• Honam Mathematical Journal
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• v.31 no.3
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• pp.369-380
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• 2009

Let $X,X_1,X_2,\;{\cdots}$ be identically distributed and negatively associated random variables with mean zeros and positive, finite variances. We prove that, if $E{\mid}X_1{\mid}^r$ < ${\infty}$, for 1 < p < 2 and r > $1+{\frac{p}{2}}$, and $lim_{n{\rightarrow}{\infty}}n^{-1}ES^2_n={\sigma}^2$ < ${\infty}$, then $lim_{{\epsilon}{\downarrow}0}{\epsilon}^{{2(r-p}/(2-p)-1}{\sum}^{\infty}_{n=1}n^{{\frac{r}{p}}-2-{\frac{1}{p}}}E\{{{\mid}S_n{\mid}}-{\epsilon}n^{\frac{1}{p}}\}+={\frac{p(2-p)}{(r-p)(2r-p-2)}}E{\mid}Z{\mid}^{\frac{2(r-p)}{2-p}}$, where $S_n\;=\;X_1\;+\;X_2\;+\;{\cdots}\;+\;X_n$ and Z has a normal distribution with mean 0 and variance ${\sigma}^2$.

• BMB Reports
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• v.57 no.6
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• pp.281-286
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• 2024

Adult hippocampal neurogenesis plays a pivotal role in maintaining cognitive brain function. However, this process diminishes with age, particularly in patients with neurodegenerative disorders. While small, non-coding microRNAs (miRNAs) are crucial for hippocampal neural stem (HCN) cell maintenance, their involvement in neurodegenerative disorders remains unclear. This study aimed to elucidate the mechanisms through which miRNAs regulate HCN cell death and their potential involvement in neurodegenerative disorders. We performed a comprehensive microarray-based analysis to investigate changes in miRNA expression in insulin-deprived HCN cells as an in vitro model for cognitive impairment. miR-150-3p, miR-323-5p, and miR-370-3p, which increased significantly over time following insulin withdrawal, induced pronounced mitochondrial fission and dysfunction, ultimately leading to HCN cell death. These miRNAs collectively targeted the mitochondrial fusion protein OPA1, with miR-150-3p also targeting MFN2. Data-driven analyses of the hippocampi and brains of human subjects revealed significant reductions in OPA1 and MFN2 in patients with Alzheimer's disease (AD). Our results indicate that miR-150-3p, miR-323-5p, and miR-370-3p contribute to deficits in hippocampal neurogenesis by modulating mitochondrial dynamics. Our findings provide novel insight into the intricate connections between miRNA and mitochondrial dynamics, shedding light on their potential involvement in conditions characterized by deficits in hippocampal neurogenesis, such as AD.

• Journal of applied mathematics & informatics
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• v.28 no.3_4
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• pp.977-986
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• 2010

Let $X_1$, $X_2$, $\cdots$ be identically distributed negatively associated random variables with $EX_1\;=\;0$ and $E|X_1|^3$ < $\infty$. In this paper we prove $lim_{{\epsilon\downarrow}0}\;\frac{1}{-\log\;\epsilon}\sum\limits_{n=1}^\infty\frac{1}{n^2}ES_n^2I\{|S_n|\;{\geq}\;{\sigma\epsilon}n\}\;=\;2$ and $lim_{\epsilon\downarrow0}\;\epsilon^{2-p}\sum\limits_{n=1}^\infty\frac{1}{n^p}$ $E|S_n|^pI\{|S_n|\;{\geq}\;{\sigma\epsilon}n\}\;=\;\frac{2}{2-p}$ for 0 < p < 2, where $S_n\;=\;\sum\limits_{i=1}^{n}X_i$ and 0 < $\sigma^2\;=\;EX_1^2\;+\;\sum\limits_{i=2}^{\infty}Cov(X_1,\;X_i)$ < $\infty$. We consider some results of i.i.d. random variables obtained by Liu and Lin(2006) under negative association assumption.

• Journal of Convergence for Information Technology
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• v.7 no.6
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• pp.79-87
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• 2017

The purpose of the convergence study is to confirm the relevance between communication awareness and communication ability and communication self-efficacy. The subjects were 128 college students studying convergence education. They answered to a self-report questionnaire during March 13 to 24, 2017. The instrument for Awareness toward communication, Communication ability, Communication self-efficacy was done by Likert 5 point scale. Data was analyzed by technical statistics, t-test, one way ANOVA, Pearson's correlation coefficient and post-hoc Scheffe test using SPSS/Win 21.0 program. As a result, awareness toward communication level $3.50{\pm}.41$ point, communication ability $3.32{\pm}.38$ point and communication self-efficacy $3.00{\pm}.40$ among. Communication Awareness was positively correlated with communication ability level and communication self-efficacy. If there is an intervention program that improve the level of communication self-efficacy, it is expected to enhance the communication ability.

