• Journal of Nutrition and Health
• /
• 제12권3호
• /
• pp.33-39
• /
• 1979

우리나라에서 시판되고 있는 각종 다류(인삼차 2종, 인삼 extract 2종, 인삼분말, 생강차, 오미자차, 홍차, 인스턴트 홍차 2종)중의 antithiamin activity (ATA)와 탑닌함량을 정량하였 다. 한펀, Wistar계의 이유기의 숫쥐 30마리를 인스턴트홍차, 인삼차 B 인삼extract B와 Lipton tea 및 물 투여구(대조구)의 5군으로 나누어 일정향의 지아민을 첨가한 기본사료로 사육하면서 등물의 증체량, 사료 및 음료섭취량, 식이효율을 매주마다 측정하였고, 4주후 24시간 동안 각 투여구의 동물뇨중의 지아민의 함량을 비교하였다. 본 실험에서 사용한 다류중 ATA는 홍차 및 인스턴트 홍차 A가 가장 높았고, 인삼차 A와 오미자차는 비교적 낮았다. 일반적으로 ATA가 높은것은 탄닌의 함량도 많았고 ATA가 낮은 것은 탄닌의 함량도 낮은 경향이었으나, 같은 종류의 차라할지라도 ATA와 탄닌의 함량은 매우 상이하였다. 한편 동물실험에서 증체량은 인삼차 B와 인삼 extract B 투여구가 물, Lipton tea, 인스턴트 홍차 B 투여구에 비해 낮았으나 유의적인 차는 없었으며, 사료 및 음료섭취량, 식이효율도모든 실험구에서 유의적인 차가 없었다. 그리고 뇨중의 지아민 함량은 대조군에 비해 Lipton tea, 인삼차차 B, 인삼 extract구에서 높았고, 인스턴트 홍차 A구는 낮았으나 유의적인 차이는 없었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권7호
• /
• pp.2929-2937
• /
• 2015

Endothelial nitric oxide synthase (eNOS or NOS3) produces nitric oxide and genetic polymorphisms of NOS3 gene play significant roles in various processes of carcinogenesis. The results from published studies on the association between NOS3 G894T and NOS3 intron 4 (4a/b) polymorphisms and cancer risk are conflicting and inconclusive. However, i n order to assess this relationship more precisely, a meta-analysis was performed with PubMed (Medline), EMBASE and Google web searches until February 2014 to select all published case-control and cohort studies. Genotype distribution data were collected to calculate the pooled odd ratios (ORs) and 95% confidence intervals (CIs) to evaluate the strength of association. A total of 10,546 cancer cases and 10,550 controls were included from twenty four case-control studies for the NOS3 G894T polymorphism. The results indicated no significant association with cancer risk as observed in allelic (T vs G: OR=1.024, 95%CI=0.954 to 1.099, p=0.508), homozygous (TT vs GG: OR=1.137, 95%CI=0.944 to 1.370, p=0.176), heterozygous (GT vs GG: OR=0.993, 95%CI=0.932 to 1.059, p=0.835), recessive (TT vs GG+GT: OR=1.100, 95%CI=0.936 to 1.293, p=0.249) and dominant (TT+GT vs GG: OR=1.012, 95%CI=0.927 to 1.105, p=0.789) genetic models. Similarly, a total of 3,449 cancer cases and 3,691 controls were recruited from fourteen case-control studies for NOS3 4a/b polymorphism. Pooled results indicated no significant association under allelic (A vs B: OR=0.981, 95%CI=0.725 to 1.329, p=0.902), homozygous (AA vs BB: OR=1.166, 95%CI=0.524 to 2.593, p=0.707), heterozygous (BA vs BB: OR=1.129, 95%CI=0.896 to 1.422, p=0.305), dominant (AA+BA vs BB: OR=1.046, 95%CI=0.779 to 1.405, p=0.763) and recessive (AA vs BB+BA: OR=1.196, 95%CI=0.587 to 2.439, p=0.622) genetic contrast models. This meta-analysis suggests that G894T and 4a/b polymorphisms of NOS3 gene are not associated with increased or decreased risk of overall cancer.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2005년도 제36회 하계학술대회 논문집 A
• /
• pp.603-605
• /
• 2005

