• Korean Journal of Radiology
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• v.2 no.1
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• pp.21-27
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• 2001

Objective: To identify and evaluate the lateral border zone by comparing the size and distribution of the abnormal signal area demonstrated by MR imaging with the infarct area revealed by pathological examination in a reperfused myocardial infarction cat model. Materials and Methods: In eight cats, the left anterior descending coronary artery was occluded for 90 minutes, and this was followed by 90 minutes of reperfusion. ECG-triggered breath-hold turbo spin-echo T2-weighted MR images were initially obtained along the short axis of the heart before the administration of contrast media. After the injection of Gadomer-17 and Gadophrin-2, contrast-enhanced T1-weighted MR images were obtained for three hours. The size of the abnormal signal area seen on each image was compared with that of the infarct area after TTC staining. To assess ultrastructural changes in the myocardium at the infarct area, lateral border zone and normal myocardium, electron microscopic examination was performed. Results: The high signal area seen on T2-weighted images and the enhanced area seen on Gadomer-17-enhanced T1WI were larger than the enhanced area on Gadophrin-2-enhanced T1WI and the infarct area revealed by TTC staining; the difference was expressed as a percentage of the size of the total left ventricle mass (T2= 39.2 %; Gadomer-17 =37.25 % vs Gadophrin-2 = 29.6 %; TTC staining = 28.2 %; p < 0.05). The ultrastructural changes seen at the lateral border zone were compatible with reversible myocardial damage. Conclusion: In a reperfused myocardial infarction cat model, the presence and size of the lateral border zone can be determined by means of Gadomer-17- and Gadophrin-2-enhanced MR imaging.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.12
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• pp.134-141
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• 2015

The purpose on this research is quantitatively comparing and analyzing signal intensity of 1.0mol and 0.5mol contrast agent. For this study, two MR phantoms were produced. One of them is used with 1.0mol Gadobutrol. The other is used with 0.5mol Gadoteridol. These two phantoms respectively have been scanned by SE T1 sequence which is used to get a general contrast-enhanced image in 1.5T MRI and 3D FLASH sequence which is used as enhanced angio MRI. Signal intensity was measured by scanned images as per contrast agent dilution ratio. The results were as follow: RSP(Reaction Starting Point) of the two sequences(2D SE, 3D FLASH) was respectively 6.0%, 60.0% in 0.5mol contrast and 2.0%, 20.0% in 1.0mol contrast, which means in 0.5mol contrast, RSP was formed faster than the one in 1.0mol contrast. MPSI was respectively 1358.8[a.u], 1573[a.u] in 0.5mol contrast and 1374[a.u], 1642.4[a.u] in 1.0mol contrast, which means 0.5mol contrast's MPP (0.4%, 10.0%) was formed faster than 1.0mol contrast's MPP (0.16%, 1.8%). Lastly, RA as per contrast agent dilution ratio was 27.4%, 11.8% wider in 0.5mol contrast(20747.4[a.u], 23204.6[a.u]) than in 1.0mol contrast(12691.9[a.u], 20747.4[a.u]). According to the study, we are able to assure that signal reaction time of 1.0mol contrast is slower than the one of 0.5mol contrast in contrast-enhanced MRI at two different sequences(2D SE, 3D FLASH). Furthermore, owing to the fact that there are not any signal intensity differences between 1.0mol and 0.5mol contrast, it is not true that high concentration gadolinium MR contrast agent does not always mean high signal intensity in MRI.

• Journal of the Korean Physical Society
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• v.73 no.9
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• pp.1334-1339
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• 2018

Spherical nickel ferrite nanoparticles were synthesized using the thermal decomposition method and coated with cetyl trimethyl ammonium bromide (CTAB) after the synthesis. Transmission electron microscopy images showed that the average diameter of the particles was 9.40 nm. The status of the CTAB-coating on the surface of the particles was checked using Fourier-transform infrared spectroscopy. Their hysteresis curve showed that the particles exhibited a superparamagnetic behavior. The $T_1$ and the $T_2$ relaxations of the nuclear spins were observed in aqueous solutions of the particles with different particles concentrations by using a magnetic resonance imaging (MRI) scanner, which showed that the $T_1$ and the $T_2$ relaxivities of the particles in water were $0.57mM^{-1}{\cdot}s^{-1}$ and $10.42mM^{-1}{\cdot}s^{-1}$, respectively. In addition, using an induction heating system, we evaluated their potentials for magnetic hyperthermia applications. The aqueous solution of the particles with a moderate concentration (smaller than 6.5 mg/mL) showed a saturation temperature larger than the hyperthermia target temperature of $42^{\circ}C$. These findings show that the CTAB-coated nickel ferrite particles are suitable for applications as $T_2$ contrast agents in MRI and heat generators in magnetic hyperthermia.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.3
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• pp.355-362
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• 2015

