• Title/Summary/Keyword: $MS^n$

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Development of Biologically Active Compounds from Edible Plant Sources-XVII. Isolation of Sterols from the Fruits of Cornus kousa Burg (식용식물자원으로부터 활성물질의 탐색-XVII. 산딸나무(Cornus kousa Burg.)의 열매로부터 sterol 화합물의 분리)

  • Lee, Dae-Young;Song, Myoung-Chong;Yoo, Jong-Su;Kim, Sung-Hoon;Chung, In-Sik;Kim, Dae-Keun;Park, Mi-Hyun;Kwon, Byoung-Mog;Kim, Se-Young;Baek, Nam-In
    • Applied Biological Chemistry
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    • v.49 no.1
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    • pp.82-85
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    • 2006
  • The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and $H_2O$, successively. From the EtOAc fraction, three sterols were isolated through the repeated silica gel and ODS column chromatographies. According to the results of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as ${\beta}-sitosterol$ (1), $stigmast-4-en-6{\beta}-ol-3-one$ (2) and daucosterol (3). They were the first to be isolated from Cornus kousa Burg.

Anaerobic Metabolism of the Herbicide, Butachlor in soil (토양중에 있어서 제초제 Butachlor의 혐기적 대사)

  • Lee, Jae-Koo;Minard, Robert D.;Bollag, Jean-Marc
    • Applied Biological Chemistry
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    • v.25 no.2
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    • pp.83-92
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    • 1982
  • In an anaerobic incubation of uniformly ring-labeled $^{14}C-butachlor$ in two Korean soils for 3 months, very little $^{14}CO_2$ and volatile products were measured. In soil A, 77.52 and 45.36% of the sterile and viable soil radioactivity, respectively, were methanol-extractable and the rest were adsorbed in soil; whereas in soil B, 58.85 and 37.23%, respectively, were methanol-extractable and the rest remained in soil. The adsorption of $^{14}C-butachlor$ depends on the characteristics of the soils. The major metabolite was 2,6-diethyl-N-(butoxymethyl) acetanilide. 2,6-Diethylaniline and 2,6-diethylacetanilide turned out to be the minor metabolites on GLC-MS.

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Association between Compliance with Dietary Guidelines and Dyslipidemia among Koreans (한국 성인의 식생활 지침 실천도와 이상지혈증의 관련성)

  • Hong, So-Young;Lee, Kye-Heui;Lee, Hong-Soo;Lee, Myoung-Sook;Jee, Sun-Ha;Joung, Hyo-Jee
    • Journal of Nutrition and Health
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    • v.40 no.8
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    • pp.745-752
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    • 2007
  • While metabolic syndrome(MS) is rapidly expanding and dietary pattern, the known risk factor of MS, goes through heavy transition to western diet, not many researches have been done on the association between dyslipidemia and dietary factors in Korean adults. The purpose of this study was to investigate the association between compliance with dietary guidelines and dyslipidemia among Koreans. The subjects of 399 adults who visited health examination center were classified into dyslipidemia(n=180) and control(n=219). Diagnosis of dyslipidemia was based on NCEP-ATPIII criteria(triglyceride>=150mg/d, HDL-C<50mg/dl for male, HDL-C<40mg/dl for female). A questionnaire based interview was done to collect information on compliance with dietary guidelines, general characteristics and health related behaviors. Anthropometric variables were measured during the survey. Mean compliance score of dietary guideline was significantly lower in dyslipidemia group than in control. It was associated negatively with waist circumference and positively with serum HDL-cholesterol(p<0.05). Risks of dyslipidemia were significantly decreased in the group with highest dietary guideline score, high serum triglyceride levels(OR=0.484, 95% CI=0.268-0.875), abdominal obesity(OR=0.296, 95% CI=0.159-0.553), and dyslipidemia(OR=0.481, 95% CI=0.266-0.869). These results indicated that increasing compliance with dietary guidelines could be an effective strategy to lower the risk of dyslipidemia among Koreans.