전력수요의 증대에 따른 계동모의 확장에 따라 관련기기는 초고압 및 대용량화 추세에 있다. 이러한 관련기기들 중에서도 특히 154/22.9kV 전력용 변압기는 고장시 수용가의 정전범위가 방대하고 변압기 내부 고장의 복구비용 또한 막대하므로 경제적 손실은 물론 사회적 영향도 크다. 우리나라에서는 1980년 초기부터 154/22.9kV 전력용 변압기의 고장이 급증하였으며, 이러한 원인은 주로 직전접지 방식을 채택하고 있는 한전 계통에서 배전선의 지락고장에 의한 지락고장 전류가 변압기 중성점을 통하여 변압기에 충격을 가함으로써 변압기 권선 단락 절연파괴 및 ULTC 고장 등이 발생하는 것으로 밝혀졌다. 따라서 한전에서는 변압기 중성점으로 흐르는 지락고장전류의 저감을 위해 변압기 중성점 접지 리액터(NGR: Neutral Ground Reactor)를 설치하여 운전하고 있으며, 결과 변압기 고장이 크게 감소하였다. 그러나 모선 절체시 변압기 1, 2차측 차단기 Trip 고장이 발생하였으며, 고장 발생 원인은 NGR 보호계전기 59GT 계전기의 오동작에 의한 86T Lock Out 계전기 동자으로 변압기 1, 2차측 차단기 Trip 고장이 발생한 것으로 추정된다. 따라서 본 논문에서는 무부하 모선 차단시 59GT 계전기에 나타나는 이상 전압을 EMTP (electro-magnetic transient program)를 이용하여 분석하였다.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 1995년도 춘계학술대회
• /
• pp.112-112
• /
• 1995

간장 손상시에는 여러 혈청의 효소 활성과 함께 혈청 $\beta$-glucuronidase의 활성도 증가한다는 것이 보고되었으나 심한 간부전이나 간암의 경우 이들의 활성은 오히려 정상치보다 감소하는 것으로 나타났다. Silymarin은 간장 보호효과로 이미 임상에 널리 사용되고 있는 약물로서 김 등에 의해 silymarin이 장내세균의 $\beta$-glucuronidase와 간장의 $\beta$-glucuronidase의 활성을 억제한다는 것이 보고되었다. 이에 연자 둥은 $\beta$-glucuronidase의 저해 효과가 관찰된 영지버섯온 유기용매로 분획하여 간장 보호효과를 검색하였다. 영지버섯의 70% MeOH 추출물(GT)과 그 ether 분획(GE)에 대해 생쥐 1군을 6마리로 하여 20% $CCl_4$0.1$m\ell$/10g(olive oil로 희석)을 경구투여 하였다. 검액 GE는 50mg/kg과 250mg/kg, GT는 100mg/kg과 500mg/kg을 각각 사염화탄소 투여 30분 전에 경구투여 하였으며 사염화탄소를 투여하고 24시간 후에 심장 채혈하고 혈청을 분리하여 혈청성분 및 혈청효소의 활성을 측정하였다. 대조군에는 생리식염수를 투여하였고 양성 비교약물로는 silymarln 100mg/kg을 경구투여 하여 비교 관찰하였다. 실험 결과, 영지버섯의 ether 분획에서는 혈청중 GOT, GPT의 활성과 triglyceride의 함량에 대해 silymarin보다 우수한 효과를 보였으며, 70% MeOH 추출물은 silymarin에 미치지 못했다.

