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硏究于浮脉主病 (부맥주병에 대한 연구)

  • Kim, Gyeong-Cheol;Ryu, Gyeong-Ho;Lee, Hae-Ung;Kim, Jung-Han;Kim, Hun;Du, Seung-Hui
    • Journal of Korean Medical classics
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    • v.24 no.3
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    • pp.65-70
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    • 2011
  • 문헌(文獻)에 기재된 내용을 근거로 병맥주병(病脉主病)을 단맥(單脈)과 상겸맥(相兼脈)을 구분하는 입장에서 연구하는 것이 단맥(單脈), 상겸맥(相兼脈)이 혼재하는 맥진학(脈診學) 분야에서 병맥주병(病脈主病) 연구에 도움이 된다고 생각되어, 먼저 부맥주병(浮脈主病)을 중심으로 단맥주병(單脈主病)과 상겸맥주병(相兼脈主病) 연구에 임하게 되었다. 부맥(浮脈) 병맥주병(病脉主病)을 단맥(單脈)과 상겸맥(相兼脈)으로 구분하여 조사한 결과, 다음과 같은 지견을 얻을 수 있었다. 맥진(脈診) 제가(諸家)는 이론적인 입장보다는 임상적인 자료에 근거한 실용적(實用的)인 입장(立場)으로서, 좌우수(左右手) 촌관척(寸關尺)의 부맥(浮脈)의 단맥주병(單脈主病)은 외감(外感) 호흡기(呼吸器) 증상(症狀)으로, 촌관척(寸關尺) 6부위별(部位別) 단독 부맥(浮脈) 단맥주병(單脈主病)은 촌관척(寸關尺)의 장상론적(藏象論的)인 증상(症狀)으로 관찰하였으며, 오장(五臟) 육부(六腑) 촌관척(寸關尺) 배속(配屬)의 입장에서는 대장(大腸)과 방광(膀胱)을 척부(尺部)에서 진맥(診脈)하는 실용적인 입장을 보였다. 제가(諸家)들은 부맥(浮脈) 상겸맥(相兼脈) 주병(主病)에서 대(大), 홍(洪), 완(緩), 긴(緊), 삽(澁), 삭(數), 지(遲), 허맥(虛脈)을 높은 빈도(頻度)의 상겸맥(相兼脈)으로 취급하고 있으며, 장(長), 활(滑), 세(細), 질(疾), 단(短), 芤, 미(微), 유(濡), 현(弦), 산맥(散脈)을 낮은 빈도(頻度)의 상겸맥(相兼脈)으로 다루고 있다. 또한 기본(基本) 단일(單一) 맥상(脈象)으로는 대(大), 삽(澁), 삭(數), 지(遲), 허(虛), 장(長), 활(滑), 세(細), 질(疾), 단(短), 현(弦), 산맥(散脈)이, 두개 이상(以上)의 맥(脈)이 결합(結合)된 합병맥상(合幷脈象)으로는 홍(洪), 완(緩), 긴(緊), 규(芤), 미(微), 유맥(濡脈)이 부맥(浮脈) 상겸맥(相兼脈)으로 주로 다루어지고 있다. 부대(浮大), 부장(浮長), 부완(浮緩), 부세(浮細), 부긴(浮緊), 부단(浮短), 부삭(浮數), 부허(浮虛), 부미(浮微), 부현(浮弦)의 상겸맥(相兼脈)은 맥위상(脈位上)으로 부맥(浮脈)의 속성(屬性)을 합리적으로 인정(認定)하는 상겸맥(相兼脈)으로 판단되나, 홍맥(洪脈), 허맥(虛脈), 규맥(芤脈), 유맥(濡脈)과의 부맥(浮脈) 상겸맥(相兼脈)은 이미 갖추고 있는 부맥(浮脈) 속성(屬性)에 또 다시 부맥(浮脈)과 상겸(相兼)하는 중복성(重複性)의 문제가 있으므로, 앞으로 부맥(浮脈)의 단맥(單脈)과 상겸맥(相兼脈) 주병(主病)에서 보다 깊은 연구가 있어야 할 것으로 생각한다.

