• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.1
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• pp.1-9
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• 1995

1, 25(OH)2-23ene-D3 is a novel vitamine D3 analog which has a double bond between C-23 and C-24. We describe the effects of this analog on cell differentiation and cell proliferation in vitro using the human histiocytic lymphoma cell line U937, and on calcium metabolism in rats in vivo. In the present investigation 1, 25(OH)2-23ene-D3 was compared to the natural metabolite of vitamin D3, 1$\alpha$, 25-dihydroxycholecalciferol[1, 25(OH)2-23ene-D3 was more potent than 1, 25(OH)2-23ene-D3 for inhibition of proliferation and induction of differentiation of U937 cells. Especially, its effect on induction of differentiation, as measured by superoxide production and nonspecific esterase(NSE) activity, was about 20-fold more potent that 1, 25(OH)2-23ene-D3. This analog morphologically and functionally differentiated U937 cells to monocyte-macrophage phenotype showing a decrease of N/C ratio in Giemsa staining and the increase of adherence ability to surface. Intraperitoneal administration of 1, 25(OH)2-23ene-D3 to rats showed that the compound had at least 50 times less activity than 1, 25(OH)2-23ene-D3 in causing hypercalcemia and hypercalciuria. The strong direct effects of 1, 25(OH)2-23ene-D3 on cell proliferation and cell differentiation, coupled with its decreased activity of calcium metabolism make this compound an interesting candidate for clinical studies including patients with leukemia, as well as several skin disorders, such as psoriasis.

• Journal of the Korea Concrete Institute
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• v.14 no.6
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• pp.864-873
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• 2002

Recently, CFT Column has reported a lot of study result, because a CFT column has certain superior structural properties as well as good productivity, execution efficiency, and improved rigidity over existing column. However, CFT column still has problems clearing the capacity evaluation between its steel tube member and high-strength concrete materials. Also, high-strength concrete filled steel square tube column(HCFT) examined numerical value explanatorily about transformation performance(M-ø) of when short-column receives equal flexure-moment from axial stress on research for concrete. hnd, with basis assumption, executed development of analysis program of moment-curvature relation for analytic analysis of transformation performance of HCFT section that get by an experiment. This study investigated to properties of structural(capacity, curvature), through a series of experiments for HCFT with key parameters, such as strength of concrete(600kgf/$\textrm{cm}^2$), D/t ratio, slenderness ratio(λ) and concrete kinds under eccentric load. And, I executed comparative analysis with AISC-LRFD, AIJ and Takanori Sato etc. and experiment result that is capacity design formula.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2001.05a
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• pp.224-231
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• 2001

Hydrogenated amorphous carbon films were deposited by ERC-PECVD with deposition conditions, such as ECR power, gas composition of methane and hydrogen, deposition time, and substrate bias voltage. The characteristics of the film were analyzed using the AES, ERDA, FTIR. Raman spectroscopy and micro hardness tester. From the results of AES and ERDA, the elements in the deposited film were confirmed as carbon and hydrogen atoms. FTIR spectroscopy analysis shows that the atomic bonding structure of a-C:H film consisted of sp³and sp²bonding, most of which is composed of sp³bonding. The structure of the a-C:H films changed from CH₃bonding to CH₂or CH bonding as deposition time increased. We also found that the amount of dehydrogenation in a-C:H films was increased as the bias voltage increased. Raman scattering analysis shows that integrated intensity ratio (I/sub D//I/sub G/) of the D and G peak was increased as the substrate bias voltage increased, and films hardness was increased.

• Korean Journal of Food Science and Technology
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• v.15 no.4
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• pp.414-420
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• 1983

Heating characteristics for retort pouches of Kimchi heated in hot water were determined as a function of various parameters for processing. Processing conditions in laboratory and commercial retort were also evaluated on the basis of storage test. D values for Lactobacillus plantarum isolated from test sample ranged from $D^{1.08}\;to\;D^{0.18}$ and z value was $10.5^{\circ}C$. Thermal diffusivity of Kimchi increased from 1.15 to $1.44{\times}10^{-3}cm/s$ by blanching for 15 min at $80^{\circ}C$. The rate of heat penetration was significantly decreased with increasing the thickness of the pouch although the decreases was less significant below 1.0cm thickness. Increasing in the ratio of solid to syrup up to 90:10 proportionately decreased $f_h$ value, but above the ratio $f_h$ values were nearly constant.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.3
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• pp.443-452
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• 1994

This study describes the effects of novel1, 25-dihydroxyvitamin D$_3$ analong[1,25(OH)$_2$-16ene-23yne-26, 27-F6-D$_3$] on proliferation of the human histiocytic lymphoma cell line U937 in vitro. We also examined the expression of c-myc oncogene in U937 cells was apparently inhibited to 62% and 87% of the control level after 4 days in the presence of 10-8M and 10-7 M of this analog, respectively. This compound morpholgically and functionally differentiated U937 cells to nonocyte-macrophage phenotype showing the increase of adherence ability to surface and a decrease of N/C ratio in Giemsa staining . Especially, nonspecific esterase activity which is a marker of cell differentiation to monocyte-macrophage was positive, and production of the positive stained cells increased in a dose dependent fashion . The expression of c-myc oncogene by 1, 25(OH)$_2$D$_3$ analog(10-7 M) was reduced by 60% at the mRNA level as determined by Northern blotting. The effects of this novel analog on cell proliferation and cell differentiation may open op new therapeutic strategies for human disorders such as psoriassis and may provide a tool to understand the mechanism of action of vitamin D$_3$ seco-steroids in malignancy.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39A no.12
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• pp.691-698
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• 2014

