• 제목/요약/키워드: $HbA_1c$

검색결과 540건 처리시간 0.028초

다른 운동 강도의 지구성 및 저항성 운동 중재가 내당능 장애 쥐들의 당뇨관련 혈액인자에 미치는 영향 (The effects of different intensity endurance and resistance exercise on diabetic-related blood profiles in impaired glucose tolerance mice)

  • 박찬호;우진희;노희태;신기옥;김도연;윤병곤
    • 한국응용과학기술학회지
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    • 제37권3호
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    • pp.571-581
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    • 2020
  • 본 연구의 목적은 내당능장애를 유도한 쥐들을 대상으로 다른 운동 강도의 지구성 및 저항성 운동을 중재하여 당뇨관련 혈액인자들에 미치는 영향을 비교 분석하는데 있다. 37주령 C57BL/6 쥐 54마리를 (1) 일반식이대조군(CO, n=9), (2) 내당능장애군(IGT, n=9), (3) 내당능장애 + VO2max 50% 지구성운동군(IGT50A, n=9), (4) 내당능장애 + VO2max 75% 지구성운동군(IGT75A, n=9), (5) 내당능장애 + 1RM의 50% 저항성운동군(IGT50R, n=9), 그리고 (6) 내당능장애 + 1RM의 75% 저항성운동군(IGT75R, n=9)으로 분류하였다. 지구성 운동 프로그램은 동물 실험용 트레드밀을 사용하여 주5일, 1일 40분씩 8주간 트레드밀운동을 실시하였다. 저항성 운동은 주5일 8주간 사다리 저항 운동을 반복사이 2분간의 휴식을 주어 총 8번의 Climbing을 실시하였다. 운동 프로그램 후 인슐린은 통계적으로 모든 그룹간의 차이가 없었다. 공복 혈당은 대조군보다 IGT 유도군들에서 통계적으로 유의하게 높게 나타났으며, 운동군들간의 차이는 없었으나 IGT군이 IGT75R군에 비해 유의하게 높은 수치를 보였다. HOMA-IR은 대조군과 IGT군에서만 유의한 차이를 보였다. 당화혈색소 검사에서는 IGT군이 다른 모든 집단들에 비해 높은 수치를 보였으며, IGT75A군과 IGT50R군에서 유의한 차이를 보였다. 총 콜레스테롤은 대조군이 내당능장애 유도군들과 비교하여 유의하게 낮은 수치를 보여주었다. 반면 중성지방은 그룹간의 차이가 없었다. HDL-C는 지구성 운동군들이 대조군과 IGT군에 비해 유의하게 높은 수치를 보였으나 저항성 운동군들과의 차이는 없었다. LDL-C는 대조군이 IGT군과 운동군들에 비해 유의하게 낮은 수치를 보였으며, IGT75A군은 IGT군과 IGT50R군에 비해 낮은 수치를 보였다. 결론적으로 75%의 저항성 운동은 혈당에 보다 긍정적인 영향을 주었으며, 75%의 지구성 운동은 당화혈색소와 LDL-C의 감소에 긍정적인 영향을 미치는 것으로 나타났다. 또한 지구성 운동은 저항성 운동에 비해 HDL-C의 증가에 보다 효과적임을 보여주었다.

Influence of Dietary Supplementation of Condensed Tannins through Leaf Meal Mixture on Intake, Nutrient Utilization and Performance of Haemonchus contortus Infected Sheep

