• Korean Journal of Acupuncture
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• v.17 no.1
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• pp.179-190
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• 2000

This study was undertaken to determine whether Juglandis semen extract solution (JLS solution) exerts protective effect against oxidant-induced inhibition of glutamate uptake by synaptosomes. Synaptosome was prepared from rabbit brain cortex. Glutamate uptake increased by incubation time during 10 minutes, which was significantly inhibited by 1mM t-buthylhydroperoxide(t-BHP). JLS solution prevented t-BHP-induced inhibition of glutamate uptake in a dose-dependent manner. t-BHP reduced glutamate uptake in dose-dependent fashion, which was significantly prevented by 2% JLS solution. t-BHP(1mM) and $ascorbate/Fe^{2+}(50/1{\mu}M)$ increased lipid peroxidation in synaptosomes by 5-fold, and it was significantly prevented by 2% JLS solution. $HgCl_2(0.1mM)$ inhibited glutamate uptake and increased lipid peroxidation. These changes were prevented by 2% JLS solution. Synaptosomal Na-K-ATPase activity was inhibited by t-BHP(1mM) and $H_2O_2(50mM)$, which was prevented by 2% JLS solution. The results indicate that JLS solution prevents oxidant-induced inhibition of glutamate by synaptosomes, and this may result from inhibition of lipid peroxidation induced by oxidants.

• Journal of Environmental Health Sciences
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• v.27 no.2
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• pp.51-59
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• 2001

Song stream is located in the upstream of the Namhan River. Normal times, the stream flows down to the east sea through the drainage pipe but at rainy season, it flows to the Namhan River. There are large stock farm, leisure town and cultivated land in this basin. The pollutants from these contamination source cause eutrophication at lake Doam and deterioration of water quality in namdai stream. In this case, this study was carried out to evaluate water quality and environmental capacity as well as economical efficiency of each industry. The basin shape factor of subject stream was 0.315, slope is higher than usual basin. The BOD, T-N and T-P productive contamination loading from each contamination source was 2,690, 974 and 194 kg/day, respectively, and major contamination source was stock farm and cultivated land. Annual BOD, T-N, T-P distribution(median value) of Song stream showed 1.0~2.2 mg/L, 3.16~5.85 mg/L and 0.024~0.197 mg/L Doam lake showed 1.1~1.9, 2.51~3.89 and 0.042~0.114 mg/L, respectively. Being compared of water quality at main stream between past and present, it showed that the water quality has improved since last five years. BOD improvement rate was 8~50%. Run off loading of BOD, T-N, T-P was 366, 1129, 17.2 kg/day, and run off rate was 13.6%, 86.2%, 11.3% respectively. Finally, the result of productivity survey of each industry, leisure town, cultivated land and large stock farm was 118, 46, 50 billion won, per T-P 1kg productive, and productivity portion was 100, 39, 42% respectively, and the highest economical efficiency industry was leisure facilities.

• Journal of Korea Society of Industrial Information Systems
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• v.28 no.6
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• pp.83-90
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• 2023

In a reefer container, temperature deviation occurs between the front of the loading part with the refrigerator and the rear of the loading part with the container door due to the external environment. In particular, this temperature deviation in the transport of fresh cargo has a great influence on the freshness of the cargo. In this study, we propose a method to minimize the temperature deviation by partially shielding the T-Floor to reduce the temperature deviation and evaluating the effect of the T-Floor shielding rate on the temperature change of the reefer container loading part. The subject of the experiment was a 40 feet smart reefer container, and the T-Floor shielding rates were set to 0%, 50%, 60%, 70%, and 80%. As a result of the experiment, it occurred differently in the temperature deviation of the reefer container loading part according to the shielding rate, and it was confirmed that the temperature deviation was the most uniform when the shielding rate was 60%. By minimizing the temperature deviation of the loading part, it is possible to prevent corruption and cold damage of cargo during transportation of fresh cargo by using the smart reefer container.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.201.3-201.3
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• 2003

