• Advances in Traditional Medicine
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• v.9 no.1
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• pp.97-99
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• 2009

The cytotoxic activity was strongly shown by (-)-ent-costunolide (1) (P388; $IC_{50}$: 687 ng/mL) which isolated from Hepatostolonophora paucistipula. These results suggest that (-)-ent-costunolide (1) has a potential cytotoxic activity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.2
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• pp.467-470
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• 2006

Bioactivity directed isolation has led to the isolation of (-)-ent-costunolide (1) as the major active compound. This compound (1) inhibited the growth of the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (4 mm inhibition zone at $15\;{\mu}g/disc$).

• Advances in Traditional Medicine
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• v.9 no.2
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• pp.192-199
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• 2009

Bioactivity-directed isolation has led to the isolation of (-)-ent-costunolide (1) as the major active compound from Hepatostolonophora paucistipula. This compound (1) was determined by spectroscopic data interpretation. This sesquiterpene lactone (1) inhibited the growth of the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185, (4 mm inhibition zone at $15{\mu}g$/disc), cytotoxic activity to murine leukaemia cell lines ATCC CCL 46 P 388D1 ($IC_{50}$ 687 ng/ml, at $0.075{\mu}g$/disk), BSC monkey kidney cell lines (100% of well at $15{\mu}g$/disk) and antiviral activity to Herpes simplex virus (0.25 mg/ml, 100% of well at $7.5{\mu}g$/disk) and Polio virus (0.125 mg/ml, 100% of well at $3.75{\mu}g$/disk). These results suggest that (-)-ent-costunolide (1) has potential antimicrobial and cytotoxic agents.