• Asian Pacific Journal of Cancer Prevention
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• v.15 no.14
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• pp.5753-5757
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• 2014

Background: The purpose of this study is to determine whether the IGF1R expression has a prognostic role in non-small cell lung cancer. Materials and Methods: Forty-seven patients histopathologically diagnosed with small cell lung cancer upon bronchoscopic biopsy or resection materials were included in the study. IGF1R expression was examined via immunohistochemical methods. In samples, >10% staining were assessed as positive and ${\leq}10%$ as negative. Information about demographic datas and treatments was obtained by retrospective searches of patient files. Results: IGF1R expression was determined as positive in 38 (80.9%) and as negative in 9 (19.1%) patients. There was no significant relation between IGF1R expression and histological sub-type, local invasion, lymph node and metastasis status (p=0.842, p=0.437, 0.064, 0.447, respectively). There was also no correlation with IGF1R expression and survival (p=0.141). Conclusions: There are conflicting results between IGF1R and its prognostic effects in the various studies. It has been claimed in some studies it is not related to prognosis as in our study, and in some studies it has been claimed that it is a good prognostic factor whereas in some studies it has been claimed as being a factor for worse prognosis. We think that IGF1R expression in non-small cell lung carcinoma patients deserves further analysis, because of its potential prognostic and predictive roles.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.6
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• pp.2277-2284
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• 2013

In this study, a groundwater table fluctuation method is suggested to predict groundwater level by means of groundwater table fluctuation due to recharge and discharge under unsteady condition. This model analyzes groundwater variation characteristics by using reaction factor related with groundwater flow and specific yield related with recharge. For the test of this model, measured groundwater level at JD Yongdam 1 and JW Konghang for 5 years (2006-2010) were used. At JD Yongdam 1, the estimated specific yield was 0.023, and the estimated reaction factor was 0.039. At JW Konghang, the estimated specific yield was 0.009 and the estimated reaction factor was 0.028, respectively. This model can estimate recharge and saturated parameters, thus it is expected that this model would be the proper tool for checking the parameter of hydrologic model and percolation features.

• Toxicological Research
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• v.29 no.4
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• pp.241-247
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• 2013

This study was carried out to examine the action mechanism of Chamaecyparis obtusa oil (CO) on hair growth in C57BL/6 mice. For alkaline phosphatase (ALP) and ${\gamma}$-glutamyl transpeptidase (${\gamma}$-GT) activities in the skin tissue, at week 4, the 3% minoxidil (MXD) and 3% CO treatment groups showed an ALP activity that was significantly higher by 85% (p < 0.001) and 48% (p < 0.05) and an ${\gamma}$-GT activity that was significantly higher by 294% (p < 0.01) and 254% (p < 0.05) respectively, as compared to the saline (SA) treatment group. For insulin-like growth factor-1 (IGF-1) mRNA expression in the skin tissue, at week 4, the MXD and CO groups showed a significantly higher expression by 204% (p < 0.05) and 426% (p < 0.01) respectively, as compared to the SA group. At week 4, vascular endothelial growth factor (VEGF) expression in the MXD and CO groups showed a significantly higher expression by 74% and 96% (p < 0.05) respectively, however, epidermal growth factor (EGF) expression in the MXD and CO groups showed a significantly lower expression by 66% and 61% (p < 0.05) respectively, as compared to the SA group. Stem cell factor (SCF) expression in the MXD and CO groups was observed by immunohis-tochemistry as significant in a part of the bulge around the hair follicle and in a part of the basal layer of the epidermis. Taking all the results together, on the basis of effects on ALP and ${\gamma}$-GT activity, and the expression of IGF-1, VEGF and SCF, which are related to the promotion of hair growth, it can be concluded that CO induced a proliferation and division of hair follicle cells and maintained the anagen phase. Because EGF expression was decreased significantly, CO could delay the transition to the catagen phase.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.672-681
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• 2018

