• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2781-2786
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• 2014

Human ${\alpha}_1$-antitrypsin (${\alpha}_1$-AT) is a natural inhibitor of neutrophil elastases and has several dozens of genetic variants. Most of the deficient genetic variants of human ${\alpha}_1$-AT are unstable and cause pulmonary emphysema. However, the most clinically significant variant, Z-type ${\alpha}_1$-AT, exhibits retarded protein folding that leads to accumulation of folding intermediates. These aggregate within the endoplasmic reticulum (ER) of hepatocytes, subsequently causing liver cirrhosis as well as emphysema. Here, we studied the role of an ER folding assistant protein Cpr5p on Z-type ${\alpha}_1$-AT folding. Cpr5p was induced > 2-fold in Z-type ${\alpha}_1$-AT-expressing yeast cells compared with the wild type. Knockout of CPR5 exacerbated cytotoxicity of Z-type ${\alpha}_1$-AT, and re-introduction of CPR5 rescued the knockout cells from aggravated cytotoxicity caused by the ${\alpha}_1$-AT variant. Furthermore, Cpr5p co-immunoprecipitated with Z-type ${\alpha}_1$-AT and facilitated its protein folding. Our results suggest that protein-folding diseases may be suppressed by folding assistant proteins at the site of causal protein biosynthesis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.12 no.4
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• pp.347-356
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• 1987

This paper is to propose a new line code suitable for a high speed unipolar pulse transmission system, such as a high speed optical digital transmission system. The original information speed can be converted into the transmission speed $\frac{(m+1)}{m}$ by the speed converter. Then this code, named mBiZ code, is generated by means of an Exclusive NOR between the bit stream inserted a space into every m bits and the bit stream delayed by the time slot allocated a single bit at the output coded sequence. Therefore, a mBiZ code can reduce a redundancy in the line code for transmission and its conversion circuits can be devised easily. The mBiZ code can also suppress undesirable long consecuitive identical digits and make line code balance in the mark and space ratio. Therefore, high frequency and low frequency components in power spectrum of a mBiZ code can be suppessed.

• Journal of Pharmacopuncture
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• v.21 no.1
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• pp.26-34
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• 2018

Objective: The purpose of this study was to investigate the efficacy and safety of spinal-Z, derived from Peganum harmala seeds and Dracocephalum Kotschyi Boiss leaves, in patients with esophageal and stomach adenocarcinoma, and squamous cell carcinoma of the esophagus. Methods: Sixty-one patients with malignancies of the upper gastrointestinal tract were randomly assigned to one of two groups (treatment or control) in a double-blind fashion. Six capsules of Spinal-Z were prescribed to the patients with the regimen of 600 mg/m2/day, and placebo to the control group, for six months. Results: There were no significant differences between the two groups with regard to age, sex, duration of cancer, type of cancer and family history of cancer. There were significant differences in abdominal pain, heartburn, constipation and vomiting between the two groups, following spinal-Z therapy. Evaluation of drug side effects showed no difference in cough or other respiratory symptoms, itching, headache or dizziness between the two groups, both before and after treatment. Conclusion: This study indicates that Spinal-Z is safe and efficacious in the management of patients with upper gastrointestinal tract cancers.

• Journal of the Korean Society of Marine Environment & Safety
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• v.13 no.2 s.29
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• pp.169-172
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• 2007

This paper presents circuit models and control algorithms of distributed generation system(DGS) which consists of Z-type converter and PWM inverter. Z-type converter which employs both the L and C passive components and shoot-through zero vectors instead qf the conventional DC/DC converter in order to step up DC-link voltage. Discrete time sliding mode control with the asymptotic observer is used for current control. This system am be used for power conversion of DC renewable energy.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.71.1-71.1
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• 2012

We have identified local analogs of strong $H{\alpha}$ Emitters (HAEs) that dominate the z~4 Lyman-break galaxy population using the Sloan Digital Sky Survey (SDSS). At z<0.4, only 0.04% of galaxies are classified as HAEs with $H{\alpha}$ equivalent width larger than $500{\AA}$, comparable to that of z~4 HAEs. The $H{\alpha}$-to-UV luminosity ratio of local HAEs is consistent with that of z~4 HAEs, indicating relatively large specific star formation rate in these galaxies compared to traditionally studied UV-selected Lyman break analogs. Local HAEs are young, less evolved galaxies with low metallicity. It is still difficult to constrain whether the star formation in local HAEs is powered by minor mergers or by cosmological cold gas accretion. However, the stacked optical spectrum of local HAEs shows several strong ionization lines, for example HeII 4686 emission line, which are shown in Wolf-Rayet galaxies. Thus it is highly likely that local HAEs are galaxies with an elevated ionization parameter, either due to a high electron density or large escape fraction of hydrogen ionizing photons.

• Korean Journal of Computational Design and Engineering
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• v.8 no.2
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• pp.65-74
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• 2003

For virtual reality, virtual manufacturing system, or simulation based design, we need to visualize very large and complex 3D models which are comprising of very large number of polygons. To overcome the limited hardware performance and to attain smooth realtime visualization, there have been many researches about algorithms which reduce the number of polygons to be processed by graphics hardware. One of these algorithms, occlusion culling is a method of rejecting the objects which are not visible because they are occluded by other objects, and then passing only the visible objects to graphics hardware. Existing occlusion culling algorithms have some shortcomings such as the required long preprocessing time, the limitation of occluder shape, or the need for special hardware implementation. In this study, an efficient occlusion culling algorithm is proposed. The proposed algorithm reads and analyzes Z-buffer of graphics hardware using Microsoft DirectX, and then determines each object's visibility. This proposed algorithm can speed up visualization by reading Z-buffer using DirectX which can access hardware directly compared to OpenGL, by reading only the region to which each object is projected instead of reading the whole Z-Buffer, and the proposed algorithm can perform more exact visibility test by using simplified model instead of using bounding box. For evaluation, the proposed algorithm was applied to very large polygonal models. And smooth realtime visualization was attained.