• 수산해양기술연구
• /
• 제16권2호
• /
• pp.69-76
• /
• 1980

This paper describes the measurement of the underwater noises produced by the engine vibration around the engine room of stern trawler MIS Sae-Ba-Da(2275GT, 3,600 PS) and pole kner M/S Kwan-Ak-San (243 GT, 1000 PS) while the ship is stopping. The underwater noise pressure level was measured with the underwater level meter of which measuring range is 100 to 200 dB(re bLPa). A and B denotes the maximum pressure level measured at right beneath the bottom of the engine room, while the main engine of the Sae-Ba-Da revoluted at 750 and 500 rpm, respectively. C denotes that of the main engine of the Kwan-Ak-San revoluted at 350 rpm, and D that of the generator of the Sae-Ba-Da revoluted at 720 rpm. Thus A, B, C and D were set for the standard sound source for the experiment. The results obtained are as follows: 1. The noise Pressure level at A, B, C and D were 170.5,165,153 and 158dB, respectively. 2. When the check points distanted vertically 1, 10, 20, 30, 40, 50m from the sound source, the underwater noise presure levels were 170.5, 155, 148, 144 and 138 dB and the directional angle was 116\ulcorner in case of A. 3. The sound level attenuated at the rate of 20dB per 10" meters of the horizontal distance from the sound sources. 4. The frequency distribution of the noise was 100Hz to 10KHz and predominant frequency was 700 to 800Hzminant frequency was 700 to 800Hz

• Korean Journal of Acupuncture
• /
• 제17권1호
• /
• pp.19-31
• /
• 2000

Effects of acupuncture at Taekjung and Ungyo($GV_{28}$) bloodletting on serum glutamic oxaloacetic transaminase (GOT) activity, glutamic pyruvic transaminase activity(GPT), total Protein, Albumin, Alkalin Phosphatase(ALP), ${\gamma}$-GT, lactic dehydrogenase (LDH), total cholesterol and triglyceride were determined. 1) In the Ungyo bloodletting group, GOT, GPT, ALP, ${\gamma}$-GT and LDH activity showed a tendency to decrease compared to those of $CCl_4$ only group and Taekjung acupuncture group. 2) Serum albumin content showed a tendency decrease by treatment of $CCl_4$ and to increase by treatment of Ungyo bloodletting. 3) The values of serum total protein, total cholesterol and triglyceride showed no significant difference among all the treatment groups. 4) All the biological values showed no significant difference between the $CCl_4$ only group and Taekjung acupuncture group except the values of albumin. Results from this study indicate that the Ungyo bloodletting showed the possibility of liver function recovery in liver-harmed rats by $CCl_4$.

• 한국가시화정보학회지
• /
• 제17권1호
• /
• pp.78-84
• /
• 2019

A gas turbine is the main equipment of a power plant that generates electricity by high-speed rotation of the rotor in a high-temperature environment. In particular, in the case of medium to large-sized gas turbines, the rotor is composed of a plurality of stages, and each component is exposed to different physical environments. Especially, in the case of the tip clearance of the turbine, it is a very important factor in the performance of the design items and the operation of the stable turbine, and a design considering the physical behavior of all major parts should be done. In this study, we will discuss the process of visualizing the physical behavior of turbine operating conditions and the method of designing tip clearance for stable operation by using commercial finite element analysis program for gas turbine assembly model and single product.

