• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2002년도 창립10주년기념 및 국립독성연구원 의약품동등성평가부서 신설기념 국재학술대회:생물학적 동등성과 의약품 개발 전략을 위한 국제심포지움
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• pp.205-205
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• 2002

Two formulations of tiropramide {(${\pm}$)${\alpha}$-(benzoylamino)-4-[2-(diethylamino)-ethoxy]-N,N-dipropyl-benzenepropanamide hydrochloride}, an antispasmodic agent, were orally administered to 16 healthy Korean male volunteers by Latin crossover design with the purpose of evaluating bioeqivalence and phamacokinetics of tiropramide. Tiropramide in human plasma was determined by a gas chromatography/nitrogen phosphorus detector. Detection limit of tiropramide was 5 ng/ml. C$\_$max/ values in test and reference formulations were 93.9 ${\pm}$ 54.3 and 96.4 ${\pm}$ 51.6 ng/ml, respectively. AUC$\_$0\longrightarrowlast/ and AUC$\_$0\longrightarrowinf/ were, respectively, 330.7 ${\pm}$ 193.9 and 349.5 ${\pm}$ 205.3 ng.hr/ml for test formulation, 348.9 ${\pm}$ 207.7 and 380.8 ${\pm}$ 239.0 ng.hr/ml for reference formulation. Terminal half-life was 2.3-2.6 hr. Bioavailability differences for C/aub max/ and AUC$\_$0\longrightarrowlast/ were 2.48% and 5.22%, respectively. Minimum detection differences were less than 20% in both C$\_$max/ AUC. Based on this results, two formulations of tiropramide were considered to be bioequivalent

• 한국대기환경학회지
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• 제16권4호
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• pp.309-316
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• 2000

Chemical compositions of air pollutants with fine particles (<2.5 ${\mu}{\textrm}{m}$, PB2.5) were evaluated at background site. Kangwha. in Korea during the winter season. The data set was obtained for seventeed days with 24-hour sampling from December 11 to 16, 1996 and from January 9 to 1997. The chemical species have been measured {{{{ {SO }`_{4 } ^{2- } }}}}, {{{{ { NO}`_{3 } ^{- } }}}}, {{{{ { NH}`_{4 } ^{+ } }}}}. OC and EC in the particulate phase, NH3 HNO3, HCl and SO2 in the gas phase using the three stage filter pack method. Mean concentration ($\mu\textrm{g}$/m3) of this study were : 35.42 for PM2.5 8.78 for organic carbon (OC) 7.25 for nss {{{{ {SO }`_{4 } ^{2- } }}}}, 4.94 for {{{{ { NO}`_{3 } ^{- } }}}}, 3.58 for {{{{ { NH}`_{4 } ^{+ } }}}} and 1.48 for elemental carbon (EC) respectively. Contributive rates of major particulate components in PM2.5 were OC (25%) nss- {{{{ {SO }`_{4 } ^{2- } }}}}(20%) ,{{{{ { NO}`_{3 } ^{- } }}}}(14%) {{{{ { NH}`_{4 } ^{+ } }}}}(10%) and EC (4%) respectively and these components could be accounted for 73% of PM2.5 mass. Reactive forms of {{{{ { NH}`_{4 } ^{+ } }}}} were considered as NH4HO3 and NH4{{{{ {SO }`_{4 } ^{2- } }}}} during the sampling periods. {{{{ { NO}`_{3 } ^{- } }}}}/({{{{ { NO}`_{3 } ^{- } }}}} + HNO3) and {{{{ {SO }`_{4 } ^{2- } }}}}/({{{{ {SO }`_{4 } ^{2- } }}}} + SO2) were calculated 0.8 and 0.9 respectively. Most of these compounds might be formed in partiiculate phase in the air. Correlation coefficient between OC and EC was 0.866 which might have the same sources during the sampling periods,.

• Journal of Astronomy and Space Sciences
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• 제26권4호
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• pp.417-420
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• 2009

We have used the near-infrared $JHK_S$ photometric data of resolved stars in a nearby dwarf elliptical galaxy NGC 205 to determine the magnitudes of the red giant branch tip (TRGB). By applying Savitzky-Golay filter to the observed luminosity functions (LFs) in each band, we derived the second derivatives of the LFs so as to determine the magnitudes of the TRGB. Absolute magnitudes of the TRGB in $JHK_S$ bands were measured from the Yonsei-Yale isochrones. By comparing the determined apparent magnitudes and the theoretical absolute magnitudes of the TRGB, we estimated the distance moduli of NGC 205 to be (m - M) = $24.10{\pm}0.08$, $24.08{\pm}0.12$ and $24.14{\pm}0.14$ in J, H, and $K_S$ bands, respectively.