The Medical Study about the Development of Pediatrics for Song(宋) Dynasty (양송시기(兩宋時期)의 소아과학(小兒科學)에 관한 연구)

  • Park, Hyun-Kuk;Kim, Ki-Wook;Yi, Yeong-Seok
    • Journal of Korean Medical classics
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    • v.21 no.2
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    • pp.1-20
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    • 2008
  • The Song Dynasty(宋代) period gained the summit in the developmental phase of the history in pediatrics. In 1076, Taeuiguk(太醫局) was founded and Sobangmaek(小方脈) was the one of nine branch in Taeuiguk(太醫局). As a result, educational agency and system was arranged in the field of pediatrics. At the same time, pediatrics have furnished with foundation to develop independent field in medical science. Especially, Byeonjeungnonchi(辦證論治) system is established in pediatrics science according to the compilation of "Soayakjeungjikgyeol(小兒藥證直訣)" by Jeoneul(錢乙). Children's doctors, Jeoneul(錢乙), Jinmunjung(陳文中) and Donggeup(董汲) arranged clinically theories, so they made that age the peak of the pediatrics. Looking at the developmental part of theory in pediatrics of the Song Dynasty period, Jeoneul(錢乙), who was the representative children's doctor in Song Dynasty period, insisted that children had formed Ojang-yukbu(五臟六腑) in the physiological part but they were not perfect like adult's. Therefore they had to consider the poor part in children's body, and then they had to cure them. 'Byeonjeung(變蒸)' was considered to be normal physiological phenomenon. Also he insisted that Yukeum(六淫), 'Pung, Han, Seo, Seup, Jo, Hwa(風, 寒, 暑, 濕, 燥, 火)' and 'Gyeong, Pung, Gon, Cheon, Heo(驚, 風, 困, 喘, 虛)' are the main cause of the children's five vital organ's pathology Like this, his academic thought, which lay emphasized on children's spleen and stomach and Ojangbyeonjeung(五臟辦證) main principles, affected on doctors, Donggeup(董汲), Yeomhyochung(閣孝忠), Yubang(劉肪), Jang-wonso(張元素), Idong-won(李東垣), Manjeon(萬全). Bangje(方劑) fields of pediatrics had developed so fast and "Taepyeongsunghyebang(太平聖惠方)" contained about 2689 kinds of children's prescription. According to this, there are so many kinds of medicinal shape, for example 'Hwan, San, Go, Dan(丸, 散, 膏, 丹)', which cured children' s disease. Through this, we find that the shape of medicine about the children's diseases had developed to the more simple direction, taking account of the children's clinical trait.

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A Study on the Correlation between the Bell's Palsy and the 7-Zone-diagnostic System - Evaluated by the Patterns of Zone 2 of Factor AA - (구안와사와 7구역진단기의 상관성 연구 - Factor AA 제2구역의 유형을 중심으로 -)

  • Cho, Yi-Hyun;Lee, Jin-Bok;Im, Jeong-Gyun;Park, Ka-Young;Yook, Tae-Han;Song, Beom-Yong
    • Journal of Acupuncture Research
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    • v.27 no.2
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    • pp.1-10
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    • 2010
  • Objectives : The 7-zone-diagnostic system is a diagnostic device to predetermine bodily locations by measuring the energy of body. This study was to investigate the relation between the different patterns of Zone 2 of Factor AA in CP-6000A (VEGA, Germany), 7-zone-diagnostic system and the factors of Bell's Palsy. Methods : This study was carried out with the data from factors of Bell's Palsy(age, sex, period after onset, postauricular pain, season which the disease happen, contributing factor). We made three groups according to the different patterns of Zone 2 of Factor AA in CP-6000A. The Factor AA pattern of Group A is that the red bar graph of zone 2 were lower than the normal range. The Factor AA pattern of Group B was that the red bar graph of zone 2 was the normal range. The Factor AA pattern of Group C was that the red bar graph of zone 2 was higher than the normal range. After collecting the data about factors of Bel's Palsy to correspond with conditions of each group were selected, the data was analyzed statistically. Results : The values of number of patient and period after onset of group A was higher than group B and C. The values of ratio of postauricular pain of group B and C was higher than group A. The season of disease happened of group A is spring and winter, group B is winter and group C is summer and autumn. The contributing factor of disease happened of group A is none, and group B and C is stress and clod. Conclusions : In Bell's Palsy, it is thought that the red bar graph of zone 2 is lower, the group have lower energy(虛) and the energy has a character of cold(寒), and zone 2 is higher, the group has the higher energy(實) and the energy has a character of fire(熱).