Purpose: To investigate the effects of the transmittance of diffusive blurson visual acuity and contrast sensitivity. Methods: Visual acuity and contrast sensitivity were measured by using Optec$^{(R)}$ 6500 in Healthy 30 subjects aged $22.83{\pm}0.50$ (male 13, female 17) who were recruited from university students. Cataract simulator was used as a tool for diffusive blur. Visual acuity and contrast sensitivity were measured with varying the transmittance of diffusive blur in order to simulate progression of cataract and concentration in fog. Results: Visual acuity was reduced proportionally with decreasing the transmittance of the diffusive blur as follows: $VA(T)=1.84{\times}10^{-2}T-0.645$. Contrast sensitivity was decreased in all spatial frequencies. Contrast sensitivity in a high spatial frequency band was a greater effect and was off the normal range of contrast sensitivity. The peak of contrast sensitivity was moved in the direction to low frequency. From an intersection point of contrast sensitivity function, we could calculated the transmittance of the diffusive blur being off the normal range and the shift to peak spatial frequency. The peak of contrast sensitivity function was observed to move from 6 to 3 cpd at transmittance of about 78.70%, the contrast sensitivities for all frequencies at transmittance of about 69.71% were deviated from the normal range. Conclusions: The transmittance of diffusive blur causes a reduction in visual acuity and contrast sensitivity, a deviation of normal range of contrast sensitivity, and a shift of peak contrast sensitivity. Therefore the more attention is required when suffering from cataracts or driving in fog.

• Investigative Magnetic Resonance Imaging
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• v.13 no.1
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• pp.9-14
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• 2009

T1-, and T2-weighted imagings and FLAIR (fluid attenuated inversion recovery) imaging are fundamental imaging methods in the brain. T1-weighted imaging is a spin-echo sequence with short TR and short TE and produces the tissue contrast by different T1 relaxation times. In other words, short TR maximizes the difference of the longituidinal magnetization recovery between the tissues. T2-weighted imaging is a spin-echo sequence with long TR and long TE and produces the tissue contrast by different T2 relaxation times. Long TE maximizes the difference of the transverse magnetization decay between the tissues. FLAIR is an inversion recovery sequence using 180 degree inversion pulse. 2500 msec of inversion time is applied to suppress the CSF signal.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.40-40
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• 2003

The purpose of this study was to characterize focal hepatic lesions through pre and post ferucarbotran-enhanced T2 and T2＊-weighted imaging and to help differentiate benign and malignant lesions 대상 및 방법： Consecutive 34 patients with 52 hepatic lesions underwent MRI before and after intravenous bolus injection of ferucarbotran (Resovist Sobering, Berlin, Germany) for evaluation of focal hepatic lesions. Lesions included hemangiomas (n=17), metastases (n=12), cysts (n=10), hepatocellular carcinomas (n=8), dysplastic nodules (n=4), and focal fat deposit (n=1). T2-weighted fast spin echo (TR/TE： 4060/138) and gradient echo T2＊-weighted images(TR/TE： 140/5.3, FA = 90) were obtained according to the institutional routine imaging protocol. Lesional signal-intensity and lesion-to-liver contrast changes were measured by contrast-to-noise ratio (CNR) from region of interest.

• Investigative Magnetic Resonance Imaging
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• v.11 no.2
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• pp.103-109
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• 2007

To develop an advanced non-linear curve fitting (NLCF) algorithm for performing dynamic susceptibility contrast study of the brain. The first pass effects give rise to spuriously high estimates of $K^{trans}$ for the voxels that represent the large vascular components. An explicit threshold value was used to reject voxels. The blood perfusion and volume estimation were accurately evaluated in the $T2^*$-weighted dynamic contrast enhanced (DCE)-MR images. From each of the recalculated parameters, a perfusion weighted image was outlined by using the modified non-linear curve fitting algorithm. The present study demonstrated an improvement of an estimation of the kinetic parameters from the DCE $T2^*$-weighted magnetic resonance imaging data with using contrast agents.

