• Journal of Korean Medical classics
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• v.23 no.3
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• pp.111-125
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• 2010

Objective: For the purpose to establish direction, goal and methods, basic attitude survey of students in The College of Oriental Medicine is necessary. Methods: For 356 students in three years of College of Oriental Medicine, survey about difficulty, preference between two methods of memorization and comprehension, direction and effectiveness of education, connectivity and overlap between related subjects, and teaching methods, is carried out and data is analyzed by subjects. Results: 1. In Chinese Literature, the survey shows that difficulty is $6.25{\pm}1.415$, contribution to read and understand is $7.23{\pm}1.801$, contribution to understand Human Nature and Gi Idea in Oriental Philosophy is $5.42{\pm}2.071$, and preference for comprehension is $6.25{\pm}2.387$. 2. In Medical Chinese Literature, the survey shows that difficulty is $5.98{\pm}1.655$, awareness about direction of education is $6.14{\pm}1.917$, overlap with subject of Oriental Medical Classics is $5.98{\pm}1.712$. 3. In Oriental Medical Classics, the survey shows that difficulty is $6.85{\pm}1.598$, preference for comprehension is $6.88{\pm}2.554$, connectivity with historical background is $5.07{\pm}1.989$, contribution of Chinese Literature is $7.27{\pm}1.882$, contribution of Medical Chinese Literature is $7.23{\pm}1.802$, connectivity with clinical area is $3.59{\pm}1.973$, preference for article-based teaching method is $6.35{\pm}2.693$, necessity to modern analysis of Oriental Medical Classics is $7.77{\pm}1.907$. 4. In Oriental Medical History, the survey shows that difficulty is $5.39{\pm}1,615$, feeling quantity of subject is $5.87{\pm}1.521$, connectivity with Oriental Medical Classics is $4.94{\pm}2.027$. Conclusion: The more comprehensive methods must be used than memorization, and modern analysis of Oriental Medical Classics have to be connected with clinical area. In addition, more close connection between Oriental Medical Classics and History is necessary, and new diverse method of education must be developed.

• Neonatal Medicine
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• v.18 no.1
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• pp.82-88
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• 2011

Purpose: This study aims to describe the clinical characteristics of adrenal insufficiency-associated hypotension in preterm infants and the effects of hydrocortisone therapy on their cardiovascular system and serum electrolytes. Methods: Twelve preterm infants less than 32 gestational weeks admitted to neonatal intensive care unit (NICU) of the Seoul National University Bundang Hospital from January 2007 to August 2009 with clinical and laboratory findings suggestive of adrenal insufficiency were analyzed retrospectively. Results: Gestational age was 27.8${\pm}$2.5 weeks and birth weight was 1,110${\pm}$307 g. Postnatal age, postmenstrual age, weight at the onset of adrenal insufficiency-associated hypotension were 19${\pm}$7 day, 30.6${\pm}$2.4 weeks, 1,285${\pm}$365 g. In preterm infants who showed vasopressor resistance, intravenous hydrocortisone was started with a stress dose of 4 mg/kg/day, maintained for 2.2${\pm}$0.7 days, and then tapered. Serum cortisol concentration before hydrocortisone administration was 11.6${\pm}$4.1 mg/dL. Mean blood pressure increased from 25.0${\pm}$5.4 mmHg to 35.0${\pm}$5.3 mmHg, 38.3${\pm}$8.0 mmHg and 41.9${\pm}$6.5 mmHg at time of hydrocortisone administration and 2, 4 and 6 hours after hydrocortisone administration. Urine output increased from 0.9${\pm}$0.6 mL/kg/hr to 4.1${\pm}$3.4 mL/kg/hr. Twelve hours after the administration of hydrocortisone, dopamine requirement decreased from 11.0${\pm}$2.9 $\mu$g/kg/min to 8.0${\pm}$2.3 $\mu$g/kg/min, and to 5.5${\pm}$3.4 ${\mu}g$/kg/min after 24 hours. Serum sodium concentration was increased from 130${\pm}$4 mEq/L to 136${\pm}$4 mEq/L, serum potassium concentration was decreased from 6.1${\pm}$1.1 mEq/L to 4.6${\pm}$0.6 mEq/L before and 12 hours after hydrocortisone administration. Conclusion: In preterm infants with adrenal insufficiency-associated hypotension, hydrocortisone administration improved blood pressure and urine output, decreased vasopressor requirement, and normalized serum electrolyte abnormalities.