This study was conducted to test the validity and reliability of the Korean version of the Professional Quality of Life Scale-Short Form (ProQOL-K-SF). Survey data were collected from 191 staff involved in long-term care insurance who worked for National Health Insurance Services. Construct validity using exploratory factor analysis and the internal consistency reliability were determined using SPSS/WIN (21.0). Factor analysis of the ProQOL-K-SF demonstrated that it has a two-factor structure (compassion satisfaction and compassion fatigues) and 13 items that support construct validity. Factor loadings of the compassion satisfaction ranged from 0.70-0.86, factor loading of the compassion fatigues ranged from 0.71-0.82 and the total variance was 60%. The ProQOL-K showed interanal consistency based on Cronbach's ${\alpha}$, with a total scale and two sub scale values of 0.76-0.90. Compassion fatigue and compassion satisfaction of 30 items of the ProQOL-K were positively correlated with those of 13 items of the ProQOL-K-SF. The results support that the ProQOL-K has satisfactory construct validity and is a reliable measure of professional quality of life in Korea.

• Journal of Korean Neurosurgical Society
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• v.44 no.6
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• pp.375-381
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• 2008

Objective : The effects on neural proliferation and differentiation of neural stem cells (NSC) of basic fibroblast growth factor-2 (bFGF). insulin growth factor-I (IGF-I). brain-derived neurotrophic factor (BDNF). and nerve growth factor (NGF) were assessed. Also, following combinations of various factors were investigated : bFGF+IGF-I, bFGF+BDNF, bFGF+NGF, IGF-I+BDNF, IGF-I+NGF, and BDNF+NGF. Methods : Isolated NSC of Fisher 344 rats were cultured with individual growth factors, combinations of factors, and no growth factor (control) for 14 days. A proportion of neurons was analyzed using $\beta$-tubulin III and NeuN as neural markers. Results : Neural differentiations in the presence of individual growth factors for $\beta$-tubulin III-positive cells were : BDNF, 35.3%; IGF-I, 30.9%; bFGF, 18.1%; and NGF, 15.1%, and for NeuN-positive cells was : BDNF, 34.3%; bFGF, 32.2%; IGF-I, 26.6%; and NGF, 24.9%. However, neural differentiations in the absence of growth factor was only 2.6% for $\beta$-tubulin III and 3.1% for NeuN. For $\beta$-tubulin III-positive cells, neural differentiations were evident for the growth factor combinations as follows : bFGF+IGF-I, 73.1 %; bFGF+NGF, 65.4%; bFGF+BDNF, 58.7%; BDNF+IGF-I, 52.2%; NGF+IGF-I, 40.6%; and BDNF+NGF, 40.0%. For NeuN-positive cells : bFGF+IGF-I, 81.9%; bFGF+NGF, 63.5%; bFGF+BDNF, 62.8%; NGF+IGF-I, 62.3%; BDNF+NGF, 56.3%; and BDNF+IGF-I, 46.0%. Significant differences in neural differentiation were evident for single growth factor and combination of growth factors respectively (p<0.05). Conclusion : Combinations of growth factors have an additive effect on neural differentiation. The most prominent neural differentiation results from growth factor combinations involving bFGF and IGF-I. These findings suggest that the combination of a mitogenic action of bFGF and post-mitotic differentiation action of IGF-I synergistically affects neural proliferation and NSC differentiation.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.05c
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• pp.131-134
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• 2001

In this paper, the piezoelectric and dielectric properties as a function of x and a in $aPbZr_xTi_{1-x}O_3-(1-a)Pb(Mn_{1/3}Nb_{2/3})O_3$ + ywt%MgO is investigated. As a results, when a is 0.95 and x is 0.505, electromechanical coupling factor$(k_p)$, permittivity${\varepsilon}_33^T/{\varepsilon}_0$, piezoelectric strain constant$(d_{33})$ and mechanical quality factor$(Q_m)$ are 58 %, 1520, 272 pC/N and 1550, respectively. From XRD analysis, when x is 0.505, it is MPB which present rhombohedral and tetragonal phase in same quantity. Also, From SEM observation, when sintering temperature is $1150^{\circ}C$, grain size is about $2\;{\mu}m$. As a results added MgO dopant in the ternary piezoelectric ceramic, when MgO content is 0.1 wt%, $k_p$ increases to 63[%].

