• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.2
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• pp.203-207
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• 2010

Purpose: Hepatitis B is infection caused by Hepatitis B virus (HBV). Currently, there are several methods, Kits and equipments for conducting Hepatitis B test. Due to ununiformed methods, it would cause some differences. To manage these differences, it needs process evaluating function of test system and reagent using particular standard substance. The aim of this study is to investigate tendency of RIA method's reagent used in Asan Medical Center through comparing several other test reagents using national standard substance. Materials and Methods: The standard substance in National Institute of Food and Drug Safety Evaluation's biology medicine consists of 5 things, 4 antigens and 1 antibody. We tested reagents using A, B company's Kits according to each test method. All tests are measured repeatedly to obtain accurate results. Results: Test result of "HBs Ag Mixed titer Performance panel" is obtained match rate compared S/CO unit standard with RIA method and EIA 3 reagents, CIA 2 reagents is that company A's reagent is 94.4% (17/18), 83.3% (15/18), B is 88.9% (16/18), 77.8% (14/18). Test result of "HBs Ag Low titer Performance panel" is obtain that EIA 2 reagents is shown 7 posive results, CIA 3 reagents is 11, and RIA method's company A's reagent is 3, B is 2 of 13 in low panel. "HBV surface antigen 86.76 IU/vial" tested dilution. A is obtain positive results to 600 times(0.14 IU/mL), B is 300 times (0.29 IU/mL). Case of "HBV human immunoglobulin 95.45 IU/vial", A is shown positive result to 10,000 times (9.5 mIU/mL) and B is 4,000 times (24 mIU/mL). Test result of "HBs Ag Working Standards 0.02~11.52 IU/mL" is shown that Company A's kit concentration level was 0.38IU/mL, company B was 2.23 IU/mL and higher level of concentration was positive results. Conclusion: When comparing various test reagents and RIA method according to National Standard substances for Hepatitis B test, we recognized that there were no significant trends between reagents. For hepatitis B virus antigen-antibody titers even in parts of the test up to 600 times the antigen, antibodies to 10,000 times the maximum positive results could be obtained. Therefore, we confirmed that results from Asan Medical Center are performed smoothly by reagents and system for hepatitis B virus test.

• 건강소식
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• v.21 no.12 s.229
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• pp.19-19
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• 1997

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.8 no.1
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• pp.41-48
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• 2005

Purpose: Non-A, B, C viral hepatitis is the name given to the disease with clinical viral hepatitis, but in which serologic evidence of A, B, C hepatitis has not been found. Little is known about the etiology and clinical features of non-A, B, C viral hepatitis in children. Methods: A clinical analysis of 45 cases with non-A, B, C viral hepatitis who were admitted to the Department of Pediatrics, Pusan National University Hospital, from January 2001 to June 2004 was carried out retrospectively. Patients who were positive for HBsAg, anti-HAV and anti-HCV and had toxic, metabolic, autoimmune, or neonatal hepatitis were excluded in this study. Results: Among 45 cases of non-A, B, C viral hepatitis, the etiology was unknown in 26 (57.8%), CMV (cytomegalovirus) in 14 (31.1%), EBV (Epstein Barr virus) in 2 (4.4%), HSV (herpes simplex virus) in 2 (4.4%) and RV (rubella virus) in 1 (2.2%). Twenty seven out of 45 (60.0%) patients were under 1 year of age. Sixteen (33.3%) patients had no specific clinical symptoms and were diagnosed incidentally. On physical examination, twenty seven out of 45 patients (60.0%) had no abnormal findings. Forty three out of 45 patients (95.6%) showed classic clinical course of acute viral hepatitis, whereas fulminant hepatitis developed in two patients. Mean serum ALT (alanine aminotransferase) level was $448.7{\pm}771.9IU/L$. Serum ALT level was normalized in 31 out of 45 patients (81.6%) within 6 months and all patients within 18 months. Aplastic anemia was complicated in a case. Conclusion: Although most patients with non-A, B, C viral hepatitis showed a good prognosis, a careful follow-up would be necessary because some of them had a clinical course of chronic hepatitis, fulminant hepatitis and severe complication such as aplastic anemia.

• 건강소식
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• v.36 no.10
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• pp.30-31
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• 2012

우리나라에서 만성 간질환으로 인한 사망자는 해마다 2만여 명에 가깝다. 이는 전체 사망자의 8.8%를 차지하는 것으로 단일 장기로 따지면 만성 간질환은 뇌혈관질환에 이어 사망 원인 2위다. 특히 40~50대 사망원인 중 3위를 차지한다고 한다. 간질환의 가장 큰 원인은 바이러스성 간염으로 B형 간염이 약 70%, C형 감염이 약 10~15%를 차지하고 있다.

• 간의등불
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• no.spc
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• pp.19-24
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• 1998

• 간의등불
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• s.33
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• pp.18-20
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• 2003

• 간의등불
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• s.5
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• pp.16-19
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• 1998

• 간의등불
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• s.4
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• pp.13-17
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• 1998

• Proceedings of the Korean Information Science Society Conference
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• 2004.10a
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• pp.733-735
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• 2004

생명 현상을 시스템적으로 이해하기 위해서는 현상에 대한 수학적 모델링이 필수적이다. 여러 가지 수학적 모델 가운데 상미분 방정식(ODE) 모델은 여러 가지 생화학 반응을 모델링 하는데 널리 사용되고 있다. 본 논문에서는 신호전달 경로에 B형 간염 바이러스가 미치는 영향을 ODE로 모델링하고, 이를 시뮬레이션 한 결과를 보인다. 또한, ODE모델을 설계하는데 있어 보다 유연하고 확장 가능한 새로운 표현 방식을 제안한다.

• Monthly Duck's Village
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• s.56
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• pp.46-52
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• 2008

최근 오리 농가수 및 사육수수의 급격한 증가와 규모화가 빠르게 진행되어 왔으나 각종 질병(전염성질병, 비전염성질병, 중독증 등)에 대한 피해가 크게 발생되고 있지만 이들 질병들이 어느 때 얼마만큼 피해가 주고 있는지 상황파악이 아주 미흡한 상태이다. 이렇게 농가수와 사육수가 늘어난 근본적인 이유는 외식산업의 발달과 붉은 고기이면서도 건강에 좋다는 선호도가 높아지면서 오리산업의 외형적 성장에 그 기반을 두고 있다. 오리에서 발생되는 질병으로는 오리패혈증(리메렐라 감염증), 오리 바이러스성 간염, 대장균증, 살모넬 라감염증, 마이코플라즈마병, 오리바이러스성 장염, 조류인플루엔자, 보튤리눔중독증 등 다양하며 국내에서는 오리바이러스성 장염을 제외한 위에 기술된 모든 질병이 현재 발생되고 있는 것으로 추정되고 있다. 위에 기술된 질병들 중에서 현재 가장 문제가 되고 있는 질병으로는 오리패혈증과 오리 바이러스성간염이다.