Effect of Stopping Drinking, Using Alcoholic Liver Disease Questionnaire, DSOM and SF-36 (알코올성 간질환 변증 설문, DSOM, SF-36을 이용한 알코올성 간질환 환자의 금주 효과 연구)

  • Lee, Jae-Wang;Hong, Sang-Hoon;Park, Sang-Eun;Son, Ho-Young;Kim, Do-Gyoung;Lee, Seung-Yeon;Lee, Su-Young;Kim, Bo-Kyoung;Kang, Chang-Wan;Lee, In-Sun
    • The Journal of Internal Korean Medicine
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    • v.31 no.2
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    • pp.356-364
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    • 2010
  • Objectives : This study was done to evaluate the effect of stopping drinking, using alcoholic liver disease questionnaire, Diagnosis System of Oriental Medicine (DSOM) and Health Related Quality of Life (HRQOL). Methods : 49 men who satisfied the requirement participated in this trial. They stopped drinking for 6 weeks. They were analyzed using DSOM, alcoholic liver disease questionnaire and SF-36. The data were classified by age (<47,$\geq$48) and alcoholic intake per day (<100g,$\geq$100g). For HRQOL, the SF-36v2 Health Survey was used and Quality Metric Health Outcomes Scoring Software 2.0 (QualityMetric, Lincoln, RI, USA) was applied for the analysis. Results : The alcoholic liver disease questionnaire had a partial correlation with DSOM. Generally stopping drinking decreased Heat (熱). Especially in the group drinking over 100g per day, the correlation was high. In the group over 48 years old, spleen (脾) was improved comparatively. In the group with low HRQOL (PCS<31.43, MCS<23.33) deficiency (虛) was improved. Conclusions : We found that stopping drinking can improve pathogenic factors of alcoholic liver disease and the alcoholic liver disease questionnaire be a useful diagnostic method on alcoholic liver disease by comparison with DSOM.

Graphic system analysis on the Chil Sung Hwa(seven stars picture) (칠성화(七星畵)의 그래픽체계 분석)

  • 나윤화
    • Archives of design research
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    • v.11
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    • pp.22-29
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    • 1995
  • I have to find standpoint of sight moulding of Chi I Sung Hwa(seven stars picture) analysis of graphic systems of a symbol sight native to our nation. And I will comprehend emotion of folkways by simple and graphic lines and colors in mathematical Grid of which ancestor had expressed in gauge moulding consciousness. This papers aim is to make a contribution to lead by on part of communication design. About structural analysis of pictorial graphic side. I) Mathematical thought of the Orient and space constitution are first basically the Orient expressed number notion of mathematics of unlimitedness and notion of zero so called space and empty second can analigize a diagonal expansion method by development of symmetry notion to basic the dual principle of the negative and positive by degrees development expressed space division method by direction notion. 2) About the proportion analysis it based the golden section globularity and in modern layout it takes vision center of position, after appointing the brow of sacred image of Chil Sung Hwa as center point of proportion and applied to the point proportion and so analigized the posibility of established. Rule in union of each elements and rule of forms about picture image. 3) Mathematical structure analysis to search a unified principle at the balanced arrangement and rule of forms it analigized the standard the rule of forms. it analigized the standard the rule of forms to body module of basic movement of protagonist and follower above basic forms of grid that is the basis of design system.