• Proceedings of the KIEE Conference
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• 2001.07c
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• pp.1439-1441
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• 2001

In this paper, the piezoelectric and dielectric properties as a function of x and r in $yPbZr_xTi_{1-x}O_3-(1-y)Pb(Mn_{1/3}Nb_{2/3})O_3$ piezoelectric ceramics is investigated. As a results, when y is 0.95 and x is 0.505, electromechanical coupling factor($k_p$), permittivity(${{\varepsilon}_{33}}^T/{\varepsilon}_0$), piezoelectric strain constant($d_{33}$) and mechanical quality factor($Q_m$) are 58[%], 1520, 272 [pC/N] and 1550, respectively. From XRD analysis, when x is 0.505, it is MPB which present rhombohedral and tetragonal phase in same quantity. Also, From SEM observation. when sintering temperature is 1150[$^{\circ}C$], grain size is about 2 [${\mu}m$]. As y decreases, piezoelectric and dielectric properties and curie temperature decreases, but mechanical quality factor and sintering temperature increases.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3202-3205
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• 2023

The k₀-standardization neutron activation analysis method has successfully determined the mass fraction of elements of interest using around a hundred analytical radionuclides. However, several very short-lived nuclides with half-life less than 100 s have not been used at Dalat research reactor. One of the reasons is that the values of k₀-factors of these nuclides are significantly different. Therefore, this work focused on re-determination and evaluation of k₀-factors of very short-lived nuclides ¹¹⁰Ag (T_1/2 = 24 s) and ^46mSc (T_1/2 = 18.75 s). The results of determination of the short-lived nuclides revealed that k₀-factor of ¹¹⁰Ag is significantly difference between the existing data and the obtained results in this work. The evaluation of the k₀-factors was done by using the obtained results for application of k₀-NAA for NIST-1566b and NIST-2711A standard reference materials.

• Journal of Power System Engineering
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• v.12 no.3
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• pp.12-18
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• 2008

In the present study, the numerical simulation has been performed to investigate K-factor for temperature variation of working fluid in spray nozzle with orifice. The commercial CFD software, Fluent with the proper modeling was applied for analyzing the internal of the spray nozzle. Numerical result for K-factor at $20^{\circ}C$ agrees with the experimental result that it applied n=0.5 within about 7% error. The pressure drop inside nozzle is showed 20% passing swirler, 70% in the region between the outlet of swirler and the orifice and 10% at the outlet of orifice. As the operating pressure is increased, K-factor is decreased by effect of flow resistance at it's inlet before pass swirler. The temperature increase of working fluid reduced the flow rate according to reducing of density, and average 1.23% decrease is showed in the present research.

• The Journal of Korean Physical Therapy
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• v.24 no.4
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• pp.282-289
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• 2012

Purpose: The purpose of this study is to analyze the home-stay disability's activity, as well as the participation domains and the environment factor domains of international classification of functioning (ICF), in order to examine the effect of the home visiting physical therapy and the disability's activity. Methods: A total of 211 home-stay disabled subjects with brain lesions or crippled disorder, living in 5 cities and districts of Jeollanam-do, underwent 90 minutes of home visiting physical therapy per week during a 6-month period, and using the ICF checklist, evaluated the subject's activity and participation domains and environmental factor domains. Results: The performance qualifier showed a significant statistical change in the movement, self-care, domestic life, interpersonal interactions and relationships, community, society and civic life domains (p<0.05); and the capacity qualifier showed a significant change only in the mobility domains in the before and after of the home visiting physical therapy (p<0.05). The barrier factor in the order of services, systems and policies domains, product and technology domains, and attitude domains it influenced significantly in the performance (p<0.05), and in the facilitator factor in the order of product and technology domains, support and relationships domains, services, systems and policies domains it influenced significantly in the performance of the disabled (p<0.05). Conclusion: The visiting physical therapy can help in the improvement of the activity and participation of the home-stay disabled subjects, and for the accurate evaluation of the home-stay disabled subjects, it is considered that an evaluation including various environmental factors, such as ICF, must be fulfilled.