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Clinical Antagonistic Effect of Atipamezole in Cats Anesthetized with Tiletamine-Zolazepam and Medetomidine (고양이에서 tiletamine-zolazepam과 medetomidine 마취에 대한 atipamezole의 임상적 길항 효과)

  • Kim, Hyung-Ung;Park, Chang-Sik;Jun, Moo-Hyung;Jeong, Seong-Mok;Kim, Myung-Cheol
    • Journal of Veterinary Clinics
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    • 제24권2호
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    • pp.104-108
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    • 2007
  • The purpose of the study is to evaluate the clinical antagonistic effect of atipamezole(0.25 mg/kg, IM) in cats anesthetized with tiletamine-zolazepam ($Zoletil^{(R)}$, 10 mg/kg, IM) and medetomidine (0.05 mg/kg, IM). Twelve healthy 1 year old Korean mixed breed cats were used for this study. They were 4 males and 8 females. These cats were randomly assigned to two groups. One was control group ($Zoletil^{(R)}$ + medetomidine, ZM), and the other was treatment group ($Zoletil^{(R)}$ + medetomidine and antagonism by atipamezole, ZMA). All cats were examined 15 minutes before, 5, 25, 65 and 105 minutes after administration of tiletamine-zolazepam and medetomidine. Atipamezole was injected intramuscularly 20 minutes after ZM administation. Recovery time, heart rate, respiratory rate, total plasma protein and blood glucose were significantly different between ZM group and ZMA group (P<0.05). However, rectal temperature was not significantly different between ZM group and ZMA group. Two groups were able to induce sternal recumbency within 2 minutes and lateral recumbency within 4 minutes after the anesthetics injection. Mean sternal position time ($mean{\pm}SD$) was $174.0{\pm}44.6\;and\;116.2{\pm}27.3$ minutes, and mean standing position time was $210.8{\pm}45.6\;and\;154.2{\pm}21.1$ minutes in ZM and ZMA group, respectively. In these two groups, adverse effects during recovery time from anesthesia were not seen. As a result, the ZMA group had a faster recovery than the ZM group. Thus it was concluded that atipamezole could exert a useful reversal effect in cats anesthetized with medetomidine-tiletamine/zolazepam combination.

PIII&D (Plasma immersion ion implantation & deposition) 기술을 이용하여 제조된 NbN 박막이 인공관절용 UHMWPE 소재의 마모에 미치는 영향 평가

  • Park, Won-Ung;Kim, Eun-Gyeom;Mun, Seon-U;Kim, Gyeong-Hun;Im, Sang-Ho;Han, Seung-Hui
    • Proceedings of the Korean Vacuum Society Conference
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    • 한국진공학회 2012년도 제43회 하계 정기 학술대회 초록집
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    • pp.228-228
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    • 2012
  • 인공관절은 노인성 질환이나 자가 면역질환, 신체적인 외상 등으로 인하여 발생하는 관절의 손상 부위를 대체하기 위하여 고안된 관절의 인공 대용물이다. 인공 관절 중 인공 고관절의 경우 관절 운동을 하는 라이너(Liner)와 헤드(Head) 부분이 마모에 관여하여 인공관절의 수명에 영향을 미치게 되는데, 헤드 소재로서는 Co-Cr-Mo 합금이, 라이너 소재로서는 고분자 소재인 UHMWPE (Ultra High Molecular Weight Polyethylene)가 주로 사용되고 있다. 이러한 MOP (Metal-On-Polymer) 구조의 인공관절의 경우, 충격흡수의 장점이 있는 반면, 관절 운동시 발생하는 UHMWPE의 wear debris에 의한 골용해로 인하여 관절이 느슨해지는 문제점이 발생하여 재시술을 필요로 하게 된다. 또한 메탈 헤드의 마모로 인한 금속이온의 용출은 세포 독성의 문제를 야기하여 인공관절의 수명을 낮추는 또 하나의 요인이 되고 있다. 이러한 문제점들을 해결 하기 위하여, 본 연구에서는 PIII&D (Plasma Immersion Ion Implantation & Deposition)공정을 이용하여 Co-Cr-Mo 합금 소재 위에 niobium nitride (NbN) 박막을 증착하여 상대재인 UHMWPE의 마모를 줄이고자 하는 연구를 진행하였다. 마모량의 감소를 위하여, 박막을 증착하기 전에 Co-Cr-Mo 합금 위에 질소를 이온주입 하는 pre-ion implantation 공정을 도입하였으며, Co-Cr-Mo 합금과 NbN박막 사이의 접착력을 증가시키기 위하여 박막의 증착 초기에 이온주입과 증착을 동시에 수행하는 dynamic ion mixing공정을 수행하였다. 실험 결과 pre-ion implantation 공정을 도입한 경우 현재 상용화 되어있는 Co-Cr-Mo 합금에 비하여 마모량을 2배 이상 감소시키는 것을 확인 할 수 있었으며, dynamic ion mixing 공정을 도입한 경우 장시간의 마모 시험에서도 UHMWPE의 마모량을 2배 가까이 줄일 수 있었다.