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척담(滌痰).축어(逐瘀).고본치료효천적경험(固本治療哮喘的經驗) -척담(滌痰).축어(逐瘀).고본(固本)의 방법에 따른 천식에 관한 치험-

  • Hwang Geum-Seong
    • The Journal of Pediatrics of Korean Medicine
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    • v.15 no.1
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    • pp.39-45
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    • 2001
  • 본 논문은 척담(滌痰) 축어(逐瘀) 고본(固本)의 방법으로 천식을 완화시킨 치험에 관한 내용이다. 천식의 병인병기는 폐(肺) 비(脾) 신(腎) 삼장(三臟)의 본허(本虛)로 인한 알레르기성 체질이 내적인 근본요인으로 간주된다. 담어복폐(談瘀伏肺)는 천식의 병리적인 결과로서 증상유발의 요인이기도 하다. 즉 담어(痰瘀)는 천식의 병리적인 부산물이며, 동시에 천식을 일으키는 치병요인이 된다. 담어(痰瘀)가 내복(內伏)하여 철저히 제거되지 않으면 천식은 결코 완치될 수 없다. 이와 같은 한의학적인 관점은 현대의학에서 천식을 기도의 만성 염증에 의하여 유발된 증상으로 파악하고 있는 기전과 일맥상통하다. 또한 담(痰) 어(瘀) 허(虛)는 천식의 병리변화 과정에서 전반적으로 영향을 미치고 있다는 인식이 지배적이며, 이는 천식치료를 위한 처방구성에 이론적 근거를 제시하고 있다. 치료: 천식은 발작기와 완화기로 분류하여 치료하며, 발작기는 냉효(冷哮)와 열효(熱哮)로 구분된다. 냉효(冷哮)의 경우 치료원칙은 온폐산한(溫肺散寒), 척담평천(滌痰平喘), 화어행체(化瘀行滯)를 기본으로 한다. 처방은 구마황(灸麻黃) 행인(杏仁) 황금(黃芩) 세신(細辛) 계지(桂枝) 오미자(五味子) 당귀(當歸) 울김(鬱金) 목단피(牧丹皮) 지룡(地龍) 정력자(?歷子) 담남성(膽南星) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 열효(熱哮)의 경우 치료원칙은 청열사폐(淸熱瀉肺) 척담평천(滌痰平喘), 화어행체(化瘀行滯)를 근본으로 삼고, 처방으로는 구마황(灸麻黃) 행인(杏仁) 황금(黃芩) 목단피(牧丹皮) 적작약(赤芍藥) 당귀(當歸) 정력자(?歷子) 담남성(膽南星) 지룡(地龍) 어성초(魚腥草) 포공영(蒲公英) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 완화단계도 역시 두가지 유형으로 나누어지는데, 폐신음허형(肺腎陰虛型)은 익기양음(益氣養陰) 척담행어(滌痰行瘀)를 치료원칙으로 하고, 처방에는 남북사삼(南北沙蔘) 구자울(灸紫?) 및 관동화(款冬花) 당귀(當歸) 목단피(牧丹皮) 울김(鬱金) 정력자(?歷子) 세신(細辛) 오미자(五味子) 구기자(枸杞子) 산수황육(山茱黃肉) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 비신양허형(脾腎陽虛型)은 온보비신(溫補脾腎) 화어척담(化瘀滌痰)을 원칙으로 하며, 처방에는 구마황( 灸麻黃) 세신(細辛) 오미자(五味子) 당귀(當歸) 단삼(丹蔘) 울김(鬱金) 정력자(?歷子) 반하(半夏) 보골지(補骨脂) 선령비(仙靈脾) 태자삼(太子蔘) 황기(黃?) 감초(甘草) 등을 기본적으로 사용한다. 치험(治驗): (1) 천식의 실증(實證)은 치료를 한 뒤 완화단계에 접어들면서 허증(虛證)으로 전화되는데, 허천(虛喘)도 역시 천식이니 만큼 단순히 보법(補法)만 사용하여서는 안된다. 시종일관 천식치료에는 척담화어(滌痰化瘀)의 원칙을 지켜야 한다. 폐내(肺內)의 담어(痰瘀)가 철저하게 제거되어야 폐(肺)의 순환기능을 개선시켜 기도(氣道)의 염증을 신속히 흡수하고 치유할 수 있다. 이와 같은 치료과정은 약 3-6개월이 필요하다. 완화단계의 기간이 길어질수록 완치될 확률도 높아진다. (2) 급성기 천식은 폐(肺)를 다스려야 한다. 폐(肺)를 다스리는 방법에는 선폐(宣肺), 청폐(淸肺), 온폐(溫肺), 윤폐(潤肺) 및 척담거어(滌痰祛瘀) 등이 있다. (3) 증상이 완화되면 신(腎)을 다스린다. 천식은 신허(腎虛)가 근본적인 원인이므로 완화단계에서 심지어 발작기에도 보신제(補腎劑)를 추가하여 사용하면 배의 효과를 얻을 수 있다. (4) 비(脾)의 기능을 강화하여 근본을 채우는 부비배본(扶脾培本)도 중요하다. 후천의 수곡정미(水穀精微)로 선천을 충족시키고 자양하는 것은 질병에 대한 저항력을 키우고 재발을 경감시키거나 방지하는 효과를 기대할 수 있으므로 역시 천식치료의 중요한 방법 중 하나이다.