An L-band single side band(SSB) mixer with CMOS switches and a C-band quadrature voltage-controlled oscillator(QVCO) have been developed using the TowerJazz 0.18-um RFCMOS process. The SSB mixer exhibits a conversion gain of 6.6 ~ 7.5 dB with a 70-dBc image rejection ratio and 65-dBc port isolation. The oscillation frequency range of the QVCO is 6.2 ~ 6.7 GHz with an output power of 4~6 dBm. For measurement, 1.8 V supply voltage is used while drawing 36 mA for the mixer and 23 mA for the QVCO.

• Journal of Microbiology and Biotechnology
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• v.30 no.2
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• pp.287-295
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• 2020

The differences between luminal microbiota (LM) and mucosal microbiota (MAM) were little known, especially in duodenum. In this study, LM and MAM in colon and duodenum of mice were investigated through 16S rRNA high-throughput sequencing. The lowest bacterial diversity and evenness were observed in duodenal LM (D_LM), followed by duodenal MAM (D_MAM). Meanwhile, the bacterial diversity and evenness were obviously increased in D_MAM than these in D_LM, while no significant difference was observed between colonic MAM (C_MAM) and colonic LM (C_LM). PCoA analysis also showed that bacterial communities of LM and MAM in duodenum were completely separated, while these in colon overlapped partly. The ratio of Firmicutes to Bacteroidetes (F/B) in D_MAM was significantly higher than that in D_LM. Lactobacillus was largely enriched and was the characteristic bacteria in D_LM. The characteristic bacteria in D_MAM were Turicibacter, Parasutterella, Marvinbryantia and Bifidobacterium, while in C_LM they were Ruminiclostridium_6, Ruminiclostridium_9, Ruminococcaceae_UCG_007 and Lachnospiraceae_UCG_010, and in C_MAM they were Lachnospiraceae_NK4A136, Mucispirillum, Alistipes, Ruminiclostridium and Odoribacter. The networks showed that more interactions existed in colonic microbiota (24 nodes and 74 edges) than in duodenal microbiota (17 nodes and 29 edges). The 16S rDNA function prediction results indicated that bigger differences of function exist between LM and MAM in duodenum than these in colon. In conclusion, microbiota from intestinal luminal content and mucosa were different both in colon and in duodenum, and bacteria in colon interacted with each other much more closely than those in duodenum.

• Journal of Broadcast Engineering
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• v.21 no.4
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• pp.506-514
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• 2016

In this study, HEVC over DVB-T2 systems with a bandwidth of 6 MHz is considered, particularly for the terrestrial 4K-UHDTV broadcasting service in the Republic of Korea. The threshold of visibility carrier-to-noise power ratio (ToV C/N) and the receiver minimum required input level (sensitivity) for satisfying the subjective picture failure (SPF) condition are measured in the laboratory. It is observed, for transmitting 26.37 Mbps data stream correctly, that ToV C/N is 18.8 dB on average, and the receiver sensitivity is varied from minimum -84.2 dBm to maximum -80.0 dBm. Based on the results, the receiver noise floor is calculated by -100 dBm on average.

• Geomechanics and Engineering
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• v.2 no.4
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• pp.303-319
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• 2010

The effect of grain crushing on the deformation of sand in 1D compression and 1D creep at high stresses was investigated theoretically and experimentally. An approach was proposed to formulate the process of grain crushing in sand in accordance with the laws of fracture mechanics and energy conservation. With this approach, the relation between the void ratio and the amount of grains crushed in 1D compression was derived. Laboratory test data were used to verify this derived relation. In addition, it was observed that there are similarities in evolution of grain size distribution in 1D compression and 1D creep tests. This implies that the changes in microstructure in sand under 1D compression and 1D creep are comparable.

• Korean Journal of Food Science and Technology
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• v.15 no.3
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• pp.220-224
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• 1983

The hydration of water, at $20^{\circ}\;30^{\circ}$ and $40^{\circ}C$ for 10-360 minutes, by the two varieties of husked barley and of naked barley which were polished to 40 and 30%, respectively, was investigated. The absorption was directly proportional to the square root of the hydration time and accounted for by the diffusion equation: 1-M = $(2/{\sqrt\pi})\;(S/V){\sqrt{Dt}}$, where 1-M is the relative moisture gain and S/V is the surface-to-volume ratio. The average diffusion coefficient (D) was given by the Arrhenius relation: D = $D_{0}\;exp\;(-Ea/RT)$, where the activation energy for both husked and naked barley was about 7.2 Kcal/mole. The average value of D for naked barley was slightly higher than that for husked barley.