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고전압 대전류용 TVS(Triggered Vacuum Switch) 특성 시험 (Characteristic Tests of High Voltage High Current TVS(Triggered Vacuum Switch))

  • 박성수;남상훈;김상희;한영진;허훈;김승환;박용정;홍만수
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2004년도 하계학술대회 논문집 C
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    • pp.1948-1950
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    • 2004
  • 가속기 연구소에서 개발한 고전압 대전류용 Seal-off TVS (Triggered Vacuum Switch)의 특성을 시험 하는 것을 목적으로 하고 있다. 제작한 TVS는 양전극과 음전극이 교대로 고정된 간격으로 각각 3개의 전극으로 배열되어 있으며 전극은 사다리꼴 모양으로 되어있고 트리거 시스템과 개스를 흡수하는 게터가 내부에 설치되어 있다. 제작한 스위치 내부는 약 $10^{-7}$ torr의 진공상태를 유지하고 있으며 세라믹 챔버를 사용하여 Seal-off 상태로 설계, 제작하였다. 스위치 시험장치는 200 ${\mu}F$, 22 kV 6개를 병렬로 연결한 커패시터 뱅크와 $20{\mu}H{\sim}160{\mu}H$의 탭변환 인덕터와 $0.1{\Omega}{\sim}0.5{\Omega}$ 의 저항을 이용하여 시험 장치를 구성하였다. TVS의 시험에서 에너지 최고 전달량은 74 C 이었으며 이때 인가전압은 30 kV, 최대 전류는 100 kA, 펄스폭은 1${\sim}$2 ms이었다. 본 논문은 제작한 스위치의 전기적인 특성 시험한 결과에 대하여 논하고자 한다.

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Selenoprotein S Suppression Enhances the Late Stage Differentiation of Proerythrocytes Via SIRT1

  • Yang, Hee-Young;Chung, Kyoung-Jin;Park, Hyang-Rim;Han, Seong-Jeong;Lee, Seung-Rock;Chay, Kee-Oh;Kim, Ick-Young;Park, Byung-Ju;Lee, Tae-Hoon
    • International Journal of Oral Biology
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    • 제35권2호
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    • pp.61-67
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    • 2010
  • Selenoprotein S (SelS) is widely expressed in diverse tissues where it localizes in the plasma membrane and endoplasmic reticulum. We studied the potential function of SelS in erythrocyte differentiation using K562 cells stably over-expressing SelS wild-type (WT) or one of two SelS point mutants, $U_{188}S$ or $U_{188}C$. We found that in the K562 cells treated with $1\;{\mu}M$ Ara-C, SelS gradually declined over five days of treatment. On day 4, intracellular ROS levels were higher in cells expressing SelS-WT than in those expressing a SelS mutant. Moreover, the cell cycle patterns in cells expressing SelS-WT or $U_{188}C$ were similar to the controls. The expression and activation of SIRT1 were also reduced during K562 differentiation. Cells expressing SelS-WT showed elevated SIRT1 expression and activation (phosphorylation), as well as higher levels of FoxO3a expression. SIRT1 activation was diminished slightly in cells expressing SelS-WT after treatment with the ROS scavenger NAC (12 mM), but not in those expressing a SelS mutant. After four days of Ara-C treatment, SelS-WT-expressing cells showed elevated transcription of $\beta$-globin, $\gamma$-globin, $\varepsilon$-globin, GATA-1 and zfpm-1, whereas cells expressing a SelS mutant did not. These results suggest that the suppression of SelS acts as a trigger for proerythrocyte differentiation via the ROS-mediated downregulation of SIRT1.

사상체질음성분석기(PSSC)를 통한 한국인 소아 ${\cdot}$ 청소년의 체질별 음성특성연구 - 단문을 중심으로 - (A Study on the Characteristics of the Korean Juvenile Sound According to Sasang Constitution using PSSC with a Sentence)

