• 대한환경공학회지
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• 제31권8호
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• pp.641-648
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• 2009

본 연구는 미세기포 발생펌프가 장착된 하수슬러지 부상농축 장치를 이용하여 화학적인 개량 및 교반조건에 따른 하수슬러지 부상농축효율을 나타내었다. 하수슬러지의 부상농축은 Gt 값보다는 응집제 종류에 더 큰 영향을 받았다. 응 집제 종류에 따른 하수슬러지 부상농축효율은 $Al_2(SO_4)_3$ < PSO-M < $Fe_2(SO_4)_3$ 응집제 순으로 높게 나타났다. 회분식 실험에서 도출된 운전조건을 이용하여 1.6 $m^3$/d 용량의 하수슬러지 부상농축장치를 2시간동안 연속적으로 운전할 수 있었으며, A/S 비가 0.029~0.019 mL/mg에서 슬러지 농축율은 300.0~335.7%로서 매우 효율적이었다.

• 상하수도학회지
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• 제23권4호
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• pp.459-469
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• 2009

It is well known that coagulation pretreatment can reduce foulants prior to membrane filtration. The purpose of this research was to investigate the effects of coagulation on fouling of ceramic microfiltration membrane($0.1 {\mu}m$) using pilot plant of $150m^3/day/train$ capacity. Train A membrane system has pretreatment process of ozonation and coagulation while train B has only coagulation. Two types of coagulation operation were investigated: back mixer(rapid mixing with or without slow mixing) which is a conventional mechanically stirred mixer and an inline static mixer. Ozone dose rate for train A was 1 mg/L and ozone contact time was 12 min. The coagulation dose(PACl 10% as $Al_2O_3$) rate was changed 20~40 mg/L according to experimental schedule. In this experimental conditions, the coagulation of back mixer type with rapid mixing(GT=72,000) and slow mixing(GT=45,000) was the best effective in reduction of ceramic membrane fouling regardless preozonation. Especially, the effect of inline static mixer was sensitive to change in water quality. Ozonation mainly affected irreversible fouling rather than reversible fouling in accordance with less adsorption of NOM on the membrane surface. Thus, the increase rate of the nomalized TMP(trans membrane pressure) at $25^{\circ}C$ for train A was relatively lower than that of train B under same coagulation process with same coagulant dosage. The best performance of ceramic membrane appeared in case of combined process with ozonation, therefore this integrated process is able to archive less coagulant dosing and secure a stability of ceramic membrane system.

• 대한화학회지
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• 제36권2호
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• pp.324-328
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• 1992

${\alpha}$-와 ${\beta}$-시클로덱스트린과 그의 메틸유도체들을 Chemical shift(${\delta}$)와 Coupling constant(J)를 470 MHz $^1H$ NMR을 이용해서 수용액 안에서 분석하였다. 정확한 ${\delta}$와 J값들을 얻기 위해서 Raccoon spin simulation program을 이용해서 실험 data를 분석하였다. 시클로덱스트린의 $C_{5-}C_6$ bond 주위의 rotamer의 분포를 $J_{56a}$ 와$J_{56b}$값을 이용하여 실험 data를 분석하였다. 위 계산에 의해 ${\alpha}$-와 ${\beta}$-시클로덱스트린에서는 gg conformer가 가장 많이 존재하였고 tg conformer가 가장 적게 존재했다. 그러나 그 메틸 유도체에서는 gg conformer가 더 많이 증가하였고 gt conformer가 가장 적게 존재함을 알았다.

• Journal of Advanced Marine Engineering and Technology
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• 제20권3호
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• pp.19-28
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• 1996