• Archives of Pharmacal Research
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• v.10 no.2
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• pp.94-99
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• 1987

By using the former equation (8), we modified the equation which can show the dissimilar osmotic behavior of liposome with composition change. The slope of the new equation was presented as the ratio of osmotically active volume (V$_{act}$= ) to the total volume (V$_{totel}$= $_{acl}$+ V$_{dead}$ ; V$_{dead}$ is osmotically inactive volume) of loposomes, we defined is as a Z-value, which can elucidate the dissimilarity of the osmotic activity of multilamellar liposomes with the change of phospholipid composition and the differences of physicochemical properties of liposomes. Z-value was applied for studying the physico-chemical properties of liposomal membrane. The factor that affects on the Z-value was not the lipid concentration of liposome stock dispersion but the lipid composition of liposomal membrane. As the content of dicetylphosphate, the negative charged phospholipid, was increased, the osmotic activity, represented by Z-value, of multilamellar liposome was decreased. Using the hypertonic conditions (shrinking region), Z-value steadily increased and reached a maximum at 10 mole percent cholesterol with increasing the cholesterol content.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.34 no.1
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• pp.62-66
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• 1998

The maneuverabilities of the training ship M.S. HEUIMANGBONG were studied, based on the data obtained from her Z test. The results obtained were summerized as follows: 1. The maneuvering indices K' and T'of the M.S. HEUIMANGBONG were 0.542, 1.305 at 10$^{\circ}$Z Test and 0.433, 1.351 at 20$^{\circ}$Z test and 0.442, 1.388 at 30$^{\circ}$Z test respectively. The above calculated values K', T' showed that her maneuverabilities were more effective when her rudder was used to small angle than to large angle. 2. As the overshoot angles of the starbord side of the M.S. HEUIMANGBONG were larger than those of port side at 10$^{\circ}$, 20$^{\circ}$and 30$^{\circ}$Z test, her maneuverabilities in port turning were found to be higher than in starbord turning. 3. The running distance of a turn at her 10$^{\circ}$Z test was about 9.9 times her own length and she was considered to have a good maneuverabilities synthetically

• English & American cultural studies
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• v.14 no.2
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• pp.49-75
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• 2014

This paper argues that John Leguizamo disguises ethical intention with humor in his one-person show, Freak. The argument proceeds in three stages. First, on the basis of Slavoj ${\check{Z}}i{\check{z}}ek^{\prime}s$ theory that fantasies teach us how to desire discussed in The Sublime Object of Ideology, I analyze how and why Leguizamo exaggerates and thus de-constructs the ideological fantasies about Latin Americans in Freak. Through this analysis the ridiculous exaggeration of the fantasies and their deconstruction emerges as the means to surface the trauma caused by the fantasies, internally and externally curing and reconciling the audience. Second, I apply ${\check{Z}}i{\check{z}}ek^{\prime}s$ theory of the quilting point introduced in Looking Awry: An Introduction to Jacques Lacan through Popular Culture to reveal how "blots" in Freak form "black holes" in the audience's consciousness to smash their established view of the reality, inducing them to encounter with "the real." The investigation into Leguizamo's use of humor as the quilting point illuminates how he invites the audience to look awry beyond the popular fantasy at "the real" America. Third, on the ground of Emmanuel Levinas's theory that theaters are the space of ethics, namely "ethotopos" to emphasize responsible actions discussed in "Ethics as First Philosophy," I assert that Leguizamo disguises his ethical message with humor so as for the audience to recognize their responsibility for others in America and take action towards change.

• Kyungpook Mathematical Journal
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• v.60 no.4
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• pp.683-710
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• 2020

Let ℕ be the set of nonnegative integers and 𝕬 be a 2-torsion free triangular algebra over a commutative ring ℛ. In the present paper, under some lenient assumptions on 𝕬, it is proved that if Δ = {𝛿_n}_n∈ℕ is a sequence of ℛ-linear mappings 𝛿_n : 𝕬 → 𝕬 satisfying ${\delta}_n([[x,\;y],\;z])\;=\;\displaystyle\sum_{i+j+k=n}\;[[{\delta}_i(x),\;{\delta}_j(y)],\;{\delta}_k(z)]$ for all x, y, z ∈ 𝕬 with xy = 0 (resp. xy = p, where p is a nontrivial idempotent of 𝕬), then for each n ∈ ℕ, 𝛿_n = d_n + 𝜏_n; where d_n : 𝕬 → 𝕬 is ℛ-linear mapping satisfying $d_n(xy)\;=\;\displaystyle\sum_{i+j=n}\;d_i(x)d_j(y)$ for all x, y ∈ 𝕬, i.e. 𝒟 = {d_n}_n∈ℕ is a higher derivation on 𝕬 and 𝜏_n : 𝕬 → Z(𝕬) (where Z(𝕬) is the center of 𝕬) is an ℛ-linear map vanishing at every second commutator [[x, y], z] with xy = 0 (resp. xy = p).