• Archives of Pharmacal Research
• /
• v.24 no.4
• /
• pp.333-337
• /
• 2001

The pharmacokinetic changes of diltiazem (DTZ) and its main metabolite, deacetyldiltiazem (DAD) were studied after oral administration of DTZ to normal rabbits and mild and medium folate-induced renal failure rabbits. DTZ 10 mg/kg was given to the rabbits either orally (n=6). Plasma concentrations of DTZ and DAD were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of DTZ were significantly increased in mild and medium folate-induced renal failure rabbits. The metabolite ratio of the DTZ to DAD were significantly decreased in mild and medium folate-induced renal failure rabbits. The volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits. The elimination rate constant ($\beta$) of DTZ was significantly decreased in folate-induced renal failure rabbits, but that of DAD was significantly increased. These findings suggest that the hepatic metabolism of DTZ was inhibited and the $V_{d}$, $CL_{t}$ and $\beta$ of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.35 no.3C
• /
• pp.287-294
• /
• 2010

MB-OFDM UWB system will adopt LDPC codes to enhance the decoding performance with higher data rates. In this paper, we will consider algorithm and architecture of the LDPC codes in MB-OFDM UWB system. To suggest the hardware efficient LDPC decoder architecture, LLR(log-likelihood-ration) calculation algorithms and check node update algorithms are analyzed. And we proposed the architecture of LDPC decoder for the high throughput application of Wimedia UWB. We estimated the feasibility of the proposed architecture by implementation in a FPGA. The implementation results show our architecture attains higher throughput than other result of QC-LDPC case. Using this architecture, we can implement LDPC decoder for high throughput transmission, but it is 0.2dB inferior to the BP algorithm.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.17 no.7
• /
• pp.776-781
• /
• 2004

We report the performance of a four-element, 11.67 GHz, $high-{T}_c$ superconducting (HTS) microstrip antenna array with corporate feed network. The HTS antenna array used in this work had a circular polarization for direct broadcasting satellite (DBS) system. Our array antennas were designed and built on a 0.5 mm thick MgO substrate. To compare the superconducting antennas with normal conducting counterpart, One antenna pattern was fabricated from gold thin film, and a second pattern was fabricated from ${YBa}_2{Cu}_3{O}_7-x(YBCO)$ superconducting thin film. To improve the axial ratio of circularly polarized arrays, sequential rotation technique were used. Efficiency, radiation pattern, return loss and bandwidth were measured for both antennas at cryogenic temperature and room temperature. The array produced good circular polarization, and the gain of the array at 77 K, relative to a copper array at room temperature was approximately 1.54 dB. The measured return loss of our HTS antenna array was 35.79 dB at the resonant frequency of 11.67 GHz and The total effective bandwidth was about 3.4 %. The results showed that high-temperature superconductors, when used in microstrip arrays, improved the efficiency of the HTS antenna array for circularly polarization.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.13 no.5
• /
• pp.938-946
• /
• 1989

Using the CT specimen of carbon steel(SM45C), we estimated the fatigue crack propagation behavior in stable crack propagation range. Furthermore the fatigue crack propagation rate, Acoustic Emission(AE) count rate, and fractography characteristics were also compared among others. The following results were confirmed by experimental observation. Near-threshold stress intensity factor range(.DELTA. $K_{th}$) is influenced by stress ratio but not at the upper limit of stable crack propagation range. As stress intensity factor range(.DELTA.K) and(or) stress amplitude increase (s), both crack propagation rate(da/dN) and AE count rate(dn/dN) increase. Effective stress intensity factor range(.DELTA. $K_{off}$) determined from the crack closure point measurement by AE method is useful for the evaluation of fatigue crack propagation rate. Fractography in stable crack propagation range showed striation, and agreed with the crack propagation rate obtained either by experiment of by the results of microscopic measurements.s.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.28 no.11
• /
• pp.1432-1439
• /
• 2004

By using unique experimental techniques and careful construction of the experimental apparatus, the characteristics of the local heat transfer were investigated using the condensing R134a two-phase flow, in horizontal single mini-channels. The circular channels (D$_{h}$=0.493, 0.691, and 1.067 mm) and rectangular channels (Aspect Ratio=1.0, D$_{h}$=0.494, 0.658, and 0.972 mm) were tested and compared. Tests were performed for a mass flux of 100, 200, 400, and 600 kg/$m^2$s, a heat flux of 5 to 20 ㎾/$m^2$, and a saturation temperature of 4$0^{\circ}C$. In this study, effect of heat flux, mass flux, vapor qualities, hydraulic diameter, and channel geometry on flow condensation are investigated and the experimental local condensation heat transfer coefficients are shown. The experimental data of condensation Nusselt number are compared with existing correlations.ons.

