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The effects of PPARβ/δ overexpression on PGC-1α mRNA and protein stability after accute endurance exercise in mice skeletal muscle (생쥐의 골격근에 PPARβ/δ 과발현이 1회 지구성 운동 후 안정시 PGC-1α mRNA와 단백질 안정성에 미치는 영향)

  • Koh, Jin-Ho;Jung, Su Ryun;Kim, Ki-Jin
    • 한국체육학회지인문사회과학편
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    • v.55 no.4
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    • pp.507-516
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    • 2016
  • The purpose of this study is to identify the effects of PPARβ/δ over-expression on PGC-1α mRNA and protein stability after single bout of swimming exercise in mice skeletal muscle. Empty vector (EV) or PPARβ/δ was over-expressed in tibialis anterior(TA) using electroporation(EPO) technique to compare with non-treatment muscle(control; Con). TA muscles were dissected at 0h, 24h or 54h after termination of exercise. PGC-1α mRNA in Con, EV and PPARβ/δ over-expressed muscles were increased 6.8 fold (p<.001), 6.2 fold(p<.001) and 7.1 fold(p<.001), respectively, than sedentary(Sed) group at 0h after exercise and then reverted to Sed group levels at 24h and 54h after termination of exercise. PGC-1α and PGC-1α ubiquitination in EV treated muscles were increased 2.2 fold and 1.74 fold, respectively, than Sed group at 24h after termination of exercise, and then reverted to Sed group levels at 54h after termination of exercise. PGC-1α in PPARβ/δ over-expressed muscles at 24h and 54h after termination of exercise were increased 2.5 fold and 2.2 fold, respectively, than Sed group, but PGC-1α ubiquitination was not increased at 24h and 54h after termination of exercise. Our results indicate that PPARβ/δ over-expression does not increase PGC-1α mRNA stability, but increase PGC-1α protein stability through post-translation mechanism after termination of exercise.

Hierarchical Circuit Visualization for Large-Scale Quantum Computing (대규모 양자컴퓨팅 회로에 대한 계층적 시각화 기법)

  • Kim, JuHwan;Choi, Byung-Soo;Jo, Dongsik
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.05a
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    • pp.611-613
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    • 2021
  • Recently, research and development of quantum computers, which exceed the limits of classical computers, have been actively carried out in various fields. Quantum computers, which use quantum mechanics principles in a way different from the electrical signal processing of classical computers, have various quantum mechanical phenomena such as quantum superposition and quantum entanglement. It goes through a very complicated calculation process compared to the calculation of a classical computer for performing an operation using its characteristics. In order to utilize each element efficiently and accurately, it is necessary to visualize the data before driving the actual quantum computer and perform error verification, optimization, reliability, and verification. However, when visualizing all the data of various elements configured inside the quantum computer, it is difficult to intuitively grasp the necessary data, so it is necessary to visualize the data selectively. In this paper, we visualize the data of various elements that make up a quantum computer, and hierarchically visualize the internal circuit components of a quantum computer that are complicatedly configured so that the data can be observed and utilized intuitively.

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Room Temperature Imprint Lithography for Surface Patterning of Al Foils and Plates (알루미늄 박 및 플레이트 표면 미세 패터닝을 위한 상온 임프린팅 기술)

  • Tae Wan Park;Seungmin Kim;Eun Bin Kang;Woon Ik Park
    • Journal of the Microelectronics and Packaging Society
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    • v.30 no.2
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    • pp.65-70
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    • 2023
  • Nanoimprint lithography (NIL) has attracted much attention due to its process simplicity, excellent patternability, process scalability, high productivity, and low processing cost for pattern formation. However, the pattern size that can be implemented on metal materials through conventional NIL technologies is generally limited to the micro level. Here, we introduce a novel hard imprint lithography method, extreme-pressure imprint lithography (EPIL), for the direct nano-to-microscale pattern formation on the surfaces of metal substrates with various thicknesses. The EPIL process allows reliable nanoscopic patterning on diverse surfaces, such as polymers, metals, and ceramics, without the use of ultraviolet (UV) light, laser, imprint resist, or electrical pulse. Micro/nano molds fabricated by laser micromachining and conventional photolithography are utilized for the nanopatterning of Al substrates through precise plastic deformation by applying high load or pressure at room temperature. We demonstrate micro/nanoscale pattern formation on the Al substrates with various thicknesses from 20 ㎛ to 100 mm. Moreover, we also show how to obtain controllable pattern structures on the surface of metallic materials via the versatile EPIL technique. We expect that this imprint lithography-based new approach will be applied to other emerging nanofabrication methods for various device applications with complex geometries on the surface of metallic materials.

