• 제목/요약/키워드: 간보호

검색결과 128건 처리시간 0.027초

해당화 뿌리에서 분리한 Catechin의 간보호효과 (Hepatoprotective Effect of Catechin Isolated from the Root of Rosa rugosa Thunb)

  • 허종문;김인호;박종철
    • 한국약용작물학회지
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    • 제15권1호
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    • pp.21-25
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    • 2007
  • 해당화 뿌리는 우리나라 민간에서 당뇨병 치료제로 사용되는 약용식물이다. Bromobenzene으로 간독성을 유발한 흰쥐에 뿌리에서 분리한 화합물인 (+)-catechin을 경구투여하여 bromobenzene대사계에 미치는 효소활성을 간독성 물질인 bromobenzene 3,4-oxide 생성에 관여하는 효소인 aminopyrine N-demetylase와 aniline hydroxylase와 독성 epoxide 대사중간체를 무독화 시키는 epoxide hydrolase와 glutathione S-transferase에 활성을 관찰하였다. (+)-Catechin의 투여가 aminopyrine N-demetylase, aniline hydroxylase 및 glutathione S-transferase에 활성에는 영향을 주지 못하였으나, epoxide hydrolase는 positive control로 사용한 ascorbic acid에 미치지 못하지만, bromobenzene 처리군 보다 39% 효소활성을 회복 시켰다. 따라서, (+)-catechin은 간독성 물질을 무독화시키는 epoxide hydrolase의 활성을 회복시켜 간보호 활성을 나타냄을 알 수 있었으며, 해당화에서 분리한 사포닌 성분인 rosamultin도 이효소의 활성을 증가시킴으로 인해 보호활성을 나타내는 것으로 보고된바 있다.

앞으로 10년...21세기의 과학기술을 예측한다(중)

  • 한국과학기술단체총연합회
    • 과학과기술
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    • 제28권7호통권314호
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    • pp.24-25
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    • 1995
  • 과학자들은 앞으로 10년간 과학기술이 지난 10년간보다 10배나 빠른 걸음으로 진보할 것으로 내다보고 있다. 본지는 세계정상급 과학기술자들이 전망하는 주요과학기술분야의 미래를 지난호에 이어 소개한다.

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세계 석학들이 내다본 21세기의 과학기술

  • 한국과학기술단체총연합회
    • 과학과기술
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    • 제28권8호통권315호
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    • pp.24-25
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    • 1995
  • 과학자들은 앞으로 10년간 과학기술이 지난 10년간보다 10배나 빠른 걸음으로 진보할 것으로 내다보고 있다. 본지는 세계 정상급 과학기술자들이 전망하는 주요 과학기술분야의 미래를 지난호에 이어 소개한다.

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소리쟁이 종자의 소염진통작용 및 간보호 효과 (Anti-Inflammatory, Analgesic and Hepatoprotective Effect of Semen of Rumex crispus)

  • 이신석;김대홍;임동술;이숙연
    • 생약학회지
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    • 제38권4호
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    • pp.334-338
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    • 2007
  • Roots of Rumex crispus (Rc) (Polygonaceae) has been used as therapeutic agents of acute and chronic cutaneous diseases, cathartics, fever and jaundice in folk medicines. Recently, Seeds of Rc has known as a digestive, an anticancer agent and a remedy of acute hepatitis, among many traditional folk medicines. So far it isn't reported about pharmacological effects of Rumecis Semen. The present study describes the preliminary evaluations of biological activities, anti-inflammatory activity (AA, Carrageenan) analgesic activity (writhing test), and hepatoprotective activities ($CCl_4$), of its methanol extract, ethyl acetate fraction and butanol fraction. Among them butanol fraction showed the highest activity in analgesic acivity.