In Asia countries the productions of ship building and marine engines have been increasing, specially Japanese marine industries have worked hard after 1960s and Korean ones after 1980s. Recently the other countries, as Taiwan and China, have been working so that these hour Asian countries are occuping the high level of shared ratio of productions for gross tonnages and horse powers, which are 74 and 64[%] of the world ones ($8.6\times10$+6[GT], $8.6\times10$+6[PS]) in 1994. Korean industries had the highest shared ratio of production of tanker vessel and 2 stroke diesel engine as 45[%]($2.2\times10$+6[GT]) and 37[%]($1.0\times10$+6[PS]) which were more than those of Japan as 34 and 16[%] in 1989 respectively. Some marine databases and their network links among Asian countries are proposed due to the posibility of collection and analyses with their own specifications by the marine industries and operators as well as Japanese ship reliability investigation works(SRIW) like SRIC in Japan. During 1966 and 1996 16 times of SRIW in Japan have been carried out by ship reliability investigation group(SRIG) in Japan. There have been collected and evaluated a great number of field data of failures and maintenances($700\times10$+3[occ], $1.6\times10$+6[MH}) during running hours($13.4\times10$+6[Hrs]), from which many kinds of evaluation indices could be gotten as the three indices of occurring rate$\lambda$(52.2[occ/1000Hrs]), average man-hour mh(2.29[MH/occ]) and manning index MI(119[MH/1000Hrs]). An estimation example having the three indices$\lambda$, mh and MI were shown by the SRIC 1990 Data Base in Japan for the two kinds of fuel oil suppling subsystems which are dual fuel oil one(DFOS) and mono fuel oil one(MFOS). Three indices MI, and mh for DFOS and MFOS results in 7.16 and 5.20[MH/1000Hrs], 2.63 and 2.06[occ/1000 Hrs]. Therefore the more simple subsystem MFOS can save approximately 30[%] of maintenance load. Finlly an utilization methods are shown for the SRIC in Japan by means of computer system and worlwide internet links.

• 한국식품영양과학회지
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• 제37권10호
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• pp.1238-1243
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• 2008

잔대 뿌리는 우리나라에서 예로부터 민간약으로 이용되어 오고 있다. 본 연구에서는 인간 간세포인 HepG2에 잔대 뿌리의 에틸아세테이트 추출물을 처리했을 때 sodium nitroprusside(SNP)에 의해 유도된 세포 독성 및 항산화 유전자 발현에 미치는 영향력을 알아보았다. 먼저, 잔대 에틸아세테이트 추출물이 NO에 의해 유도된 세포 사멸을 저해할 수 있는지를 알아보기 위하여 HepG2 세포에 잔대 에틸아세테이트 추출물(각각 50과 100 $\mu$g/mL)을 24시간 먼저 처리한 후 세포내에서 NO을 생성시킬 수 있는 0.5 mM SNP를 처리하였다. NO에 의한 세포독성이 에틸아세테이트 추출물에 의해 저해되었다는 것을 mitochondrial dehydrogenase 활성을 알아보는 MTT assay를 실시하여 알아보았다. 더하여 우리는 잔대 에틸아세테이트 추출물이 세포내 항산화 방어 시스템인 Cu,Zn superoxide dismutase(SOD 1), Mn SOD(SOD 2), glutathione peroxidase(GPx), catalase와 glutathione metabolism과 관련되어져 있는 glutathione reductase(GR), $\gamma$-glutamyl-cystein synthetase(GCS), glutathione-S-transferase(GST), $\gamma$-glutamyltranspeptidase($\gamma$-GT), glucose-6-phosphate dehydrogenase(G6PD)의 mRNA 발현에 미치는 영향을 RT-PCR로 알아보았다. CAT, GCS 그리고 G6PD mRNA 수준이 잔대 에틸아세테이트 추출물 처리 후 증가하였으나, SOD 1, SOD 2, GPx, GST 그리고 $\gamma$-GT mRNA 수준은 변화지 않았다. 따라서 잔대 에틸아세테이트 추출물이 간접적 항산화 효과가 있고, 이들 효과는 아마 CAT, GCS, GR 그리고 G6PD 유전자 발현 증가에 의한 것이라고 추정되었다.

• 대한방사선기술학회지:방사선기술과학
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• 제39권1호
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• pp.99-105
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• 2016

