• 동의생리병리학회지
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• 제26권4호
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• pp.437-440
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• 2012

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation. In the present study, we examined that Cryptotanshione(CT), a tanshinone from oriental traditional medicinal herb Danshen (Salvia miltiorrhiza Bunge), had the inhibitory effects on hypoxia-mediated activation of STAT3 in androgen independent human prostate cancer PC-3 cells. CT inhibited the protein expression of hypoxia-inducible factor-1alpha (HIF-$1{\alpha}$) under hypoxic condition. Consistently, CT blocked hypoxia-induced phosphorylation and nuclear accumulation of STAT3. In addition, CT reduced cellular of vascular endothelial growth factor (VEGF), a critical angiogenic factor and a target gene of STAT3 induced under hypoxia. Of note, chromatin immunoprecipitation (ChiP) assay revealed that CT inhibited binding of STAT3 to VEGF promoter. Taken together, our results suggest that CT has anti-angiogenic activity by disturbing the binding STAT3 to the VEGF promoter in PC-3 cells.

• 한국산업보건학회지
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• 제7권1호
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• pp.49-59
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• 1997

This study was performed to analyze the purity of technical grade ${\alpha}$-naphthylamine, to establish optimal analytical condition of ${\alpha}$-naphthylamine in urine and to determine the urine sample of workers exposed to ${\alpha}$-naphthylamine. The purity of technical grade ${\alpha}$-naphthylamine were $96.5{\pm}2.38%$, $94.1{\pm}0.97%$, $97.0{\pm}0.02%$ by gas chromatography-mass selective detector. To analyze ${\alpha}$-naphthylamine in urine, high performance liquid chromatography-electrochemical detector and gas chromatography-electron capture detector operating conditions have been optimized by preliminary expriment. In high performance liquid chromatography-electrochemical detector, the mobile phase was consisted of acetonitrile(35%) and water(65%), and the flow rate was maintained at 1.0ml per minute. Optimal detective condition was 9.0V(10nA/V) of electrochemical detector. The recovery of sep-pak treatment method was highly estimated as pretreatment of ${\alpha}$-naphthylamine in urine. The free amine was isolated by gas chromatography-electron capture detector after basic hydrosis, sep-pak treatment, toluene elution and HFBA(heptafluoro-butyric anhydride) derivatization of urine. The recovery of ${\alpha}$-naphthylamine in urine was $98.73{\pm}3.29%$ by gas chromatography-electron capture detector. The sensitivity was more higher than that of high performance liquid chromatography-electrochemical detector. Urinary ${\alpha}$-naphthylamine was detected in only one worker among nine workers. The level of ${\alpha}$-naphthylamine in urine was 6.42 ng/ml.

• 충청수학회지
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• 제13권1호
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• pp.71-78
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• 2000

The main goal of this paper is to prove the following theorem ; Let (X, ${\rho}_1$) be a fuzzy normed linear space over K and (Y, ${\rho}_2$) be a fuzzy Banach space over K. If ${\chi}_{B_{{\parallel}{\cdot}{\parallel}}}{\supseteq}{\rho}*$, then (CF(X,Y), ${\rho}*$) is a fuzzy Banach space, where ${\rho}*(f)={\vee}{\lbrace}{\theta}{\wedge}\frac{1}{t({\theta},f)}\;{\mid}\;{\theta}{\in}(0,1){\rbrace}$, $f{\in}CF(X,Y)$, $B_{{\parallel}{\cdot}{\parallel}}$ is the closed unit ball on (CF(X, Y), ${\parallel}{\cdot}{\parallel}$ and ${\parallel}f{\parallel}={\vee}{\lbrace}P^2_{{\alpha}^-}(f(x))\;{\mid}\;P^1_{{\alpha}^-}(x)=1,\;x{\in}X{\rbrace}$, $f{\in}CF(X,Y)$, ${\alpha}{\in}(0,1)$.