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A study about Views of the Great Learning(大學) of the Three Countries in East Asia at 17th Century (17세기(世紀) 동(東)아시아 3국(國)의 『대학(大學)』관(觀) 고찰(考察))

  • Lee, Yongsoo
    • (The)Study of the Eastern Classic
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    • no.36
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    • pp.265-299
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    • 2009
  • The Great Learning is an essential scripture of Confucianism that has had great influence on the politics, thoughts, society and culture of the East Asia which contains Korea, Japan and China. In case of Japan, the doctrine of Toegye(退溪) is flown into pre-Tokugawa era, and as the doctrine of Zhu Xi(朱熹) exercise influences over the other thoughts, the importance of the Great Learning is embossed relatively in Tokugawa era. The characteristic of Japanese confucianism of Tokugawa era is to lay weight on real world as such, and the Japanese confucianism has grown up academically centers on exhaustive reinterpretation about some Confucian classics. And Backho-Yoon Hyu(白湖 尹?), Seokye-Park Sedang(西溪 朴世堂) who lived in 17th century of Joseon dynasty attempt new interpretation about the Great Learning and they have an objection to the explanatory notes of Zhu Xi. In the same period of China, there are similar academic trends around Whang Jong Hi(黃宗羲), Ko Yeom Mu(顧炎武), Wang Fu Chi(王夫之). In other words, new views of real scholarship which reject emptiness and put much value on reality were current of thoughts that have been common to the oriental three countries in early and middle 17th century. The main object of this paper is to understand the attitude and understanding about the Confucian classics especially the Great Learning of the scholars who lived in early and middle Tokugawa era. It will be a decisive clue to understand the ninucture of thoughts system of them. Through these work, we understand how it has had influenced to thinking-ninucture and lives of the Japanese. And the other purpose of this paper is to understand characteristics of them when we compare that vking-ninucture and lives of the Japanese Confuciang-ninearly and middle Tokugawa era with in the same period of Jeseon and the later Ming(明) and early Ching(淸) dynasty.

A Study on Qian Yi(錢乙)'s Medical Though (전을(錢乙)의 의학사상(醫學思想)에 관(關)한 연구(硏究))