• The Korean Journal of Physiology
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• v.16 no.1
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• pp.51-56
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• 1982

We must encourage the use of the spirometer as part of routine examination of nearly all adult patients. Despite the theoretical problems of the water spirometer and its Poor frequency response, the water spirometer is adequate for the physiological function tests even in healthy people. The aim of this study was to report the pulmonary function studies of athletic swimmers. Subjects were 85 athletic swimmers from 9 to 25 years of age. They were elementary school boys and girls, middle school boys and girls, high school boys and girls, and college students. The results are as follows: 1) Frequency of breath: (cycle/min, $M{\pm}SD$) Elementary school boys show $19{\pm}4.7$, elementary school girls $22{\pm}7.9$, middle school boys $17{\pm}2.4$, middle school girls $18{\pm}8.2$, high school boys $15{\pm}3.4$, high school girls $15{\pm}9.7$, and college male students $12{\pm}3.2$. 2) Vital capacity: (1, $M{\pm}SD$) Elementary school boys show $2.60{\pm}0.480$, elementary school girls $2.22{\pm}0.412$, middle school boys $3.63{\pm}0.598$, middle school girls $2.80{\pm}0.303$, high school boys $4.70{\pm}0.487$, high school girls $3.23{\pm}0.509$, and college male students $4.30{\pm}0.608$. 3) Tidal volume: (ml, $M{\pm}SD$) Elementary school boys show $462{\pm}59$, elementary school girls $395{\pm}110$, middle school boys $524{\pm}78$, middle school girls $421{\pm}59$, high school boys $612{\pm}101$, high school girls $494{\pm}123$, and college male students $603{\pm}121$. 4) Breath holding time: (sec, $M{\pm}SD$) Elementary school boys show $58{\pm}21.2$, elementary school girls $36{\pm}11.1$, middle school boys $61{\pm}16.7$. middle school girls $53{\pm}21.0$, high school boys $64{\pm}9.1$, high school girls $49{\pm}15.3$, and college male students $81{\pm}23.0$.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.54 no.1
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• pp.1-6
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• 2009

This study is to analyze the effects of the growth temperature of mungbean sprouts ($15{\sim}30{\pm}1^{\circ}C$) on the yield ratio, content of phenolic compounds and DPPH (1,1-diphenyl-2-picrylhydrazyl), ADH (alcohol dehydrogenase), ALDH (aldehyde dehydrogenase) activities of the sprouts. When the growth temperature of mungbean sprouts was higher, the yield ratio of the sprouts was higher while the hard seed rate was lower, but $25{\pm}1^{\circ}C$ and $30{\pm}1^{\circ}C$ showed no regular tendency. The content of the total phenol from the ethanol extract of the sprouts was higher in the growth temperature of $15{\pm}1$, $20{\pm}1$, and $25{\pm}1^{\circ}C$, while the content of total flavonoid was higher in the growth temperature of $15{\pm}1$, and $20{\pm}1^{\circ}C$. The DPPH radical scavenging activity of the ethanol extract of the sprouts was higher when the growth temperature was lower, while the activity of ADH and ALDH showed no regular tendency according to the growth temperature. Considering the yield ratio, content of phenolic compounds, biological activities of mungbean sprouts, the optimum cultivation temperature of mungbean sprouts may be $20{\sim}25^{\circ}C$.

• Journal of Chest Surgery
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• v.33 no.6
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• pp.445-468
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• 2000

