• Journal of Oriental Neuropsychiatry
• /
• v.17 no.2
• /
• pp.91-122
• /
• 2006

Objective : This research investigates the effect of the Jangwon-Dan,(JWD) on Alzheimer's disease. Method : The effects of the JWN extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA, the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, and $TNF-{\alpha}$ mRNA, (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. Result : 1. The JWN extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-1 cells treated with LPS. 2. The JWN extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The JWN extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. For the JWN extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The JWN extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and CD68/GFAP, in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The JWN extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusion : These results suggest that the JWN extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the JWN extract for Alzheimer's disease is suggested for future research.

• Journal of Korea Port Economic Association
• /
• v.21 no.1
• /
• pp.59-72
• /
• 2005

There were many theoretical studies using mathematical models about a yard storage capacity in a container terminal so far, but a simulation approach is newly popularizing. The reason why the simulation studies about yard storage capacity were a few was that once the most important part in a container terminal was a quay part. However, from the economic crisis year of 1977, the yard storage part in a container terminal became a critical resource because of the shortage of SOC investment resources. Therefore, after discharging or loading even through there was a waiting in the quay part or not, it can be swiftly improved the efficiency of a container terminal if it was handled rapidly or smoothly in a container yard. So the accurate assessment of yard storage capacity in a container terminal was needed. This study planed to assess the operation capability of a container yard via a simulation model. The model included many chatacteristics of three Korean container terminals such as Gamman Hanjin, Uam, and Hutchinson Busan at the period of 1999 to 2000. The 95% percentile was chosen as a criterion for judging of the storage capability by the recommendation of KPC (1998) and JWD (1998). A simulation approach with system dynamics concept considering the multi-directional impacts within the related variables can probavly foresee the future storage capacity of a terminal not just the past.