• Geomechanics and Engineering
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• v.36 no.2
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• pp.183-204
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• 2024

In current investigation, a novel beam finite element model is formulated to analyze the buckling and free vibration responses of functionally graded porous beams resting on Winkler-Pasternak elastic foundations. The novelty lies in the formulation of a simplified finite element model with only three degrees of freedom per node, integrating both C⁰ and C¹ continuity requirements according to Lagrange and Hermite interpolations, respectively, in isoparametric coordinate while emphasizing the impact of z-coordinate-dependent porosity on vibration and buckling responses. The proposed model has been validated and demonstrating high accuracy when compared to previously published solutions. A detailed parametric examination is performed, highlighting the influence of porosity distribution, foundation parameters, slenderness ratio, and boundary conditions. Unlike existing numerical techniques, the proposed element achieves a high rate of convergence with reduced computational complexity. Additionally, the model's adaptability to various mechanical problems and structural geometries is showcased through the numerical evaluation of elastic foundations, with results in strong agreement with the theoretical formulation. In light of the findings, porosity significantly affects the mechanical integrity of FGP beams on elastic foundations, with the advanced beam element offering a stable, efficient model for future research and this in-depth investigation enriches porous structure simulations in a field with limited current research, necessitating additional exploration and investigation.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.47 no.2
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• pp.1-9
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• 2024

New motor development requires high-speed load testing using dynamo equipment to calculate the efficiency of the motor. Abnormal noise and vibration may occur in the test equipment rotating at high speed due to misalignment of the connecting shaft or looseness of the fixation, which may lead to safety accidents. In this study, three single-axis vibration sensors for X, Y, and Z axes were attached on the surface of the test motor to measure the vibration value of vibration. Analog data collected from these sensors was used in classification models for anomaly detection. Since the classification accuracy was around only 93%, commonly used hyperparameter optimization techniques such as Grid search, Random search, and Bayesian Optimization were applied to increase accuracy. In addition, Response Surface Method based on Design of Experiment was also used for hyperparameter optimization. However, it was found that there were limits to improving accuracy with these methods. The reason is that the sampling data from an analog signal does not reflect the patterns hidden in the signal. Therefore, in order to find pattern information of the sampling data, we obtained descriptive statistics such as mean, variance, skewness, kurtosis, and percentiles of the analog data, and applied them to the classification models. Classification models using descriptive statistics showed excellent performance improvement. The developed model can be used as a monitoring system that detects abnormal conditions of the motor test.

• International Journal of Oncology
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• v.54 no.5
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• pp.1875-1883
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• 2019

Reversine, a 2,6-diamino-substituted purine analogue, has been reported to be effective in tumor suppression via induction of cell growth arrest and apoptosis of cancer cells. However, it remains unclear whether reversine exerts anticancer effects on human colorectal cancer cells. In the present study, in vitro experiments were conducted to investigate the anticancer properties of reversine in human colorectal cancer cells. The effect of reversine on human colorectal cancer cell lines, SW480 and HCT-116, was examined using a WST-1 cell viability assay, fluorescence microscopy, flow cytometry, DNA fragmentation, small interfering RNA (siRNA) and western blotting. Reversine treatment demonstrated cytotoxic activity in human colorectal cancer cells. It also induced apoptosis by activating poly(ADP-ribose) polymerase, caspase-3, -7 and -8, and increasing the levels of the pro-apoptotic protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI. The pan-caspase inhibitor Z-VAD-FMK attenuated these reversine-induced apoptotic effects on human colorectal cancer cells. Additionally, reversine treatment induced cell cycle arrest in the subG1 and G2/M phases via increase in levels of p21, p27 and p57, and decrease in cyclin D1 levels. The expression of Fas and death receptor 5 (DR5) signaling proteins in SW480 and HCT116 cells was upregulated by reversine treatment. Reversine-induced apoptosis and cell cycle arrest were suppressed by inhibition of Fas and DR5 expression via siRNA. In conclusion, Reversine treatment suppressed tumor progression by the inhibition of cell proliferation, induction of cell cycle arrest and induction of apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells. The present study indicated that reversine may be used as a novel anticancer agent in human colorectal cancer.

