• The Journal of Korean Medicine
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• v.17 no.1 s.31
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• pp.336-344
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• 1996

Clinical studies were done on 72 peoples (1 male, 71 females) who were treated with the electric acupuncture therapy to decrease body weight and abdominal length in the Yong oriental medicine clinic from march 1, 1994 to June 30, 1995. The result were obtained as follows : 1. Total judgement of efficacy: good(18.0%) moderate(31.0%) unchanged(32.0%) 2. Degree of average body weight loss during 1 week: 0-0.9Kg(22.2%) 1-1.9Kg(20.8%) 2-2.9Kg(16.6%). 3. Degree of average abdominal length decreased during electric acupuncture treatment : 1-1.9cm (40.2%) 2-2.9cm(22.2%) 3-3.9cm(9.7%)

• Environmental Analysis Health and Toxicology
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• v.21 no.1 s.52
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• pp.87-92
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• 2006

This study was done to investigate the protective effect of novel 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives on the hepatoprotective effect intoxicated rats induced by carbon tetrachloride ($CCl_4$). A series of currently derivatives of 9-amino-1, 2, 3, 4-tetrahydroacridine have been prepared through the alkly substitution or the ring expansion for the treatment of the Alzheimer's disease. The activities of aminotransferase (aspartate and alanine) and contents of alkaline phosphatase, triglyceride and glutathione S-transferase in 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives pretreated rats were significantly decreased compared to the only carbon tetrachloride treated rats but the contents of cholesterol were increased compared to the only $CCl_4$ treated rats. The result indicated that 9-amino-1, 2, 3, 4-tetrahydroacridine derivatives showed hepatoprotective effect in $CCl_4$ treated rats.

• Nuclear Engineering and Technology
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• v.45 no.3
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• pp.311-322
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• 2013

High-Cr martensitic steel HT-9 is one of the candidate materials for advanced nuclear energy systems. Thanks to its excellent thermal conductivity and irradiation resistance, ferritic/martensitic steels such as HT-9 are considered for in-core applications of advanced nuclear reactors. The harsh neutron irradiation environments at the reactor core region pose a unique challenge for structural and cladding materials. Microstructural and microchemical changes resulting from displacement damage are anticipated for structural materials after prolonged neutron exposure. Consequently, various irradiation effects on the service performance of in-core materials need to be understood. In this work, the fundamentals of radiation damage and irradiation effects of the HT-9 martensitic steel are reviewed. The objective of this paper is to provide a background introduction of displacement damage, microstructural evolution, and subsequent effects on mechanical properties of the HT-9 martensitic steel under neutron irradiations. Mechanical test results of the irradiated HT-9 steel obtained from previous fast reactor and fusion programs are summarized along with the information of irradiated microstructure. This review can serve as a starting point for additional investigations on the in-core applications of ferritic/martensitic steels in advanced nuclear reactors.

• Archives of Pharmacal Research
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• v.20 no.6
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• pp.519-524
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• 1997

Steroid $9{\alpha}$-hydroxylase is an enzyme found in nocardioform microorganisms which can utilize steroids as a sole carbon source. After fractional centrifugation of the cell homogenates, the enzyme activity in Nocardia and Rhodococcus was found in cytoplasmic membrane fraction. On the contrary, Mycobacterium had its 9.alpha.-hydroxylation activity in cytosolic fraction. To characterize the enzyme in these microorganisms, several potential inhibitors of 9.alpha.-hydroxylase were tested and the cofactor requirement for the same enzyme was also examined. The inhibitory effect of ferrous ion chelators indicated involvement of iron containing proteins in the 9.alpha.-hydroxylase system. On the other hand, metyrapone, an inhibitor known to be specific for cytochrome P450 interfered with the enzyme in Mycobacterium, but didn't inhibit the enzyme activity in Nocardia and Rhodococcus. While the $9{\alpha}$-hydroxylase system in Nocardia and Rhodococcus required NADPH, NADH was required as an election donor in Mycobacterium.