• 대한수학회보
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• 제21권2호
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• pp.107-113
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• 1984

Throughout the paper let A be a semifinite, infinite von Neumann algebra acting on a Hilbert space H, .alpha. an infinite cardinal. The main purpose of our work is to give several characterizations of a class of closed ideals in A, by introducing the notions of relative ranks of elements in A and the relative .alpha.-topology on H. The relative .alphi.-topology is an analogue to the .alpha.-topology that we have defined in ([7], [8]). The present work is regarded as an extension of [7], [8] and motivated by works of M. Breuer ([1], [2]), V. Kaftal ([5], [6]) and M.G. Sonis [9].

• 대한화학회지
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• 제7권4호
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• pp.225-229
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• 1963

The nature of the two isomers of 4-nitroazoxybenzenes in strongly acidic solution have been analyzed by U.V. spectrophotometry. Oxygen atom in the azoxy-group of $\alpha$-and $\beta$-4-nitroazoxybenzene in strong acid solution migrates neither to para position nor ortho position of the unsubstituted benzene ring of the compound in contrast with the cases of methyl-and bromo-substituted azoxybenzene, and shown no Wallach rearrangement. Since the $^1A{\rightarrow}^1H$ bands of the spectra shown hyperchromic effect whereas the ${\pi}{\rightarrow}{\pi}^*$ bands of them exhibit extream hypochromic effect, it appears most likely that trans ${\rightarrow}$cis isomerization take place in the media. A mechanism of a triangular transition state by which the transformation might be proceeded, is proposed.

• 대한화학회지
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• 제7권3호
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• pp.197-202
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• 1963

The ${\alpha}-and\;{\beta}$-isomer of 4-nitroazoxybenzenes have been separated by liquid chromatography and their U.V. spectra were examined. The n${\to}{\pi}^{\ast}$ transition band of the compounds did not appear, likewise the cases of other compounds of the series. Transition band of the new isomer were as usual as those of other azoxy-compounds, whereas the ${\pi}{\to}{\pi}^{\ast}$ transition band of the other isomer which is reported in the literature shown peculier hypochromic shift and hypochromic effect. From the spectroscopic point of view it is very likely that the new isomer (m.p. $184-5^{\circ}C$) is ${\alpha}$-isomer and the other one (m.p. $152^{circ}C$) is ${\beta}$-isomer contrary to the literature.

• International Journal of Reliability and Applications
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• 제2권4호
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• pp.263-268
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• 2001

Shanmugam(1991) generalized the Poisson distribution to capture a restriction on the incidence rate $\theta$ (i.e. $\theta$ ＜ $\beta$, an unknown upper limit), and named it incidence rate restricted Poisson (IRRP) distribution. Using Neyman's C($\alpha$) concept, Shanmugam then devised a hypothesis testing procedure for $\beta$ when $\theta$ remains unknown nuisance parameter. Shanmugam's C ($\alpha$) based .results involve inverse moments which are not easy tools, This article presents an alternate testing procedure based on likelihood ratio concept. It turns out that likelihood ratio test statistic offers more power than the C($\alpha$) test statistic. Numerical examples are included.

• 환경생물
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• 제24권2호
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• pp.172-178
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• 2006

