• Title/Summary/Keyword: $F_1$ development

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Maturity and Spawning of Spinyhead Sculpin, Dasycottus setiger (Bean) in the East Sea, Korea (동해안 고무꺽정이, Dasycottus setiger (Bean)의 성숙과 산란)

  • Yang, Jae Hyeong;Lee, Sung Il;Hwang, Seon Jae;Park, Jong Hwa;Kwon, Hyeok Chan;Park, Kie Young;Choi, Soo Ha
    • Korean Journal of Ichthyology
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    • v.19 no.3
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    • pp.179-184
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    • 2007
  • Maturity and spawning of spinyhead sculpin, Dasycottus setiger were investigated using samples collected by the eastern sea danish seine and gillnet in the East Sea of Korea from January to December 2004. We analyzed monthly changes in maturity stages, gonadosomatic index (GSI), egg diameter, fecundity, total length at 50% group maturity, and sex ratio. GSI began to increase in August, reached a maximum between September and November, and decreased in December. The spawning period was August to December, and the main spawning period was September to November. The fecundity ranged from 6,210 eggs at 22.3 cm (TL) to 15,898 eggs at 32.2 cm (TL). The relationship between total length (TL) and fecundity (F) was $F=25.475TL^{1.818}$ ($R^2=0.761$), and F increased with TL. The TL at 50% group maturity was estimated to be 23.4 cm. The sex ratio was 1 : 1.3 (female : male), indicating the male population was seem to be slightly predominant.

The Effects of Learners' Job Competency Development on the Improvement of Their Vocational Key Competencies in Lifelong Education Based on National Competency Standards(NCS) (국가직무능력표준(NCS)기반 평생교육에서 학습자의 직무능력개발이 직업기초능력 향상에 미치는 영향)

  • Nam, Gi-Young;Yoon, Jun-Sang;Im, Gwi-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.2
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    • pp.130-141
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    • 2017
  • This study examined the effects of learners' job competency development on their vocational key competency improvement in lifelong education based on national competency standards. A survey was empirically carried out to 480 learners of lifelong education institutions in Seoul and the results were statistically analyzed. Covariance analysis was conducted to allow for external influences of lifelong education learners' educational environment in the process that verifies the effects of job competency development on vocational key competencies classified into 4 units, namely, mathematical skill, problem-solving skill, resource management skill, and communication skill. The findings are summarized as follows. First, all factors of job competency development had no effect on mathematical competency in the single dimension. Second, the testing of hypothesis 2 showed that education system(F=3.021, p<.05) and curriculum(F=6.684, p<.05) of job competency development factors had a significant positive effect on mathematical competency in the single dimension. Third, the testing of hypothesis 3 showed that only curriculum(F=5.865, p<.05) of job competency development factors had a significant positive effect on resource management in the single dimension. Fourth, the testing of hypothesis 4 showed that all factors of job competency development had no effect on communication in the single dimension. These findings suggest that the proper harmony of both education system and curriculum or all education system, curriculum and evaluation management in the combination of lifelong education support with teaching interaction can have a positive effect on the improvement of communication.

Effect of Anti-inflammation on Oryeong-san Formulation for Mix Extract Tablet (오령산 정제 개발 및 항염증 효과)

  • Kim, Se Jin;Leem, Hyun Hee;Nam, Won Hee;Son, Su Mi;Choi, Hye Min;Kim, Myung Jin;Kim, Jung Ok;Lee, Hwa Dong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.34 no.6
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    • pp.348-354
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    • 2020
  • Oryeong-san (ORS) is a traditional Korean herbal medicine widely used for renal associated diseases, composed of five medicine herbs; Atractylodes japonica Koidzumi, Cinnamomum cassia Presl, Polyporus umbellatus Fries, Poria cocos Wolf and Alisma orientale Juzepzuk. We studied to improve the convenience of intake and portability by developing modernized dosage forms, and examined the effect on anti-inflammation of ORS. In order to develop the tablet formulation of ORS (ORS-F), the tablets were evaluated on the basis of physical characteristics include diameter, thickness, weight variation, hardness, friability and disintegration. To analyze the marker components of ORS-F, eight index markers from five herbal medicines were chosen. And the method using high performance liquid chromatography (HPLC) with diode-array detector method was established for the simultaneous analysis. The biological activities were examined the effect of ORS-F on pro-inflammation mediated by LPS-stimulation. The production of nitric oxide (NO) and cytokines were determined by reacting cultured medium with griess reagent and enzyme-linked immunosorbent assay (ELISA). The expression of cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) were investigated by Western blot and RT-PCR. The anti-oxidant activities of OJS-F increased markedly, in a dose-dependent manner. and, The total phenolic compound and flavonoids contents of OJS-F were 10.20±0.09 ㎍/㎎ and 12.86±0.86 ㎍/㎎. OJS-F which is LPS has diminished in the LPS-induced release of inflammatory mediators (NO, iNOS, COX2 and PGE2) and pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) from the RAW264.7 macrophages. Therefore, the developed formulation for tablet of ORS-F provide efficiency and usability, and indicated effect of anti-inflammation.

