• 제목/요약/키워드: (3R)-(-)-8-hydroxy-3-(6'-pentadecenyl)-3,4-dihydroisocoumarin

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은행(銀杏) 종의(種衣)의 Phospholipase $C{\gamma}1$ 저해 활성 성분 (2) (Phospholipase $C{\gamma}1$ Inhibitory Principles from the Sarcotestas of Ginkgo biloba (2))

  • 이지숙;조유선;이현선;안종석;김진웅
    • 생약학회지
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    • 제30권3호
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    • pp.280-283
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    • 1999
  • Using the bioassay-guided fractionation and isolation technique, two $PLC{\gamma}1$ inhibitors were isolated from the sarcotestas of Ginkgo biloba (Ginkgoaceae). The structures of these compounds were identified as (3R)-(-)-8-hydroxy-3-(6'-pentadecenyl)3,4-dihydroisocoumarin (1) and 3-heptadecen-2-one (2) by UV, IR, MS, $^1H-NMR$, $^{13}C-NMR$ and $^1H-^{13}C\;COSY$. Isolate compounds 1 and 2 have not been reported previously from the sarcotestas of G. biloba and Ginkgoaceae, respectively. In addtion, these compounds showed significant $PLC{\gamma}1$ inhibitory effects with the $IC_{50}$ of the 9.7 (1) and $25.6\;{\mu}M\;(2)$.

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