• Steel and Composite Structures
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• v.52 no.4
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• pp.419-434
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• 2024

A flat slab is a structural system where columns directly support it without the presence of beam elements. However, despite its wide advantages, this structural system undergoes a major deficiency where stresses are concentrated around the column perimeter, resulting in the progressive collapse of the entire structure as a result of losing the shear transfer mechanisms at the cracked interface. Predicting the punching shear capacity of RC flat slabs is a challenging problem where the factors contributing to the overall slab strength vary broadly in their significance and effect extent. This study proposed a new expression for predicting the slab's capacity in punching shear using a nonuniform concrete tensile stress distribution assumption to capture, as well as possible, the induced strain effect within a thick RC flat slab. Therefore, the overall punching shear capacity is composed of three parts: concrete, aggregate interlock, and dowel action contributions. The factor of the shear span-to-depth ratio (a_v/d) was introduced in the concrete contribution in addition to the aggregate interlock part using the maximum aggregate size. Other significant factors were considered, including the concrete type, concrete grade, size factor, and the flexural reinforcement dowel action. The efficiency of the proposed model was examined using 86 points of published experimental data from 19 studies and compared with five code standards (ACI318, EC2, MC2010, CSA A23.3, and JSCE). The obtained results revealed the efficiency and accuracy of the model prediction, where a covariance value of 4.95% was found, compared to (13.67, 14.05, 15.83, 19.67, and 20.45) % for the (ACI318, CSA A23.3, MC2010, EC2, and JSCE), respectively.

• Nuclear Engineering and Technology
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• v.56 no.8
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• pp.3378-3384
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• 2024

Investigations were conducted on the addition of barium's impact on the radiation shielding and physical attributes of five different glasses, designated S1-S5, with varying BaO contents. Using two point sources namely Co⁶⁰ and Cs¹³⁷ along with a scintillation detector [NaI(TL)], experimental measurements were made of the shielding parameters of γ-rays, namely the effective atomic number (Z_eff), electron density (N_el), half-value layer (HVL), linear attenuation coefficient (μ), mass attenuation coefficient (μ_m), mean free path (λ), and radiation protection effectiveness at the energies of 0.664, 1.177, and 1.334 MeV, and comparisons made with recently considered glasses as well as frequently employed materials for γ-ray shielding. The results show that the examined glasses' physical and radiation shielding qualities are improved by the addition of BaO. The μ values increased from 0.245 to 0.275 cm^-1 (0.662 MeV), from 0.174 to 0.198 cm^-1 (1.173 MeV), and from 0.161 to 0.189 (1.332 MeV). The observed values of HVL decreased from 2.83, 3.98, and 4.3 cm to 2.5, 3.5, and 3.62 cm at 0.662, 1.173, and 1.332 MeV, respectively, for the samples S1 and S5. In addition, the S5 glass sample was determined to have the best protection against photon among all the samples that were evaluated, as well as against recently considered glasses and those materials often utilized for gamma-ray shielding purposes.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.3
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• pp.241-246
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• 2007