• Asian Journal of Atmospheric Environment
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• 제9권3호
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• pp.205-213
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• 2015

The objective of the current study was to assess the comparative risk associated with exposure to particulate matter (PM) while commuting via different public transport modes in Fukuoka, Japan. For the given routes and measuring days, a trip-maker carried a lightweight portable bag loaded the real-time measurement devices which take simultaneous measurement for size-fractioned particle number concentration, $PM_{2.5}$ mass concentration, and total suspended particle (TSP) collection. The results of the present study have shown significant differences between public transports as commuting modes in Fukuoka. The PM exposure levels on subway platform and inside subway train were overwhelmingly higher than those of other points on commuting route. The relative ratio between modes (i.e., the ratio of $PM_{2.5}$ inside subway to that inside bus) provides an idea for choosing a right commuting mode for our health. This study clearly provided evidence of the extremely high levels of iron exposure by subway uses compared to bus uses. The result of theoretically reconstructed mass concentration of $PM_{2.0-0.3}$ collected on subway platform suggests that the PM of underground subway will be associated with PM both generated in subway system and inleakaged from outdoor environment.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2009년도 한국우주과학회보 제18권2호
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• pp.35.3-36
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• 2009

To investigate properties of the stellar contents of the resolved asymptotic giant branch stars in the nearby dwarf galaxies, we obtained wide-field JHKs images of the dwarf irregular galaxies NGC 6822, IC 1613 and the dwarf elliptical galaxy NGC 205, using the WIRCam near-infrared imager of the CFHT. The obtained (J-Ks, Ks) and (H-Ks, Ks) color-magnitude diagrams for the resolved stars in the galaxies contain populations of foreground stars, super giant stars, red giant stars and the asymptotic giant branch (AGB) stars. Using corollary photometric data in the visible bands, AGB stars were selected in the color-magnitude diagrams with a wide wavelength baseline in color indices. In color-color diagrams of the resolved AGB stars, we identified C stars from M giant stars for each galaxies, i.e., 726 C stars in NGC 6822, 126 C stars in IC 1613 and 593 C stars in NGC 205. The number ratios of C stars to M-giants were estimated to be $0.59\pm0.03$ in NGC 6822, $0.30\pm0.03$ in IC 1613 and $0.14\pm0.01$ in NGC 205. From analyses of the correlations of the spatial distribution of the C/M ratios with the HI properties and dynamical structures of the target galaxies, we discuss environmental effects of the star formation in the galaxies. We also discuss the epochs of the AGB star formation in the galaxies by comparing theoretical isochrones with the color distributions and luminosity functions of the AGB stars.

• Journal of Korean Neurosurgical Society
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• 제49권4호
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• pp.205-211
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• 2011

Objective : We investigated the neuroprotective effect of anthocyanin, oxygen radical scavenger extracted from raspberries, after traumatic spinal cord injury (SCI) in rats. Methods : The animals were divided into two groups : the vehicle-treated group (control group, n=20) received an oral administration of normal saline via stomach intubation immediately after SCI, and the anthocyanin-treated group (AT group, n=20) received 400 mg/kg of cyanidin 3-O-${\beta}$-glucoside (C3G) in the same way. We compared the neurological functions, superoxide expressions and lesion volumes in two groups. Results : At 14 days after SCI, the AT group showed significant improvement of the BBB score by $16.7{\pm}3.4%$, platform hang by $40.0{\pm}9.1%$ and hind foot bar grab by $30.8{\pm}8.4%$ (p<0.05 in all outcomes). The degree of superoxide expression, represented by the ratio of red fluorescence intensity, was significantly lower in the AT group ($0.98{\pm}0.38$) than the control group ($1.34{\pm}0.24$) (p<0.05). The lesion volume in lesion periphery was $32.1{\pm}2.4\;{\mu}L$ in the control and $24.5{\pm}2.3\;{\mu}L$ in the AT group, respectively (p<0.05), and the motor neuron cell number of the anterior horn in lesion periphery was $8.3{\pm}5.1$ cells/HPF in the control and $13.4{\pm}6.3$ cells/HPF in the AT group, respectively (p<0.05). Conclusion : Anthocyanin seemed to reduce lesion volume and neuronal loss by its antioxidant effect and these resulted in improved functional recovery.