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Characteristics on Volcanoes Monitoring and Disaster System of Japan (일본의 화산감시 및 분화대응 특성)

  • Jang, Eun Suk
    • 한국방재학회:학술대회논문집
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    • 한국방재학회 2011년도 정기 학술발표대회
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    • pp.188-188
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    • 2011
  • 작년 아이슬란드에서의 화산폭발로 발생된 화산재가 대기 중으로 이동하면서 유럽 공항 곳곳의 항공기 수천 편이 운항 중지되기도 하였다. 한반도내의 백두산은 약 1000전(서기 946년~947년 경) 대규모로 분화하였고, 서기 1903년, 소규모 분화한 후, 앞으로 수년~수십 년 사이에 폭발적인 분화를 재개할 가능성이 제기되고 있으며, 백두산 분화 시, 아이슬란드 화산폭발 때보다 훨씬 심각한 피해가 예상되고 있다. 따라서 백두산 화산에 대한 현지 자료의 수집과 꾸준한 모니터링(감시, 관측) 자료의 분석과 재해 예상 범위 및 대응 방안의 모색이 필요한 시점이다. 본 연구에서는 지리적으로 가까이 있으며 108개 활화산의 화산재해 방재에 관하여 꾸준히 활동하고 있는 일본에서의 화산감시 및 분화대응 시스템을 파악하고, 우리나라의 화산재해대책을 수립하기위한 시사점들을 고찰하였다. 화산의 평균적인 분화 간격은 풍수해나 지진 등 다른 재해에 비해 길기 때문에 일본 기상청에서는 과거1만년 이내에 분화한 증거가 있는 화산이 활화산으로서 인정되고 있다. 백두산은 약 1000년 전에 분화한 뒤 최근 분화의 전조현상을 보이고 있으며, 중국과 북한에 인접하여 있으므로 우리나라에 직접적인 피해는 예상되지 않으나, 우리나라에 일본과 같은 활화산이 존재하지 않기 때문에 생소하였던 화산재해란 어떠한 것이며, 향후 잠재적인 분화 가능성을 가지고 있는 백두산폭발로 인한 재해의 종류를 미리 예상하고 준비할 필요가 있다. 일본의 경우 계속적인 감시와 관측을 통한 분화예보, 경보를 발령하고 분화 시 즉각적인 방재정보를 전달, 지역주민들이 빠르게 인지, 주의하도록 화산재해 대책 시스템이 갖추어져 있다. 우리나라는 아직 중국과 북한에 인접한 백두산에 대한 관측 자료가 거의 없고, 연구를 위한 접근 또한 쉽지 않은 상황이다. 분화로 인한 직접적인 영향권에서는 벗어난다할지라도 계절적인 기상장의 영향 및 아직 예측 불가능한 백두산의 잠재적인 폭발규모에 따라 간접적인 영향을 받을 경우에 대비하여야 할 필요성이 있다고 사료된다. 또한 우리나라의 화산재해 방재력을 향상시키기 위하여 백두산 폭발로 인한 재해위험범위를 가시화하고, 분화 시에 대한 구체적인 가상시나리오를 작성하여, 화산재 및 대기오염물질의 확산시뮬레이션, 기후변화에 끼치는 영향 등을 포함하는 화산재해대책을 미리 세워 피해를 저감시킬 수 있는 방재대책을 수립해야 할 것이다.