  • Pathak, A.K.;Dutta, Narayan;Banerjee, P.S.;Pattanaik, A.K.;Sharma, K.
    • Asian-Australasian Journal of Animal Sciences
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    • 제26권10호
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    • pp.1446-1458
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    • 2013
  • The study assessed the effect of dietary supplementation of leaf meal mixture (LMM) containing condensed tannins (CT) on feed intake, nutrient utilization and performance of sheep infected with Haemonchus contortus. Eighteen adult sheep of similar age and body weight ($25.03{\pm}1.52$) were included in this study and out of these, 12 sheep were infected with single dose of infective third stage larvae of H. contortus at 2,000 larvae per sheep. The experimental sheep were allocated in three different groups' i.e. negative control (NC; no infection), control (C; H. contortus infected) and treatment (T; H. contortus infected+CT at 1.5% of the DM through LMM) and the experiment was conducted for a period of 90 d. The intake of dry matter (DM), organic matter (OM) and digestibility of DM, OM, neutral detergent fibre (NDF) and acid detergent fibre (ADF) were comparable among three animal groups. However, digestibility of crude protein (CP) and ether extract (EE) were significantly (p<0.05) higher in NC group as compared to both C and T groups. Nitrogen (N) retention (g/d or % of N intake) was significantly (p = 0.038) lower in C group as compared to T and NC groups. Daily intake (g/kg $W^{0.75}$) of digestible crude protein (DCP), digestible organic matter (DOM) and total digestible nutrient (TDN) did not differ significantly (p<0.05) in the three groups. Haemoglobin (Hb) and packed cell volume (PCV) were significantly (p<0.001) higher in treatment group as compared to control. The level of Hb and PCV reduced (p<0.001) after 30 days of experimental feeding. CT significantly (p<0.001) reduced serum urea in T group as compared to NC and C groups. Serum proteins differed significantly (p<0.01) among the three groups. The activity of serum enzymes AST, ALT, ALP and LDH were also statistically non significant (p<0.05) among treatments. The weight of abomasal lymph nodes (ALN) in T group was higher (p<0.05) than in C group. Treatment group had lower (p<0.05) total worms and fecal egg count compared to control group. It may be concluded that dietary supplementation of CT through LMM significantly improved the N retention, and inhibited the different developmental stages of Haemonchus contortus in experimental sheep.

제2형 당뇨병 환자의 D-chiro-inositol의 혈당강하 효과와 당뇨 자가관리 및 삶의 질: 경로분석 (Effect of Glucose Control, SDSCA and Quality of Life of D-chiro-inositol(DCI) in patients with type 2 diabetes: A Path Analysis)

  • 강영미;김현진;이태용;구본정
    • 한국산학기술학회논문지
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    • 제19권10호
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    • pp.243-253
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    • 2018
  • 본 연구 목적은 제2형 당뇨병 환자에서의 D-chiro-inositol(DCI)의 혈당강하 효과, 당뇨 자가관리(Summary of Diabetes Self-Care Activities, SDSCA) 및 삶의 질(SF-36 Version 2.0, Korean)에 미치는 요인을 파악하고자 하였다. 연구대상은 충남대학교병원 내분비대사내과에 내원한 제2형 당뇨병 환자 중에서 3제의 경구 혈당강하제를 12주 이상 투여 했음에도 불구하고 당화혈색소 7.0% 이상인 환자를 2015년 3월부터 2016년 5월까지 24주간 무작위 이중맹검 위약대조 임상시험으로 총 46명을 분석하였다. 연구결과, 실험군에서 DCI 투여 이후 당화혈색소 $8.75{\pm}0.79%$(베이스라인), $8.36{\pm}1.03%$(투여 12주), $8.65{\pm}0.81%$(투여 24주)으로 유의하게 감소하였으나(p<0.05), 대조군과의 변화량은 차이가 없었다. 흥미롭게도 실험군과 대조군에서 당뇨 자가관리 점수가 높아졌으며, 특히 실험군 변화량에서의 하부영역인 혈당검사 만이 유의한 차이를 보였고, 삶의 질은 투여 전 $73.05{\pm}16.85$점에서 투여후 $82.74{\pm}10.68$점으로 향상되었다. DCI 투여에 따른 실험군에서의 요인간 경로분석에서 공복 혈당 변화량은 당뇨 자가관리 변화량이 높을수록(${\beta}=-0.505$, t=-2.743) 높다고 확인되었다. 삶의 질 변화량에 가장 큰 영향을 준 변수는 공복 c-펩타이드 변화량이 높을수록(${\beta}=-0.445$, t=-2.668), 당뇨 자가관리 변화량이 높을수록(${\beta}=0.411$, t=2.024) 높은 것으로 확인되었다. 결론적으로 제2형 당뇨병 환자에게 DCI 투여는 투여 12주차에 혈당 강하 효과를 보이고, 24주차에는 없었지만, 혈당강하 효과는 환자의 당뇨 자가관리를 높이고 삶의 질을 향상시켰다. 본 연구에 기초하여 결과적인 지표와 제2형 당뇨병 환자의 주관적인 관점에서 평가될 수 있는 삶의 질에 대한 경로분석을 통하여 모형의 적합도에 관한 연구로써 그 의의가 있다고 본다.