• Kidney Research and Clinical Practice
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• v.34 no.1
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• pp.53-56
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• 2015

MYH9-related disorder is an autosomal dominant disease caused by a mutation in the MYH9 gene, which encodes nonmuscle myosin heavy chain IIA (NMMHC-IIA). This disease is characterized by giant platelets, thrombocytopenia, granulocyte inclusion bodies, proteinuria, and high-pitch sensorineural deafness. Nephropathy has been observed in 30% of patients with MYH9-related disorder. The characteristic features are early onset proteinuria and rapidly progressing renal disorder. However, the prognosis of MYH9 nephropathy remains unclear. Herein, we describe a 36-year-old woman who presented with proteinuria and was diagnosed with MYH9 nephropathy via renal biopsy and gene analysis. Her proteinuria improved after administration of an angiotensin II receptor blocker, but was aggravated after changing to a calcium channel blocker.

• Archives of Pharmacal Research
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• v.15 no.2
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• pp.138-141
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• 1992

The new N-aryl-benz[f]-indole-4, 9-dione derivatives were synthesized via in tramolecular cyclization when triethylamine was employed as a base for the reaction of 2-chloro-3-$(\alpha$-cyano-$\alpha$-ethoxycarbonyl-methyl)-1, 4-naphthoquinone and arylamines.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.05a
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• pp.387-390
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• 2014

In this paper, we propose to study on the application of the alarm algorithm to the platform of portable radiation detection device based on Coretex-A9 to ensure the safety of user. The analog board transforms sensor's signal and the platform based on Cortex-A9 outputs the results. The radiation detection's alarm is realized to LED and Buzzer to ensure safety of user.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.210.1-210.1
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• 2003

Keokhachukeu-tang is the one of Chinese traditional prescription used for the treatment of liver disease. This prescription consists of Carthami Flos (6g), Persicae Semen (9g), Pteropi Faeces (9g), Corydalis Tuber (9g), Moutan Radicis Cortex (6g), Paeoniae Radix rubra (9g), Angelicae gigantis Radix (9g), Cnidii Rhizoma (9g), Linderae Radix (12g), Cyperi Rhizoma (12g), Aurantii Fructus (9g), and Glycyrrhizae Radix (3g). Water extract of Keokhachukeu-tang showed a moderate hepatoprotective effect on tacrine-induced cytotoxicity in Hep G2 cells. (omitted)

• Journal of the Korean Magnetic Resonance Society
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• v.27 no.4
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• pp.23-27
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• 2023

Hoxc, or the Homeobox C cluster, is a group of genes that play a crucial role in embryonic development, particularly in patterning the body along the anterior-posterior axis. These genes encode transcription factors, which are proteins that bind to DNA and regulate the expression of other genes. Hoxc9 is specifically involved in the development of the skeletal system, nervous system, and adipose tissue. Hoxc9 overexpression has been linked to the development of various cancers such as leukemia and breast cancer. Here, we assigned the chemical shifts Hoxc9 DNA binding domain (DBD) using heteronuclear NMR techniques. The helical regions of Hoxc9 DBD correspond to the residues T200 - F213 (Helix I), T218 - L229 (Helix II), and T232 - K249 (Helix III). Our result would be helpful for studing the molecular interactions of the Hoxc9 DBD and other proteins.

• IMMUNE NETWORK
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• v.20 no.6
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• pp.45.1-45.16
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• 2020

IL-9 has been reported to play dual roles in the pathogenesis of autoimmune disorders and cancers. The collaboration of IL-9 with microenvironmental factors including the broader cytokine milieu and other cellular components may provide important keys to explain its conflicting effects in chronic conditions. In this review, we summarize recent findings on the cellular sources of, and immunological responders to IL-9, in order to interpret the role of IL-9 in the regulation of immune responses. This knowledge will provide new perspectives to improve clinical benefits and limit adverse effects of IL-9 when treating pathologic conditions.