Purpose: $[^{11}C]6-OH-BTA-1$ ([N-methyl-$^{11}C$]2-(4'-methylaminophenyl)-6-hydroxybenzothiazole, 1), a -amyloid imaging agent for the diagnosis of Alzheimer's disease in PET, can be labeled with higher yield by a simple loop method. During the synthesis of $[^{11}C]1$, we found the formation of by-products in various solvents, e.g., methylethylketone (MEK), cyclohexanone (CHO), diethylketone (DEK), and dimethylformamide (DMF). Materials and Methods: In Automated radiosynthesis module, 1 mg of 4-aminophenyl-6-hydroxybenzothiazole (4) in 100 l of each solvent was reacted with $[^{11}C]methyl$ triflate in HPLC loop at room temperature (RT). The reaction mixture was separated by semi-preparative HPLC. Aliquots eluted at 14.4, 16.3 and 17.6 min were collected and analyzed by analytical HPLC and LC/MS spectrometer. Results: The labeling efficiencies of $[^{11}C]1$ were $86.0{\pm}5.5%$, $59.7{\pm}2.4%$, $29.9{\pm}1.8%$, and $7.6{\pm}0.5%$ in MEK, CHO, DEK and DMF, respectively. The LC/MS spectra of three products eluted at 14.4, 16.3 and 17.6 mins showed m/z peaks at 257.3 (M+1), 257.3 (M+1) and 271.3 (M+1), respectively, indicating their structures as 1, 2-(4'-aminophenyl)-6-methoxybenzothiazole (2) and by-product (3), respectively. Ratios of labeling efficiencies for the three products $([^{11}C]1:[^{11}C]2:[^{11}C]3)$ were $86.0{\pm}5.5%:5.0{\pm}3.4%:1.5{\pm}1.3%$ in MEK, $59.7{\pm}2.4%:4.7{\pm}3.2%:1.3{\pm}0.5%$ in CHO, $9.9{\pm}1.8%:2.0{\pm}0.7%:0.3{\pm}0.1%$ in DEK and $7.6{\pm}0.5%:0.0%:0.0%$ in DMF, respectively. Conclusion: The labeling efficiency of $[^{11}C]1$ was the highest when MEK was used as a reaction solvent. As results of mass spectrometry, 1 and 2 were conformed. 3 was presumed.

• Journal of the Korean Wood Science and Technology
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• v.10 no.3
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• pp.96-108
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• 1982

Pinus is one of the most important species supplying domestic industrial timbers such as constitutional lumber, pulpwood, and mine props. It occupies nearly 50 percent of the total forest resources in Korea. With above conception, to develop this forest resources and to obtain the basic data on the reasonable and effective utilization of Pinus, this study was carried out. Five species (P. koraiensis S. et Z., P. densiflora S. et Z., P. thunbergii Parlat, P. densiflara far erecta, P. rigida Miller) grown in Kwangnoong experimental forest stand, Chungcheongnam-Do, and Gangwon-Do regions were selected as sample trees. Anatomical, physical, mechanical and chemical properties of them were investigated.

• Korean Journal of Environmental Biology
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• v.27 no.4
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• pp.397-405
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• 2009

We assessed the physical habitat conditions of pale chub (Zacco platypus) considering various stream order in the Geum river basin. Field monitoring was conducted for ecological and habitat conditions for 28 sites from October 2007 to October 2008. The number of Z. platypus sampled during this period was 2,362. In more than 3rd stream, water depth and velocity showing the highest number of samples were 0.8 m and $0.8\;m\;s^{-1}$, respectively. In addition, the highest number of samples was observed under the condition of total length (TL) (8~10 cm), velocity ($0.3\;m\;s^{-1}$), water depth (0.4 m), substrate size (send, 0.1~1.0 mm~coarse gravel, 50.0~100.0 mm) and habitat type (run). Based on the monitoring data (n=1059) the relationship between body weight (BW) and TL in male and female were estimated as $BW=0.0068{\times}TL^{3.0274}$ ($r^2=0.9102$) and $BW=0.0075{\times}TL^{2.9995}$ ($r^2=0.8517$), respectively. Growth equations on days after parturition (DAP) to the TL were estimated as TL=0.0108DAP+1.5795 ($r^2=0.9721$). By equations (TL 6.9 cm), BW were 2.7 g (male) and 2.4 g (female), and DAP was about 490 days.

• Journal of the Korean Ceramic Society
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• v.29 no.5
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• pp.347-356
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• 1992