개의 Babesia gibsoni 감염예방에 관한 연구 1. 항원의 Sonication 및 Formalin 처리에 의한 예방접종 (Studies on the Prophylaxis against Babesia gibsoni Infection in Dogs 1. Vaccinations with the Sonicated and the Formalin-treated Antigen)

  • 채준석;인동철;이주묵;윤창모
    • 한국임상수의학회지
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    • 제7권1호
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    • pp.391-402
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    • 1990
  • To examine the effects of vaccination against Babesia gibsoni infection in dogs, 15 normal mixed-breed dogs(5 month to 1 year old) divided into 3 groups with 5 dogs in a group. One of them was selected as control group(group A) and others were selected as experimental groups(group B and C). The group B was vaccinated with sonicated antigens and the group C was vaccinated with 0.2% of formalin treated antigens. The results obtained in the examination were summarized as follows : 1. In the western blot, the lane A revealed specific two bands on the regions of 54kd and 100kd, respectively. 2. After the first vaccination, the antibody titers of group B and C were higher 5 times(1 : 200) than those of control group(1:40). After the second vaccination, the antibody titers of group B and C have not changed. When challenged with the protozoa(Babesia gibsoni), the antibody titers(1 : 5,000) were elevated in all groups. But these were not exceeded over 1 : 5,000 for 4 weeks. 3. After challenge, the peak time of increased numbers of the protozoa was the 15th day (12-18 days) in all groups. During these days, the rate of parasitized erythrocytes in control group was 55.0${\pm}$5.4%. But those of group B and group C were 26.0${\pm}$6.4%, and 15.6${\pm}$7.8%, respectively. 4. After challenge, all of the values of PCV, Hb, RBC were shown to decrease in all of the control and experimental groups. 5. The total leukocytes counts are shown a tendency of reduction in all groups after challenge. 6. In all groups, there were increase in lymphocytes and monocytes after challenge.

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소양인(少陽人) 당뇨병환자(糖尿病患者)에 인동등지골피탕(忍冬藤地骨皮湯)을 투여(投與)한 증례(症例) (A Clinical Study about the diabetes mellitus patients administration of Indongdeungjikolpitang)

  • 정성일;이현민;김종원
    • 사상체질의학회지
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    • 제14권2호
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    • pp.138-146
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    • 2002
  • 1. Background and Purpose 1 intented to be helpful to treat diabetes through a clinical study of lndongdeungjikolpitang effect of soyangm 2. Methods I studied 6 patients with middle diabetes who were diagnosed by Soyangin at department of Sasang constitutional Medicine in Dongeui Oriental Hospital during 1 year from August. 2001 to July. 2002. and then I investigated the clinical symptoms of the diabetics and analyzed level of examination after administration of lndongdeungjikolpitang 3. Results and Conclusion lndongdeungjikolpitang was administered to six diabetic patients, So-yang-in for 8 weeks. The symptoms such as frequent hunger(P<0.05), decrease of body weight(P<0.05) have improved after the treatment. As results, level of HbAlC(P<0.05), total protein(P<0.05) and blood pressure(P<0.05) significantly decreased after administration of Indongdeungjikolpitang.

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Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage

  • Kim, Doo Young;Cho, Kwang-Chun
    • Journal of Korean Neurosurgical Society
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    • 제64권3호
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    • pp.460-468
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    • 2021
  • Objective : Extremely low alanine transaminase (ALT) levels are associated with all-cause mortality in frail elderly individuals; the clinical significance of ALT as a reliable biomarker is now being considered. Predicting mortality with routine tests at the time of diagnosis is important for managing patients after intracranial hemorrhage. We aimed to investigate whether an extremely low ALT level is associated with mortality in the elderly after intracranial hemorrhage. Methods : A retrospective review was performed on 455 patients with intracranial hemorrhage admitted to a university-affiliated tertiary care hospital from February 2014 to May 2019. Multivariate Cox regression analysis was performed for all ages and for each age group to determine whether an extremely low ALT level is an independent predictor of mortality only in the elderly. Results : Overall, 294 patients were enrolled, and the mean age of the subjects was 59.1 years, with 99 (33.8%) aged ≥65 years. The variables associated with all-cause mortality in all subjects were age, C-reactive protein (CRP) levels, hemoglobin (Hb) levels (<11 g/dL), and initial Glasgow coma scale (GCS) scores. In young patients, CRP, low Hb levels, and initial GCS scores were significantly associated with all-cause mortality. However, in the elderly (≥65 years), the variables significantly associated with all-cause mortality were extremely low levels of ALT (<10 U/L) (adjusted hazard ratio, 3.313; 95% confidence interval, 1.232-8.909; p=0.018) and initial GCS scores. Conclusion : Extremely low ALT level (<10 U/L) at the time of diagnosis is a significant risk factor for all-cause mortality in the elderly after intracranial hemorrhage.

Babesia gibsoni 항원접종과 Theileria sergenti를 비특이 항원으로 접종한 개의 면역효과에 관한 연구 (Studies on the effects of immunization against Babesia gibsoni antigen and Theileria sergenti as a non-specific antigen in dog)

  • 윤창모;이주묵;채준석;권오덕
    • 대한수의학회지
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    • 제33권1호
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    • pp.101-108
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    • 1993
  • To examine the effects of vaccination against Babesia gibsoni(B gibsoni) infection in dogs, 15 normal mixed-breed dogs(5 months to 1 year old) were divided into 3 groups with 5 dogs in each group. One of them was selected as control group(group A) and other were selected as experimental groups(group B and C). The group B was vaccinated with antigen which were mixed 0.2% of formalin treated B gibsoni and sonicated one. The group C was inoculated Theileria sergenti as a non-specific antigen. The results obtained in this experiment were summarized as follows; 1. After first vaccination, antibody titers of group B and C were increased 5 times(1:200) than those of control group(1 : 40). The antibody titers of group C were increased more than that of group B after second vaccination. When challenged with the living protozoa(Babesia gibsoni), the antibody titers of C group were elevated higher than that of B group and maintained steadly. Those were not exceeded over 1 : 5,000 for 4 weeks in all 3 groups. 2. After challenge, the peak time of the parasitemia appeared nearly on the 15th day(12~18 days) in all groups. During this period, the rate of parasitized erythrocytes in control group was $55.0{\pm}5.4$‰. But that of group B and C were $41.3{\pm}38.8$‰ and $15.2{\pm}16.3$‰, respectively. 3. After challenge with B gibsoni, all of the values of PCV, Hb, RBC and total leukocytes counts were decreased in both of the experimental and the control. 4. In all groups, there were increased lymphocytes and monocytes after challenge with the protozoa.