  • Oh, Jun Hwan;Kim, Ki Wook;Park, Hyun Kook
    • The Journal of Korean Medical History
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    • v.14 no.2
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    • pp.109-152
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    • 2001
  • Throughout this paper, I adjusted the study of 'Qian Yi'(錢乙)'s Medical Thought, and the following is the summary. 1. 'Qian Yi' wrote 'Xiao Er Yao Zheng Zhi Jue'("小兒藥證直訣", edited by 誾季忠), and there were 'Shang Han Lun Zhi Wei'("傷寒論指微"), 'Ying Ru Lun', however those are loss of the record. 2. Qian Yi's 'Zhi Jue'("直訣") was influenced by 'Lu Xin Jing', yet if we compare the quality of 'Sheng Li, Byeng Li, Bang Jae'(生理, 病理, 方劑), 'Lu Xin Jing' cannot be the foundation of 'Zhi Jue'. He took over 'Nei Jing, Shang Han Lun, Jin Gui Yao Lue, Shen Long Ben Cao Jing, Tai Ping Sheng Hui Fang'("內經", "傷寒論", "金?要略", "神膿本草經", "太平聖惠方") and put them together to the direct clinical experiences of pediatrics. 3. There is no reference regarding the difficulties of pediatric diagnosis and diseases in 'Huang Di Nei Jing'("黃帝內經") Before 'Bei Song'(北宋), regardless of the lack of data related to pediatric diseases, 'Qian Yi' established the pediatric system in 'Xiao Er Yao Zheng Zhi Jue' for the first time. 4. In his diagnosis of the pediatric diseases, he 'Si Zhen He Can'(四診合參), also considered in the eye exam seriously. In addition, he closely combined 'Wu Zang Bian Zheng'(五臟辨證), and diagnosis the pediatric diseases. 5. 'Wu Zang Bian Zheng', what Qian established method was based on 'Zheng Ti Guan'(整體觀) in 'Huang Di Nei Jing'. It was based on clinical experiences and established the perspectives of 'Tian Ren Xiang Ying'(天人相應). First of all, he pinpointed 'Zhu Zheng'(主證) clearly. Secondly, he pinpointed the relationships to symptoms and then, he distinguished a generic character of 'Xu, Shi, Han, Re'(虛, 實, 寒, 熱). Finally, he made an induction from genealogical pediatric physiology. 6. 'Qian Yi' took a serious view of 'Ban Zhen'(斑疹), the inadequate field in those days. At that time, he criticized on the habituation of the misuse of medication. He treated separately which 'Ji Jing'(急驚) as 'Liang Xie'(凉瀉) and 'Man Jing'(慢驚) as 'Wen Bu'(溫補). He proposed 'Cong Gan Zhu Feng, Xin Zhu Jing'(從肝主風, 心主驚) theory and formulated 'Jing Feng'(驚風) theory as well. 7. As an opponent of a tendency to misusage of medicine, 'Qian Yi' made out a prescription with pliant medicine. He emphasized on the treatment to 'Gong Bu Shang Zheng, Bu Bu Zhi Xie, Xiao Bu Jian Shi'(攻不傷正, 補不滯邪, 消補兼施) because he had so lucid demonstration to 'Xu Shi Han Re'(虛實寒熱) of the five viscera in the field of 'Bang Yak'(方藥). 