Vasorelaxant properties of cyclic nucleotide phosphodiesterase inhibitors in rat aorta (흰쥐 대동맥에서 cyclic nucleotide phosphodiesterase 억제제들의 혈관 이완 특성)

  • Kang, Hyung-sub;Choi, Cheol-ho;Kim, Jin-shang
    • Korean Journal of Veterinary Research
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    • v.43 no.4
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    • pp.615-624
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    • 2003
  • Vascular smooth muscle relaxation is modulated by an increase in cGMP subsequent to nitric oxide (NO) production by endothelial cells. The effects of cAMP and cGMP phosphodiesterase (PDE) inhibitors were investigated in phenylephrine-precontracted rat aorta rings by using the specific inhibitors of PDE I, III, IV and V as relaxing agents (calmodulin-activated PDE inhibitors, IBMX and $W_7$, type I; cAMP-specific PDE inhibitors, milrinone, type IV; Ro 20-1724, type III and cGMP-specific PDE inhibitor, zaprinast, type V). All the PDE inhibitors produced a concentration-dependent relaxation in the ring with intact endothelium (+E). Except for milrinone, all the PDE inhibitors-induced relaxations were inhibited by removal of extracellular $Ca^{2+}$, $N^G$-nitro-L-arginine, $N^G$-nitro-L-arginine methyl ester, methylene blue (MS) or nifedipine. The specific PDE I and PDE IV inhibitors both produced endothelium-independent relaxations which were inhibited by MS in -E rings. However, zaprinast had no effect in -E rings. Except for milrinone, sodium nitroprusside (a NO donor)-induced relaxation was significantly augmented by all PDE inhibitors in +E rings. The results suggest that I) the vasorelaxant properties of IBMX, $W_7$, Ro 20-1724 and zaprinast are dependent on endothelium or on interaction with $Ca^{2+}$ regulation, 2) each PDE is differently distributed in vascular tissues (endothelial and smooth muscle cells), 3) the vasodilations of PDE inhibitors are due to the increase of cAMP and cGMP formation through inhibition of cAMP- and cGMP-PDE and 4) the vasodilation action of milrinone does not involve in endothelial-cyclic nucleotide system.

A Study on the Extractives of Domestic Major Softwood Needles (II) - Antioxidant Activity of the Extractives from the Needles of Chamaecyparis pisifera (Sieb. et Zucc.) Endlicher - (국내산 주요 침엽수 잎의 추출성분 (II) - 화백나무 (Chamaecyparis pisifera (Sieb. et Zucc.) Endlicher)잎 추출성분 및 항산화 활성 -)

  • Lee, Sang-Keug;Bae, Young-Soo
    • Journal of the Korean Wood Science and Technology
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    • v.34 no.4
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    • pp.76-82
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    • 2006
  • The dried ground needles (2.0 kg) of Chamaecyparis pisifera (Sieb. et Zucc.) Endlicher were extracted with acetone-$H_2O$ (7:3, v/v), concentrated, and fractionated with a series of n-hexane, methylene chloride, ethyl acetate and water on a separation funnel. Each fraction was freeze dried, then a portion of ethyl acetate soluble powder was chromatographed on a Sephadex LH-20 column using a series of aqueous methanol and ethanol-n-hexane mixture as eluents. The isolated compounds were identified by cellulose TLC, $^1H$-, $^{13}C$-NMR, COSY, HETCOR, FAB and EI-MS. (+)-catechin, taxifolin-3-O-${\beta}$-D-xylopyrano-side, quercetin-3-O-${\alpha}$-L-rhamnopyranoside were isolated from the ethyl acetate soluble fraction of Chamaecypairs pisifera needle. Antioxidative tests on the isolated compounds indicated that all of the compounds showed similar values to ${\alpha}$-tocopherol and BHT as controls.

Effects of NaOH and Humic Acid on the UV Photolysis of PCBs (PCBs의 광화학적 연구: NaOH 및 휴믹산 (humic acid, HA)에 의한 분해특성)

  • Shin, Hae Seung;Kim, Jae Hyoun
    • Journal of Environmental Health Sciences
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    • v.40 no.2
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    • pp.147-156
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    • 2014
  • Objectives: This study was carried out to examine whether the apparent photolysis with or without sensitizers [NaOH and humic acid (HA)] was prompted photodegradation of polychlorinated biphenyl (PCB) in aqueous solution. Methods: PCBs photodegradation occurred using fluorescence black lamps at ${\lambda}_{max}=300nm$. PCB congeners were exposed in 10 ppm HA or 0.05N NaOH solutions, to investigate the decreasing profile of PCB concentration with time. The PCBs were then analyzed by gas chromatography/mass spectrometry (GC-MS). Reductive degradation profile of PCB congeners in the presence of both sensitizers under oxygen-saturated protic conditions was described using the wind-rose diagrams. Results: Use of HA or NaOH decreased PCB concentration with time in the dark and on irradiation, indicating that photolysis underwent through reductive dechlorination through energy transfer and possibly with reactive oxygens. The dechlorination was marked by a chromatographic shift, observed in the GC-MS plots. Therefore it is logical to assume that increasing the dose of sensitizers would increase the photodegradation rates of PCBs. The half-lives of pentachloro-PCB (penta-3) in 0.05N NaOH and 10 ppm HA were estimated at about 47 hours and 39 hours, respectively, under the same experimental conditions of photolysis. It was found that the rate of photolysis of pentachloro-PCB in aqueous solution followed apparent first-order kinetics compared to other congeners. Conclusion: Photochemical degradation (using 328 nm UV light) of penta- and hexa-PCBs in HA or alkaline solution is a viable method for pretreatment method. The results are helpful for the further comprehension of the reaction mechanism for photolytic dechlorination of PCBs in aquatic system.