당뇨성 모델에서 차전초의 간보호 및 지질개선효과 (Hepatoprotective and Hypolipidemic Activity of Plantaginis Herba Extracts in Diabetic Model)

  • 윤수홍;하헌
    • Environmental Analysis Health and Toxicology
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    • 제16권3호
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    • pp.127-131
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    • 2001
  • The antihepatic and hypolipidemic activities and total lipid levels of water extract of Plantaginis Herba, used for respiratory and renal disorder in folk medicine, were evaluated in streptozotocin-induced diabetic rats. Diabetes was induced by a single injection of streptozotocin (50 mg/kg, i.p.). Water extract of Plantaginis Herba recovered enzyme activities such as GOT, GPT, ALP and LDH increased by streptozotocin (STZ) treatment. This crude drug also suppressed the enhanced production of lipid in hyperglycemia. These results strongly suggest that Plantaginis Herba be a promising liver-protective and hypolipidemic agent.

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일차 배양 흰쥐 간세포에서 $CCl_4$ 유발 세포독성을 이용한 간보호 효과 검색방법 (Screening Method for Antihepatotoxic Activity Using $CCl_4-induced$ Cytotoxicity in Primary Cultured Rat Hepatocytes)

  • 김영숙;박기현
    • 생약학회지
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    • 제26권1호
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    • pp.51-56
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    • 1995
  • To devise an in vitro screening method for antihepatotoxic activity, $CCl_4-induced$ cytotoxicities in primary cultures rat hepatocytes were examined. When rat hepatocytes were intoxicated with 0.5, 1.0 or 1.5 mM $CCl_4$ for 1.5, 3 or 19hr, in order of LDH>GOT>GPT release form hepatocytes was increased in a dose-dependent manner. Treatment with 1.5 mM $CCl_4$ for 1.5 hr showed maximum increase in activity of LDH, GOT or GPT released in the medium compared with the control. At this experimental condition, well known antihepatotoxic substances, glycyrrhizin and silybin markedly inhibited $CCl_4-induced$ cytotoxicities. These results demonstrated that the screening method using $CCl_4-induced$ injury in primary cultured rat hepatocytes might be suitable in vitro assay for antihepatotoxic activity.

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가미청간탕의 간보호 및 면역조절효과 (A Study on the Immune Modulation and Hepatoprotection of Gamichunggan-tang (GCT))

  • 손창규;한성수;조종관
    • 대한한의학회지
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    • 제23권2호
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    • pp.28-38
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    • 2002
  • Objectives : This study was to examine the efficacy of GCT on the hepatoprotective effect in the liver function and immune octivity. Methods : The experiment to investigate the hepatoprotective effect of GCT on the liver damage was conducted with D-galactosamine. The experiments to verify the effects of GCT on the immune activity were conducted by carbon clearance assay, plaque-forming cell SRBC assay of IgM, lymphoproliferation assay of T and B cells, and adherence and phagocytosis of mocrophages. Results: In the damage of liver induced by D-galactosamine, GCT carried hepatoprotective effect on AST. In carbon clearance assay GCT showed significant effect on phagocytosis of Kuffer cells. In the plaque-forming cell assay, GCT improved the formation of IgM. In the lymphoproliferation assay, GCT activated the formation of T and B lymphocytes. In macrophages, GCT activated adherence and phagocytosis. Conclusion : Though further study is needed, our findings suggest that GCT could be recommended as hepatoprotector and immune modulator for liver disease.

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간보호 효과를 나타내는 Isowogonin의 전합성 및 Wogonin 합성을 위한 반응조건 탐색 (Total Synthesis of Hepatoprotective Isowogonin and a Synthetic Approach to Wogonin)

  • 김광식;김학성
    • 약학회지
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    • 제53권6호
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    • pp.377-381
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    • 2009
  • Isowogonin, 5,8-dihydroxy-7-methoxyflavone, is a flavonoid isolated from the root of Scutellaria baicalensis Georgi, a medicinal plant traditionally used since the ancient time. It was thought to possess a variety of biological activities, such as antioxidation, anti-inflammation and hepatoprotective effect. But a quantity of isowogonin obtained from Scutellaria baicalensis Georgi is not that enough for in vivo test. There have been no appropriate approaches available for a facile synthesis of isowogonin. So we describe a concise and efficient scheme for synthesis of isowogonin from a commercial available 2,4,6-trimethoxyphenol, which includes the Fries rearrangement and selective demethylation as key steps.