잡음전력스펙트럼 (noise power spectrum, NPS)는 noise 진폭의 측정과 균일한 방사선 영역으로부터 획득된 영상의 품질에 가장 일반적인 방법 중 하나이다. 이 연구의 목적은 megavoltage X-ray 에너지를 사용하여 다른 잡음 전력스펙트럼 방법론들을 비교하는 것이다. 진단 영역에서의 잡음전력스펙트럼 평가 방법들은 국제 전기 규격 international electro-technical commission(IEC 62220-1) 기준을 사용하여 치료 영역에 적용되었다. 우리가 사용한 전자포털영상장치(electronic portal imaging device, EPID)는 Varian TrueBeam$^{TM}$, Siemens BEAMVIEW$^{PLUS}$, Elekta iViewGT 그리고 Varian Clinac$^R$ iX aS1000이었다. 잡음전력스펙트럼의 관심영역을 측정하기 위해, 우리는 겹침 (overlapping), 비겹침 (non-overlapping), 평탄도 (flatness), 반음영 (penumbra) 4가지 인자를 사용하였다. 결과적으로는 Siemens BEAMVIEW$^{PLUS}$, Varian TrueBeam$^{TM}$ flattening filter, Varian Clinac$^R$ iX aS1000, Varian TrueBeam$^{TM}$ flattening filter free에서의 잡음 (noise) 분포는 기존의 첫번째, 두번째, 세번째 실험방법보다는 Elekta iViewGT보다 현격하게 높은 noise 분포가 나타남을 알 수 있다. 이번 연구는 다양한 인자들이 잡음전력스펙트럼의 megavoltage imaging (MVI)영상에서 MVI영역에서 잡음전력 스펙트럼의 기준의 방법론으로 사용되어질 수 있다는 것을 보여주었다.

• 디자인학연구
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• 제12권3호
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• pp.227-234
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• 1999

본 논문은 디자인 프로젝트 관리의 리엔지니어링으로서 프로젝트의 기획, 조직, 일정, 그리고 제어하는 통합적인 어플리케이션 소프트웨어 개발의 기초모델을 설정하고, 이를 토대로 프로젝트 관리 시스템의 연구/개발을 목표로 삼고 있다. 프로젝트의 성과, 소요기간, 소요예산, 그리고 소요자원 등을 관리하는 과정이 프로젝트 매니지먼트 기술의 근간을 이루는 것으로, 디자인 프로젝트 상의 수많은 정보를 적시에 효율적으로 처리함으로써 프로젝트를 성공으로 이끌 수 있게 된다. 한편, 디자인프로젝트의 관리를 집단의사결정에 의해 처리함으로써 신뢰도와 합리성의 제고는 물론, 이를 통한 사기앙양이 기대된다. 따라서, 여기에서 야기되는 의사집합의 곤란, 시간손실, 구성원의 갈등 등의 프로젝트 관리에서 비롯되는 부수적인 문제도 전자의 기본적인 관리요소와 함께 통합하여 디자인 프로젝트 관리 시스템(DPMS)을 연구/개발하였다. DPMS 시스템은 디자인 프로젝트의 선정과 디자인 프로젝트의 기획/실행관리/ 평가로 주요 모듈을 설정함으로써 프로젝트 매니저는 해당 프로젝트 과업(Task)과 활동(Activity)에 대한 팀의 운용을 융통성 있게 관리할 수 있게 된다. 이와 더불어 프로젝트 관리를 On-Line DBMS 시스템 환경 상에 운용되도록 하여 정보의 재생산성, 운용의 동시성, 그리고 보안성 등을 도모하였다.

• 대한약침학회지
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• 제8권3호
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• pp.39-50
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• 2005

In order to study comparatively the effects of "Palmisoyo-San gamibang(八味消遙散加味方)"(AP), "Gyebu-Tang(桂附湯)"(GT) and "Boganyangje(補肝陽劑)" (BG) on the thyrotoxicosis rats, we have made thyrotoxicosis rat model by administration sodium levothyroxine p.o. during 4 days(Control group), and have administered solid extract of AP(236.8mg/200g/day : Sample I group), GT(80mg/200g/day : Sample II group) and BG(70.4mg/200g/day : Sample III group) p.o. to thyrotoxicosis rats during 3 days from 3rd day. We measured the body weight(BW), body temperature(BT), levels of Serum $T_3{\cdot}T_4{\cdot}free\;T_3{\cdot}free\;T_4$ and TSH after administrating solid extract of AP, GT and BG. The results are summarized as follows: 1. Sample I group showed significantly high increasing rate compared with Control, Sample II and Sample III group, but it showed significantly lower levels of BT, $T_4$ and free $T_4$ than those of Control, Sample II and Sample III. group. 2. We could know that AP suppress the alteration of $T_4$ to $T_3$. 3. Sample II and Sample III group showed opposite results to Sample I group in the BW., BT, $T_4$ and free $T_4$ Especially Sample III was significantly higher than Control, Sample I and Sample II, so we could guess that BG stimulates the formation of thyroid hormones. According to the above experimental results, "Palmisoyo-San\;gamibang(八味消遙散加味方)" is assumed to have a curative effect against the thyrotoxicosis rat induced by sodium levothyroxine, and to suppress the alteration of $T_4$ to $T_3$. And we can suppose that "Boganyangje(補肝陽劑)" has a curative effect against the hypothyroidism.