Seasonal Change Analysis of Groundwater in Nakdong Riverside Greenhouse Complex Using Groundwater Monitoring (지하수관측을 이용한 낙동강변 시설농업단지 지하수의 계절적 변화 분석)

  • Baek, Mi Kyung;Shin, Hyun Chae;Kim, Sang Min
    • Proceedings of the Korea Water Resources Association Conference
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    • 2020.06a
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    • pp.283-283
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    • 2020
  • 국가의 논의 타작물 재배 권장 정책과 농한기 수익을 위해서 동절기에도 농사가 가능한 시설농업이 발달했으며, 1990년 초부터 재배면적이 증가하여 2000년에는 10만 ha를 넘어섰고, 2018년에는 80만ha의 규모를 보이고 있다(농사로, 2019). 시설농업단지의 동절기 난방을 위한 에너지원으로 화석연료와 전기열원을 사용하고 있고, 특히 강변의 경우 지하수를 난방 열원으로 사용가능해 수막재배를 이용한 대규모 시설단지가 발달함에 따라 지하수의 이용량이 증가하고, 2015년 농업용 지하수 이용량은 연간 20억 톤에 이른다(GIMS, 2019). 난방이 필요한 동절기에 수막용수를 위한 지하수 이용량이 급증하여 계절적인 수위변화를 보이며, 특히 강변의 대규모 시설농업단지의 지하수의 부족현상이 빈번히 발생하는 실정이다(송성호, 2017). 본 연구지역은 낙동강 하구댐 설치 전만조 시 해수의 유입으로 암반지하수의 심도가 증가할수록 EC가 증가하는 특성을 보이는 곳으로, 지하수의 이용량이 급증하는 동절기에 특히 급격히 증가하여 지하수의 안정적인 수질관리를 위해 염분변화의 관리가 필요한 지역이다. 지하수의 계절적인 변화를 위해 시설농업단지내에 지하수 관측정이 설치되어 관측되고 있으며 본 연구에서는 관측정의 2013년 1월~2019년 1월까지 지하수의 EC변화를 관측하였다. 지하수의 수위(GL.m), 온도, EC를 1시간 주기로 관측하여 계적적인 변화를 분석하였고, EC의 증가가 큰 곳은 심도별로 센서(다중심도)를 설치하여 염도의 변화를 관측하였다. 지하수성분의 지질학적 기원분석을 위한 양음이온 분석을 연 1회 실시하였다. 또한 관측정의 심도별 변화를 알기 위해 동일지역에 충적, 암반 관측정을 따로 설치하고 관측하여 지표수와 지하수의 심도별 영향의 차이를 분석하였다. 동일지역의 관측결과 평균 5m이하의 수위변화를 보이나, 5m 이상의 수위변동을 보이는 관측망은 15년 14개소 17년 19개소로 증가추세를 보이며, 이는 주로 밀집된 시설하우스 단지의 수막재배를 위한 겨울철 지하수 사용량 증가가 원인인 것으로 판단된다. 본 연구지역은 강변지역에 밀집된 시설하우스단지의 동절기 수막재배를 위한 지하수 과다 사용으로 수위급감 및 수량부족현상이 반복되고 있어, 예방과 대책강구를 위해 지표수의 함양과 지하수사용량의 상관관계 분석과 자료축적 및 추가연구를 위한 장기관측이 요구된다.

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Assessment of physical condition of old large Chionanthus retusus(Chinese Fringe Tree) using structural stability analysis (천연기념물 이팝나무 노거수 구조안정성 진단을 통한 물리적 생육상태 평가)

