• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 춘계학술대회 논문집
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• pp.47-52
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• 2004

$HgGa_2S_4$ single crystals were grown by the chemical transport reaction method. The $HgGa_2S_4$ single crystal crystallized into a defect chalcopyrite structure $(I\bar{4})$. The lattice constants of the single crystal were found to be a=5.635 ${\AA}$ and c=10.473 ${\AA}$. The direct and indirect optical energy gaps were found to be 2.84 eV and 2.78 eV, respectively. Photoluminescence peaks of $HgGa_2S_4$ single crystal were observed at 2.37 eV, 2.18 eV, and 1.81 eV. In the single crystal, the donor level of 0.25 eV, the acceptor levels of 0.97 eV and 0.41 eV were obtained by TSC, PICTS, and absorption measurements. The photoluminescence peaks were analyzed to relate to the indirect conduction band, the donor level, and the acceptor levels.

• Bulletin of the Korean Chemical Society
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• 제31권12호
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• pp.3707-3710
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• 2010

A chromo/fluorogenic $NO_2S_2$-macrocycle L functionalized with nitrobenzofurazan unit as a dual-signaling probe was synthesized and structurally characterized by single crystal X-ray analysis. In a cation-induced color change experiment, L exhibited excellent $Hg^{2+}$ ion selectivity by showing the color change from orange-red to yellow. However, this hypochromic shift by $Hg^{2+}$ was observed for the weaker coordinating anion system such as ${NO_3}^-$ and ${ClO_4}^-$ ions. The observed anion effect is due to the strong coordination of anions inhibits the bond formation between $Hg^{2+}$ and the macrocyclic tert-N atom, which is sensitive to induce the color change. In the fluorometric experiment, L showed chelate-enhanced fluorescence change effect only with $Hg^{2+}$ ion, together with a change from yellow to green emission. The sensing ability for $Hg^{2+}$ with the proposed chemosensor L is due to the stable complexation with 1:1 stoichiometry (metal-to-ligand).

• 한국환경과학회지
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• 제29권2호
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• pp.201-207
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• 2020

A new chemosensor based on a self-assembled system has been devised to detect Hg²⁺ions efficiently. We demonstrated that the amphiphilic building blocks consisting of pyrene and boronic acid (1) aggregate in aqueous solutions and provide an outstanding sensing platform for sensitive detection. The self-assembled 1 exhibited high selectivity and sensitivity for Hg²⁺ion detection via fluorescence quenching, where the Hg²⁺ion detection ensued from a fast transmetallation of 1. The Stern-Volmer (SV) quenching constant for its fluorescence quenching by Hg²⁺ions was approximately 1.58 × 10⁸ M^-1. In addition, self-assembled 1 exhibited excellent sensing abilities at nano-molar concentration levels when tap water and freshwater samples were contaminated with of Hg²⁺ ions.

• Bulletin of the Korean Chemical Society
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• 제35권4호
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• pp.1077-1081
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• 2014

Polyacrylamide (PAM) -HgS nanocomposites were successfully prepared in polyacrylamide (PAM) matrix. From TEM and XRD characterizations, the synthesized HgS nanocrystals were chain-like spherical in shape with a diameter of about 40-60 nm and high crystalline quality. The quantum-confined effect of HgS nanocrystals was confirmed by UV-vis diffuse reflection spectra. The optical properties of products were investigated by using photoluminescence (PL) spectra, which showed that HgS nanocrystals exhibited good optical properties with maximum emission peak at about 640 and 650 nm at different reaction temperatures. The interaction of HgS nanocrystals with PAM was studied through FT-IR spectroscopy and TG analysis, which suggested that $Hg^{2+}$ could interact with functional groups of PAM. The experimental results indicated that PAM not only induced nucleation, but also inhibited further growth of HgS crystals and play an important role in the formation of PAM/HgS nanocomposites. In addition, the possible mechanism of HgS nanoparticles growth in PAM solution was also discussed.

• Bulletin of the Korean Chemical Society
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• 제33권7호
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• pp.2359-2364
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• 2012

Two new chemosensors, rhodamine 6G derivative bearing hydroxyethyl group (1) and rhodamine base derivative bearing 15-crown-5 group (2) were synthesized and their sensing behaviors toward various metal ions were investigated by UV/Vis and fluorescence spectroscopies. Addition of $Hg^{2+}$ ion to a $CH_3CN$ solution of 1 and 2 gave visual color changes as well as fluorescent OFF-ON observations. Selectivity and sensitivity of 1 towards $Hg^{2+}$ are excellent enough to detect micromolar level of $Hg^{2+}$ ion, even in equeous media and biological sample (HeLa cell).