• Animal cells and systems
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• 제16권2호
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• pp.127-134
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• 2012

We investigated the effects of fadrozol, an aromatase inhibitor (AI), and $17{\alpha}$-methyltestosterone (MT) on the induction of sex change in juvenile longtooth grouper $Epinephelus$ $bruneus$, via histological observation of gonads. Changes in the mRNA expression of GtH subunits (FSH-${\beta}$ and LH-${\beta}$) in the pituitary, and estradiol-$17{\beta}$ (E2) and 11-ketotestosterone (11-KT) levels in the blood were also surveyed after AI and MT treatment. Juvenile longtooth groupers ($113{\pm}17g\;body\;weight$; $16.2{\pm}1.2cm\;body\;length$) received intramuscular injections of AI at 3 (3-AI) and 5 (5-AI) mg/kg BWdoses and MT at a 5 mg/kg BW (5-MT) dose. At week 7 post-injection, 3-AI and 5-MT oocytes were degenerated, and gonads of the 5-AI group initiated spermatogenesis. At week 21 post-injection, 3-AI- and 5-MT-treated gonads contained spermatogonia and spermatocytes, while 5-AI treatment induced advanced stages of spermatogenesis. The serum E2 level showed no significant differences throughout the experimental period, whereas that of 11-KT was significantly elevated in the 5-AI group at weeks 7 and 21 post-injection. A significant increase in the expression of FSH-${\beta}$ mRNA was evident in the 5-AI group at week 21 post-injection. In contrast, LH-${\beta}$ mRNA expression did not significantly differ among groups during the experimental period. These results imply that sex change has two stages in the longtooth grouper. In the first stage, oocytes are degenerated by the stimulation by 11-KT, and in the second stage spermatogenesis occurs, owing to the co-effects of 11-KT and FSH-${\beta}$.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5317-5324
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• 2014

Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of cancer, but the results are still debatable. Therefore, we performed a systematic review to provide a more complete picture and conducted a meta-analysis to derive a precise estimation. We searched PubMed, EMBASE, EBSCO, Google Scholar and China National Knowledge Infrastructure (CNKI) databases until April 2014 to identify eligible studies. Thirty-one studies with cancer patients and controls were included in the meta-analysis. Overall, the polled analysis revealed that the T-786C polymorphism was significantly associated with increased cancer risk under multiple genetic models (C vs T: OR=1.135, 95%CI=1.048-1.228; CC vs TT: OR=1.278, 95%CI=1.045-1.562; TC vsTT: OR=1.136, 95%CI=1.023-1.261; CC+TC vs TT: OR=1.159, 95%CI=1.047-1.281; CC vs TC+TT: OR=1.204, 95%CI= 1.003-1.447). G894T was associated with significant risk for females (TT vs GG: OR=1.414, 95%CI=1.056-1.892; TT vs GT+GG: OR=1.356, 95%CI=1.108-1.661) and for breast cancer (T vs G: OR=1.097, 95%CI=1.001-1.203; TT vs GG: OR=1.346, 95%CI=1.012-1.789; TT vs GT+GG: OR=1.269, 95%CI=1.028-1.566). Increased susceptibility was revealed for prostate cancer with 4a/b (ba vs bb: OR=1.338, 95%CI=1.013-1.768; aa+ba vs bb: OR=1.474, 95%CI=1.002-2.170). This meta-analysis indicated that the eNOS T-786C polymorphism is associated with elevated cancer risk; the G894T polymorphism contributes to susceptibility to breast cancer and cancer generally in females; and the 4a/b polymorphism may be associated with prostate cancer risk.