• Journal of the Optical Society of Korea
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• v.10 no.3
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• pp.99-104
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• 2006

We introduce a novel contrast mechanism for imaging superparamagnetic iron oxide (SPIO) nanoparticles (average diameter ${\sim}100nm$) using magneto-motive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect the nanoparticles flowing through a glass capillary tube. A solenoid cone-shaped ferrite core extensively increased the magnetic field strength ($B_{max}=1\;T,\;{\Delta}|B|^2=220T^2/m$) at the tip of the core and also focused the magnetic force on targeted samples. Nanoparticle contrast was demonstrated in a capillary tube filled with the SPIO solution by imaging the Doppler frequency shift which was observed independent of the flow rate and direction. Results suggest that MM-ODT may be a promising technique to enhance SPIO nanoparticle contrast for imaging fluid flow.

• Korean Journal of Radiology
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• v.22 no.8
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• pp.1369-1378
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• 2021

Objective: Few attempts have been made to investigate the prognostic value of dynamic contrast-enhanced (DCE) MRI or dynamic susceptibility contrast (DSC) MRI of non-enhancing, T2-high-signal-intensity (T2-HSI) lesions of glioblastoma multiforme (GBM) in newly diagnosed patients. This study aimed to investigate the prognostic values of DCE MRI and DSC MRI parameters from non-enhancing, T2-HSI lesions of GBM. Materials and Methods: A total of 76 patients with GBM who underwent preoperative DCE MRI and DSC MRI and standard treatment were retrospectively included. Six months after surgery, the patients were categorized into early progression (n = 15) and non-early progression (n = 61) groups. We extracted and analyzed the permeability and perfusion parameters of both modalities for the non-enhancing, T2-HSI lesions of the tumors. The optimal percentiles of the respective parameters obtained from cumulative histograms were determined using receiver operating characteristic (ROC) curve and univariable Cox regression analyses. The results were compared using multivariable Cox proportional hazards regression analysis of progression-free survival. Results: The 95th percentile value (PV) of Ktrans, mean Ktrans, and median Ve were significant predictors of early progression as identified by the ROC curve analysis (area under the ROC curve [AUC] = 0.704, p = 0.005; AUC = 0.684, p = 0.021; and AUC = 0.670, p = 0.0325, respectively). Univariable Cox regression analysis of the above three parametric values showed that the 95th PV of Ktrans and the mean Ktrans were significant predictors of early progression (hazard ratio [HR] = 1.06, p = 0.009; HR = 1.25, p = 0.017, respectively). Multivariable Cox regression analysis, which also incorporated clinical parameters, revealed that the 95th PV of Ktrans was the sole significant independent predictor of early progression (HR = 1.062, p < 0.009). Conclusion: The 95th PV of Ktrans from the non-enhancing, T2-HSI lesions of GBM is a potential prognostic marker for disease progression.

• Journal of the Korean Magnetics Society
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• v.26 no.3
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• pp.105-114
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• 2016

In this study, For assessment of triangular fibrocartilage complex (TFCC) injury, we acquired images by fat suppressed 3D fast spoiled gradient recalled T1 and fat suppressed Isotropic 3D fast spin echo T1 techniques. For quantitative evaluation, measured signal to noise ratio and contrast to noise ratio and verified statistical significance between two imaging techniques by Mann-Whitney U verification. And for qualitative evaluation, marked 4-grade scoring (0: non diagnostic, 1: poor, 2: adequate, 3: good) on shape of TFCC, artifacts by partial volumes, description of the lesions by two radiologist, verified coincidence between 2 observer using Kappa-value verification. We used 3.0 Tesla MR equipment and 8-channel RF coil for imaging acquisition. As quantitative evaluation results, signal to noise ratio and contrast to noise ratio value of Isotropic 3D fast spin echo T1 technique is higher in every image sections, also between two imaging techniques by Mann-Whitney U verification was statistically significant (p < 0.05). As qualitative results, observer 1, 2 marked a higher grade on Isotropic 3D FSE T1 technique, coincidence verification of evaluation results between two observers by Kappa-value verification was statistically significant (p < 0.05). As a result, during MRI examination on TFCC injury, fat suppressed Isotropic 3D fast spin echo T1 technique is considered offering more useful information about abnormal lesion of TFCC.