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Effects of Natrually Occurring Furanocoumarins on Lipid Peroxidation and Carbon Tetrachloride Induced Hapatotoxicity in Mice

  • Shin, Kuk-Hyun;Woo, Won-Sick;Moon, Ki-Ho;Yoo, Seung-Jo
    • Archives of Pharmacal Research
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    • v.16 no.1
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    • pp.13-17
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    • 1993
  • Several naturally occurring furanocoumarins significantly inhibited microsomal lipid peroxidation not only mediated by endogeneous iron and NADPH but also initiated by $CCL_4$ metabolites, phellopterin, a potent inhibibitor of cytochrome p-450, exhibited an almost complete inhibition of $CCL_4$-induced hepatotoxicity as measured by sGPT activity 24 hr after $CCL_4$ intoxication, whereas other furanocoumarins such as imperation, byakangelicin and oxypeucedanin methanolate exerted no protective effect. When compared with other cytochrome P-450 inhibitors(SKF-52A, AIA) and silymarin given at the same dose level $(ED_{50})$, phellopterin still showed a significant inhibition of hepatotoxicity which was even stronger than that of AIA, known as a typical suicide inhibitor. Phellopterin was partially effective when given 30 min after $CCL_4$ treatment. Repeated administrations of phellopterin, however, resulted in a complete loss of the protection against $CCL_4$-induced hepatotoxicity.

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Hydrogen production from the natural gas steam reforming over Ni-coated metal structured catalyst (Ni 촉매가 코팅된 금속 구조체를 적용한 천연가스 수증기 개질 반응에서의 수소 생산)

  • Choi, Eunjeong;Koo, KeeYoung;Jung, UnHo;Rhee, YoungWoo;Yoon, WangLai
    • 한국신재생에너지학회:학술대회논문집
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    • 2010.06a
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    • pp.230.2-230.2
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    • 2010
  • 천연가스 수증기 개질 반응에 사용되는 펠릿 촉매의 단점인 열 및 물질 전달 제한, 낮은 effectiveness factor, 압력강화와 channeling 등의 문제점을 해결 하고자 모노리스 형태의 금속 구조체 촉매를 본 연구에 적용 하였다. Fecralloy 재질의 금속 구조체에 Ni 촉매를 워시코팅 (wash coating) 하여 제조 하였으며, 이를 천연가스 수증기 개질 반응에 적용하여 수소를 생산하였다. 실험 조건으로는 S/C ratio를 3으로 고정하여 온도를 $600^{\circ}C{\sim}800^{\circ}C$로 변화 시켰으며, GHSV $3000{\sim}30000h^{-1}$에서 진행 되었다. 구조체 촉매 코팅에 사용된 Ni 촉매의 BET, TPR, H2-chemisorption, SEM, EDS의 특성분석을 수행 하였다. 온도별 테스트에서 모노리스 형태의 금속 구조체 촉매가 펠릿 형태의 촉매에 비해 우수한 열전달 효과로 인해 낮은 퍼니스 온도와 높은 반응 활성을 나타내었으며, GHSV 변화에 따른 성능평가 결과도 15wt% $Ni/MgAl_2O_4$펠릿 촉매와 비교하여 금속 구조체 촉매가 높은 활성을 보였다.

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Implementation of Secur ed Remote EMR Medical Information using Encryption Algorithm (암호화 알고리즘을 이용한 안전한 원격 EMR 의료정보 구현)

  • Yang, Jaesoo;Lee, You-Sik;Hong, Yousik
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.14 no.4
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    • pp.133-139
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    • 2014
  • Nowadays, telemedicine and remote prescription has been operating as a pilot basis. However, in case of remote hospitals without encrypting the biometric data transmission and its contents, the patient prescription data hacked from hackers who changed prescription medications can be serious obstacles to the patient. Therefore, in this paper, to solve this problem, password encryption, personal identification information, biometric data security on the patient's prescription and remote medical information system, and implementation of the encryption algorithm are proposed.

Rumex crispus Suppresses Type I Hypersensitive Immune Response (소리쟁이(Rumex crispus) 추출물의 제1형 알레르기 반응 억제 효과)

  • Ko, Eun Kyo;Kim, Young Mi
    • Korean Journal of Pharmacognosy
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    • v.50 no.4
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    • pp.277-284
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    • 2019
  • Rumex crispus is known to have anticancer, antioxidant, antibacterial, and bone loss inhibitory activities. Mast cells are critical immune cells that induce a type 1 IgE-mediated allergic reaction. However, there are no reports of inhibitory effects of Rumex crispus on mast cells and allergic reactions. In this study, we performed some experiments to investigate whether Rumex crispus ethanol extract(RCE) has any inhibitory effect on antigen-induced type I allergic response in vitro and in vivo. RCE inhibited degranulation of IgE-mediated mast cells(IC50, ~57 ㎍/ml) and cytokine production such as TNF-α and IL-4 in a dose-dependent manner. In vivo, RCE significantly inhibited passive cutaneous anaphylaxis(PCA)(ED50, ~198 mg/kg) in mice. Furthermore, RCE inhibited degranulation of MCs in ear tissue of mice with PCA. Mechanism studies showed that RCE inhibited the activation of Syk and Syk-dependent pathway such as LAT, PLC-γ, Akt, and MAP Kinase. Our results demonstrate for the first time that RCE inhibits type I hypersensitive response by suppressing the activity of Syk in mast cells, thereby reducing degranulation and cytokine production. Taken together, RCE could be used as a novel therapeutic material to suppress allergic diseases.