• 한국운동역학회지
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• 제18권1호
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• pp.53-62
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• 2008

본 연구는 플랫폼 다이빙 종목 205B를 3차원 영상분석을 통하여 운동학적 분석을 하였다. 총소요시간은 평균 $1.112{\pm}0.12s$로 나타났으며 여유 있는 연기를 수행하기 위해 많은 소요시간을 확보하여야 할 것으로 사료된다, 이지시 신체중심의 높이는 평균 88.8cm이며 수평거리는 144.8cm, 수평, 수직속도는 평균 1.08m/s, 1.3m/s로 나타났으며, 회전동작은 높은 위치에서 수행해야 하며, 수평거리는 짧아야 입수자세에 유리 할 것으로 판단된다. 하지분절의 속도변화는 이지 시 속도가 감소한 이후 회전이 이루어지는 시점까지 상승하며 이지 순간에는 회전보다는 점프동작에 더 큰 영향을 미치며, 신체중심을 축으로 회전동작으로 이어지고 속도가 상승하는 것으로 판단된다. 몸통각속도는 이지 시에 크게 나타났는데, 이는 상 방향으로 점프하여 회전에 필요한 힘을 얻기 위해 상체분절을 최대한 곧게 펴고 신체중심을 높게 유지하여 도약을 해야 효과적인 동작을 수행 할 수 있기 때문으로 사료된다.

• 디지털융복합연구
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• 제16권10호
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• pp.531-536
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• 2018

본 연구는 젊은 성인에서 근업시간에 따른 눈 피로도의 정도를 파악하고, 시각적 불편함의 종류를 분석하였다. 평균 연령 25.37세의 347명(남 142명, 여 205명)을 대상으로 눈 피로도와 관련 요인에 대해 설문하였다. 눈 피로도는 Conlon 등이 개발한 시각적 불편함에 관한 설문 도구를 이용하였고, 근업시간은 일일 컴퓨터와 스마트폰 사용을 조사하였다. 대상자의 눈 피로도는 근업시간이 2시간미만, 2~4시간, 4~6시간, 그리고 6시간 이상일 때 각각 $13.65{\pm}7.11$점, $16.83{\pm}6.77$점, $18.88{\pm}6.60$점, 그리고 $18.83{\pm}5.62$점으로 증가하였다(p=0.001). 또한 근업시간에 따라 두통(p<0.030)과 함께 다시 읽기(p<0.036), 안구운동과 탈색(p<0.001)과 같은 시각활동에서 불편함을 느꼈다.

• Archives of Pharmacal Research
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• 제16권3호
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• pp.205-208
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• 1993

($\pm$)-Myodesmone was synthesized, starting from 2-cyclopentenone. The key reaction involved $\alpha$-dimethoxymethylation of 2-cyclopentenone and organocopper conjugate addition reaction.

• 약학회지
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• 제39권6호
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• pp.666-670
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• 1995

The plasmin activity of euglobulin fraction treated with earthworm extract(EWE) increased concentration dependently when EWE(0.5, 1.0 and 2.0 mg each) were added to normal plasma. It was shown that lumbrokinase in EWE may be moved to euglobulin fraction and activated plasminogen. Also anticoagulation and fibbrinolysis were studied when EWE(7.5, 30 and 120 mg/kg) were added to rat model. Prothrombin time (PT) were 19.7${\pm}$ 3.8, 22.5${\pm}$ 2.5 and 24.5${\pm}$ 5.0sec. activated partial thromboplastin time (APTT) were 25.7${\pm}$ 5.9, 28.7${\pm}$ 5.2 and 36.5${\pm}$ 19.1 sec. After 15 days, the production of D-dimer were 242.3${\pm}$ 47.4, 250.0${\pm}$ 11.9 and 205.8${\pm}$ 12.2mg/ml plasma, respectively. These data showed that EWE acted on the coagulation factor of intrinsic and extrinsic system.