• Neonatal Medicine
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• 제17권1호
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• pp.34-43
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• 2010

목 적 : 기계적 환기요법을 시행 받은 미숙아에서 생후 첫 7일 동안 고탄산혈증과 중증 뇌실내 출혈의 발생과의 연관성을 알아보고자 본 연구를 시행하였다. 방 법:출생 후 7일 이상 기계적 환기 요법을 받은 재태주령 37주 미만의 미숙아를 대상으로 하여, 3단계 이상의 뇌실내 출혈로 진단받은 경우 IVH 군(n=19)으로, 정상 또는 1단계 뇌실내 출혈을 보인 경우, 출생 체중과 주수를 대응하여 대조군(n=38)으로 선정하였다. 두 군간의 생후 첫 7일 동안 혈중 이산화탄소 분압($PaCO_2$)의 최대값, 최소값, 평균값과 변화 정도(fluctuation)를 측정하기 위한 지표로 혈중 이산화탄소 분압의 최대값과 최소값의 차이(maximum-minimum)와 평균값의 표준편차를 비교 분석하였다. 결 과:재태주령과 출생체중은 IVH 군은 26.9$\pm$1.7주, 975.3$\pm$262.5g이었고, 대조군은 26.8$\pm$1.5주, 915.6$\pm$198.2 g이었다. IVH 군에서 생후 7일 동안 혈중 이산화탄소 분압의 최대값(IVH 군 vs. 대조군, 86.1$\pm$ 18.4 mmHg vs. 60.1$\pm$11.6mmHg, P <0.001), 평균값 (47.5$\pm$5.6 mmHg vs. 41.2$\pm$6.3mmHg, P=0.004), 최대값과 최소값의 차이(60.3$\pm$20.9 mmHg vs. 35.5$\pm$ 11.8 mmHg, P < 0.001), 평균값의 표준편차(14.0$\pm$4.4mmHg vs. 9.0$\pm$2.4 mmHg, P <0.001)는 유의하게 높았으나 최소값은 두 군 간의 차이가 없었다. 또한 IVH군에서 파종성혈관내응고[11 (57.9%):9 (23.7%), P=0.011], 폐출혈[12 (63.2%):10 (26.3%), P=0.007], 공기누출 증후군[4 (21.1%):1 (2.6%), P=0.021]의 빈도가 많았고, 생후 7일 동안 인공 호흡기 지수의 최대값이 통계적으로 유의하게 높았다. 출혈성 경향, 공기누출증후군, 인공 호흡기 지수의 영향력을 통제한 후에는 혈중 이산화탄소 분압의 최대값이 odds ratio 1.324 (95%CI: 1.011-1.733, P=0.041)로 중증 뇌실내 출혈과 통계적으로 유의한 연관성을 보였다. 결 론 : 기계적 환기 요법을 시행 받은 미숙아에서 출생 후 첫 7일 동안 극심한 고탄산혈증은 뇌출혈의 다른 위험 인자의 영향을 배제한 후에도 중증 뇌실내 출혈의 발생과 연관성을 보였다. 따라서 생후 초기에 호흡기 유발 폐손상을 막기 위해 고탄산혈증을 허용하는 시도는 중요하지만, 과도한 고탄산혈증과 심한 이산화탄소 분압의 변화를 피하고 적절한 이산화탄소 분압을 유지하는 노력이 필요할 것으로 생각된다.

• 생약학회지
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• 제15권4호
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• pp.179-187
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• 1984

To investigate the recorded efficacy in Oriental medical references and effects in clinics, experimental studies were undertaken to estimate 'Palmiwhan' to the diuretic effect in normal rats, rabbits and rats with $HgCl_2-induced$ acute renal failure and hypotensive effects on the nephrogenous hypertension in rabbits with $HgCl_2-induced$ acute renal failure. The results of this study were summarized as follows; Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly recognized in normal rats and rabbits. Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly shown in rats with 2mg/kg $HgCl_2-induced$ acute renal failure. Although plasma electrolyte and creatinine levels were little affected, plasma urea nitrogen levels were significantly elevated in normal rats and 2mg/kg $HgCl_2-induced$ acute renal failure of rats. Although the blood pressure was not affected in normal rabbits and cats, hypotensive actions due to the diuretic effect were recognized in rabbits $HgCl_2-induced$ acute renal failure.