The ethanol extract from the fruit of Terminalia chebula (Combretaceae) and the hook of Uncaria sinensis (Rubiaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, human epidermal keratinocytes-neonatal foreskin (HEK-N/F) cells were treated with the T. chebula and U. sinensis extracts. The results showed a notable enhancing effect on the cell viability of 60.5 ${\pm}$ 3.8 and 65.0 ${\pm}$ 3.0%, respectively, by 50 $\mu\textrm{g}$/ml of the extracts. (omitted)

• Electronics and Telecommunications Trends
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• v.35 no.2
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• pp.50-68
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• 2020

Distributed Ledger Technology (DLT) refers to a process and related technologies that enable a person to safely suggest, verify, and record state changes (usually updates) to synchronize ledgers distributed across network nodes. DLTs are becoming increasingly important as data management requirements evolve. Therefore, they need to understand the current state of standards (such as distributed storage and access technologies) to address future requirements. This paper provides ITU-T FG-DLT standard activities, such as standardization ization trends, use cases, reference architectures, platform evaluation criteria and future prospects.

• Environmental Analysis Health and Toxicology
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• v.19 no.2
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• pp.141-151
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• 2004

We exposed juvenile puffer fish, Takifugu obscurus(30 days after hatching) to various aqueous pollutants including 4 kinds of inorganic metals (Ag, Cd, Cu and Hg), 2 organotin compound.; (tributyltin ［TBT］ and triphenyltin［TPhT］) and 5 polycyclic aromatic hydrocarbon (PAH) compounds (chrysene, fluoranthene, naphthalene, phenanthrene and pyrene) to estimate median lethal concentrations (LC50s) of each pollutant after the 96-hour acute exposure. Among the inorganic metals, Hg (52 $\mu\textrm{g}$/L; 96-h LC50) was most toxic to test animals and followed by Ag (164 $\mu\textrm{g}$/L), Cu (440 $\mu\textrm{g}$/L) and Cd (1180 $\mu\textrm{g}$/L). Aqueous TBT was more toxic between the two organotins; the 96-h LC50 for TBT (5.1 $\mu\textrm{g}$/L) was 3 times lower than that of TPhT (17.3 $\mu\textrm{g}$/L). The acute toxicity of PAH compounds was highest for chrysene (1.5 $\mu\textrm{g}$/L; 96-h LC50) and decreased in the order of pyrene (65 $\mu\textrm{g}$/L) > fluoranthene (158 $\mu\textrm{g}$/L) > phenanthrene (432 $\mu\textrm{g}$/L) > naphthalene (8690 $\mu\textrm{g}$/L). The toxicity of PAH compounds wat closely related to their physico-chemical characteristics such as $K_{ow}$ and water solubility, and well explained by simple QSAR relationship. The sensitivity of puffer fish to various inorganic and organic pollutants was generally comparable to various fish species widely used as standard test species in previous studies and further evaluation should be conducted to develop adequate testing procedure for T. obscurus when used in various toxicity tests.

• Journal of Ocean Engineering and Technology
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• v.20 no.6 s.73
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• pp.88-92
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• 2006

Large-scale model tests of welded topside joints were carried out to observe the fatigue behavior of API 2W Gr.50 steel produced by POSCO. The fatigue crack behaviors for various loading conditions were measured and investigated around the critical joint sections. The experimental results have been verified with numerical approaches and also compared with the AWS D1.1 and DnV RP-C203 design curves. The large-scale experiment models were fabricated, based on the actual operating east area fixed platform. The dimensions of the models were slightly modified to accommodate the test facilities and capacities. The fatigue test was carried out having ${\Delta}Q$ of T1=705.6kN, T2=749.7kN and T3=793.8kN. The three specimens were statically loaded 20 times, with various loadings of about 50kN intervalsbetween the maximum and minimum loads required in the fatigue tests. This loading removed the residual stress in the specimen before the fatigue tests. The topside joint crack was initiated from the brace heel, where the maximum tensile stress occurred. The API 2W Gr.50 steel satisfied the AWS D1.1 detail category C and DnV RP-C203 detail category F ${\Delta}S-N$ curve.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5805-5810
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• 2013