  • 허재범;정운기;최민기;전종원;김달래;유준상
    • 사상체질의학회지
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    • 제19권2호
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    • pp.40-52
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    • 2007
  • 1. Objectives and Methods The purpose of this study was to objectify the diagnosis of Sasang Constitution. 63 Male Juvenile's and 151 Female Juvenile's sentences were analyzed into 73 factors like Pitch, APQ, Shimmer, Octave and Energy, etc. Juvenile's sentences were classified into 6 categories: total Male Juvenile group, under 12 years old Male Juvenile grout, over 13 years old Male Juvenile group, total Female Juvenile group, under 12 years old Female Juvenile group and over 13 years old Female Juvenile group. 2. Results 1) In Total Male Juvenile group, there were no significant differences among constitutional groups in APQ and Octave segment. Taeumin's Center freq.(3) was significantly high compared with Soyangin group. Soeumin's Center freq.(5) was significantly high compared with Soyangin and Taeumin groups. Taeumin's Octave3 Shimmer was significantly high compared with Soeumin group. Soeumin's Octave6 Shimmer was significantly high compared with Taeumin group. Solyangin's D# Tot E was significantly high compared with Taeumin group. 2) In Under 12 years old Male Juvenile group, there were on significantly among constitutional groups in Pitch, APQ, Octave and Energy segment. Taeumin's Octave3 Shimmer and G Shimmer(1) were significantly high compared with Soeumin group. 3) In Over 13 years old Male Juvenile group, there were no signigicant differences among constitutional groups in Pitch, APQ and Shimmer segment. Soyangin's and Soeumin's Octave6 were significantly high compared with Taeumin group. Soyangin's $0k{\sim}2k$ Total Sum, $0k{\sim}2k$ Dev., $2k{\sim}4k$ Total Sum, $2k{\sim}4k$ Dev., A Dev.(1), D# Dev.(1) and G# Dev.(1) were significantly high compared with Taeumin group. Soyangin's and Soeumin's G# Tot E were significantly high compared with Taeumin group. 4) In Total Female Juvenile group, there were no significant differences among constitutional groups in Pitch and APQ segment. Soeumin's Octave4 Shimmer was significantly high compared with Soyangin group. Soyangin's Octave6 was significantly high compared with Soeumin group. Solyangin's 2k-4k Total Sum and B Tot E were significantly high compared with Soeumin group. 5) In Under 12 years old Female Juvenile group, there were no significant differences among constitutional groups in APQ and Energy segment. Soeumin's and Taeumin's Center Pitch and Pitch were significantly high compared with Soyangin group. Soyangin's Center freq.(1) and Center freq.(7) were significantly high compared with Soeumin and Taeeunin groups. Soyangin's and Taeumin's B Shimmer(1) and F# Shimmer(1) were significantly high compared with Soeumin group. Soeumin's D Shimmer(1) was significantly high compared with Soyangin group. Taeumin's and Soeumin's G# Shimmer(1) were significantly high compared with Soyangin group. Soyangin's and Taeumin's Octave2 were significantly high compared with Soeumin group. 6) In Over 13 years old Female Juvenile group, there were no significant differences among constitutional groups in Pitch, APQ and Octave segment. Soeumin's Octave4 Shimmer was significantly high compared with Soyangin group. Soyangin's B Dev.(1) and F Dev.(1) were significantly high compared with Soeumin group. 3. Conclusions In juvenile groups, some sound factors are regarded as useful. PSSC are thought to be the objertive way to diagnose the Consitution and more participants are needed to get more efficiencies using PSSC.

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$GPScreen^{TM}$ 이용한 천연 항암물질인 plumbagin의 약물 작용점 연구: 분열 효모인 S. pombe 유전체 이종 결손 변이 라이브러리에서의 약물에 의한 haploinsufficiency를 이용한 약물 작용점 규명을 위한 혁신 기술 (Drug Target Identification of a natural anticancer agent plumbagin using $GPScreen^{TM}$: An innovative Technology for Drug Target Discovery using Drug-induced haploinsufficiency in S. pombe Genome-wide Heterozygous Deletion Mutant Library)

  • 이주희;연지현;윤평오;노휘재;박한오;김동명
    • 한국약용작물학회:학술대회논문집
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    • 한국약용작물학회 2011년도 춘계학술발표회
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    • pp.106-107
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    • 2011
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무인 자동차의 승차감 향상을 위한 퍼지 제어 알고리즘 (Fuzzy Control Algorithm for the Improvement of Auto-Vehicle's Comfortability)

  • 배종일;조봉관;김영식;안두성;양순용
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2000년도 하계학술대회 논문집 D
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    • pp.3187-3188
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    • 2000
  • Based on fuzzy control algorithm this paper constructed fuzzy controller for automated vehicles. For passenger's convenience especially comfortability controller need to reduce the frequency of input variable's changing. So we established membership functions for comfortability as well as speed following. It made possible to control comfortability directly. To demonstration the efficiency of fuzzy controller, we carried out simulation with a automobile's transfer function. Also we compared the difference of input variable. By comparing two controller's response, we can confirm the merit of fuzzy controller about comfortability. Fuzzy controller can reduce input changing frequency.

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