8. There were no pediatrics schools at that time, however, the pediatrics was being made up gradually by 'Jin Yuan Si Da Jia'(金元四大家) who was influenced by 'Qian Yi'. He raised an objection to medical treatment using pliant medicine. 'Qian Yi' applied 'Qu Xia'(驅下) treatment using 'Han Liang'(寒凉) medicine. 'Han Liang Pai'(寒凉派) is greatly influenced by Qian. 'Chen Wen Zhong'(陳文中) had a great impact on 'Han Liang Pai' who used a 'Zao Shu Wen Bu'(燥熟溫補) medicine for treatment. Since 'Song Jin'(宋金), he had a tremendous influence on pediatrics treating patients in both 'Han Wen'(寒溫) ways. 9. 'Qian Yi' had an influence on his medical thoughts on future generations, especially to 'Wan Quan'(萬全) of 'Ming Dai', 'Wu Tang'(吳塘) of 'Qing Dai'(淸代) and 'Yun Shu Jie'(?樹珏) of 'Min Guo'(民國). 'Wan Quan' is an advocate of 'You Yu, Bu Zu Zhi Shuo'(有餘, 不足之說)of 'Xiao Er Wu Zang'(小兒五臟) that he revealed Qian's 'Wu Zang Bian Zheng'(五臟辨證). 'Wu Tang' disclosed Qian's 'Xiao Er Ti Zhi Shuo'(小兒體質說) and 'Xiao Er Ke'(小兒科)'s 'Yong Yao Lun'(用藥論), therefore, he uncovered pediatric physiological characteristics through the advocate of Qian's 'Zang Fu Rou Ruo, Ji Gu Nen Qie, Yi Xu Yi Shi, Yi Han Yi Re' (臟腑柔弱, 肌骨嫩怯, 易虛易實, 易寒易熱). 'Yun Shu Jie' developed intrinsic relationships among time, symptom and 'Tian Ren Xiang Ying Guan'(天人相應觀), What 'Qian Yi' stated about them. And also, he developed Qian's 'Di Huang Wan'(地黃丸), 'Xie Qing Wan'(瀉靑丸), 'Yi Huang San'(益黃散) clinical usages as well. 10. Regarding Qian's 'Wu Zang Xu Shi'(五臟虛實), it has an influence on 'Zhang Yuan Su'(張元素)'s 'Zang Fu Bing Ji Bian Zheng'(臟腑病機辨證). 'Di Huang Wan', 'Xie Qing Wan', 'Xie Xin Tang'(瀉心湯), 'Yi Huang San', 'Xie Huang San'(瀉黃散) are the standard prescription of 'Wu Zang Bu Xie'(五臟補瀉). It is under the influence of Qian's treatment. Besides, 'Qian Yi' took a serious view of 'Xiao Er'(小兒)'s 'Pi Wei'(脾胃). 'Qian Yi' had an impact on 'Li Dong Yuan'(李東垣) one of the member of 'Bu Tu Pai'(補土派). 'Di Huang Wan', which placed great importance on 'Bu Yi Shen Yin'(補益腎陰), had a great impact on 'Da Bu Yin Wan'(大補陰丸) and 'Jin Yuan Si Da Jia' as well. 11. In a theory of Qian's 'Wu Zang Bian Zheng', though it had been stated clearly in 'Wu Zang Bian Zheng', but he neglected in 'Liu Fu Bian Zheng'(六腑辨證). In prescription field, The problem with the medicine is that it is either toxic or mineral, therefore, we are not able to use those medicine in a clinical testing at the present time.