Various kaolin samples with different alumina content were prepared from calcined admixture of kaolin and ammonium sulfate by varying the treatment time in sulfuric acid. Samples were nitridated under N2 or N2-H2 atmosphere with changing the amount of added carbon, the reaction time and temperature. As the alumina content lowered, the size of kaolin particles decreased and the specific surface area increased. XRD analysis indicated that ${\alpha}$-quartz remained by decomposition of halloysite and meta-halloysite. Experimental results of nitridation behavior are summerized as follows; 1) Nitridation under N2 atmosphere. With the increase of C/SiO2 ratio and with the decrease of Al2O3 content, disappearance of XRD pattern peaks of mullite, ${\alpha}$-quartz and ${\alpha}$-Al2O3 were accelerated at 1300$^{\circ}C$. SiC was the main phase in the reaction product of acid-treated kaolin samples nitridated at 1300$^{\circ}C$ for 10 hours regardless of C/SiO2 ratio. But the XRD peak intensities of ${\beta}$-Si3N4, ${\beta}$-sialon and SiC did not show much difference when untreated raw kaolin was fired at the same condition. When the ratio of C/SiO2 was 3.5, ${\beta}$-sialon and ${\beta}$-Si3N4 existed in the reaction product of about 22% alumina containing kaolin sample fired at 1350$^{\circ}C$ for 7 hours. Only ${\beta}$-sialon existed in the same sample fired at 1400$^{\circ}C$ for 10 hours. ${\beta}$-sialon was obtained from all of the acid-treated kaolin samples fired at 1400$^{\circ}C$ for 40 hours, but AlN and SiC remained in the untreated kaolin sample. Z value of the ${\beta}$-sialon obtained from the 22% alumina containing kaolin sample fired at 1400$^{\circ}C$ for 40 hours was about 1.3(XRD) and 1.5(EDS). 2) Nitridation under 80N2+2OH2 mixed gas atmosphere with the C/SiO2 ratio of 1 Mullite was not found, but ${\alpha}$-Si3N4, and ${\beta}$-sialon were present in the reaction product of about 22% alumina containing kaolin sample fired at 1300$^{\circ}C$ for 10 hours. When untreated kaolin sample was nitridated at the same condition, mullite remained. AlN and SiC were not found in the reaction product of about 22% alumina containing kaolin sample fired at 1350$^{\circ}C$ for 5 hours. On the other hand, AlN and SiC remained in the product of untreated kaolin fired at the same condition.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.45 no.1
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• pp.46-55
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• 2009

To compare and evaluate the suitability and comfort levels of the environment on board a stern trawl training ship, KAYA(GT: 1737 tons, Pukyong National University), with the international standardization guide ISO 6954:2000(E), measurements of the hull vibration on accommodation areas and working areas of the training ship from July 8 to July 10, 2008 were completed upon KAYA's linear sea route. The vibrations along the z-axis were measured with the use of a 3-axis vibration level meter, which included a marine vibration card. Results show accelerations of the vibrations on the passenger's accommodation area to be 42.0-115.8(average: 78.0, standard deviation(SD): 21.0) mm/$s^2$, which is largely below the permissible upper limit, but 75 % of the observation points exceeded the permissible lower limit of 71.5 mm/$s^2$, indicating a comfortable environment. The accelerations of the vibration in a frequency of 10-24Hz lowering the visual performance were measured at 2.5-12.0(average: 7.6, SD: 3.1) mm/$s^2$. The crew s accommodation area experienced vibration accelerations of 42.9-82.3(average: 93.1, SD: 53.1) mm/$s^2$, which is generally below the permissible upper limit of 214.0 mm/$s^2$, and 62.5% of the observation points did not exceed the permissible lower limit of 107.0 mm/$s^2$, denoting a level of comfort. The acceleration of the vibration in a frequency of 10-24Hz were 4.7-28.3(average: 12.4, SD: 8.8) mm/$s^2$. On the crew s working area the accelerations were measured at 86.9-153.9(average 119.3, SD 18.0) mm/$s^2$. These values were generally below the permissible upper limit of 286.0 mm/$s^2$ and only 12.5% of the observation points did not exceed the permissible lower limit of 143.0 mm/$s^2$, the level at which a high level of comfort is maintained. The accelerations in frequency of 10-24Hz and 30Hz were 9.1-29.8 (average 13.8, SD= 4.5) mm/$s^2$ and 8.9-13.7 (average 11.8, SD 2.1) mm/$s^2$, respectively. In conclusion the boarding environment of the training ship was good in general although an improvement of the vibration condition partially needed on the crew s accommodation area near the engine room.