• Title/Summary/Keyword: $GT_1$

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Development of Predictive Growth Model of Listeria monocytogenes Using Mathematical Quantitative Assessment Model (수학적 정량평가모델을 이용한 Listeria monocytogenes의 성장 예측모델의 개발)

  • Moon, Sung-Yang;Woo, Gun-Jo;Shin, Il-Shik
    • Korean Journal of Food Science and Technology
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    • v.37 no.2
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    • pp.194-198
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    • 2005
  • Growth curves of Listeria monocytogenes in modified surimi-based imitation crab (MIC) broth were obtained by measuring cell concentration in MIC broth at different culture conditions [initial cell numbers, $1.0{\times}10^{2},\;1.0{\times}10^{3}\;and\;1.0{\times}10^{4}$, colony forming unit (CFU)/mL; temperature, 15, 20, 25, 37, and $40^{\circ}C$] and applied to Gompertz model to determine microbial growth indicators, maximum specific growth rate constant (k), lag time (LT), and generation time (GT). Maximum specific growth rate of L. monocytogenes increased rapidly with increasing temperature and reached maximum at $37^{\circ}C$, whereas LT and GT decreased with increasing temperature and reached minimum at $37^{\circ}C$. Initial cell number had no effect on k, LT, and GT (p > 0.05). Polynomial and square root models were developed to express combined effects of temperature and initial cell number using Gauss-Newton Algorism. Relative coefficients of experimental k and predicted k of polynomial and square root models were 0.92 and 0.95, respectively, based on response surface model. Results indicate L. monocytogenes growth was mainly affected by temperature and square root model was more effective than polynomial model for growth prediction.

Screening of 185DelAG, 1014DelGT and 3889DelAG BRCA1 Mutations in Breast Cancer Patients from North-East India

  • Hansa, Jagadish;Kannan, Ravi;Ghosh, Sankar Kumar
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.11
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    • pp.5871-5874
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    • 2012
  • Around 1.35 million people of worldwide suffer from breast cancer each year, whereas in India, 1 in every 17 women develops the disease. Mutations of the Breast Cancer 1 (BRCA1) gene account for the majority of breast/ovarian cancer families. The purpose of study was to provide a prevalence of BRCA1 germline mutations in the North-East Indian population. In relation to the personal and family history with the breast cancer, we found mutations in 6.25% and 12.5% respectively. Three mutations, 185DelAG, 1014DelGT and 3889DelAG, were observed in our North-East Indian patients in exons 2 and 11, resulting in truncation of the BRCA1 protein by forming stop codons individually at amino acid positions 39, 303 and 1265. Our results point to a necessity for an extensive mutation screening study of high risk breast cancer cases in our North-East Indian population, which will provide better decisive medical and surgical preventive options.

The Clustering of Parts with Qualitative and Quantitative Quality Properties using λ-Fuzzy Measure (λ-퍼지측도를 사용한 질적, 양적혼합품질특성을 가진 부품의 군집화)

  • Kim, Jeong-Man;Lee, Sang-Do
    • Journal of Korean Society for Quality Management
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    • v.24 no.1
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    • pp.126-136
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    • 1996
  • In multi-item production system, GT(Group Technology) is used effectively in order to cluster various parts into groups. GT is based on clustering parts which have similar features, and these features are classified into two properties, namely crisp(quantitative) feature and fuzzy(qualitative) feature. Especially, many difficult problems are often faced that have to evaluate the properties of parts with the crisp and fuzzy feature together. As the basis of determining the similarity of inter-parts, in this method, one aggregate value is calculated on each part. However, because the above aggregate value is only gained from simple additive weighted sum, there is one problem in this method that has been handled the combination effect of inter-parts. For these reasons, in this paper, a proposed method is suggested for representing combination effect in order to cluster parts that have crisp and fuzzy properties into groups using ${\lambda}$-fuzzy measure and fuzzy integral.

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A Performance Modeling of the Lean NOx Trap Catalyst with GT-POWERTM (GT-POWERTM를 이용한 Lean NOx Trap 촉매 성능 모델링)

  • Kim, Hyunjun;Han, Manbae;Jeon, Ji-Yong;Kim, Tae-Min
    • Transactions of the Korean Society of Automotive Engineers
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    • v.21 no.6
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    • pp.64-71
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    • 2013
  • In this study we designed a lean $NO_x$ trap (LNT) model with $GT-POWER^{TM}$ program and then the LNT model was compared to the bench flow reactor test results. This model consists of 9 kinetic reactions to represent the main steps of NO oxidation, $NO_x$ adsorption, $NO_x$ release and then its reduction. The comparison was performed on the operating conditions at the space velocity of 50,000 1/hr and 80,000 1/hr with the temperature range of $200^{\circ}C{\sim}500^{\circ}C$ with the even spaced temperature step of $50^{\circ}C$. The experimental results show that the $NO_x$ conversion efficiency was enhanced by the temperature up to $350^{\circ}C$ and then decayed at higher temperatures. The LNT model predicts the similar trend of the $NO_x$ conversion efficiency to the experimental results below $350^{\circ}C$, but overestimates above $350^{\circ}C$. This overestimation comes from the higher reduction efficiency which was obtained by the different reduction gas composition such as $C_3H_6$ in the model to replace $CH_4$, $C_2H_4$ in the bench test.