EFFECT OF ADDITIVES ON THE DENSIFICATION PROCESSES AND PROPERTIES OF SILICA-BASED CMCs

  • S.-Y. KO;S.-M. YONG;S.J. LEE;D.-I. CHEONG;S. BAEK
    • Archives of Metallurgy and Materials
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    • v.63 no.3
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    • pp.1485-1488
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    • 2018
  • The effect of additives on the densification behavior and mechanical properties of pure and additive (Zr, B and Mg)-added silica ceramics were investigated for their application to the matrix phase of a silica fiber reinforced silica (SiO2/SiO2f) composite. The additives affected the rate of densification and crystallization (or transformation) of the amorphous silica. Among the compositions, pure silica ceramics sintered at 900℃ for 1 h showed the maximum flexural strength. Based on the results, SiO2/SiO2f was fabricated by a repeated vacuum-assisted infiltration method followed by the heat treatment at 900℃ for 1 h. The relative density of the composite was 78.2% with a flexural strength of 22.4 MPa. Fractography revealed that the composite was damaged by strong bonding at the fiber/matrix interface and the fracture of fiber.

Growth Characteristics and Variation in Amino Acids Composition of Quality Protein Maize Lines (고라이신(QPM) 주요 계통과 교잡계의 생육특성 및 아미노산 조성 변이)

  • Bae, Hwan-Hee;Son, Beom-Young;Go, Young-Sam;Park, Hye-Young;Yi, Gibum;Ha, Jun Young;Kim, Mi-Jung;Kim, Sun-Lim;Baek, Seong-Bum
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.65 no.3
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    • pp.222-230
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    • 2020
  • Maize grain quality can be improved by raising lysine content, which is an essential amino acid present in insufficient quantities in normal maize. Maize varieties with such modifications are known as quality protein maize (QPM). To date, no Korean maize cultivars contain high amounts of lysine. To introduce quality protein maize to Korean cultivars, we crossed QPM CIMMYT maize lines (CML) with KS140, an elite inbred line used as a parent of several cultivars such as 'Gangdaok' and 'Pyeonganok'. We analyzed the phenotypic characteristics of F1 plants as well as the protein contents, amino acids, and fatty acids profiles of the self-pollinated seeds of the F1 hybrids, and evaluated the feasibility of CML as a source of QPM. Days to anthesis of the CML ranged from 78 to 90 days after planting (DAP), whereas a range of 81~87 was recorded for F1 hybrids. The average days to anthesis was 85 for KS140, CML, and the F1 hybrids. The protein content of the CML was measured to be between 9.1 and 12.1%, with the highest and lowest values being recorded in CML153 and 191, respectively. The F1 hybrids had protein contents of 9.1~11.1%, and the highest content was observed in KS141/CML188. The fatty acids profiles were very similar across all analyzed maize samples, and linoleic acid (C18:2) composed the greatest proportion. Glutamic acid made up the largest proportion of amino acids in all maize samples. Lysine composition was highest in CML155 (6.92% of all amino acids), with an average composition of 4.83% across the CML. In contrast, KS140 showed a lysine content of 2.51%. In F1 hybrids, the average lysine composition was 3.46%, and KS140/CML164 (4.18%) and KS140/CML163 (4.99%) contained more lysine than either parent. Taken together, these results indicate that CML could become promising QPM sources to improve grain quality in Korean maize cultivars.

Machine learning-based Predictive Model of Suicidal Thoughts among Korean Adolescents. (머신러닝 기반 한국 청소년의 자살 생각 예측 모델)

  • YeaJu JIN;HyunKi KIM
    • Journal of Korea Artificial Intelligence Association
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    • v.1 no.1
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    • pp.1-6
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    • 2023
  • This study developed models using decision forest, support vector machine, and logistic regression methods to predict and prevent suicidal ideation among Korean adolescents. The study sample consisted of 51,407 individuals after removing missing data from the raw data of the 18th (2022) Youth Health Behavior Survey conducted by the Korea Centers for Disease Control and Prevention. Analysis was performed using the MS Azure program with Two-Class Decision Forest, Two-Class Support Vector Machine, and Two-Class Logistic Regression. The results of the study showed that the decision forest model achieved an accuracy of 84.8% and an F1-score of 36.7%. The support vector machine model achieved an accuracy of 86.3% and an F1-score of 24.5%. The logistic regression model achieved an accuracy of 87.2% and an F1-score of 40.1%. Applying the logistic regression model with SMOTE to address data imbalance resulted in an accuracy of 81.7% and an F1-score of 57.7%. Although the accuracy slightly decreased, the recall, precision, and F1-score improved, demonstrating excellent performance. These findings have significant implications for the development of prediction models for suicidal ideation among Korean adolescents and can contribute to the prevention and improvement of youth suicide.