Background: Retrograde cerebral perfusion(RCP) is currently used for brain protection during aorta surgery, however, for the safety of it, various data published so far are insufficient. We performed RCP using pig and investiaged various parameters of cerebral metabolism and brain injury after RCP under deep hypothermia. Material and Method: We used two experimental groups: in group I(7 pigs, 20 kg), we performed RCP for 120 minutes and in group II (5 pigs, 20 kg), we did it for 90 minutes. Nasopharyngeal temperature, jugular venous oxygen saturation, electroencephalogram were continuously monitored, and we checked the parameters of cerebral metabolism, histological changes and serum levels of neuron-specific enolose(NSE) and lactic dehydrogenase(LDH). Central venous pressure during RCP was mainained in the range of 25 to 30 mmHg. Result: Perfusion flow rates(ml/min) during RCP were 130$\pm$57.7(30 minutes), 108.6$\pm$55.2(60 minutes), 107.1$\pm$58.8(90 minutes), 98.6$\pm$58.7(120 minutes) in group I and 72$\pm$11.0(30 minutes), 72$\pm$11.0(60 minutes), 74$\pm$11.4(90 minutes) in group II. The ratios of drain flow to perfusion flow were 0.18(30 minutes), 0.19(60 minutes), 0.17(90 minutes), 0.16(120 minutes) in group I and 0.21, 0.20, 0.17 in group II. Oxygen consumptions(ml/min) during RCP were 1.80$\pm$1.37(30 minutes), 1.72$\pm$1.23(60 minutes), 1.38$\pm$0.82(90 minutes), 1.18$\pm$0.67(120 minutes) in group I and 1.56$\pm$0.28(30 minutes), 1.25$\pm$0.28(60 minutes), 1.13$\pm$0.26(90 minutes). We could observe an decreasing tendency of oxygen consumption after 90 minutes of RCP in group I. Cerebrovascular resistance(dynes.sec.cm-5) during RCP in group I incrased from 71370.9$\pm$369145.5 to 83920.9$\pm$49949.0 after the time frame of 90 minutes(p<0.05). Lactate(mg/min) appeared after 30 minutes of RCP and the levels were 0.15$\pm$0.07(30 minutes), 0.18$\pm$0.10(60 minutes), 0.19$\pm$0.19(90 minutes), 0.18$\pm$0.10(120 minutes) in group I and 0.13$\pm$0.09(30 minutes), 0.19$\pm$0.03(60 minutes), 0.29$\pm$0.11(90 minutes) in group II. Glucose utilization, exudation of carbon dioxide, differences of cerebral tissue acidosis between perfusion blood and drain blood were maintained constantly during RCP. Oxygen saturation levels(%) in drain blood during RCP were 22.9$\pm$4.4(30 minutes), 19.2$\pm$4.5(60 minutes), 17.7$\pm$2.8(90 minutes), 14.9$\pm$2.8(120 minutes) in group I and 21.3$\pm$8.6(30 minutes), 20.8$\pm$17.6(60 minutes), 21.1$\pm$12.1(90 minutes) in group II. There were no significant changes in cerebral metabolic parameters between two groups. Differences in serum levels of NSE and LDH between perfusion blood and drain blood during RCP showed no statistical significance. Serum levels of NSE and LDH after resuming of cardipulmonary bypass decreased to the level before RCP. Brain water contents were 0.73$\pm$0.03 in group I and 0.69$\pm$0.06 in group II and were higher than those of the controls(p<0.05). The light microscopic findings of cerebral neocortex, basal ganglia, hippocampus(CA1 region) and cerebellum showed no evidence of cerebral injury in two groups and there were no different electron microscopy in both groups(neocortex, basal ganglia and hippocampus), but they were thought to be reversible findings. Conclusion: Although we did not proceed this study after survival of pigs, we could perform the RCP successfully for 120 minutes with minimal cerebral metabolism and no evidence of irreversible brain damage. The results of NSE and LDH during and after RCP should be reevaluated with survival data.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.247-253
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• 2015

