• Journal of The Korean Astronomical Society
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• v.48 no.1
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• pp.21-55
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• 2015

If the Universe is dominated by cold dark matter and dark energy as in the currently popular ${\Lambda}CDM$ cosmology, it is expected that large scale structures form gradually, with galaxy clusters of mass $M{\geq}10^{14}M_{\odot}$ appearing at around 6 Gyrs after the Big Bang (z ~ 1). Here, we report the discovery of 59 massive structures of galaxies with masses greater than a few times $10^{13}M_{\odot}$ at redshifts between z = 0.6 and 4.5 in the Great Observatories Origins Deep Survey fields. The massive structures are identified by running top-hat filters on the two dimensional spatial distribution of magnitude-limited samples of galaxies using a combination of spectroscopic and photometric redshifts. We analyze the Millennium simulation data in a similar way to the analysis of the observational data in order to test the ${\Lambda}CDM$ cosmology. We find that there are too many massive structures (M > $7{\times}10^{13}M_{\odot}$) observed at z > 2 in comparison with the simulation predictions by a factor of a few, giving a probability of < 1/2500 of the observed data being consistent with the simulation. Our result suggests that massive structures have emerged early, but the reason for the discrepancy with the simulation is unclear. It could be due to the limitation of the simulation such as the lack of key, unrecognized ingredients (strong non-Gaussianity or other baryonic physics), or simply a difficulty in the halo mass estimation from observation, or a fundamental problem of the ${\Lambda}CDM$ cosmology. On the other hand, the over-abundance of massive structures at high redshifts does not favor heavy neutrino mass of ~ 0.3 eV or larger, as heavy neutrinos make the discrepancy between the observation and the simulation more pronounced by a factor of 3 or more.

• Atmosphere
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• v.23 no.3
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• pp.265-273
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• 2013

To investigate properties of cloud and rainfall occurred at Boseong on 10 July 2012, Raindrop Size distributions (RSDs) and other parameters were analyzed using observation data collected by Micro Rain Radar (MRR) and PARticle SIze and VELocity (PARSIVEL) disdrometer located in the National center for intensive observation of severe weather at Boseong in the southwest of the Korean peninsula. In addition, time series of RSD parameters, relationship between reflectivity-rain rate, and vertical variation of rain rates-fall velocities below melting layer were examined. As a result, good agreements were found in the reflectivity-rain rate time series as well as their power relationships between MRR and PARSIVEL disdrometer. The rain rate was proportional to reflectivity, mean diameter, and inversely proportional to shape (${\mu}$), slope (${\Lambda}$), intercept ($N_0$) parameter of RSD. In comparison of the RSD, as rain rate was increased, the slope of RSD became less steep and the mean diameter became larger. Also, it was verified that reflectivities are classified in three categories (Category 1: Z (reflectivity) > 40 dBZ, Category 2: 30 dBZ < Z < 40 dBZ, Category 3: Z < 30 dBZ). As reflectivity was increased, rain rate was intensified and larger raindrops were existed, while reflectivity was decreased, shape (${\mu}$), slope (${\Lambda}$), intercept ($N_0$) parameter of RSD were increased. We expected that these results will lead to better understanding of microphysical process in convective rainfall system occurred during short-term period over Korean peninsula.

• Korean Journal of Remote Sensing
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• v.24 no.5
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• pp.483-496
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• 2008

Qualified ground control points (GCPs) are required to construct a digital elevation model (DEM) from a pushbroom stereo pair. An inverse geolocation algorithm for extracting GCPs from ERS SAR data and the SRTM DEM was recently developed. However, not all GCPs established by this method are accurate enough for direct application to the geometric correction of pushbroom images such as SPOT, IRS, etc, and thus a method for selecting and removing inaccurate points from the sets of GCPs is needed. In this study, we propose a method for evaluating GCP accuracy and winnowing sets of GCPs through orientation modeling of pushbroom image and validate performance of this method using SPOT stereo pair of Daejon City. It has been found that the statistical distribution of GCP positional errors is approximately Gaussian without bias, and that the residual errors estimated by orientation modeling have a linear relationship with the positional errors. Inaccurate GCPs have large positional errors and can be iteratively eliminated by thresholding the residual errors. Forty-one GCPs were initially extracted for the test, with mean the positional error values of 25.6m, 2.5m and -6.1m in the X-, Y- and Z-directions, respectively, and standard deviations of 62.4m, 37.6m and 15.0m. Twenty-one GCPs were eliminated by the proposed method, resulting in the standard deviations of the positional errors of the 20 final GCPs being reduced to 13.9m, 8.5m and 7.5m in the X-, Y- and Z-directions, respectively. Orientation modeling of the SPOT stereo pair was performed using the 20 GCPs, and the model was checked against 15 map-based points. The root mean square errors (RMSEs) of the model were 10.4m, 7.1m and 12.1m in X-, Y- and Z-directions, respectively. A SPOT DEM with a 20m ground resolution was successfully constructed using a automatic matching procedure.