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Large-scale Ambient Display Environment for providing Multi Spatial Interaction Interface (멀티 공간 인터랙션 인터페이스 제공을 위한 대규모 앰비언트 디스플레이 환경)

  • Yun, Chang Ok;Park, Jung Pil;Yun, Tae Soo;Lee, Dong Hoon
    • Proceedings of the Korea Contents Association Conference
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    • 한국콘텐츠학회 2009년도 춘계 종합학술대회 논문집
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    • pp.30-34
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    • 2009
  • Recently, systems providing the interaction different according to an interval between a user and the display were developed in order to construct the ambient or the ubiquitous computing environment. Therefore, we propose a new type of spatial interaction system; our main goal is to provide the interactive domain in the large-scale ambient display environment. So, we divide into two zones of interaction dependent on the distance from the interaction surface interactive zone and ambient zone. In interactive zone, the users can approach the interaction surface and interact with natural hand-touch. When the users are outside the range of the interactive zone, the display shows only general information. Therefore, this system offers the various interactions and information to users in the ubiquitous ambient environment.

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Continuous Monitoring of k-Exclusive Closest Pairs in Road Network (도로네트워크 기반 이동 객체들 간의 배타적 최근접 쌍 모니터링 방법)

  • Li, Ki-Joune;Kwon, O-Je;Baek, Yun-Sun
    • Spatial Information Research
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    • 제17권2호
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    • pp.213-222
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    • 2009
  • Finding exclusive closest pairs in road network is very useful to real applications such as, for example, finding a closest pair between a passenger and a nearby taxi in a road network. Few studies, however, have been interested in this problem. To match two close moving objects exclusively, one object must belong to only one result pair. Because moving objects in a road network change their position continuously, it is necessary to monitor closest pair results. In this paper, we propose a methodology to monitor k exclusive closest pairs via a road network. Proposed method only updates the results which are influenced by objects' movement. We evaluated the performance of the proposed method with various real road network data. The results show that our method produces better accuracy than normal batch processing methods.

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Mesh Segmentation With Geodesic Means Clustering of Sharp Vertices (첨예정점의 측지거리 평균군집화를 이용한 메쉬 분할)

  • Park, Young-Jin;Park, Chan;Li, Wei;Ha, Jong-Sung;Yoo, Kwan-Hee
    • The Journal of the Korea Contents Association
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    • 제8권5호
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    • pp.94-103
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    • 2008
  • In this paper, we adapt the $\kappa$-means clustering technique to segmenting a given 3D mesh. In order to avoid the locally minimal convergence and speed up the computing time, first we extract sharp vertices from the mesh by analysing its curvature and convexity that respectively reflect the local and global geometric characteristics from the viewpoint of cognitive science. Next the sharp vertices are partitioned into $\kappa$ clusters by iterated converging with the $\kappa$-means clustering method based on the geodesic distance instead of the Euclidean distance between each pair of the sharp vertices. For obtaining the effective result of $\kappa$-means clustering method, it is crucial to assign an initial value to $\kappa$ appropriately. Hence, we automatically compute a reasonable number of clusters as an initial value of $\kappa$. Finally the mesh segmentation is completed by merging other vertices except the sharp vertices into the nearest cluster by geodesic distance.

Daily Gas Demand Forecast Using Functional Principal Component Analysis (함수 주성분 분석을 이용한 일별 도시가스 수요 예측)

  • Choi, Yongok;Park, Haeseong
    • Environmental and Resource Economics Review
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    • 제29권4호
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    • pp.419-442
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    • 2020
  • The majority of the natural gas demand in South Korea is mainly determined by the heating demand. Accordingly, there is a distinct seasonality in which the gas demand increases in winter and decreases in summer. Moreover, the degree of sensitiveness to temperature on gas demand has changed over time. This study firstly introduces changing temperature response function (TRF) to capture effects of changing seasonality. The temperature effect (TE), estimated by integrating temperature response function with daily temperature density, represents for the amount of gas demand change due to variation of temperature distribution. Also, this study presents an innovative way in forecasting daily temperature density by employing functional principal component analysis based on daily max/min temperature forecasts for the five big cities in Korea. The forecast errors of the temperature density and gas demand are decreased by 50% and 80% respectively if we use the proposed forecasted density rather than the average daily temperature density.

Cloning of the Hepatitis B Surface Antigen Containing Pre-surface Antigen Region and Poly(A) Addition Site (Pre-surface antigen 지역과 poly(A) addition site가 포함된 B형 간염 표면항원 유전자의 재조합)