골재채취가 수층의 세균군집구조에 미치는 영향을 알아보기 위해 낙동강 중류, 골재채취가 이루어 지지 않은 수역인 구미대교와 장기간에 걸쳐 연속적으로 골재채취가 행해지는 지역인 성주군 소학리 (성주대교 인근)에서 $\alpha\;\beta\;\gamma-subclass$ proteobacteria, Cytophaga-Flavobacterium (CF) group 세균군과 황산염화원세균을 FISH법으로 정량분석하였다. 아울러 수온, pH, EC, 엽록소-$\alpha$ 양 등의 이화학적인 환경요인도 측정하였다. DAPI로 염색된 세균수로 측정한 총세균수의 경우, 두 정점간의 괄목할 만한 양적인 차이는 없었으나 그 시간차에 따른 변동이 골재채취 수역에서 더욱 심했다. 또한 높은 엽록소-$\alpha$ 양을 나타낸 골재채취 수역에서 검출한 CF group 세균군과 황산염환원세균이 총세균수에서 차지하는 비율이 비골재채취 수역에 비해 높았다. 이같은 결과는 저니질이 수층으로 재유입되었기 때문으로 판단된다. 그러나 본 연구에서 검출한 세균군이 총세균수에서 차지하는 비율을 합하면 그 비율은 골재채취 수역보다 비골재채취 수역에서 더 높았다. FISH법에 의한 세균의 검출가능성이 해당세균의 물질대사능과 연관이 있으므로 골재채취 수역에서의 낮은 세균 검출율은 골재채취가 세균의 물질순환에서의 역기능을 초래하고 이는 또한 연차적으로 그들의 먹이연쇄에 부정적인 영향을 미칠 가능성을 시사하는 것이다.

• 한국측량학회지
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• 제31권2호
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• pp.111-119
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• 2013

항공 라이다로부터 획득한 대용량의 3차원 점 데이터로부터 대상 물체의 윤곽정보를 추출하는 것은 데이터 처리 과정에서 필수적이며 기반적인 기술 중의 하나이다. 특히 인공 구조물인 건물은 복잡한 현대 도시를 구성하는 주요 구조물이며 그 형태가 명확하기에 윤곽 정보의 추출 과정이 더욱 중요하다 할 수 있다. 본 연구에서는 항공 라이다를 이용하여 얻어진 건물을 구성하는 3차원 점 데이터로부터 건물의 윤곽정보를 추출하기 위하여 점 데이터의 기하정보만을 이용한 확장 카이(${\chi}$-Chi) 알고리즘을 제안한다. 제안된 알고리즘은 임의의 점군을 델로니(Delaunay) 삼각망으로 구성하고 특정 조건을 만족하는 변(edge)를 제거하는 과정을 통하여 구현된다. 덧붙여, 전체적인 추출과정의 효율화를 위해서 델로니 삼각망의 구성을 스윕헐 알고리즘을 적용하여 수행하였다. 본 연구에서 제안하는 확장 카이 알고리즘의 성능을 확인하기 위하여 본 연구와 같은 목적으로 개발된 인케이싱 폴리곤 제작 알고리즘과 알파 쉐이프 알고리즘을 비교하였고 기 제작된 건물의 도화정보를 이용하여 윤곽정보 추출의 정확도를 비교하였다. 실험결과, 본 연구에서 제안한 알고리즘은 기존의 알고리즘들보다 윤곽정보 추출 속도 및 정확도가 향상됨을 확인하였다.

• The Journal of Asian Finance, Economics and Business
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• 제7권9호
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• pp.621-629
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• 2020

This research focuses on determining the impact of human resource management activities on the compatibility and work results of employees of Ho Chi Minh Stock Exchange (HOSE) listed companies. The paper includes five parts: introduction, literature review, research methodology, research results, and conclusion and policy implications. The data are collected from the survey of 350 listed companies in HOSE, in which 315 survey notes filled with sufficient information are used for analysis. The paper employs both qualitative method and quantitative method. Group discussion of 10 experts is for qualitative research. Quantitative method performs analysis of Statistics, Cronbach's Alpha, EFA analysis, CFA analysis and SEM model. The results of the research clearly indicate that human resource management (HRM) activities are measured through improving the ability, improving the motivation and improving the opportunity. While compatibility is measured through suitability, connection and sacrifice; whereby HRM activities of ability improvement have a positive effect on the job suitability and connection; HRM activities of motivation improvement have a positive effect on the job suitability, connection and sacrifice; and HRM activities of opportunity improvement have a positive effect on the job suitability, sacrifice and connection; Finally, the job suitability, sacrifice and connection positively affect the work results of employees.