• Annals of Surgical Treatment and Research
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• v.95 no.5
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• pp.240-248
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• 2018

Purpose: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases. Results: Cell viability of MDA-MB-231 after combination treatment with ABT-737 and docetaxel was significantly lower than that after docetaxel or ABT-737 monotherapy based on MTT assay (both P < 0.001), with a combination index of 0.41. The proportion of sub-G1 population after combination treatment was significantly higher than that after docetaxel or ABT-737 monotherapy (P = 0.001, P = 0.003, respectively). Pretreatment with z-VAD-fmk completely restored cell viability of MDA-MB-231 from apoptotic cell death induced by combination therapy (P = 0.001). Although pro-caspase-8 or Bid did not show significant change in expression level, pro-casepase-9 showed significantly decreased expression after combination treatment. Cleaved caspase-3 showed increased expression while poly (ADP-ribose) polymerase cleavage was induced after combination treatment. However, hypoxia-inducible factor 1-alpha and aldehyde dehydrogenase 1 totally lost their expression after combination treatment. Conclusion: Combination of ABT-737 with docetaxel elicits synergistic therapeutic effect on MDA-MB-231, a TNBC cell line overexpressing Bcl-2, mainly by activating the intrinsic pathway of apoptosis. Therefore, adjunct of ABT-737 to docetaxel might be a new therapeutic option to overcome docetaxel resistance of TNBCs overexpressing Bcl-2.

• Journal of the Korea Furniture Society
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• v.10 no.2
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• pp.55-61
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• 1999

This research was carried out to investigate the fundamental properties such as the structure of annual ring, density distribution, compressive strength with parallel to grain, relative crystallinity, and microfibril angle of Gumgangsong(Pinus densoflora for. erecta Uyeki). The wood specimens, Gumgangsong and Sonamu(Pinus densiflora S. et Z.), for this experiment were prepared at Ulijingoon Sokwangri and Kyungpook university's forest in Kyungpook province, respectively. Average annual ring width is $2.0mm{\pm}0.3$ in heartwood of Gumgangsong. The respectively of heart wood was over 60 percent in Gumgangsong and 20~50 percent in Sonamu. Heartwood density were ranged from 0.5 to $0.8{\;}g/cm^3$ in Gumgangsong and from 0.4 to $0.5{\;}g/cm^3$ in sonamu. Compressive strength in Gumgangsong and Sonamu was about $30{\pm}5MPa$ and $25{\pm}5MPa$, resepectively. But the relative crystallinity and microfibril angle of two species were not different clearly. From these results of Gumgangsong and Sonamu, therefore, it was considered the main difference factors for both species were annual ring width and heartwood percentage.

• The Korean Journal of Mycology
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• v.21 no.2
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• pp.133-139
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• 1993

Common dermatophytosis in upper Egypt were studied at three hospitals in Minia city. Tinea corporis (ringworm of glabrous skin) was diagnosed in 127 patients (84 males and 53 females). Trichophyton was the most common genus and was represented by 6 species among which T. violaceum was the commonest fungus. Microsporum was represented by 4 species and M. canis was the prevalent species. Tinea pedis (ringworm of the foot) was noticed in 22 cases (13 males and 9 females) and also Trichophyton and Microsporum were the causal organisms. Three species of Trichophyton namely: T. violaceum, T. kuryngei and Trichophyton sp. were isolated. Tinea cruis (ringworm of the groin) was diagnosed in 21 patients (16 males and 5 females). Epidermophyton floccosum was the most prevalent fungus associated with tinea cruris whereas Trichophyton and Candida were less frequent. Tinea unguium (ringworm of the nail) was diagnosed in 9 patients, 8 were females and one was male and the age incidence ranged between 5 and 55 years. M. canis occurred in 2 cases and T. mentagrophytes in one case. Out of 86 cases of tinea versicolor, 71 were males and 15 were females. Malassezia furfur was the main causal agent. All patients of candidiasis and paronychia were females and Candida was the most prevalent causal agent.

• Interaction and multiscale mechanics
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• v.6 no.2
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• pp.157-172
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• 2013

This paper presented an investigation of macromolecular suspension in a grooved channel by using the dissipative particle dynamics (DPD) with finitely extensible non-linear elastic (FENE) bead spring chains model. Before studying the movement and evolution of macromolecules, the DPD method was first validated by modeling the simple fluid flow in the grooved channel. For both simple fluid flow and macromolecular suspension, the flow fields were analyzed in detail. It is found that the structure of the grooved channel with sudden contraction and expansion strongly affects the velocity distribution. As the width of the channel reduces, the horizontal velocity increases simultaneously. Vortices can also be found at the top and bottom corners behind the contraction section. For macromolecular suspension, the macromolecular chains influence velocity and density distribution rather than the temperature and pressure. Macromolecules tend to drag simple fluid particles, reducing the velocity with density and velocity fluctuations. Particle trajectories and evolution of macromolecular conformation were investigated. The structure of the grooved channel with sudden contraction and expansion significantly influence the evolution of macromolecular conformation, while macromolecules display adaptivity to adjust their own conformation and angle to suit the structure so as to pass the channel smoothly.