  • SON Jiwon;SHIN Jinho
    • Korean Journal of Heritage: History & Science
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    • v.56 no.1
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    • pp.118-130
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    • 2023
  • Decay or large cavities inside trees are the main causes of trees overturning and broken branches, and structurally weakened trees are more vulnerable to strong winds and heavy snowfall. Recently, as strong winds and typhoons increase due to climate change, the damage to human life and property due to trees overturning continues to increase, and cultural assets are in a similar situation. In particular, old big trees are structurally vulnerable to external shocks such as strong winds and heavy snowfall. This study was aimed at providing a scientific basis for preventive protection measures by conducting a structural stability diagnosis of seven retusa fringe trees designated as natural monuments. For the structural stability diagnosis, tree risk assessment and internal tree defect measurements were performed. As a result of the tree risk assessment, the Retusa Fringe Trees in Sinjeon-ri, Yangsan and Gwangyangeupsu had the highest risk of broken branches due to weak branch attachment strength. As a result of the diagnosis of internal defects of cross sections of measured trees, there were suspected cavities or severe decay in all except two trees of the population of Retusa Fringe Trees in Pyeongji-ri. Natural disasters due to climate change are increasing, and the scale is getting larger, so it is very important to preemptively manage large old trees through scientific structural safety diagnosis to manage trees that are vulnerable to environmental changes.

Quantitative preliminary hazard level simulation for tunnel design based on the KICT tunnel collapse hazard index (KTH-index) (터널 붕괴 위험도 지수(KTH-index)에 기반한 터널 설계안의 정량적 사전 위험도 시뮬레이션)

  • Shin, Hyu-Soung;Kwon, Young-Cheul;Kim, Dong-Gyou;Bae, Gyu-Jin;Lee, Hong-Gyu;Shin, Young-Wan
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.11 no.4
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    • pp.373-385
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    • 2009
  • A new indexing methodology so called KTH-index was developed to quantitatively evaluate a potential level for tunnel collapse hazard, which has been successfully applied to tunnel construction sites to date. In this study, an attempt is made to apply this methodology for validating an outcome of tunnel design by checking the variation of KTH-index along longitudinal tunnel section. In this KTH-index simulation, it is the most important to determine the input factors reasonably. The design factor and construction condition are set up based on the designed outcome. Uncertain ground conditions are arranged based on borehole test and electro-resistivity survey data. Two scenarios for ground conditions, best and worst scenarios, are set up. From this simulation, it is shown that this methodology could be successfully applied for providing quantitative validity of a tunnel design and also potential hazard factors which should be carefully monitored in construction stage. The hazard factors would affect sensitively the hazard level of the tunnel site under consideration.

Preferences and Consumption Patterns of General Consumers of Meat Dishes (일반소비자들의 고기 요리에 대한 기호도 및 소비행태)

  • Kim, Eun-Mi;Seo, Sang-Hee;Lee, Min-A;Kwon, Ki-Hyun;Jun, Gi-Hong
    • Journal of the Korean Society of Food Culture
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    • v.25 no.3
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    • pp.251-261
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    • 2010
  • This paper examines the dining tendencies of Koreans toward meat dishes and their related factors, with 301 people residing in Korea as subjects. We questioned this population on their restaurant choices, eating habits, preferences and a dislike with respect to method of cooking. All age groups, with the exception of 50~60 year-olds, were found to consume meat dishes in specialized restaurants. The selection factor for restaurants varied, depending on the age group: affordable cost was the most important factor for whom under 20 year-old. Whereas 20-40 year-old people considered taste and ambience the most for choosing restaurant. The 50-60 year-old people found to seek for convenient restaurant. In terms of the most preferred parts of beef, 20-30 year-old people preferred tenderloin (42.3%) while 40-60 year-old people preferred sirloin (45.6% and 41.2% each). All the other age groups preferred ribs the most (It was also found that) men preferred the rib parts and women preferred tenderloin. With respect to pork, all age groups preferred pork belly, with the highest response rate in the under 20 age group. When consuming meat dishes, 91.0% of respondents pointed to roasting as the most frequent preparation method, the reason being good taste was deemed the highest number of responses. In a survey on preference for stewed meats, 74.8% of the sample pool was found to prefer stew dishes but 24.9% of respondents provided negative answers, the reason for dislike was found to be poor taste for women, and both a long preparation time and poor taste for men. In fact, regardless of marital status, a high number of responses were given for poor taste as the reason for disliking stew dishes. Based on the examined factors for inconveniences in preparing meat dishes, the most common inconvenience factor was the odor of meat left on clothes after the dining experience, followed by the smoke generated in roasting meat, and the safety risk involved with changing the grill. In terms of stir fry preparation, the negative thoughts were due to the splashing of food and spices while cooking, followed by the meat odor left on clothes after dining experience, and the sanitation level of the cooking containers. For deep frying the sanitation level of cooking containers was the biggest reason for dislike, followed by splashing of food when preparing. Lastly, it was indicated that the problem of steaming method was a difficulty of judging the portion, on the top of this, people found that the sanitation level of cooking container and a long preparation time were also the problem of this cooking method.