• Journal of the Korea Convergence Society
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• v.12 no.12
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• pp.125-137
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• 2021

This study is a descriptive investigation study to identify the Convergence factors of the subjective health status, communication with medical personnel and drug misuse on medication adherence. The subjects of this study were 179 senior citizens who used community elderly welfare centers. Data were collected from January 13, 2020 to January 17, 2020. Data analysis was performed using frequency, percentage, mean, standard deviation, t-test, ANOVA. Post-Hoc Test Was performed using Scheffe test, Pearson's correlation coefficients and multiple regression analysis. The regression equation of this study explained 24% of medication adherence. Drug misuse(𝛽=-4.32, p=<.001) was the factor that had the greatest influence on the medication adherence, followed by the presence or absence of chronic disease (𝛽=-3.04, p=.003), marital status (𝛽=2.64, p=.009), and communication with medical personnel (𝛽=2.26, p=.025 ) in that order. Therefore, it is necessary to establish a convergence system of medication adherence for the elderly using community welfare centers.

• Journal of the Korea Convergence Society
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• v.11 no.6
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• pp.311-318
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• 2020

This was a basic study to ascertain the changes in sleep patterns and the factors disrupting sleep in hospitalized children. The participants were children aged 6 years or younger who had been hospitalized in an advanced general hospital in a particular region. A total of 81 participants were included, and for data analysis using SPSS/WIN 21.0. The results showed that children's sleep duration decreased significantly after hospitalization compared to before (p<.001), and there were significant differences in sleep onset latency (p<.001) and frequency of sleep deprivation (p<.001). Factors perceived by the children's mothers to disrupt sleep included the child's health state, noise in the ward, nurses' treatments, and lighting in the ward. This study verified that children's sleep quality and duration decreases during hospitalization, demonstrating the need to prepare measures to improve sleep in hospitalized children based on an understanding of changes in sleep patterns and disrupting factors.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.6
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• pp.631-640
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• 2011

This paper proposes a M & S Tool for simulating the detection performance in the bistatic radar system. After examing the interrelationship among the bistatic radar parameters, $P_d$(probability of detection), $P_{fa}$(probability of false alarm) and ��SNR of the received signal, we analyze the range of the bistatic radar range product and range sum. We derive the number of integration of the received pulses that satisfies the required detection performance of the bistatic radar system, along with the analysis of the performance degradation in the jammer scenario. Finally, the analyzed results are implemented in the M & S Tool which consists of 4 modules.

• Journal of the Korea Convergence Society
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• v.8 no.3
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• pp.133-140
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• 2017

The purpose of this study was to determine the effects of coaching leadership on organizational effectiveness of dental hygienists. A survey was conducted on dental hygienists in Busan and Kyungnam from December 7, 2016 to January 15, 2017. A total of 215 questionnaires were included in analysis. The influence factors of coaching leadership on the rapport-building between the leaders and the members included the leader's direction (p<0.001) and relationship (p<0.001). The influence factors of coaching leadership on organizational commitment included the leader's relationship (p<0.001), direction (p<0.05), development (p<0.05), and accountability (p<0.05). The influence factors of coaching leadership on job satisfaction included the leader's relationship (p<0.001) and development (p<0.01). The coaching leadership of dental hygienists has been found to make a positive influence on the organizational effectiveness. It is believed that systematic and comprehensive coaching leadership training for dental hygienists must be conducted to build up trust between the leaders and the members, facilitate communication, and enhance job commitment and performance. Furthermore.

• BMB Reports
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• v.42 no.10
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• pp.685-690
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• 2009

Angiogenesis is essential for tumor growth and vascular endothelial cell growth factor (VEGF) plays a key role in this process. Conversely, sphingosine 1-phosphate (S1P) is a biologically active sphingolipid known to play a key role in cancer progression by regulating endothelial cell proliferation and migration. In this study, the authors found that S1P increases the level of VEGF mRNA in human umbilical vein endothelial cells (HUVECs) and immortalized HUVECs (iHUVECs). Additionally, S1P was found to increase VEGF promoter activity in MS-1 mouse pancreatic islet endothelial cells. Furthermore, a pharmacological inhibitory study revealed that $G_{\alpha i/o}$-mediated phospholipase C, Akt, Erk, and p38 MAPK signaling are involved in this S1P-induced expression of VEGF. A component of AP1 transcription factor is important for S1P-induced VEGF expression. Taken together, these findings suggest that S1P enhances endothelial cell proliferation and migrat ion by upregulating the expression of VEGF mRNA.

• Journal of the Korea Convergence Society
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• v.10 no.3
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• pp.297-306
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• 2019

The purpose of this study was to investigate the convergence between ego-resilience, major satisfaction and clinical competency of nursing students. This study used data from 183 nursing college students who experienced clinical practice at a college located in G city of Korea. Clinical competency was positively correlated with ego-resilience (r = .446, p <.000), major satisfaction (r = .439, p <.000). The factors influencing clinical competency were ego - resilience and major satisfaction, and explanatory power was 29.1%. Based on the above results, it is necessary to improve the convergence education program and diversify the teaching and learning methods to improve the major satisfaction, ego - resilience and clinical competency of nursing students.