• Nutritional Sciences
• /
• v.5 no.1
• /
• pp.20-25
• /
• 2002

The vitamin $B_{6}$ status of 49 healthy college student (women, aged 20-26 y) was estimated for evaluation of vitamin $B_{6}$ status and the Korean Recommended Dietary Allowance (RDA) for vitamin $B_{6}$. The average daily vitamin $B_{6}$ intake of the subjects was 0.86 $\pm$ 0.289 mg/d or 61.43 $\pm$ 24.10% of Korean RDA. The average ratio of vitamin $B_{6}$ intake to daily protein intake was 0.014 $\pm$ 0.003 mg/g protein. Foods from animal and plaint sources provided 34.25 $\pm$ 18.62% and 65.78 $\pm$ 18.72%, respectively, of total vitamin $B_{6}$. Plasma pyridoxal 5'-phosphate (PLP) concentration was significantly (p<.01 - p<.001) positively correlated to intakes of all other nutrients except vitamin C. However, no significant correlation was found between plasma PLP and nutrient intake. Vitamin $B_{6}$ intake only tended to have a positive correlation with plasma PLP concentration. Plasma total cholesterol was correlated to plasma PLP concentration (p<.05). Plasma PLP had no correlation with levels of glucose, triglyceride, and albumin. These results confirm that the present Korea RDA for vitamin $B_{6}$ of 1.4mg/d based on 0.02 mg/g protein is adequate.

• Proceedings of the Earthquake Engineering Society of Korea Conference
• /
• 2006.03a
• /
• pp.327-336
• /
• 2006

Site coefficients in IBC and KBC codes have some limits to predict the rational seismic responses of a structure, because they consider only the effect of the soil amplification without the effects of the structure-soil interaction. In this study, upper and lower limits of site coefficients are estimated through the pseudo 3-D elastic seismic response analyses of structures built on linear or nonlinear soil layers considering the structure-soil interaction effects. Soil characteristics of site classes of A, B, and C were assumed to be linear, and those of site classes of D and E were done to be nonlinear and the Ramberg-Osgood model was used to evaluate shear modulus and damping ratio of a soil layer depending on the shear wave velocity of a soil layer. Seismic analyses were performed with 12 weak or moderate earthquake records, scaled the peak acceleration to 0.1g or 0.2g and deconvoluted as earthquake records at the bedrock 30m beneath the outcrop. With the study results of the elastic seismic response analyses of structures, new standard response spectrum and upper and lower limits of the site coefficients of Fa and Fv at the short period range and the period of 1 second are suggested Including the structure-soil interaction effects.

• Archives of Pharmacal Research
• /
• v.25 no.4
• /
• pp.541-545
• /
• 2002

Pharmacokinetic characteristics of Acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of acebutolol were significantly increased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. The ratio of the diacetolol to total acebutolol in plasma (i.e., metabolite percentage rate) was significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of acebutolol were significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Slope of terminal phase ($\beta$) of acebutolol was significantly decreased in hepatic failure rabbits. These findings suggest that the $V_{d},{\;}CL_{t}$ and $\beta$ of acebutolol were significantly decreased as a result of inhibition of the hepatic metabolism in moderate to severe hepatic failure rabbits. Therefore, dose adjustment may be necessary for acebutolol in hypertensive patients with hepatic damage.

• Korean Journal of Metals and Materials
• /
• v.48 no.11
• /
• pp.1028-1034
• /
• 2010

In the development of 3D package, through silicon via (TSV) formation technology by using deep reactive ion etching (DRIE) is one of the key processes. We performed the Bosch process, which consists of sequentially alternating the etch and passivation steps using $SF_6$ with $O_2$ and $C_4F_8$ plasma, respectively. We investigated the effect of changing variables on vias: the gas flow time, the ratio of $O_2$ gas, source and bias power, and process time. Each parameter plays a critical role in obtaining a specified via profile. Analysis of via profiles shows that the gas flow time is the most critical process parameter. A high source power accelerated more etchant species fluorine ions toward the silicon wafer and improved their directionality. With $O_2$ gas addition, there is an optimized condition to form the desired vertical interconnection. Overall, the etching rate decreased when the process time was longer.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.55 no.3
• /
• pp.273-283
• /
• 2019

The authors has predicted the maneuvering characteristics of a fishing vessel in deep water using Kijima's empirical formula in a previous study. Since the Kijima's empirical formula was developed by a regression analysis of merchant vessels which have dimensions ($C_b$, L/B, etc.) that are different from those of fishing vessels, it was possible to make a prediction approximately even with inaccurate estimation. In this study, the authors estimated the turning-motion characteristics of a model ship of fisheries training ship in shallow water based on the results of its previous study. The turning-motion characteristics of the model ship in shallow water was found out through quantitative analysis according to the water depth to ship draft ratio (H/d). In conclusion, the turning-motion characteristics of the model ship had significant changes immediately after an H/d 1.5, and this result will be helpful for sailing in shallow water.