COMPARISON OF SHAPING ABILITY OF NICKEL-TITANIUM ROTARY FILES WITH DIFFERENT TAPER IN SIMULATED RESIN CANALS (모형레진 근관에서 엔진 구동용 니켈-타이타늄 파일의 경사도의 차이에 따른 근관성형력의 비교)

  • Kum, Kee-Yeon;Lim, Kyoung-Ran;Jung, Il-Young;Lee, Sung-Jong;Lee, Chan-Young
    • Restorative Dentistry and Endodontics
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    • v.25 no.1
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    • pp.78-84
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    • 2000
  • The aim of this study was to compare shaping ability of nickel-titanium rotary files with different taper in simulated resin canals. The instruments used in this study were GT with .04 taper ProFile with ISO-sized tip, .04 taper ProFile with ISO-sized tip alone, and .02 taper Naviflex file and all canals were prepared by crown-down technique. A total of 30 composite images were made from pre- and post-canal scanned images using Scanjet 4C scanner and Corel photopaint 8.0 and then, prevalence of canal aberrations was measured. The amount of coronal substance the instruments removed was also calculated two-dimensionally on digitized images with the Brain C software to compare the relative enlarging efficiency. Finally, the prepared internal canal form was evaluated three-dimensionally with impression technique. The results were as follows; 1. The incidence of zipping in Naviflex group was significantly high compared to the other two groups(P<.05). 2. The amount of coronal substance the GT combined group removed was significantly larger than the other two groups(P<.05). 3. The GT combined group produced canals with good taper and flow. Under the conditionas of this study, the combined use of larger tapered nickel-titanium rotary files prepared simulated canals safely, efficiently and with good three-dimensional form.

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Numerical Simulajtions of Non-ergodic Solute Transport in Strongly Heterogeneous Aquiferss (불균질도가 높은 대수층내에서의 비에르고딕 용질이동에 관한 수치 시뮬레이션)

  • Seo Byong-Min
    • The Journal of Engineering Geology
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    • v.15 no.3
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    • pp.245-255
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    • 2005
  • Three dimensional Monte-Carlo simulations of non-ergodic transport of a non-reactive solute plume by steady-state groundwater flow under a uniform mean velocity in isotropic heterogeneous aquifers were conducted. The log-normally distributed hydraulic conductivity, K(x), is modeled as a random field. Significant efforts are made to reduce the simulation uncertainties. Ensemble averages of the second spatial moments of the plume, $$lt;S_{ij}'(t',l')$gt;$ and plume centroid variances, $$lt;R_{ij}'(t',l')$gt;$ were simulated with 3200 Monte Carlo runs for three variances of log K, $\omega^2_y1.0,,2.5,$ and 5.0, and three dimensionless lengths of line plume sources ( l=,5 and 10) normal to the mean velocity. The simulated second spatial moment and the plume centroid variance in longitudinal direction fit well to the first order theoretical results while the simulated transverse moments are not fit well with the first order results. The first order theoretical results definitely underestimated the simulated transverse second spatial moments for the aquifers of large u: and small initial plume sources. The ergodic condition for the second spatial moments is far from reaching, and the first order theoretical results of the transverse second spatial moment of the ergodic plume slightly underestimated the simulated moments.

Effect of Korean Traditional Tea Materials Water Extract on Hepatic Oxygen Free Radical Generating and Scavenging Enzyme Activities in Lead Administered Rats (한국전통차 재료의 열수추출물이 납투여 흰주의 간조직 중 유해 활성산소 생성과 제거효소 활성에 미치는 영향)

