• Journal of the Korean Society for Precision Engineering
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• v.14 no.1
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• pp.58-68
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• 1997

In order to provide economic high-quality products to customers in a timely manner, companies have tried much effort to decrease the time period of engineering design and information management. As a part of this effort, we have developed the Drawing Information Management System(DIMS) based ofn GT(Group Technology) that could decrease design processing time by speedy and rational management of design processes. The characteristics of DIMS are as follows: First, the concept of Concurrent Engineering was applied to DIMS. Through LAN, reviewers are able to attach comments to dlectronic documents by anno- tation functions called Mark-up. The reviewer annotations are collected and combind with the original document to revise the documents. Second, we have developed a Classification and Coding(C&C) system suitable for electronic component parts bassed on GT(Group Technology). The C&C system makes both parts and drawing with similar characteriscs into families and helps users search existing documents or create new drawings promptly. Finally, DIMS provides the Engineering BOM(Bill of Material) using the concept of Family BOM based on model options.

• Korean journal of applied entomology
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• v.46 no.1 s.145
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• pp.63-69
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• 2007

This study was conducted to examine the problems that would arise in our cropping systems when introducing Gain Threshold (GT) which is an important element in determining Economic Injury Level (EIL). Cain Threshold (GT) can be defined as the amount of damage (=yield loss) to justify management, and calculated by dividing the management costs by the market crop price. GTs for some pests in rice, soybean, and greenhouse vegetable crops cultivation were estimated and also compared with those in foreign countries. GTs and percentage of yield loss equivalent to them were estimated to be 4.6-6.1kg/10a/season and 1.0-1.3% for brown planthopper, white-backed planthopper, rice water weevil, and sheath blight, whereas for rice blast in rice cultivation were 12.7kg/10a/season and 2.7%. In soybean cultivation, the values for bean bug were 6.2 kg/10a/season and 3.6%. GTs and percentage of yield loss estimated for melon thrips, whitefly, and downy mildew in cucumber cultivation were 10.0-12.6kg/10a/week, 1.4-1.7%, and the values for two spotted mite and gray mildew in strawberry cultivation were 3.1-3.5kg/10a/week, 1.3-1.5%, and the values for American leaf minor, whitefly, and gray mold in tomato were 8.4-9.7kg/10a/week, 1.7-1.9%. Overall GTs in our cropping systems were so low compared to those in foreign countries, which meant that the low GTs might yield the low EILs. Therefore, we could suggest that prior to direct introduction of GTs calculated from current cultivation systems in developing EILs it is necessary to seriously consider reasonable values of GTs or the yield loss equivalents to them.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2153-2155
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• 2012

Objective: This study was to assess liver involvement in multiple myeloma with the aid of liver function tests. Materials and Methods: A hospital based retrospective study was undertaken using data retrieved of multiple myeloma from the register maintained in the Department of Biochemistry of the Manipal Teaching Hospital, Pokhara, Nepal between $1^{st}$ January, 2007 and $28^{th}$ February, 2012. We collected biomarkers of liver profiles including bilirubin (Total, Direct and Indirect), total protein, albumin, AG ratio, SGOT, SGPT, ALP, ${\gamma}GT$, LDH, ferritin, renal profile and hematological profile. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO and SPSS 16 software. Results: Out of 37 cases of multiple myeloma, serum level of AST, ALT, ALP, ${\gamma}GT$ and LDH were increased above the cut-off point in 22 (59.5%), 24 (64.86%), 13 (35.13%), 9 (24.3%) and 11 (29.7%) respectively. The mean values of AST ($65.5{\pm}28.18$ U/L), ALT ($68.37{\pm}29.74$ U/L), ALP ($328.0{\pm}148.4$ U/L), ${\gamma}GT$ ($44.5{\pm}29.6$ U/L) and LDH ($361.7{\pm}116.5$ U/L), total protein ($9.79{\pm}1.03$ gm/dl) were significantly increased when compared with controls. In contrast, albumin ($3.68{\pm}0.43$ gm/dl) and the AG ratio ($0.62{\pm}0.15$) were significantly decreased. Similarly, anemia, hyperuricemia, azotemia, hypercalcaemia and Bence Jones proteinuria were found in 30 (78.9%), 27 (71.1%), 19 (51.5%), 15 (39.5%) and 16 (42.1%) respectively, in cases of multiple myeloma. Conclusions: While clinical manifestation of liver disease among the multiple myeloma was not common, abnormalities in liver function were characteristic.