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소적백출산(消積白朮散)이 항암효과(抗癌效果) 및 Cisplatin부작용(副作用) 감소(減少)에 미치는 영향(影響)

  • Jo, Jong-Gwan
    • Journal of Haehwa Medicine
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    • v.4 no.2
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    • pp.255-272
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    • 1996
  • 소적백출산(消積白朮散)은 ${\ll}$화제국방(和劑局方)${\gg}$에 삼령백출산(蔘笭白朮散)에 정열해독약(淸熱解毒藥)인 와송(瓦松) 금은화(金銀花) 포공영(蒲公英)을 가미(加味)한 처방(處方)으로, 본방(本方)인 삼령백출산(蔘笭白朮散)은 비위허약(脾胃虛弱), 음식부진(飮食不振), 다곤소력(多困少力) 중만비대(中滿痺臺), 심정기천(心柾氣喘), 구토(嘔吐), 설사(泄瀉), 상한해수(傷寒咳嗽)를 치료목적(治療目的)으로 쓰여 온 이래(以來) 임상에서는 대편부실(大便不實), 구설(久泄), 옹달궤후(癰疸潰後) 불사식자(不思食者)를 치료(治療)하는데 다용(多用)되어 왔다. 종양(腫瘍)(Neoplasia)은 새로운 성장(成長)(New+ Glowth) 이라는 세포학적(細胞學的)으로 비정상세포(非正常細胞)의 과다증식(過多增殖)으로 인해 실질장기(實質臟器), 유강장기(有腔腸器), 및 골격(骨格), 피부조직(皮膚組織)에 비정상조직(非正常組織)을 형성(形成)하는 질환(疾患)이다. 현대적(現代的) 종양(腫瘍)과 유사(類似)한 한의학적(韓醫學的)인 병증(病症)은 ${\ll}$소문(素問)${\gg}$에서는 "궐산(厥疝), 복량(伏梁), 식적(息積)"으로 ${\ll}$영추(靈樞)${\gg}$에서는 "장담(腸覃), 석가"로 표시(表示)된 이후(以後)로 소원방(巢元方)은 징가, 식일, 석옹(石癰), 완저(緩疽), 석저(石疽) 등으로 표현(表現)하였다. 원인(原因)에 대(對)해서는 ${\ll}$내경(內經)${\gg}$에서는 허(虛)와 한기(寒氣), 한(寒) 열(熱)로 보았고, 그 외(外)의 학자(學者)들은 내허(內虛)와 기혈불순(氣血不順), 화(火), 한(寒), 기울(氣鬱), 음양불화(陰陽不和)등으로 보았다. 치료(治療)는 ${\ll}$내경(內經) 자법론(刺法論)${\gg}$에서 "정기재내(正氣在內) 사불가우(邪不可于)" 이라 하여 생명활동(生命活動)의 원동력(原動力)인 정기(正氣)의 역할(役割)을 강조(强調)하였고, ${\ll}$육원정기대론(六元正氣大論)${\gg}$에서는 "대적대취(大積大聚) 불가범야(不可犯也) 쇠기태반이지(衰其太半而止)"라 하여 공벌약(攻伐藥)을 과용(過用)하여 정기(正氣)를 손상(損傷)시켜서는 안된다고 하는 등 부정위주(扶正爲主), 거사위주(祛邪爲主) 혹은 부정거사(扶正祛邪) 겸용(兼用)의 방법(方法)이 혼용(混用)되고 있다. 현대(現代) 서양의학(西洋醫學)의 항암제(抗癌劑)는 치료효과(治療效果)는 우수(優秀)하지만 악심(惡心), 구토(嘔吐)를 비롯하여 골수억제효과(骨髓抑制效果)와 간(肝), 심(心), 신(腎), 폐(肺)의 손상(損傷)을 초래(招來)하는 등(等)의 부작용(副作用)을 나타내며, 빈번(頻繁)한 화학요법제(化學療法劑)의 투여(投與)로 인(因)한 암세포(癌細胞)의 약제저항성(藥劑抵抗性) 출현(出現)등이 항암제(抗癌劑)의 문제점(問題點)으로 제시(提示)되고 있다. 이에 저자(著者)는 비위기능(脾胃機能)을 강화(强化)시켜 정기형성(正氣形成)에 깊이 관여(關與)하는 삼령백출산(蔘笭白朮散)에 청열해독(淸熱解毒), 소종산결지제(消腫散結之劑)인 금은화(金銀花), 포공영(浦公英), 와송(瓦松)을 가미(加味)하여 암발생(癌發生) 백서(白鼠)에 투약(投藥)한 후(後) sarcoma 180암세포(癌細胞)에 대(對)한 생명연장효과(生命延長效果)와 항암제(劑)의 일종(一種)인 cis-platin을 이용(利用)하여 양방항암제(洋方抗癌劑)의 부작용(副作用)에 대(對)한 본(本) 방(方)의 효과(效果)를 실험(實驗)하여 관찰(觀察)하였던 바 다음과 같은 결론(結論)을 얻었다. 1. 소적백출산(消積白朮散)은 sarcoma 180 암세포(癌細胞) 이식종양(移植腫瘍)에 대(對)해 생명연장효과(生命延長效果)가 인정(認定)되었다. 2. 소적백출산(消積白朮散)은 치암제(治癌劑)인 cis-platin 치사독성(致死毒性)에 대(對)해 생존연장효과(生存延長效果)가 인정(認定)되었다. 3. 소적백출산(消積白朮散)은 cis-platin 현독성(腎毒性) 생쥐 및 흰쥐에 있어서 유의성(有意性) 있는 체중감소억제효과(體重減少抑制效果) 및 serum BUN 상승억제효과(上昇抑制效果)가 인정(認定)되었다. 4. 소적백출산(消積白朮散)은 cis-platin 현독성(賢毒性) 흰쥐에 대(對)해 유의성(有意性) 있는 serum creatinine 상승억제효과(上昇抑制效果)가 나타났으며, cis-platin의 혈액학적(血液學的) 부작용(副作用)인 RBC, WBC 감소(減少)에 대(對)해 감소억제효과(減少抑制效果)가 인정(認定)되었다. 5. 소적백출산(消積白朮散)은 cis-platin 현독성(腎毒性) 흰쥐에 대(對)해 뇨량감소억제(尿量減少抑制) 효과(效果) 및 ureanitrogen과 creatinine 배수감소억제효과가 관찰(觀察)되었다. 이상(以上)의 결과(結果)로부터 소적백출산(消積白朮散)은 악성종양치료(惡性腫瘍治療) 및 항암제(劑)의 부작용(副作用)을 경감(輕減)시키는 데 응용(應用)할 수 있을 것으로 사료(思料)된다.

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