Inheritance of Resistance to Bacterial Leaf Blight Caused by Xanthomonas oryzae (Uyeda at Isheyama) Dowson in Rice (벼 흰빛잎마름병 저항성유전에 관한 연구)

  • Sohn J.K.;Kim M.H.
    • Korean journal of applied entomology
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    • v.19 no.3 s.44
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    • pp.156-162
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    • 1980
  • The inheritance and varietal differences of resistance to bacterial leaf blight caused by Xanthomonas oryzae in rice were studied. Among eighteen cultivars used, 'IR2061-465-1-5-5', 'IR2061-552-6-9', 'IR 1561-228-9-3', ana 'Milyang42, were found to have a high level of resistance to the three isolates of X. oryzae at maximum tillering and flowering stage. Varietal differences in lesion development of the cultivars belonging to the same varietal group were clearly recognized. For the genetic study on bacterial leaf blight resistance, two rice breeding lines 'IR2061-465-1-5-5', 'IR1561-228-3-3' were crossed with susceptible cultivar 'Milyang 23'. The $F_1,F_2,\;and\;F_3$ progenies were evaluated at flowering stage using the bacterial isolate 'JN 7853'(II). Average lesion length of the $F_1$ plants of the crosses showed longer than that of resistant parents, and the frequency distribution of lesion length in the $F_2\;and\;F_3$ populations showed continuous variation.

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The investigation of photochemical reaction of phototoxic antimalarial compounds

  • Yoon, Ung-Chan;Epling, Gary-A.
    • Archives of Pharmacal Research
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    • v.3 no.2
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    • pp.87-88
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    • 1980
  • The goal of this research is to provide information that will lead to the development of new non-phototoxic antimalarial compounds. The goal was approached by first learning the chemical mechanism of phototoxicity of six representative compounds 1a-f: a[(diethyl-, -dihexyl-, and -dioctyl- aminomethyl)]-2-(3', 4' -dichlorophenyl)-6-methoxy-4-quinolinemethanol (1a, 1b, and 1c) and .alpha. [(diethyl-, -dibutyl-, and -dihexyl-aminomethyl)]-2-(-4'-methoxyphenyl-6-methoxy-7-chloro-4-quinolinemethan ol (1d, 1e, and 1f). The photochemical reaction of these compounds was investigated in 2-propanol. Similar photochemical fragmentation reactions accurred in all compounds.

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Association between IDH3B Genotypes and Economic Traits in a Crossbred F2 Population between Duroc and Jeju Native Black Pigs (제주재래흑돼지와 듀록 교배 세대에서 IDH3B 유전자형과 경제형질의 연관성)

  • Park, Hee-Bok;Han, Sang-Hyun;Kang, Yong-Jun;Shin, Moon-Cheol;Lee, Jae-Bong;Cho, In-Cheol
    • Journal of Life Science
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    • v.27 no.3
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    • pp.295-300
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    • 2017
  • This study examined the association between genotypes of the isocitrate dehydrogenase 3, beta subunit (IDH3B) gene and economic traits in an $F_2$ population of Duroc and Jeju (South Korea) native black pigs (JBPs). The genotypes was determined the presence/absence of a 304-bp insertion/deletion fragment in the promoter region of the IDH3B gene for JBP, Duroc, and their $F_1$ and $F_2$ progeny. Three genotypes (AA, AB and BB) were found in the $F_1$ and $F_2$ populations, but there was no AA genotype found in JBP and no BB in Duroc. Association analysis results showed the significant differences with carcass weights (CW), backfat thicknesses (BFT) and eye muscle area (EMA) (p<0.05), but not with growth traits including body weights and average daily gains at different stages, reproductive traits including teat numbers, and crude fat contents (CFAT) measured in longissimus dorsi (p>0.05). The $F_2$ pigs possessing the IDH3B BB homozygote had heavier CW ($72.92{\pm}11.133kg$), thicker BFT ($25.75{\pm}6.06mm$), and larger EMA ($23.82{\pm}4.825cm^2$) than those from the other genotypes (p<0.05). These results were estimated that there are biological roles related with IDH3B genotypes resulting development of EMA, BFT, and CW but not with intramuscular fat deposition during late period of pig production. Our findings suggest that the 304-bp insertion allele of porcine IDH3B may be a genetic marker for marker assistant selection for improving meat productivity of the Jeju Black pig and Duroc-related molecular breeding systems.

Beta-amyloid imaging in dementia

  • Chun, Kyung Ah
    • Journal of Yeungnam Medical Science
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    • v.35 no.1
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    • pp.1-6
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    • 2018
  • Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta ($A{\beta}$), in the brain. Although the precise mechanism underlying the neurotoxicity of $A{\beta}$ has not been established, $A{\beta}$ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia. In particular, the $A{\beta}$ burden, as assessed by neuroimaging, has proved to be an excellent predictive biomarker. Positron emission tomography, using ligands such as $^{11}C$-labeled Pittsburgh Compound B or $^{18}F$-labeled tracers, such as $^{18}F$-florbetaben, $^{18}F$-florbetapir, and $^{18}F$-flutemetamol, which bind to $A{\beta}$ deposits in the brain, has been a valuable technique for visualizing and quantifying the deposition of $A{\beta}$ throughout the brain in living subjects. $A{\beta}$ imaging has very high sensitivity for detecting AD pathology. In addition, it can predict the progression from mild cognitive impairment to AD, and contribute to the development of disease-specific therapies.