New Store Positioning Algorithm to ensure Competitive Advantage in Monopoly Market (독점시장에서 경쟁우위 확보를 위한 신설점포 위치 결정 알고리즘)

  • Lee, Sang-Un
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.18 no.5
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    • pp.251-257
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    • 2018
  • We will be establish the new k stores of identical product firm $F_B$ to gain competitive advantage over rival firm $F_A$ that has already monopolize a market with k stores. In this situation, how we can decide the location of k stores? For this problem, Serra and Revelle proposes k-Median and MAXCAP integer programming using LP+BB to decide the k stores of firm $F_B$. Then they exchange the k stores to another location that cover more customers. This paper suggests non-neighborhood search method that finds the ${\upsilon}{\not\in}N_G(u)$nodes for u of firm $F_A$ without most outer loop nodes using just MS-Excel. As a result of experiment, the proposed algorithm can be get the optimal solution easier and faster than integer programming.

Multiplatform Game Development using Wire and Wireless Communication (멀티플랫폼 유무선 연동게임 개발)

  • Kang, Youn-Jun;Park, Dong-Gyu
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.13 no.4
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    • pp.828-834
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    • 2009
  • To get a better profit, standalone mobile game market shifts network-based mobile game. Currently, most of the game platform are separated into mobile to mobile, desktop to desktop, and console to console. Multi platform network game has a diverse problems including consistency control, object management technique, and bandwidth inconsistency. n this paper, we will introduce a multi-platform arcade game "Push-Push", which is played on desktop to mobile environment. The game guarantees realtime play between heterogeneous machine users and game item sharing between two platforms. e will focus n the issues of the 3rd generation multi platform games and propose some techniques or solving these problems. Our server database is implemented on MS SQL database, also the desktop programming tool is Visual Basic, and WIPI(Wireless Internet Platform or Interoperability) as a mobile platform.

Extractives from Epimedium koreanum Nakai (삼지구엽초(Epimedium koreanum Nakai)의 추출성분)

  • Lee, Tae-Seong;Cho, Jae-Hyun;Hwang, Byung-Ho
    • Journal of Korea Foresty Energy
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    • v.24 no.2
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    • pp.16-23
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    • 2005
  • The air dried of Epimedium koreanum Nakai was extracted with MeOH and its extractives were concentrated with a vacuum evaporator. The extractives were fractionated with a series of n-hexane, chloroform (${CHCl}_3$), butanol (BuOH), ethyl acetate (EtOAc) and water on a separately funnel. Each fraction was freeze dried to give some dark brown powder. The EtOAc and BuOH soluble fractions were chromatographed on a Sephadex LH-20 column using a series of aqueous methanol and ethanol-n-hexane mixture as eluents. The isolated compounds were tested with a cellulose TLC developed with TBA and 6% acetic acid and then visualized on UV lamp or sprayed with vanillin-HCl-EtOH. The purified compounds were flavonoids and their glycosides, and organic acid as follows : (+)-catechin, icariin, hyperoside, Ikarisoside A and caffeic acid. The structures of each compounds were confirmed by $^1H-NMR,\;^{13}C-NMR$ and Mass spectra. Also, executed qualitative analysis as use GC/MS(Libraries search) about ${CHCl}_3$ soluble compounds of each part.

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The compatible non-explosive separation device for various pre-loads using the Ni-Cr wire and Kevlar rope (다양한 사전하중에 적용할 수 있는 Ni-Cr wire와 Kevlar rope를 이용한 위성 분리장치)

  • Hwang, Hyun-Su;Kim, Byung-Kyu;Jang, Young-Keun
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.41 no.2
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    • pp.150-155
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    • 2013
  • We present a kevlar rope based Non-Explosive Actuator(NEA) device which has simple structure and is activated by burning Ni-Cr wire. Through performance test, we find it can be operated under various pre-load by simply changing turn number of Ni-Cr wire. It shows release time of 680ms and shock level of 110G under pre-load of 6.0kN. Launching environment and space environment tests are planned to verify performance of the NEA based on European Satellite Agency test manual. Conclusively, we expect the proposed NEA can be applicable to release solar panel and fairing separation.