• The Korean Journal of Pesticide Science
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• v.12 no.2
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• pp.168-176
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• 2008

Recently damage of rice bakanae disease disseminated by infected seeds increased in paddy field in Korea. For controlling rice bakanae disease, the efficacy of 17 fungicides was assessed by 5 kinds of bioassay, spore germination test (SGT), mycelial growth test, detection test on Komada's medium (KDT), pouch test (PT) and greenhouse test (GT). Among ergosterol biosynthesis inhibiting fungicides, prochloraz showed a high controlling activity in all the assay systems while the others showed very low activity except for $500\;{\mu}g/ml$ of hexaconazole in GT and $500\;{\mu}g/ml$ of triflumizole in KDT. Although benomyl and the mixture of benomyl and thiram showed a good activity at 100 and $500\;{\mu}g/ml$ in SGT and PT, respectively, in GT they did a middle activity. Trifloxystrobin and kresoxim-methyl included in strobilurins showed a good activity even at $20\;{\mu}g/ml$ in KDT as well as a middle activity in SGT. Also a high activity not only at $10\;{\mu}g/ml$ in SGT but also at $100\;{\mu}g/ml$ KDT was detected in thiram. The activity of fludioxonil was confirmed in SGT, KDT and PT. Based on these results, it is very important to determine a bioassay system, because the fungicidal activity against rice bakanae disease was fluctuated depending on a assay systems as well as the mechanism of fungicide.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3131-3138
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• 2016

Several studies have addressed the possible role of hepatitis C virus genotype-4 (HCV GT4) in apoptosis. However, this still not fully understood. In the current study a re-constructed clone of E1/E2 polyprotein region of the HCV GT4 was transfected into the Huh7 cell line and a human apoptotic PCR array of 84 genes was used to investigate its possible significance for apoptosis. Out of the 84 genes, only 35 showed significant differential expression, 12 genes being up-regulated and 23 down-regulated. The highest-up regulated genes were APAF1 (apoptotic peptidase-activating factor 1), BID (BH3 interacting domain death agonist) and BCL 10 (B-cell CLL/lymphoma protein 10) with fold regulation of 33.2, 30.1 and 18.9, respectively. The most down-regulated were FAS (TNF receptor super family), TNFRSF10B (tumor necrosis factor receptor super-family member 10b) and FADD (FAS-associated death domain) with fold regulation of -30.2, -27.7 and -14.9, respectively. These results suggest that the E1/E2 proteins may be involved in HCV-induced pathogenesis by modulating apoptosis through the induction of the intrinsic apoptosis pathway and disruption of the BCL2 gene family.

• Journal of the Korean neurological association
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• v.35 no.4
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• pp.211-214
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• 2017

Acute disseminated encephalomyelitis (ADEM) and Guillain-$Barr{\acute{e}}$ syndrome (GBS) are both rare post-infectious neurological disorders. The co-existence of these conditions has often been reported despite of low incidence. We describe a 20-year-old male, who presented with acute flaccid paralysis and encephalopathy. The patient showed reversible MRI lesions suggesting ADEM. This case showed anti-GT1a IgG and anti-GM1 IgM antibodies positivity. We suggest that certain immunogenicity within central and peripheral nervous system may share a common autoimmune process during the disease course.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4327-4330
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• 2012

The mouse double minute 2 (MDM2) gene plays a key role in the p53 pathway, and the SNP 309T/G single-nucleotide polymorphism in the promoter region of MDM2 has been shown to be associated with increased risk of cancer. However, no consistent results were found concerning the relationships between the polymorphism and prostate cancer risk. This meta-analysis, covering 4 independent case-control studies, was conducted to better understand the association between MDM2-SNP T309G and prostate cancer risk focusing on overall and subgroup aspects. The analysis revealed, no matter what kind of genetic model was used, no significant association between MDM2-SNP T309G and prostate cancer risk in overall analysis (GT/TT: OR = 0.84, 95%CI = 0.60-1.19; GG/TT: OR = 0.69, 95%CI = 0.43-1.11; dominant model: OR = 0.81, 95%CI= 0.58-1.13; recessive model: OR = 1.23, 95%CI = 0.95-1.59). In subgroup analysis, the polymorphism seemed more likely to be a protective factor in Europeans (GG/TT: OR = 0.52, 95%CI = 0.31-0.87; recessive model: OR = 0.58, 95%CI = 0.36-0.95) than in Asian populations, and a protective effect of the polymorphism was also seen in hospital-based studies in all models (GT/TT: OR = 0.74, 95%CI = 0.57-0.97; GG/TT: OR = 0.55, 95%CI = 0.38-0.79; dominant model: OR = 0.69, 95%CI = 0.54-0.89; recessive model: OR = 0.70, 95%CI = 0.51-0.97). However, more primary studies with a larger number of samples are required to confirm our findings.