• Journal of Preventive Medicine and Public Health
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• 제50권6호
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• pp.377-385
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• 2017

Objectives: Although mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate whether total Hg exposure in Korean adults was associated with elevated serum levels of the liver enzymes aspartate aminotransferase (AST), alanine transaminase (ALT), and gamma-glutamyltransferase (GGT). Methods: We repeatedly examined the levels of total Hg and liver enzymes in the blood of 508 adults during 2010-2011 and 2014-2015. Cross-sectional associations between levels of blood Hg and liver enzymes were analyzed using a generalized linear model, and nonlinear relationships were analyzed using a generalized additive mixed model. Generalized estimating equations were applied to examine longitudinal associations, considering the correlations of individuals measured repeatedly. Results: GGT increased by 11.0% (95% confidence interval [CI], 4.5 to 18.0%) in women and 8.1% (95% CI, -0.5 to 17.4%) in men per doubling of Hg levels, but AST and ALT were not significantly associated with Hg in either men or women. In women who drank more than 2 or 3 times per week, AST, ALT, and GGT levels increased by 10.6% (95% CI, 4.2 to 17.5%), 7.7% (95% CI, 1.1 to 14.7%), and 37.5% (95% CI,15.2 to 64.3%) per doubling of Hg levels, respectively, showing an interaction between blood Hg levels and drinking. Conclusions: Hg exposure was associated with an elevated serum concentration of GGT. Especially in women who were frequent drinkers, AST, ALT, and GGT showed a significant increase, with a significant synergistic effect of Hg and alcohol consumption.

• 대한화학회지
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• 제31권6호
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• pp.534-541
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• 1987

$Hg^{2+}$이온의 존재하에서 $[CoCl(Hedta)]^-$ 착이온에 대한 에틸렌디아민(en) 치환반응기구에 대해서 uv 및 CD스펙트럼을 이용하여 조사하였다. 속도론적인 자료로부터 $Hg^{2+}$ 이온이 금속과 작용하여 첫 en이 치환될때는 회합반응 경로를 거치며 제2, 제 3의 en은 단계적으로 치환됨을 알 수 있었다. 그리고 생성된 $[Co(en)_3]^{3+}$의 광학순도로 부터 광학수율을 결정짓는 적절한 중간체를 제시하여 치환반응에 대한 새로운 반응경로를 제시하였다.

• Journal of Chest Surgery
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• 제26권11호
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• pp.856-860
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• 1993

We performed serial pulmonary function test and arterial blood gas analysis at preoperative period and postoperative 1st week in 337 patients who underwent pulmonary resection from May 1988 to April 1992 at Dept. of Thoracic and Cardiovascular Surgery, Seoul adventist hospital. Follow-up study for PFT and ABGA were possible in 30 % of the patients at postoperative 3rd or 4th month. In patient who underwent pneumonectomy, VC was decreased from 57.7% to 46.1%, FVC was decreased from 53.5 % to 41.2 % and MBC also decreased from 68.1% to 49.6 % at postoperative 1st week. But ABGA revealed that POa-, was increased from 87.2 mmHg to 92.7 mmHg, and PCO2 was decreased from 43.2 mmHg to 35.9 mmHg at postoperative 1st week. In patients who underwent lobectomy, VC was decreased from 78.1% to 68.30 %, FVC was decreased from 72.5% to 55.3% and MBC was decreased from 73.5% to 68% at postoperative 1st week.But, ABGA revealed that PO2 was increased from 95.2 mmHg to 97.9 mmHg and PCO2 was decreased from 42.3 mmHg to 39.0 mmHg at postoperative 1st week. The pulmonary function recovered at postoperative 3rd or 4th month and its ratio to preoperative value was 90% in lobectomy cases, but in pneumonectomy cases VC and MBC were recovered 20% and 15 % above the preoperative values. We concluded that resection of atelectasis, destructed lung, open negative and open positive cavity in the pulmonary tuberculosis were beni~t to improve ventilation-perfusion ratio,and pulmonary function was recovered nearly to preoperative level at postoperative 3rd or 4th month.