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THEORETICAL STUDY ON OBSERVED COLOR-MAGNITUDE DIAGRAMS

  • Lee, See-Woo
    • 천문학회지
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    • 제12권1호
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    • pp.41-70
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    • 1979
  • From $B\ddot{o}hm$-Vitense's atmospheric model calculations, the relations, [$T_e$, (B-V)] and [B.C, (B-V)] with respect to heavy element abundance were obtained. Using these relations and evolutionary model calculations of Rood, and Sweigart and Gross, analytic expressions for some physical parameters relating to the C-M diagrams of globular clusters were derived, and they were applied to 21 globular clusters with observed transition periods of RR Lyrae variables. More than 20 different parameters were examined for each globular cluster. The derived ranges of some basic parameters are as follows; $Y=0.21{\sim}0.33,\;Z=1.5{\times}10^{-4}{\sim}4.5{\times}10^{-3},\;age,\;t=9.5{\sim}19{\times}10^9$ years, mass for red giants, $m_{RG}=0.74m_{\odot}{\sim}0.91m_{\odot}$, mass for RR Lyrae stars, $m_{RR}=0.59m_{\odot}{\sim}0.75m_{\odot}$, the visual magnitude difference between the turnoff point and the horizontal branch (HB), ${\Delta}V_{to}=3.1{\sim}3.4(<{\Delta}V_{to}>=3.32)$, the color of the blue edge of RR Lyrae gap, $(B-V)_{BE}=0.17{\sim}0.21=(<(B-V)_{BE}>=0.18),\;[\frac{m}{L}]_{RR}=-1.7{\sim}-1.9$, mass difference of $m_{RR}$ relative to $m_{RG},(m_{RG}-m_{RR})/m_{RG}=0.0{\sim}0.39$. It was found that the ranges of derived parameters agree reasonably well with the observed ones and those estimated by others. Some important results obtained herein can be summarized as follows; (i) There are considerable variations in the initial helium abundance and in age of globular clusters. (ii) The radial gradient of heavy element abundance does exist for globular clusters as shown by Janes for field stars and open clusters. (iii) The helium abundance seems to have been increased with age by massive star evolution after a considerable amount (Y>0.2) of helium had been attained by the Big-Bang nucleosynthesis, but there is not seen a radial gradient of helium abundance. (iv) A considerable amount of heavy elements ($Z{\sim}10{-3}$) might have been formed in the inner halo ($r_{GC}$<10 kpc) from the earliest galactic co1lapse, and then the heavy element abundance has been slowly enriched towards the galactic center and disk, establishing the radial gradient of heavy element abundance. (v) The final galactic disk formation might have taken much longer by about a half of the galactic age than the halo formation, supporting a slow, inhomogeneous co1lapse model of Larson. (vi) Of the three principal parameters controlling the morphology of C-M diagrams, it was found that the first parameter is heavy clement abundance, the second age and the third helium abundance. (vii) The globular clusters can be divided into three different groups, AI, BI and CII according to Z, Y an d age as well as Dickens' HB types. BI group clusters of HB types 4 and 5 like M 3 and NGC 7006 are the oldest and have the lowest helium abundance of the three groups. And also they appear in the inner halo. On the other hand, the youngest AI clusters have the highest Z and Y, and appear in the innermost halo region and in the disk. (viii) From the result of the clean separations of the clusters into three groups, a three dimensional classification with three parameters, Z, Y and age is prsented. (ix) The anomalous C-M diagrams can be expalined in terms of the three principal parameters. That is, the anomaly of NGC 362 and NGC 7006 is accounted for by the smaller age of the order of $1{\sim}2{\times}10^9$ years rather than by the helium abundance difference, compared with M 3. (x) The difference in two Oosterhoff types I and II can be explained in terms of the mean mass difference of RR Lyrae variables rather than in terms of the helium abundance difference as suggested by Stobie. The mean mass of the variables in Oosterhoff type I clusters is smaller by $0.074m_{\odot}$ which is exactly consistent with Rood's estimate. Since it was found that the mean mass of RR Lyrae stars increases with decreasing Z, the two Oosterhoff types can be explained substantially by the metal abundance difference; the type II has Z<$3.4{\times}10^{-4}$, and the type I has higher Z than the type II.

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Escherichia coli에서 발현된 Recombinant Bacillus pasteurii Urease의 정제 및 효소학적 특성 (Purification and Enzymatic Characteristics of the Bacillus pasteurii Urease Expressed in Escherichia coli)