  • Kim, Sang-Hae;Kim, Yong-Sok;Park, Mee-Young;Park, Hyune-Mo
    • The Korean Journal of Zoology
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    • 제28권3호
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    • pp.166-178
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    • 1985
  • In order to express hepatitis B surface antigen $(HB_sAg)$ containing pre-surface antigen region in mammalian calls, 2.7 kb DNA fragment containing pre-surface region-$HB_sAg$ gene poly(A) addition site of HBV genome was cloned into simian virus 40(SV 40) based chimeric vector pSVOB. 2.7 kb DNA fragment was derived from pHBVD 107 containing tandem copies of the HBV genome in a head-to-tail arrangement by Bgl II digestion. Construction of the vector pSVOE involved the incorporation of SV40 sequences spanning the viral origin of replication and 72 bp repeats (enhancer) into a pBR 322 derivative lacking sequences which inhibit replication in mammalian cells. Bam HI linker was inserted at the Pvu II site in the proximity of SV40 late promoter of pSVOE and named as pSVOB. To construct the recombinant plasmid pSVBS, pHBVD 107 was digested with Bgl II to isolate 2.7kb DNA fragment and the fragment was ligated into the Bam HI site of pSVOB by ligation. Preliminary result showed that the recombinant plasmid pSVBS produced $HB_sAg$ in the monkey cell producing large T antigen (COS cell).

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Classifier Selection using Feature Space Attributes in Local Region (국부적 영역에서의 특징 공간 속성을 이용한 다중 인식기 선택)

  • Shin Dong-Kuk;Song Hye-Jeong;Kim Baeksop
    • Journal of KIISE:Software and Applications
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    • 제31권12호
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    • pp.1684-1690
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    • 2004
  • This paper presents a method for classifier selection that uses distribution information of the training samples in a small region surrounding a sample. The conventional DCS-LA(Dynamic Classifier Selection - Local Accuracy) selects a classifier dynamically by comparing the local accuracy of each classifier at the test time, which inevitably requires long classification time. On the other hand, in the proposed approach, the best classifier in a local region is stored in the FSA(Feature Space Attribute) table during the training time, and the test is done by just referring to the table. Therefore, this approach enables fast classification because classification is not needed during test. Two feature space attributes are used entropy and density of k training samples around each sample. Each sample in the feature space is mapped into a point in the attribute space made by two attributes. The attribute space is divided into regular rectangular cells in which the local accuracy of each classifier is appended. The cells with associated local accuracy comprise the FSA table. During test, when a test sample is applied, the cell to which the test sample belongs is determined first by calculating the two attributes, and then, the most accurate classifier is chosen from the FSA table. To show the effectiveness of the proposed algorithm, it is compared with the conventional DCS -LA using the Elena database. The experiments show that the accuracy of the proposed algorithm is almost same as DCS-LA, but the classification time is about four times faster than that.

Studies on a Plan for Afforestation at Tong-ri Beach Resort - Analysis of Factors Causing Disasters around Beach - (통리해수욕장(桶里海水浴場) 녹지대조성(綠地帶造成)에 관(關)한 연구(研究)(I) - 사구지주변(砂丘地周邊)의 재해요인분석(災害要因分析) -)

  • Cho, Hi Doo
    • Journal of Korean Society of Forest Science
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    • 제77권2호
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    • pp.178-185
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    • 1988
  • This study is carried out for analyzing the factors causing several disasters occurring around beach area in order to set a plan for an afforestation which will fulfill its function as facilities for prevention of disasters and for relaxation around beach resort at Tong-ri, Pokil-my$\bar{o}$n, Wando-gun. The results are as follows : 1. The main wind direction was summer was SE. 2. The first class in the rate of frequency of the hourly average wind speed and the instantaneous wind speed in summer were 2.1-3.0m/sec (29.2%) and 1.1-2.0m/sec (30.6%) respectively. 3. The particle sizes of the dune sands was a little small (82.5% in 0.125 to 0.25mm, $D_{50}=0.178mm$). 4. The mineral composition and the chemical components were as follows : The main mineral : Quartz The accessary minerals : Calcite, Feldspars(Orthoclase), Sericite. The chemical components : $SiO_2$ ; 75.6%. $Al_2O_3$ ; 8.1%, CaO ; 7.76%, Ign. loss ; 6.8%, MgO ; 0.23%, $K_2O$ ; 0.72%, $Na_2O$ ; 0.41%, $Fe_2O_3$ ; 0.32%. 5. The threshold friction velocity equation for the diameter class of the dune sands was $y=4.191x^{0.221}$. 6. The amount of floating salt was maximum at the point of 65m away from beach line, dropped abruptly at 135m and remained almost same on its way to the inland. The equation of the amount of floating salt was $y=28.181{\times}(-0.369^x)$. 7. The amount of extracted salt(33%) in seawater in summer was the same as the one of the nearest seawater of Korea.

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