• The Journal of Korean Physical Therapy
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• 제31권5호
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• pp.322-327
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• 2019

Purpose: This study examined the influence of the maximal aerobic capacity on the two-year cardiac-related re-hospitalization in patients with heart failure with a reduced ejection fraction (HFrEF) in Korean society. Methods: The maximal aerobic capacity of the study population (n=95, male 63%) was evaluated using a cardiopulmonary exercise (CPX) testing system. Each patient was followed up for two years to divide the HFrEF patients into two groups according to cardiac-related re-hospitalization: re-hospitalization (RH) group (n=29, 30%) and no re-hospitalization (NRH) group (n=66, 70%). Results: The relative peak $VO_2$ (mL/kg/min, p<0.001), exercise duration (p<0.001), respiratory exchange ratio ($VCO_2/VO_2$, p=0.001), systolic blood pressure (SBP) reserve (p=0.004), heart rate (HR) reserve (p=0.007), SBP max (p=0.02), and HR max (p=0.039) were significantly lower in the RH group than the NRH group during the CPX test. On the other hand, the ventilatory efficiency (VE/VCO2 slope, p=0.02) and age (p=0.022) were significantly higher in the RH group than in the NRH group. In binary logistic regression analysis, the relative peak $VO_2$ (p=0.001, Wald Chi-square 10.137) was the strongest predictive factor on cardiac-related re-hospitalization, which was followed by $VCO_2/VO_2$ (p=0.019, Wald Chi-square 5.54). On the other hand, age (p=0.063, Wald Chi-square 3.445) did not have a significant influence on cardiac related re-hospitalization. Conclusion: The maximal aerobic capacity, especially the relative peak $VO_2$, is the strongest factor on cardiac-related re-hospitalization within two years in patients with HFrEF in Korean society.

• Tuberculosis and Respiratory Diseases
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• 제48권1호
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• pp.14-23
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• 2000

연구배경: 폐암은 근치적 폐절제술이 가장 효과적인 치료법이지만 폐암 환자들은 흔히 고령이면서 흡연으로 인한 폐 기능저하가 동반된 경우가 많고 정상 폐조직을 광범위하게 절제하게 되므로 다른 수술보다 수술후 사망률 및 폐합병증이 더욱 문제시되고 있다. 이에 저자들은 폐기능이 저하된 폐암환자에서 폐절제술후 사망 및 합병증과 관련된 수술전 인자를 일아보고자 본 연구를 시행하였다. 방 법: 1995년 10월부터 1997년 8월까지 삼성서울병원에서 폐절제술을 시행받는 환자중에 $FEV_1$ 이 2L 이하이거나 예측치의 60% 이하인 환자를 대상으로 전향적 연구를 시행하였고 수술후 최종진단이 폐암이 아니거나 폐절제가 시행되지 않았던 환자는 최종대상에서 제외하였다. 수술 전에 대상환자의 성별, 연령, 체중 감소의 정도, 동반질환, 폐쇄성 폐렴여부를 조사하였고, 헤마토크릿, 혈청알부민, 심전도, 안정시동맥혈가스, $FEV_1$, DLco를 비롯한 폐활량검사, 운동부하 폐 기능검사를 시행하였으며 폐관류주사를 이용하여 수술후 폐기능예측지표를 산출하였다. 수술시 집도의, 폐절제술범위, 수술시간, 수술후 병기, 수술후 중환자실 체류시간을 기록하였고 사망 및 합병증은 수술후 30 일내의 사망, 폐렴이나 호흡부전 등과 같은 폐합병증, 48시간 이상의 중환자실 입원, 심장계 합병증, 농흉, 출혈, 반회후두신경손상 등 기타 합병증으로 분류하여 수술 후 발생여부를 확인하였다. 결 과: 최종 대상환자는 36명이었고 연령은 44-82세로 중앙값은 65세였으며 $FEV_1$은 $1.78\pm0.06L$이었다. 수술은 14예가 엽절제술, 8예가 이엽절제술, 14예가 전폐절제술을 시행 받았다. 수술후 사망이 2예에서 있었고 폐합병증이 10예, 48 시간이상의 중환자실 입원이 12예, 심장합병증이 3예, 기타 합병증이 4예에서 각각 발생하였으며 사망과 관련된 수술전 인자로는 혈청 알부민, DLco, 체중감소정도, ppo-DLco, ppo-DLco%, Wmax, 폐절제 정도, ppo-$VO_2$max등 이었고(p<0.05), ppo-$VO_2$max가 10ml/kg/min 이하인 환자 2명은 모두 사망한 반면 10ml/kg/min 이상인 환자에서는 사망이 없었다(p<0.01). 수술 후폐합병증은 체중감소정도, 호흡곤란정도, DLco, ppo-DLco, Wmax, MVV와 밀접한 관련이 있었다(p<0.05). 그러나 다변량분석에 의해 사망과 관련하여 유의한 지표는 없었으며 폐합병증과 관련하여 유의한 지표는 MVV(p<0.05) 였다. 결 론: 폐기능이 저하된 폐암환자의 수술후 사망 및 폐합병증과 관련하여 유용한 예견지표는 체중감소 정도, 호흡곤란 정도, 폐절제범위 등 폐기능검사와 관련되지 않은 지표들이 중요한 예견지표였고 운동부하폐기능검사지표들은 수술후 사망 및 합병증을 예측하는데 유용한 정보를 제공할 것으로 생각되며, 특히 ppo-$VO_2$max가 10ml/kg/min 이하인 환자는 수술후 사망률이 높을 것으로 추정된다.