A Design of Ultra-low Noise LDO Regulator for Low Voltage MEMS Microphones (저전압 MEMS 마이크로폰용 초저잡음 LDO 레귤레이터 설계)

  • Moon, Jong-il;Nam, Chul;Yoo, Sang-sun
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2021.10a
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    • pp.630-633
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    • 2021
  • Microphones can convert received voice signals to electric signals. They have been widely used in various industries such as radios, smart devices and vehicles. Recently, the demands for small size and high sensitive microphones are increased according to the minimization of wireless earphone with the development of smart phone. A MEMS system is a good candidate for an ultra-small size microphone of a next generation and a read out IC for high sensitive MEMS sensor is researched from many industries and academies. Since the microphone system has a high sensitivity from environment noise and electric system noise, the system requires a low noise power supply and some low noise design techniques. In this paper, a low noise LDO is presented for small size MEMS microphone systems. The input supply voltage of the LDO is 1.5-3.6V, and the output voltage is 1.3V. Then, it can support to 5mA in the light load condition. The integrated output noise of proposed LDO form 20Hz to 20kHz is about 1.9uV. These post layout simulation results are performed with TSMC 0.18um CMOS technology and the size of layout is 325㎛ × 165㎛.

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A Policy Study to Improve the Utilization of Public Data in Busan (부산지역 공공데이터 활용도 향상을 위한 정책연구)

  • Bae, Soohyun;Kim, Sungshin;Jeong, Seok Chan
    • The Journal of Bigdata
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    • v.6 no.2
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    • pp.1-15
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    • 2021
  • The unprecedented pandemic of infectious diseases called COVID-19 has dampened human and material movement, and changes in the global economic structure have caused various economic and industrial problems such as worsening employment along with the domestic and international economic recession. In this crisis situation, the government announced the "New Deal" as a new card to enhance economic vitality following the "emergency disaster support fund." This means that the first business of the Digital New Deal, the beginning and core of the New Deal, begins digital transformation from collecting data, which is the "rice" of digital transformation to the data dam. Until now, not only the government but also local governments have established and operated platforms for collecting and sharing public data by establishing various data portals. It is evaluated that it lacks utilization for commercialization as not only the government but also local governments focus only on building the platform without considering the business model when building the initial public data platforms. In particular, in the case of regions, there is a lack of public data to be used for data business, so it is necessary to utilize data from public institutions in the region. In this study, various data collection, data quality improvement, and data utilization improvement were suggested as measures to solve these problems.

Optimal Capacity Determination of Hydrogen Fuel Cell Technology Based Trigeneration System And Prediction of Semi-closed Greenhouse Dynamic Energy Loads Using Building Energy Simulation (건물 에너지 시뮬레이션을 이용한 반밀폐형 온실의 동적 에너지 부하 예측 및 수소연료전지 3중 열병합 시스템 적정 용량 산정)

  • Seung-Hun Lee;Rack-Woo Kim;Chan-Min Kim;Hee-Woong Seok;Sungwook Yoon
    • Journal of Bio-Environment Control
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    • v.32 no.3
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    • pp.181-189
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    • 2023
  • Hydrogen has gained attention as an environmentally friendly energy source among various renewable options, however, its application in agriculture remains limited. This study aims to apply the hydrogen fuel cell triple heat-combining system, originally not designed for greenhouses, to greenhouses in order to save energy and reduce greenhouse gas emissions. This system can produce heating, cooling, and electricity from hydrogen while recovering waste heat. To implement a hydrogen fuel cell triple heat-combining system in a greenhouse, it is crucial to evaluate the greenhouse's heating and cooling load. Accurate analysis of these loads requires considering factors such as greenhouse configuration, existing heating and cooling systems, and specific crop types being cultivated. Consequently, this study aimed to estimate the cooling and heating load using building energy simulation (BES). This study collected and analyzed meteorological data from 2012 to 2021 for semi-enclosed greenhouses cultivating tomatoes in Jeonju City. The covering material and framework were modeled based on the greenhouse design, and crop energy and soil energy were taken into account. To verify the effectiveness of the building energy simulation, we conducted analyses with and without crops, as well as static and dynamic energy analyses. Furthermore, we calculated the average maximum heating capacity of 449,578 kJ·h-1 and the average cooling capacity of 431,187 kJ·h-1 from the monthly maximum cooling and heating load analyses.