperature $25^{\circ}C$ were showed a high relationship to moisture damage of the asphalt mixtures caused by the amount of repeated immersion.

• Korean Journal of Social Welfare
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• v.59 no.1
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• pp.223-249
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• 2007

This study is intended to investigate if the standard of vocational rehabilitation service could be solely determined by medical standard for disability definement and to find out what alternatives are available to resolve practical problems for those who are not identified as the severely disabled by the disability definement but do experience severe handicaps at work. Through the literature review, the researcher argued that the concept of 'functional limitation' would be a criteria, and thereby applied Modified Barthel Index to measure the degree of functional limitation. In view of researching the relationship among physical impairment, functional limitation, and job status based on 381 cerebral palsied, variables such as the type of cerebral palsy and the part of paralysis, have neither direct nor indirect influence to the job status; however, the pain and the mobility have indirect effects, and the ability of self-management has direct effect on the job status. The researcher concluded that future research about disabilities needs to provide a serious thought on what it is to be defined as 'disabilities', as well as to focus on further research conceptualizing the degree of physical 'functional limitation'.