• The Korean Journal of Physiology
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• 제27권2호
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• pp.209-215
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• 1993

The aim of the present study was to derive regression equations for $\dot{V}o_{2max}\;vs.\;\dot{V}o_{2peak},\;and\;\dot{V}o_2\;vs.$ heart rate, exercise time, and other variables from maximal exercise tests on a treadmill using the Bruce and inclined protocols. Twelve male and 10 female Korean college students aged between 19 and 23 years voIunteered for this study. After the resting measurements, the subjects performed a maximal exercise on a treadmill according to the Bruce protocol. When the resting conditions were restored, the subjects performed another maximal exercise according to an inclined protocol where the speed was fixed at 8.05 $km{\cdot}h^{-1}$ and the grade was incremented starting from 09t by 2.5% for every 2 min. Peak $\dot{V}o_2$ observed during the Bruce exercise $(\dot{V}o_{2peak})$ was $37.7{\pm}2.4\;and\;31.7{\pm}1.8\;ml\;kg^{-1}\;min^{-1}$ in the male and female groups, respectively. Peak $\dot{V}o_2$ observed during the inclined exercise was higher than $\dot{V}o_{2peak}$ during the Bruce exercise. Maximum $\dot{V}o_2$ value observed during the tyro exercises $(\dot{V}o_{2max})$ was $43.0{\pm}2.8\;and\;36.2{\pm}1.4\;ml\;kg^{-1}\;min^{-1}$ in the male and female groups, respectively. Thus, $\dot{V}o_{2peak}$ by the Bruce protocol was about 12% (male) or 13% (female) lower than $\dot{V}o_{2max}$, and a linear relationship was found between $\dot{V}o_{2peak}$ and $\dot{V}o_{2max}$. The peak values of % $\dot{V}o_{max}$ with the Bruce protocol were $89.2{\pm}3.3\;and\;87.5{\pm}3.6%$ and those with the inclined protocol $97.7{\pm}1.8\;and\;96.9{\pm}2.0%$ in the male and female groups, respectively. In the female group, $%\dot{V}o_{2max}$ at a given workload was higher than in the male group, while $\dot{V}o_{2}$ per kg body weight was the same. Maximum HR observed during the two exercises was $204{\pm}2\;and\;195{\pm}3\;beat\;min^{-1}$ in the male and female groups, respectively. Linear relationships were found, excluding the last points, between 1) $\dot{V}o_{2}$ and exercise time, 2) $\dot{V}o_{2}$ and $%\dot{V}o_{2max}\;and\;%HR_{max}$.

• 운동영양학회지
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• 제16권2호
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• pp.101-111
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• 2012

The purpose of this thesis is to investigate whether taurine supplementation in combination with fructose improves both energy metabolism and exercise capacity. Eight collegiate female subjects were recruited for the study. Each subject went through threecross-over designs: control(fluid), fructose, and taurine plus fructose supplementation trials. Subjects received taurine supplementation 100 mg/kg a day for two weeks. After the supplementation, all subjects take 10% fructose at 15 min prior to exercise, immediately before exercise, and every 15 min during exercise. Subjects received 150 ml fluid as placebo during the same procedure. The subjects performed submaximal exercise at the exercise intensity of 60% for 45 min and then 80% of maximal oxygen uptake (VO_2max) until exhaustion time. A 10ml blood sample was taken for measuring the level of glucose, ammonia, lactate, free fatty acids, and insulin every 15 min during exercise at 60% of VO_2max. The blood glucose levels was significantly higher at 45 min and 50 min exercise after supplementation of fructose, and immediately before exercise and 50 min exercise after taurine plus fructose compared to the placebo trial. However, the values tended to be lower in taurine plus fructose supplementation compared to the fructose trial. The levels of both lactate and ammonia were significantly lower compared to the placebo, while the exhaustion time was significantly increased. The level of free-fatty acids was significantly lower at 30, 45, and 50 min after fructoseand fructose plus taurine supplementation compared to the placebo trial. The level of glucagon was significantly lower at 15, 30, 45, and 50 min after fructose and fructose plus taurine supplementation compared to the placebo trial. There was no differences in insulin concentration among three treatments. This thesis concludes that combined taurine and fructose supplementation prior to exercise may improve exercise tolerance time and energy metabolism, lowering the muscle fatigue factors such as lactate and ammonia.