Purpose: The purpose of this study was to compare and analyze the ocular surface and the palpebral conjunctiva of categorized subjects, which were divided into normal eye group and dry eye group, by using a thermal camera. Methods: Subjects were 144 eyes of 72 normal university students, who didn't have any corneal disease, abnormal lacrimal ducts, medical records regarding ocular surgeries, or experience of using contact lens. Subjects were divided into two groups, which were normal eye group and dry eye group, based on the results of TBUT, Schirmer I test, and McMonnies test. After categorizing the subjects, the temperature of the subjects' ocular surface and the palpebral conjunctiva were measured and analyzed by using a thermal camera (Cox CX series, Answer co., Korea). Results: In the normal eye group's Central Ar.1, Nasal Ar.2, Temporal Ar.3, Superior Ar.4, Inferior Ar.5, the measured amount of temperature change on each area was $-0.13{\pm}0.08$, $-0.14{\pm}0.08$, $-0.12{\pm}0.08$, $-0.14{\pm}0.08$, $-0.10{\pm}0.09(^{\circ}C/sec)$. The dry eye group's results were $-0.17{\pm}0.08$, $-0.16{\pm}0.07$, $-0.16{\pm}0.08$, $-0.17{\pm}0.09$, $-0.15{\pm}0.08(^{\circ}C/sec)$. When compared with the normal eye group, the values of Ar.1, Ar.3, Ar.5 were significantly different in the dry eye group(p<0.05). The amount of temperature change, which was observed on the palpebral conjunctiva(Ar.1:central, Ar.2: nasal, Ar.3: temporal) of the normal eyes, measured by thermography, was $34.36{\pm}1.12$, $34.17{\pm}1.10$, $34.07{\pm}1.12^{\circ}C$ on each area. Same values taken from the dry eye group was $33.55{\pm}0.94$, $33.43{\pm}0.97$, $33.51{\pm}1.06^{\circ}C$ on each area. The values of Ar.1, taken from the dry eye group, had a significant difference, compared to the values of the normal eye group(p=0.05). Conclusion: The temperature of the ocular surface decreased faster on the dry eyes, compared to the normal eyes. The temperature measured on the palpebral conjunctiva of the dry eyes were also lower than the normal eyes. The temperature changes on the ocular surface, observed with a thermal camera, were objective values to assess the stability of tear films, and might provide useful data for studies related to dry eye syndrome.

• Journal of Life Science
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• v.29 no.6
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• pp.688-696
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• 2019

This study investigated changes in triglyceride and cholesterol synthesis and tyrosinase activity induced by ice plant (Mesembryanthemum crystallinum L.) extract, which cannot be stored for long periods of time due to its high moisture content when it was fermented to improve its storage stability. The accumulation of triglyceride and cholesterol in HepG2 cells inhibited the accumulation with a relatively large magnitude in n-butanol and aqueous fractions that generally have high polarity, however, changes in inhibition potency due to the fermentation were not significant. As for the effect to inhibit tyrosinase activity, when L-tyrosine was used as a substrate, the inhibitory activity was the highest for the aqueous fraction at $60.58{\pm}4.03%$ and $63.35{\pm}4.35%$, before and after fermentation, respectively, which amounted to 72% of that of the positive control group (arbutin, $100{\mu}g/ml$). In addition, when L-3,4-dihydroxyphenylalanine (L-DOPA) was used as a substrate, the inhibitory activity was also found the highest for the aqueous fraction at $56.85{\pm}1.57%$ and $59.38{\pm}1.74%$, before and after fermentation, respectively, which amounted to at least 88% of that in the positive control (kojic acid, $100{\mu}g/ml$). Overall, the activity of the fermented ice plant extract was similar or a little higher compared to that of the one without fermentation, indicating that fermentation can be a good approach to improve the storage stability of the ice plant.

• Journal of Chest Surgery
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• v.26 no.8
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• pp.591-594
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• 1993

To clarify the apparent hypoplasia of the descending aorta in infants with atrioventricular septal defect[AVSD] patients, we reviewed the catheterization data and angiograms of 34 consecutive patients with AVSD less than 1 year of age who underwent repair at our institution since 1985. We compared them to 10 patients with Atrial Septal Defect[ASD] and 10 patients with Ventricular Septal Defect[VSD] who were matched for age, size and Qp/Qs. The Descending Aorta Index [DAI] of the AVSD group was not different from the VSD or ASD groups, [147.9$\pm$ 34.8 mm2/m2 versus 158.6$\pm$ 31.5 mm2/m2 and 153.2$\pm$ 43.1 mm2/m2].However, the Pulmonary Artery Index [PAI] of the AVSD group was significantly larger than the other groups [684.3$\pm$ 170.7 mm2/m2 versus 454.1$\pm$ 109.1 mm2/m2 and 534.9$\pm$ 148.4 mm2/m2][p<0.05], as was the ratio of PAI/DAI in the AVSD group [4.99$\pm$ 1.77 versus 2.89$\pm$ 0.81 and 3.6$\pm$ 0.92][p<0.05]. Despite similar Qp/Qs ratios, both the mean PA pressure and the Rp/Rs in the AVSD group was higher than the VSD and ASD groups: 43.1$\pm$ 15.6 mmHg versus 29$\pm$ 11.6 mmHg and 24$\pm$ 18.1 mmHg [p<0.05], and 0.27$\pm$ 0.22 versus 0.14$\pm$ 0.03 and 0.11$\pm$ 0.05 [p<0.05] respectively. The apparent hypoplasia of the descending aorta in infants with AVSD is an illusion created by the abnormally large pulmonary arteries, which are significantly larger than in patients with ASDs or VSDs.

