• 프린팅코리아
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• v.11 no.7
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• pp.135-135
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• 2012

(주)성도GL/(주)성도솔루윈(대표이사 김상래)은 지난 6월 2일 파주 헤이리 예술마을에 위치한 미술관 공간퍼플에서 제11회 헤이리 심포니 오케스트라 정기연주회를 개최했다고 밝혔다.

• Bulletin of Food Technology
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• v.19 no.2
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• pp.116-129
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• 2006

• Bulletin of Food Technology
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• v.19 no.2
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• pp.130-139
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• 2006

• Food Science of Animal Resources
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• v.31 no.5
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• pp.668-675
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• 2011

The effects of adding goldenrod leaf (GL) and stem powder (GS) (1 and 2%) to sausage meat were evaluated for quality characteristics. The compositional properties, pH, cooking yield, instrumental color, emulsion stability, viscosity, texture, and sensory properties were investigated. Adding GL and GS increased the moisture and ash concentration in sausages. Furthermore, increasing the amount of added GL and GS helped to develop (p<0.05) cooking yield, emulsion stability, and viscosity in the meat batters. Sausages with 2% GL and GS had significantly higher springiness and hardness than those of the control. No significant differences in cohesiveness were observed among the treatments. CIE L*and CIE a*values were highest (p<0.05) in the control sausage. Treatment with 2% GL resulted in the highest CIE b* values (p<0.05) in batter and sausages. No significant difference was observed between the control and other treatments for the overall acceptability. Overall, this study indicated that GL and GS could be used as dietary fiber in sausages to improve quality characteristics.

• Journal of Nutrition and Health
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• v.52 no.4
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• pp.354-368
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• 2019

Purpose: This study evaluated the glycemic response of diets using estimated glycemic load (eGL), which had been developed for mixed meals for Korean adults, and examined its associations with cardiometabolic risk factors among Korean adults. Methods: A total of 4,655 men and 6,760 women aged 19 years and above were included from the 2013 ~ 2016 Korea National Health and Nutrition Examination Survey. eGL was calculated by each meal (breakfast, lunch, dinner, and snack) and then summed to give daily total eGL. A multiple logistic regression analysis was used to examine the association. Results: Mean daily total eGL was 112.6 in men and 99.3 in women. Daily total eGL was positively associated with carbohydrate and fiber intakes, but negatively associated with protein and fat intakes in both men and women (p < 0.05 for all). Daily total eGL showed an inverse association with HDL-cholesterol level in both men and women (p = 0.0036 for men and p = 0.0008 for women). Men in the highest quintile of daily total eGL showed a 66% increased risk of hypercholesterolemia (OR, 1.66; 95% CI, 1.10 ~ 2.50; p for trend = 0.0447) compared with those in the lowest quintile. Conclusion: These findings suggest that eGL based on carbohydrate, protein, fat and fiber intakes can reflect glycemic response and therefore can be used as an index for dietary planning, nutrition education and in the food industry.

• Bulletin of the Korean Mathematical Society
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• v.40 no.1
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• pp.29-51
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• 2003

In this paper we construct a natural filtration associated to the plethysm $S_{r}(\wedge^2 \varphi)$ over arbitrary commutative ring R. Let $\phi$ : G longrightarrow F be a morphism of finite free R-modules. We construct the natural filtration of $S_{r}(\wedge^2 \varphi)$ as a $GL(F){\times}GL(G)$- complex such that its associated graded complex is ${\Sigma}_{{\lambda}{\in}{\Omega}_{\gamma}}=L_{2{\lambda}{\varphi}$, where ${{\Omega}_{\gamma}}^{-}$ is a set of partitions such that $│\wedge│\;=;{\gamma}\;and\;2{\wedge}$ is a partition of which i-th term is $2{\wedge}_{i}$. Specializing our result, we obtain the filtrations of $S_{r}(\wedge^2 F)\;and\;D_{r}(D_2G).

• Nutrition Research and Practice
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• v.16 no.1
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• pp.14-32
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• 2022

BACKGROUND/OBJECTIVES: Peroxisome proliferator-activated receptor-gamma co-activator-1α (PGC-1α) has a central role in regulating muscle differentiation and mitochondrial metabolism. PGC-1α stimulates muscle growth and muscle fiber remodeling, concomitantly regulating lactate and lipid metabolism and promoting oxidative metabolism. Gynostemma pentaphyllum (Thumb.) has been widely employed as a traditional herbal medicine and possesses antioxidant, anti-obesity, anti-inflammatory, hypolipemic, hypoglycemic, and anticancer properties. We investigated whether G. pentaphyllum extract (GPE) and its active compound, gypenoside L (GL), affect muscle differentiation and mitochondrial metabolism via activation of the PGC-1α pathway in murine C2C12 myoblast cells. MATERIALS/METHODS: C2C12 cells were treated with GPE and GL, and quantitative reverse transcription polymerase chain reaction and western blot were used to analyze the mRNA and protein expression levels. Myh1 was determined using immunocytochemistry. Mitochondrial reactive oxygen species generation was measured using the 2'7'-dichlorofluorescein diacetate assay. RESULTS: GPE and GL promoted the differentiation of myoblasts into myotubes and elevated mRNA and protein expression levels of Myh1 (type IIx). GPE and GL also significantly increased the mRNA expression levels of the PGC-1α gene (Ppargc1a), lactate metabolism-regulatory genes (Esrra and Mct1), adipocyte-browning gene fibronectin type III domain-containing 5 gene (Fndc5), glycogen synthase gene (Gys), and lipid metabolism gene carnitine palmitoyltransferase 1b gene (Cpt1b). Moreover, GPE and GL induced the phosphorylation of AMP-activated protein kinase, p38, sirtuin1, and deacetylated PGC-1α. We also observed that treatment with GPE and GL significantly stimulated the expression of genes associated with the anti-oxidative stress response, such as Ucp2, Ucp3, Nrf2, and Sod2. CONCLUSIONS: The results indicated that GPE and GL enhance exercise performance by promoting myotube differentiation and mitochondrial metabolism through the upregulation of PGC-1α in C2C12 skeletal muscle.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.309-314
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• 2013