노인 주야간보호시설 환경 평가에 관한 연구 (A Study on the Environmental Evaluation of the Elderly's Day Care Center)

  • 박성준
    • 한국실내디자인학회논문집
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    • 제24권3호
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    • pp.165-175
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    • 2015
  • Korean medical welfare facilities for the elderly provide the conveniences to care geriatric illness such as dementia and stroke. The medical welfare facility categorizes elderly care facilities, nursing homes, and geriatrics hospitals based on the Korean welfare of the aged act. The government makes an effort to secure feed rate and finances of medical welfare facilities. However, the qualitative improvement of facilities is inadequate. The purpose of this study is to analyze the conditions and problems of existing facilities using an environmental evaluation and to discuss the improvement direction related to the daycare centers for the elderly. The method of this study is literature review and field survey. Firstly, we analyzed the previous studies to develop the tool, evaluating the environment of day care centers for the old. Secondly, the items of environmental evaluation are deduced. Thirdly, we select the facilities to conduct field survey and analyze the results of field survey. Lastly, We discussed the problems and improvement directions through the results. It is judged that this study is an useful as the basic guideline to strengthen the minimum legal standards of day care center for the elderly due to the suggestion of insufficient environmental evaluation items.

양파(Allium cepa) 추출물의 간보호 및 항산화 효과 (The Hepatotprotective and Antioxidative Effects of Onion (Allium cepa) Extracts in Rat Hepatocyte Primary Culture)

  • 임태진;임상철
    • 한국자원식물학회:학술대회논문집
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    • 한국자원식물학회 2005년도 춘계 학술발표대회
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    • pp.52-60
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    • 2005
  • 본 연구의 목적은 양파추출물의 간보호 및 항산화 효과를 조사하기 위함이다. 간 손상을 유발시키는 t-BHP (1.5mM) 존재하에 간세포를 0, 0.01, 0.05, 0.1 및 0.3 mg/ml의 다양한 농도의 양파추출물로 1시간 동안 일차배양하였다. 간세포 독성과 생존율은 배양액의 GOT와 LDH 활성 및 MTT 값으로 결정하였고, 지질과산화는 TBARS 농도로 측정하였다. 항산화에 미치는 효과는 catalase, GSH-Px, GSH-Rd 활성 및 DNA strand breaking assay로 결정하였다. t-BHP는 GOT와 LDH 활성 및 TBARS 농도를 증가시켰으며 MTT값은 감소시켰다. 0.05 mg/ml 이상 농도의 양파추출물 첨가는 1.5 mM 농도의 t-BHP에 의해 증가된 GOT 및 LDH 활성을 감소시켰으며 0.01 mg/ml 이상 농도의 양파추출물은 t-BHP에 의해 감소된 MTT 값을 증가시켰다. 또한 0.01 mg/ml 이상 농도의 양파추출물 첨가는 t-BHP에 의해 증가된 TBARS 농도를 감소시켜 양파추출물이 t-BHP에 의해 유발된 간손상과 지질과산화를 억제시켰다. 1시간 동안 1.5 mM 농도의 t-BHP 처리는 간세포의 catalase, GSH-Px 및 GSH-Rd 활성을 현저히 감소시켰다. 그러나 0.01 mg/ml 이상 농도의 양파추출물 첨가는 t-BHP에 의해 감소된 catalase, GSH-Px 및 GSH-Rd 활성을 증가시켰으며 특히 catalase 활성은 t-BHP 무첨가군 수준까지 증가시켰다. 또한 hydroxyl radical을 생성하는 Fenton 시약의 존재하에 plasmid DNA를 양파추출물과 함께 배양하였을 때양파추출물은 농도 의존적으로 hydroxyl radical에 의해 유도된 single-strand 절단을 억제하였다. 이상과 같이 간세포 일차배양에서 양파추출물은 t-BHP에 의해 유발된 간독성, 간세포 생존율 감소, 지질과산화를 농도 의존적으로 억제시켰고 또한 t-BHP에 의해 억제된 GSH-Px, GSH-Rd 및 catalase의 활성을 증가시켰다. 이와 같이 양파추출물의 간보호 및 항산화 효과는 항산화 효소, 특히 catalase의 활성 증가와 hydroxyl radical에 의해 유도된 산화억제 및 이에 따른 지질과산화 억제에 기인하는 것으로 사료된다.

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