This study was conducted to analyze the molecular mechanisms responsible for anti-proliferation effects of glaucocalyxin A in cultured MCF-7 and Hs578T breast cancer cells. The concentration that reduced cell viability to 50% (IC50) after 72 h treatment was derived and potential molecular mechanisms of anti-proliferation using the IC50 were investigated as changes in cell cycle arrest and apoptosis. Gene and protein expression changes related to apoptosis were investigated by semi-quantitative RT-PCR and western blotting, respectively. Involvement of phosphorylated mitogen-activated protein kinases and JNK signaling in regulation of these molecules was characterized by western blotting. Cell viability decreased in a concentration-dependent manner and the IC50 was determined as $1{\mu}M$ in MCF-7 and $4{\mu}M$ in Hs578T cell. Subsequently, we demonstrated that the GLA-induced MCF-7 and Hst578T cell death was due to cell cycle arrest at the G2/M transition and was associated with activation of the c-jun N-terminal kinase (JNK) pathway. We conclude that GLA has the potential to inhibit the proliferation of human breast cancer cells through the JNK pathway and suggest its application forthe effective therapy for patients with breast cancer.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.8
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• pp.50-55
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• 2005

An advanced method of Relaxed Static Stability (RSS) is utilized for improving the aerodynamic performance of modern version supersonic jet fighter aircraft. The laws of flight control system utilize RSS criteria in both longitudinal and lateral-directional axes to achieve performance enhancements. Particularly, the design of longitudinal control laws for utilizing RSS methods greatly affects the performance of the aircraft in Air-to-Air Tracking and Air-to-Ground modes, which improves weapon delivery. In the area of Air-to-Air Tracking, the development of longitudinal control laws aids in the fine tracking and gross acquisition of other aircraft. This paper proposes that new concept of longitudinal control law introduce in order to improve fine tracking performance in air-to-air tracking maneuver. Result of HQS pilot simulation and flight test, fine tracking performance improve without degradation of gross acquisition when new concept of control law is applied.

• Journal of Pharmaceutical Investigation
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• v.34 no.3
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• pp.185-192
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• 2004

The objective of this study was to evaluate the effects of surfactant type and concentration upon dissolution rates of carbamazepine from an immediate-release tablet. The dissolution media used in this study were aqueous solutions containing 0.1-2% sodium lauryl sulfate, cetyltrimethylammonium bromide, or polysorbate 80. The solubility of carbamazepine in the dissolution media was determined at first. A dissolution study was then conducted by using the USP dissolution apparatus II (paddle method) with an agitation rate of 75 rpm. Aliquots of the dissolution media were taken at predetermined time intervals, and the amount of carbamazepine dissolved was measured spectrophotometrically at 285 nm. The dissolution data obtained were fitted into a biphasic exponential equation with four parameters. Excellent correlations were observed between the experimental data and the theoretical ones predicted by the equation. This equation permitted the calculation of $T_{50%}$ (the time required for dissolving 50% of carbamazepine) under various experimental conditions. Differentiation of the equation also led to the attainment of dissolution rates at dissolution time points. The addition of a surfactant to an aqueous solution led to increasing the solubility of carbamazepine by 3- to 12-folds, depending upon its type and concentration. This event also resulted in enhancing the magnitude of a sink condition during the dissolution study. As a result, the dissolution rate of carbamazepine was affected by the aqueous surfactant concentration in a proportional manner. Subsequently, $T_{50%}$ values declined rapidly, as the surfactant concentration increased. Such effects were observed in decreasing order of sodium lauryl sulfate, cetyltirmethylammonium bromide, and polysorbate 80. These results clearly demonstrated that it was possible to tailor a dissolution rate and $T_{50%}$ of carbamazepine by manipulating the type and concentration of a surfactant. Relevant information would be beneficial to setting up dissolution specifications for poorly water-soluble drug products.