  • 이은탁;김상달
    • 한국미생물·생명공학회지
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    • 제20권5호
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    • pp.519-526
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    • 1992
  • Bacillus pasteurii의 urease gene이 Escherichia coli HB101에서 발현된 Bacillus성 recombinant urease를 단일단백질으로 정제하고 그 효소학적 특성을, 별도로 정제한 B.pasteurii urease의 그것과 비교검토하였다. B.pasteurii urease gene이 cloning 된 E.coli HB101(pBU11)의 균체파쇄액으로 부터 TEAE-cellulose, DEAE-Sephadex A-50, Sephadex G-150, sephadex G-200 등의 이온교환 크로마토그래피와 gel filtration을 이용하여 E.coli내에서 발현된 B. pasteurii성제하였으며, 또한 B.pasteurii로부타 비활성도 185.2배의 urease를 정제하여 disc gel electrophoresis로 단일 단백으로 정제되었음을 확인하였다. 정제된 두 urease 들의 native 상태의 분자량은 공히 280,000$pm$10,000 정도로 확인되었고, SDS-electrophoresis에의 해 subunit 유무와 분자량을 확인한 결과도 67,000정도의 subunit 4개와 20,000의 subunit 1개로 된 $\alpha$$\beta$ 구조의 동일한 효소단백으로 추정할 수 있었다. Gene donor인 B. pasteurii와 cloning 된 균주 E. coli(pBU11)이 생산한 두 urease의 효소학적 특성을 비교 조사해본 결과 두 urease의 최적반응 pH는 공히 7.5로 나타났으며, pH에 대한 안정성도 두 ureaserk 공히 pH 5.5에서 10.5 사이에서 50% 이하로 활성이 떨어지지 않는 강한 pH 안정성을 보였다. 두 urese의 최적반응의 온도는 $60^{\circ}C$였으며, 비교적 온도에 대한 저항이 강한 효소임을 알았다. 두 urease의 활성에 미치는 금속이온의 영향은 $Ag^{2+}$, $Hg^{2+}$ 등에서 양효소가 모두 강한 저해현상을 받는 반면, $Mn^{2+}$, $Mg^{2+}$ 에서는 다소 촉진되는 현상을 보였다. 효소반응 저해제들의 영향을 조사해 본 결과 p-CMB, acetohydroxamic acid에 두 urease가 모두 강한 저해를 받았다. 두 urease의 $K_m$ 값과 $V_{max}$ 값은 E. coli(pBU11)의 urease는 $4.21{\times}10^{-2}mol/\ell$, $86.96\ell$mol/min 이었고, B. pasteurii urease는 $4.04{\times}10^{-2}mol/\ell$, $160\ell$mol/min이었다. 따라서 B. pasteurii의 urease나 그 urease gene으로 cloning되어 E. coliso에서 발현된 recombinant urease는 분자량이나 효소학적 특서에서 거의 동일한 효소단백임을 알 수 있었다.

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금식 여부에 따른 혈당치 분포와 당뇨병 선별을 위한 혈당조절지표의 평가 (The Assessment of Blood Glucose Distribution according to the Fasting State and Glycemic Control Indicators for Diabetes Screening)

  • 권필승;임인수
    • 대한임상검사과학회지
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    • 제48권4호
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    • pp.312-320
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    • 2016
  • 본 연구는 금식 여부에 따른 혈당치 분포 차이를 분석하였고 공복 혈당치와 혈당조절지표인 당화혈색소, 프록토사민, 1,5-AG의 상관성을 분석하여 전당뇨병 선별에 필요한 추가 정보를 제공하고자 하였다. 단국대학교병원에 내원한 707명의 외래 환자를 금식 군과 비금식 군으로 나누어 혈당 검사를 시행한 후 각 군의 혈당치 평균을 산출하고 성별, 연령별 및 임상과 별 결과치 분포를 분석을 하였다. 또한 건강검진을 목적으로 내원한 금식 상태의 153명에 대해 혈당치와 당화혈색소, 프록토사민, 1,5-AG을 측정하여 혈당치와 혈당조절지표의 상관성을 평가하였다. 비금식 군의 혈당 평균치는 111.9 mg/dL, 금식 군은 103.6 mg/dL로서 유의한 차이가 있었고 (p<0.05) 평균치 차이는 여자가 4.8 mg/dL로서 남자의 12.2 mg/dL보다 적었다. 연령대에 따른 중앙값의 차이는 비금식 군에서만 유의한 차이가 있었고(Kruskal-Wallis test, p<0.01) 금식 군에서는 유의하지 않았다. 공복 시 포도당 장애 선별 구간에서 혈당 농도와 상관성이 높은 검사 종목은 1,5-AG로 평가되었다. 저자들은 금식 여부에 따른 혈당치 분포의 차이를 외래 환자를 대상으로 분석하였으며, 건강검진 대상자의 결과치 분석을 통해 1,5-AG가 프록토사민, 당화혈색소보다 공복 혈당치와 유의한 상관성이 있는 것으로 평가하였다. 당뇨병 선별 시 혈당 측정과 함께 단기 혈당 조절능력을 반영하는 지표가 활용될 수 있을 것으로 사료된다.