  • 김덕진;조수열;신경희;이미경;김명주
    • Journal of Nutrition and Health
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    • v.36 no.2
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    • pp.117-124
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    • 2003
  • This study was designed to test the effect of Korean traditional tea materials on oxygen-free radical metabolism in lead (Pb) -administered rats. Male rats were divided into normal, Pb-control (Pb-Con) and Pb-water extract of green tea (Camellia sinensis; GT) , persimmon leaf (Diospyros kaki; PL) , safflower seed (Carhamus tinctorius: SS) , Du-Zhong (Eucommia ulmoides; EU) groups, respectively. Pb intoxication was induced by administration of lead acetate (25 mg/kg. B.W., oral) weekly. The extract was administered based on 1.26 g of raw material/kg B.W./day for 4 weeks. When the GT, PL, SS and EU were supplemented to the Pb-administered rats, hepatic lipid peroxide levels were significantly lower compared to the Pb-Con group. Hepatic cytochrom P-450 content and aminopyrine N-demethylase activity was lower in the Pb-Con group than in the normal group, whereas xanthine oxidase activity was significantly elevated in Pb-administered rats. The water extract of GT, PL, SS and EU supplementation attenuated changes in enzyme activities generating reactive oxygen species in the liver. Hepatic superoxide dismutase, catalase and glucose 6-phosphate dehydrogenase activities were significantly higher in the Pb-Con group than in the normal group, while monoamine oxidase activity also tended to increase in the Pb-administered rats. However, glutathione peroxidase and glutathione S-transferase activities, and glutathione content significantly decreased through Pb intoxication. The supplementation of GT, PL, SS and EU induced alleviation changes of hepatic antioxidant enzyme activity.

A study of Succinyl trialanine p-nitroanilide hydrolytic activity in workers exposed to organic solvents (유기용제 취급 근로자들의 Succinyl trialanine p-nitroanilide 가수분해 효소 활성에 관한 연구)

  • Oh, Hae-Ju;Roh, Jae-Hoon
    • Journal of Preventive Medicine and Public Health
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    • v.26 no.1 s.41
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    • pp.74-85
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    • 1993
  • To measure the serum succinyl trialanine p-nitroanilide hydrolytic activity as new index of liver function in workers exposed to organic solvents, this study conducted 114 workers in department of shoe-making of shoes factories. The results obtained from this study were as follows : 1. The mean values of serum GOT, GPT, ${\gamma}GT$ in whole workers were $22{\pm}12.32,\;20{\pm}9.05,\;28{\pm}21.35IU/l$, respectively and the mean value of serum STN hydrolytic activity was $0.08{\pm}0.05$. 2. The serum STN hydrolytic activity was significantly higher for male (p<0.05) and there was no difference among the groups of age. 3. There was no difference in the groups by working hours but significant difference in persons who worked over 3 years or were exposed to toluene over 100ppm (p<0.05). 4. The correlation of the exposed dose of toluene and serum GOT, GPT, ${\gamma}GT$ and serum STN hydrolytic activity were statistically significant (r=0.027-0.518). 5. The exposed dose of toluene was most explainable variable and statistically significant among the factors affecting serum STN hydrolytic activity (p<0.05).

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Development of Predictive Growth Model of Imitation Crab Sticks Putrefactive Bacteria Using Mathematical Quantitative Assessment Model (수학적 정량평가모델을 이용한 게맛살 부패균의 성장 예측모델의 개발)

  • Moon, Sung-Yang;Paek, Jang-Mi;Shin, Il-Shik
    • Korean Journal of Food Science and Technology
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    • v.37 no.6
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    • pp.1012-1017
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    • 2005
  • Predictive growth model of putrefactive bacteria of surimi-based imitation crab in the modified surimi-based imitation crab (MIC) broth was investigated. The growth curves of putrefactive bacteria were obtained by measuring cell number in MIC broth under different conditions (Initial cell number, $1.0{\times}10^2,\;1.0{\times}10^3$ and $1.0{\times}10^4$ colony forming unit (CFU)/mL; temperature, $15^{\circ}C,\;20^{\circ}C\;and\;25^{\circ}C$) and applied them to Gompertz model. The microbial growth indicators, maximum specific growth rate constant (k), lag time (LT) and generation time (GT), were calculated from Gompertz model. Maximum specific growth rate (k) of putrefactive bacteria was become fast with rising temperature and fastest at $25^{\circ}C$. LT and GT were become short with rising temperature and shortest at $25^{\circ}C$. There were not significant differences in k, LT and GT by initial cell number (p>0.05). Polynomial model, $k=-0.2160+0.0241T-0.0199A_0$, and square root model, $\sqrt{k}=0.02669$ (T-3.5689), were developed to express the combination effects of temperature and initial cell number, The relative coefficient of experimental k and predicted k of polynomial model was 0.87 from response surface model. The relative coefficient of experimental k and predicted k of square root model was 0.88. From above results, we found that the growth of putrefactive bacteria was mainly affected by temperature and the square root model was more credible than the polynomial model for the prediction of the growth of putrefactive bacteria.