• Atmosphere
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• v.20 no.3
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• pp.221-228
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• 2010

Aerosol particles with different size-cuts ($PM_{10}$, $PM_{2.5}$, and $PM_{1.0}$) were collected at Gosan Superstation on Jeju Island from August 2007 to June 2008. Mean concentrations of $PM_{10}$, $PM_{2.5}$ and $PM_{1.0}$ were $29.28{\mu}gm^{-3}$, $17.83{\mu}gm^{-3}$, and $14.30{\mu}gm^{-3}$, respectively. Soluble ions comprised 45.7%, 53.9%, and 60.3% of the total mass of $PM_{10}$, $PM_{2.5}$, and $PM_{1.0}$, respectively. While sulfate was the most dominant species of fine mode ($PM_{1.0}$), nitrate was enriched in coarse mode ($PM_{1.0-10}$). When the concentrations of coarse mode particles were greatly increased, nitrate tended to be enhanced in coarse mode with high calcium but low sulfate concentrations. During the high $PM_{1.0}$ events, however, nitrate was increased with sulfate at fine mode. Particularly, nitrate concentrations were substantially enhanced during high particle episodes, leading high ratios of nitrate to sulfate in air under northwest wind during wintertime. On the other hand, the levels of nitrate were lower than those of sulfate at average particle concentrations. The backward air mass trajectories indicated that nitrate concentrations were elevated in air arriving Gosan passing through Santung peninsula or near South Korea.

• Korean Journal of Veterinary Service
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• v.13 no.1
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• pp.49-53
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• 1990

In order to know the range in blood chemical values and enzyme activities of korean native cattle and pigs being raised in kyongbuk province, the mean values of serum protein compositions, enzyme activities(GOT, GPT, ALP), cholesterol, glucose, bilirubin, creatinine, urea nitrogen and uric acid were determined and the results obtained were as follows ; 1. Mean contents of total protein, albumin, globulin and A / G ratio for the korean native male cattle were $7.28{\pm}0.86$ g / dl, 43.39{\pm}0.65$ g / dl, 43.83{\pm}0.92$ g / dl & 40.95{\pm}0.34$；for the male pigs were 47.39{\pm}0.84$ g / dl, 43.63{\pm}0.43$ g / dl, 43.77{\pm}0.88$ g / dl, 40.97{\pm}0.26$；for the female pigs were 47.60{\pm}0.68$ g/ dl, 43.54{\pm}0.58$ g / dl, 43.90{\pm}0.74$ g / dl, 41.02{\pm}0.34. 2.$ Mean activities of GOT, GPT and ALP for the korean native male cattle were 448.3{\pm}11.6$ U, 429.6{\pm}4.6$ U, 413.7{\pm}2.8$ U； for the male pigs were 458.6{\pm}10.6$ U, 438.6{\pm}5.3$ U, 424.9{\pm}9.2$ U； for the female pigs were 443.9{\pm}10.8$ U, 440.5{\pm}4.6$ U, 413.9{\pm}3.4$ U. 3. Mean contents of cholesterol, glucose and bilirubin for the korean native male cattle were 4108.7{\pm}31.8$ mg / dl, 488.2{\pm}26.4$ mg / dl, $0.69{\pm}0.52$ mg / dl; for the male pigs were 4105.9{\pm}18.3$ mg / dl, 4102.9{\pm}22.3$ mg / dl, 40.70{\pm}0.18$ mg / dl: for the female pigs were $113.1{\pm}20.9$ mg / dl , 4103.2{\pm}23.9$ mg / dl, 40.49{\pm}0.21$ mg / dl. 4. Mean contents of creatinine, urea nitrogen and uric acid for the korean native male cattle were 42.86{\pm}0.69$ mg / dl, $18.1{\pm}5.0$ mg / dl, 41.38{\pm}0.66$ mg /dl; for the male pigs were 42.20{\pm}0.51$ mg / dl, $18.2{\pm}4.3$ mg / dl, 40.29{\pm}0.10$ mg /dl: for the female pigs were 42.36{\pm}0.70$ mg / dl, $20.5{\pm}5.4$ mg / dl, 40.69{\pm}0.27$ mg / dl.