• 한국항해항만학회지
• /
• 제48권2호
• /
• pp.125-136
• /
• 2024

This research presents an innovative integrated ethanol solid oxide fuel cell (SOFC) system designed for applications in marine vessels. The system incorporates an exhaust gas heat recovery mechanism. The high-temperature exhaust gas produced by the SOFC is efficiently recovered through a sequential process involving a gas turbine (GT), a regenerative system, steam Rankine cycles, and a waste heat boiler (WHB). A comprehensive thermodynamic analysis of this integrated SOFC-GT-SRC-WHB system was performed. A simulation of this proposed system was conducted using Aspen Hysys V12.1, and a genetic algorithm was employed to optimize the system parameters. Thermodynamic equations based on the first and second laws of thermodynamics were utilized to assess the system's performance. Additionally, the exergy destruction within the crucial system components was examined. The system is projected to achieve an energy efficiency of 58.44% and an exergy efficiency of 29.43%. Notably, the integrated high-temperature exhaust gas recovery systems contribute significantly, generating 1129.1 kW, which accounts for 22.9% of the total power generated. Furthermore, the waste heat boiler was designed to produce 900.8 kg/h of superheated vapor at 170 ℃ and 405 kP a, serving various onboard ship purposes, such as heating fuel oil and accommodations for seafarers and equipment.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권13호
• /
• pp.5277-5281
• /
• 2014

Published studies have evaluated associations between the MDM2 SNP309T>G polymorphism and bladder cancer susceptibility. However, these generated inconsistent results. The aim of the present investigation was to quantify the strength of association between MDM2 SNP309T>G polymorphism and bladder cancer risk by conducting a meta-analysis. We searched PubMed and Embase for related studies that had been published in English before April 1, 2014 and associations were assessed by summarizing the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Five case-control studies with a total of 972 cases and 1,012 controls were finally identified to be eligible for the meta-analysis. Overall, the results indicated that there was no significant association between the MDM2 SNP309T>G polymorphism and bladder cancer risk (for the allele model G vs. T: OR=1.08, 95% CI 0.85-1.36, p=0.54; for the co-dominant model GG vs. TT: OR=1.20, 95% CI 0.74-1.93, p=0.46; for the dominant model GG+GT vs. TT: OR=0.98, 95% CI 0.80-1.20, p=0.83; for the recessive model GG vs. GT+TT: OR=1.20, 95% CI 0.83-1.74, p=0.33). However, on subgroup analysis by ethnicity, significant associations were found in Caucasians in three models (for the allele model G vs. T: OR=1.41, 95% CI 1.10-1.81, p=0.006; for the co-dominant model GG vs. TT: OR=2.16, 95% CI 1.28-3.63, p=0.004; for the recessive model GG vs. GT+TT: OR=2.06, 95% CI 1.31-3.22, p=0.002). In summary, the present meta-analysis provides evidence that the genotype for the MDM2 SNP309T>G polymorphism may be associated with genetic susceptibility to bladder cancer among Caucasians.

• 사물인터넷융복합논문지
• /
• 제4권2호
• /
• pp.21-28
• /
• 2018

본 연구에서는 ALK receptor tyrosine kinase (ALK) 유전자의 단일염기다형성이 뇌출혈의 발병에 관여하는 지를 연구하였다. 156명의 뇌출혈 환자와 425명의 정상인를 모집하였으며 네 개의 단일염기다형성에 대하여 상관성을 살펴보았다. 통계분석에서는 SNPstats, SPSS22.0, Haploview 프로그램을 활용하였다. Odd ratio, 95% 신뢰구간에서는 genotype 모델 및 allele 모델에서 계산하였다. 통계분석결과, rs1881421, rs1881420, rs3795850, rs2246745 의 단일염기다형성이 뇌출혈과 관련하여 유의성을 보였다. (rs1881421, OR=2.02, 95% CI=1.54-2.64, p<0.001; rs1881420, OR=0.53, 95% CI=1.16-2.01, p=0.003; rs3795850, OR=1.54, 95% CI=1.17-2.02, p=0.002; rs2246745, OR=1.95, 95% CI=1.46-2.60, p<0.001 in each allele analysis). CC, GT, and GC haplotypes 빈도 역시 유의성을 보였다. 네 개의 단일염기다형성의 minor allele 가 뇌출혈의 발병을 증가시키는데 기여하였다. 이러한 연구 결과는 ALK 유전자가 뇌출혈의 위험성과 관련 있음을 시사한다.