• Journal of Welding and Joining
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• v.12 no.1
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• pp.102-115
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• 1994

This paper is to evaluate the fatigue strength of lap joints of materials applied to LNG carrier cargo containment of GAZ-TRANSPORT(GT) type, which was welded by manual and automatic TIG welding process. The thicknesses of lapped members were 1.5mm/1.5mm or 1.5mm/0.7mm in Invar to Invar joint, and 1.5mm/8.0mm in Invar to stainless steel joint, respectively. These lap joints were mainly applied to the membrance fabrication of GT-LNG carrier. Fatigue tests of Invar/Inar lap joints were conducted under the stress ratio R=0 at room temperature. The effect of mean stress and cumulative fatigue damage on the allowable stress of Invar lap joint was evaluated on the basis of test results. Fatigue test was also conducted on Inver/Stainless steel lap joints welded by automatic TIG process without filler metals. The fatigue test of the joint was carried out under the same conditions as those of Invar/invar lap joints. The fatigue strength of the joint welded without filler metal was comparable to those welded with filler metal quoted from reference. The fatigue strength of Invar/stainless steel lap joint was only dependent on the lap throat thickness, and not on the welding process. Based on test results, the applicability of TIG welding process without filler metal in Invar/stainless steel lap joint was reviewed by controlling welding variables to assure the valid throat thickness of lap joints.

• Journal of Periodontal and Implant Science
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• v.52 no.4
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• pp.298-311
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• 2022

Purpose: The aim of this study was to evaluate the clinical outcomes of periodontal granulation tissue preservation (PGTP) in access flap periodontal surgery. Methods: Twenty patients (stage III-IV periodontitis) with 42 deep periodontal pockets that did not resolve after non-surgical treatment were consecutively recruited. Access flap periodontal surgery was modified using PGTP. The clinical periodontal parameters were evaluated at 9 months. The differences in the amount of granulation tissue width (GTw) preserved were evaluated and the influence of smoking was analyzed. Results: GTw >1 mm was observed in 97.6% of interproximal defects, and the granulation tissue extended above the bone peak in 71.4% of defects. At 9 months, probing pocket depth reduction (4.33±1.43 mm) and clinical attachment gain (CAG; 4.10±1.75 mm) were statistically significant (P<0.001). The residual probing depth was 3.2±0.89 mm. When GTw extended above the interproximal bone peak (i.e., the interproximal supra-alveolar granulation tissue thickness [iSUPRA-GT] was greater than 0 mm), a significant CAG was recorded in the supra-alveolar component (1.67±1.32 mm, P<0.001). Interproximal gingival recession (iGR) was significant (P<0.05) only in smokers, with a reduction in the interdental papillary tissue height of 0.93±0.76 mm. In non-smokers, there was no increase in the iGR when the iSUPRA-GT was >0 mm. The clinical results in smokers were significantly worse. Conclusions: PGTP was used to modify access flap periodontal surgery by preserving affected tissues with the potential for recovery. The results show that preserving periodontal granulation tissue is an effective and conservative procedure in the surgical treatment of periodontal disease.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.3
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• pp.361-365
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• 2005

For the EXP 1, the objective of this study was to determine the effect of MSM (methyl sulfonyl methane) supplementation on growth performance and nutrient digestibility in pigs. Sixty crossbred (Landrace × Yorkshire × Duroc) pigs (48.15±0.15㎏ average initial body weight) were used in a 35 days growth assay. Dietary treatments included 1) Control (basal diet), 2) T1 (basal diet＋0.01% MSM) and 3) T2 (basal diet＋0.02% MSM). For overall period, average daily gain, average daily feed intake and feed efficiency were not significantly different among the treatments (p＆gt;0.05). Digestibilies of DM, N, Ca and P were not significant defferences (p＆gt;0.05). For the EXP 2, the objective of this study was to determine the effect of MSM and antibiotic supplementation on growth performance and nutrient digestibility in pigs. One hundred crossbred (Landrace × Yorkshire × Duroc) pigs (33.85±0.15㎏ average initial body weight) were used in a 42 days growth assay. Dietary treatments included 1) Control (basal diet), 2) T1 (basal diet＋0.05% neomycin sulfate, 0.055% oxytetracycline), 3) T2 (Con diet＋0.01% MSM) and T3 (T1＋0.01% MSM). For overall period, average daily gain and average daily feed intake of pigs fed T3, T2 diets were higher than those of CON diet (p＆lt;0.05). Average daily gain was not significantly different between T2 and T3. However, food efficiency of pigs fed CON was the highest among the treatments (p＆lt;0.05). Pigs fed T3 diet increased nutrient digestibility compared to other treatments (p＆lt;0.05). In conclusion, the results suggest that the dietary addition of MSM and antibiotics into diets for pigs affect growth performance and nutrient digestibility.