Aim: Brain tumors almost universally have fatal outcomes; new therapeutics are desperately needed and will only come from improved understandins of glioma biology. Methods: Exosomes are endosomally derived 30~100 nm membranous vesicles released from many cell types. Examples from GL26 cells were here purified using density gradient ultracentrifugation and monitored for effects on GL26 tumor growth in C57BL/6j mice (H-2b). Lactate dehydrogenase release assays were used to detect the cytotoxic activity of CD8+T and NK cells. Percentages of immune cells producing intracellular cytokines were analyzed by FACS. Results: In this study, exosomes from murine-derived GL26 cells significantly promoted in vivo tumor growth in GL26-bearing B6 mice. Then we further analyzed the effects of the GL26 cells-derived exosomes on immune cells including CD8+T, CD4+T and NK cells. Inhibition of CD8+T cell cytotoxic activity was demonstrated by CD8+T cell depletion assays in vivo and LDH release assays in vitro. The treatment of mice with exosomes also led to a reduction in the percentages of CD8+T cells in splenocytes as determined by FACS analysis. Key features of CD8+T cell activity were inhibited, including release of IFN-gamma and granzyme B. There were no effects of exosomes on CD4+T cells and NK cells. Conclusion: Based on our data, for the first time we demonstrated that exosomes from murine derived GL26 cells promote the tumor growth by inhibition of CD8+T cells in vivo and thus may be a potential therapeutic target.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.5
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• pp.633-639
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• 2008

The genetic relationship of gestation length (GL) with birth and weaning weight (BW, WW) was investigated using data collected from the Hanwoo Experiment Station, National Institute of Animal Science, RDA, Republic of Korea. Analytical mixed models including birth year‐season, sex of calf, linear and quadratic covariates of age of dam (days) and linear covariate of age at weaning (days) as fixed effects were used. Corresponding restricted maximum likelihood (REML) and Bayesian estimates of variance components and heritability were obtained with two models; Model 1 included only direct genetic effect and Model 2 included direct genetic, maternal genetic and permanent environmental effect. All the genetic parameter estimates from REML were corresponding to the Bayesian estimates. Direct heritability estimates for GL, BW, and WW were 0.48, 0.33 and 0.25 by Model 1. From Model 2, direct and maternal heritability estimates were 0.38 and 0.03 for GL, 0.14 and 0.05 for BW, and 0.08 and 0.05 for WW. Genetic correlation estimates between direct and maternal effects were 0.05 for GL, 0.59 for BW, and 0.52 for WW. Estimates of direct genetic correlation between GL and BW (WW) were 0.44 (0.21). Positive genetic correlation of GL with BW and WW imply that selection for greater BW or WW would lead to prolonged gestation length.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.79.2-79.2
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• 2015

The $M_{BH}-{\sigma}$ relation for galaxies is a stand-out illustration of the co-evolution of galaxies and their central supermassive black holes (SMBHs); however, how this co-evolution occurs and whether this relation holds for SMBHs of the early universe is still a matter of debate. In order to study this at higher redshifts, quasi-stellar objects (QSOs) are the best targets, due to their large sample size and effective $M_{BH}$ estimation. Nevertheless, it is difficult to examine properties of their host galaxies, simply due to the sheer brightness of the QSO itself. Here, we discuss a distinctive method in studying these QSO host galaxies, via gravitational lensing (GL). GL offers a unique approach in determining the mass of the lens object, in this case the host galaxy. QSOs from the SDSS quasar catalog were searched in the Hubble Space Telescope archives, and GL features around them were visually inspected. One such candidate is SDSS J1114-00; to increase its robustness as a GL system candidate, it was observed with the Inamori-Magellan Areal Camera & Spectrograph (IMACS) on the Magellan Baade Telescope at Las Campanas Observatory, to check whether the GL features have identical colors, meaning they are likely to originate from the same source. After confirmation of such GL systems, a sufficiently large sample will enable us to examine the $M_{BH}-{\sigma}$ relation at various redshifts, and in turn, investigate the co-evolution of SMBHs and their host galaxies.