• 대한임상검사과학회지
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• 제48권2호
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• pp.137-143
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• 2016

본 연구는 22명의 남자 아마추어 선수를 대상으로 100 km 울트라 마라톤에서의 전해질 대사 반응의 안전성을 평가하기 위해 실시하였다. 대상자의 평균 연령은 $50.91{\pm}4.77$세, $VO_2max$는 $48.19{\pm}6.43mL/kg/min$, 그리고 평균 경기 완주시간은 $829.64{\pm}89.31$분이었다. 혈액검사에 포함된 전해질 지표로는 칼슘, 무기인, 마그네슘, 소디움, 포타슘, 염소, 총이산화탄소, 음이온 차이, 혈장량 변화와 삼투압 농도를 경기 전, 50 km 지점, 경기 종료 직후 측정하였다. 본 연구결과 소디움 농도는 경기 전보다 50 km 지점에서 감소하였고 50 km 지점보다 100 km 지점에서 감소하였으나, 고나트륨혈증 및 저나트륨혈증은 나타나지 않았다. 100 km 울트라 마라톤 경기에서 다른 모든 전해질 지표들의 거리별 변화는 참고범위 내에서 이루어졌으며, 혈장량 변화는 나타나지 않았다. 결론적으로 아마추어 지구력 선수들의 전해질 대사에 있어서 경기중 통계적인 차이는 있었으나 임상적으로 의미 있는 삼투압 농도와 전해질의 변화는 나타나지 않았으며 안전한 경기로 나타났다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 1998년도 춘계학술발표회 논문집
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• pp.163-185
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• 1998

The purpose of this study was to analyze the physiology changes by circuit weight training(CWT). The subject of this study consists of 16 student on ship(experimental groups(SE) N=8, control group(SCa) N=8) and 16 students on land (experimental groups(LE) n=8, control groups(LCb) N=8). The items of measurement were the changes of CWT time and heart rate per week, musclear functino and cardiopulmonary function. The conclusions are as follows : 1. Muscular fuction 1) Back strength in SE and LE group was increased significantly (p<.01, p<.05, 8.86% and 7.08%).Grip strength was increased slightly in 4 groups but there was no significance. 2) In push-ups, all 4 groups were increased significantly (p<.05, p<.01), sit-ups also were increased significantly in SE and LE group (p<.05, 6.71% and 9.62%). 3) In SE and LE group , standing long jump was in significantly (p<.01, p<.05, 4.49% and 6.09%), but only in LE group , side step was increased significantly (p<0.1, 5.84%). 2. Cardiopulmonary function 1) HRrest was decreased slightly in all 4 groups but was not significant changes. HRmax was increased only in LE group significantly (p<.05, 2.81%), treadmill running time was increased significantly in SE and LE group respectively (p<.01, p<.05, 10.78% and 11.07%). 2) VEmax was increased significantly in SE and LE group(p<.05, p<.01, 10.59% and 13.68%), but only in LE group Rfmax was increased significantly (p<.01, 4.83%). 3) In VO2max, LCb group was increased significantly (p<.05, 6.835), but SCa group was decreased significantly (p<.05, 4.32). VO2max/kg$.$min was increased significantly in LE and LCb group respectively (p<.01 p<.05. 4.75% and 3.98%).

• 근관절건강학회지
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• 제12권2호
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• pp.132-142
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• 2005

Purpose: The purpose of this study is to analyze the effect of Tai Chi exercise on Cardiorespiratory function and to identify directions for future research. Method: 19 articles from Medline search of english journals(1981-2004) and 2 from Korean nursing journals were surveyed. The contents analysis were focused on outcome measures and relative factors regarding cardiopulmonary function. Results: There are 21 articles including 8 articles with quasi experimental design, 7 articles with randomized controlled design and 6 articles with comparative non experimental research design. The major subjects of research were older adults, but hypertensive patients, cardiac rehabilitative patient, and osteoarthritic patient also included. The major style of Tai Chi was Yang style with 108-form. The duration of Tai Chi exercise was from 12weeks to 13.2 years in comparative non experimental studies, but 6 weeks to 16weeks in randomized controlled experimental studies. The most effective duration for cardiopulmonary function was over 16weeks. The variables for cardiopulmonary function were blood pressure, heart rate and cardiopulmonary function via $VO_2$ max(ml/kg/min). To reduce the blood pressure in the result was found in 2 articles, to reduce the heart beat was found in 1 article, to improve the cardiopulmonary function via $VO_2$ max in results were found in 7 articles(73%) among 11 articles. Conclusion: The Tai Chi exercise over 16weeks improves the cardiopulmonary function. It is suggested that to verify the effect of Tai Chi on cardiopulmonary function, the difference of gender, age, health status will be identified through repeated experiments.

• 운동영양학회지
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• 제13권1호
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• pp.75-81
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• 2009

This study aims to find out the effect of ingestion of 3 mg·kg^-1 caffeine on fluid-electrolyte balance and Tty change during exercise under heat environment of 30~32℃ (40-50% humidity). Five trained males who routinely trained for approximately 60 min·d^-1, 3-6 d·wk^-1 (age; 28.20±3.56yrs, height; 174.56±5.46 cm, body mass; 76.13±9.02 kg, body fat(%); 14.24±3.99, VO₂max; 54.00±4.30 mL·kg^-1·min^-1, exercise career; 4.20±1.95yrs) performed 40min of treadmill running in heat chamber. The study was a double-blind, randomized, crossover design. Body mass change following exercise was higher for the PLAC (Placebo) and CAFF (Caffeine) in comparison to the CON (Control), there was no significant difference between the CAFF, PLAC, CON (p= .997). The U_sg not significant differences (p= .731) and Osm_urine not significant differences between the CAFF, PLAC, CON (p= .901). There also were not significant between the CAFF, PLAC, CON for [Na⁺]_urine and [K⁺]_urine (p= .928, p= .469). In the case of Tty, although the increase rate of Tty was the highest for the CAFF on exercise early, exercise the second half in comparison to the CON and PLAC, there was not significant interaction effect between the CAFF, PLAC, and CON of Tty (p= .067), In conclusion, it was confirmed that the 3 mg·kg^-1 caffeine ingestion prior to exercising in heat environment does not impart negative effect on body fluid, electrolyte balance and changes in Tty.

• 생명과학회지
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• 제19권6호
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• pp.825-831
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• 2009

본 연구에서는 저압.저산소환경의 노출을 시켜 30분간의 유산소성 자전거운동이 호흡기계 반응 및 면역기능의 응답에 미치는 영향을 검토하였다. 그 결과 몇 가지 지견을 도출해낼 수 있었다. 첫째로 75 $%HR_{max}$ 강도에서 30분간의 유산소성 운동 중에 저산소성 환기억제 또는 저하(hypoxic ventilatory depression or decline)라고 하는 현상은 평지뿐만이 아니라 3,000 m 고도에서도 나타나고 있고, 둘째 호흡기계의 반응은 축구선들이 특히 고소에서 적응과 감수성이 우수하다고 할 수 있으며, 셋째 면역기능의 항목인 단구(monocyte)는 운동습관의 유무 및 3,000 m의 고도에 따라 서로 다른 양상(상호작용)으로 변화를 하고 있다고 할 수 있다.

• 생명과학회지
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• 제20권7호
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• pp.1066-1072
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• 2010

본 연구의 목적은 유산소 운동이 비만과 제1형 당뇨병 어린이들에게 adipokines과 염증반응에 미치는 영향을 알아보고자 실시되었다. 피험자들은 비만군(OG, n=9), 제1형 당뇨병군(DG, n=9), 그리고 정상군(NG, n=9) 어린이로 연구하였다. 모든 인자는 체중, 체지방률, 체질량지수(BMI), 최대산소섭취량(ml/kg/min), 지질 인자와 adipokines를 분석하였다. 그 결과 체중, 체지방률, BMI, 최대산소섭취량에서 OG에 비해 DG와 NG는 유의한 차이가 나타났다(p<0.05). LDL-C와 HDL-C 역시 OG에 비해 DG와 NG에서 유의한 차이가 나타났다(p<0.05). 게다가 adiponectin과 retinol binding protein (RBP)-4는 12주 운동 후에 DG와 NG에서 유의한 변화가 나타났으며 (p<0.05), OG에 비해 DG와 NG에서 유의한 차이가 나타났다(p<0.05). Monocyte chemoattractant protein (MCP)-1에서 모든 그룹은 12주 운동후 유의하게 증가하였다(p<0.05). 결론적으로 규칙적인 운동은 비만과 제1형 당뇨병 어린이에게 신체조성의 변화는 가져오지 못했으나 제1형 당뇨병 어린이의 혈관 염증을 줄여줄 수 있으며, 비만어린이에서는 대사 증후군을 보호할 수 있을 것으로 사료된다.