A Study of the Hanbok Industry through Its Survey Research

  • You, Soon-Lye;Jin, Sun-Young;Song, Kyung-Sook;Park, Hyun-Joo
    • International Journal of Costume and Fashion
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    • v.4
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    • pp.113-130
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    • 2004
  • Korea may have the social environment that has a high interest and demand for the fashion industry, but the relative importance that the Hanbok industry occupies in the fashion industry is very low. It can be found that this is attributed to the difficulty in identifying the trends of Hanbok due to the smallness of Hanbok material producers and Hanbok producers, a change in consumers' consciousness of Hanbok, the difficulty of ties and integration between Hanbok-related organizations, the lack of support from government and the like. Given the recent trend that the principal factor that enables the Korean fashion industry to be competitive in the world fashion business community is based on the beauty of Hanbok, this indifference to the Korean Hanbok industry would be the roadblock to internationalizing the Korean fashion industry. Accordingly, this study attempted to identify the problem of Hanbok-rela1ed department as the basic work for the development of the Hanbok industry and present the plan to activate it, thereby providing basic materials for exploiting the new arena of the Hanbok cultural industry the domestic and foreign fashion market in the 21st century.

TERNARY UNIVERSAL SUMS OF GENERALIZED PENTAGONAL NUMBERS

  • Oh, Byeong-Kweon
    • Journal of the Korean Mathematical Society
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    • v.48 no.4
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    • pp.837-847
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    • 2011
  • For an integer $m{\geq}3$, every integer of the form $p_m(x)$ = $\frac{(m-2)x^2(m-4)x}{2}$ with x ${\in}$ $\mathbb{Z}$ is said to be a generalized m-gonal number. Let $a{\leq}b{\leq}c$ and k be positive integers. The quadruple (k, a, b, c) is said to be universal if for every nonnegative integer n there exist integers x, y, z such that n = $ap_k(x)+bp_k(y)+cp_k(z)$. Sun proved in [16] that, when k = 5 or $k{\geq}7$, there are only 20 candidates for universal quadruples, which h listed explicitly and which all involve only the case of pentagonal numbers (k = 5). He veri ed that six of the candidates are in fact universal and conjectured that the remaining ones are as well. In a subsequent paper [3], Ge and Sun established universality for all but seven of the remaining candidates, leaving only (5, 1, 1, t) for t = 6, 8, 9, 10, (5, 1, 2, 8) and (5, 1, 3, s) for s = 7, 8 as candidates. In this article, we prove that the remaining seven quadruples given above are, in fact, universal.

Properties of Belite with Cooling Rate (냉각속도의 변화에 따른 벨라이트의 특성)

  • Kim, Jin-Ho;Park, Hyun
    • Journal of the Korean Ceramic Society
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    • v.38 no.1
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    • pp.68-73
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    • 2001
  • Active belite cement clinker 합성을 위하여 안정제로 borax (3 wt%)를 사용하였으며, 1300, 1350, 140$0^{\circ}C$에서 소성하고, 각각의 소성온도에서 아세톤 급냉, 공냉, 로냉의 3가지 방법으로 냉각속도를 달리하여 합성하였다. 클링커의 특성분석은 TG-DTA, XRD, FT-IR, SEM-EDS로 조사 분석하였으며, free-CaO 함량은 KSL 5120의 ethylene glycol법으로 정량하였다. Borax(3 wt%)를 첨가한 시료의 시차열분석에서 ${\gamma}$상으로의 전이는 관찰되지 않았으며, 각각의 소성온도와 냉각속도에 따른 free-CaO 분석에서 0.07~0.14%의 범위로 낮게 나타났으며, borax가 첨가되지 않은 시료는 140$0^{\circ}C$에서 소성하고 급냉시켰지만 ${\gamma}$상으로 전이되어 dusting 현상을 나타내었다. Borax(3 wt%) 첨가된 시료의 SEM 미세구조는 140$0^{\circ}C$에서 소성하고 급냉시켰지만 ${\gamma}$상으로 전이되어 dusting 현상을 나타내었다. Borax(3 wt%) 첨가된 시료의 SEM 미세구조는 140$0^{\circ}C$에서 소성된 모든 시료와 135$0^{\circ}C$에서 소성하고 급냉과 공냉시킨 시료는 type I belite, type III belite($\alpha$상) 구조를 나타낸다. 135$0^{\circ}C$에서 소성하고 로냉한 시료와 130$0^{\circ}C$에서 소성된 모든 시료는 type II belite($\beta$상) 구조를 나타내었다.

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Design of an Intelligent Speed Control System for Marine Diesel Engines (선박용 디젤엔진을 위한 지능적인 속도제어시스템의 설계)

  • J.S.Ha;S.J.Oh
    • Journal of Advanced Marine Engineering and Technology
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    • v.21 no.4
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    • pp.414-420
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    • 1997
  • An intelligent speed control system for marine diesel engines is presented. The approach adopt¬ed is to use a conventional PID controller for normal operation and a feedforward controller for adaptive control. The feedforward controller is a neural network. The neural network is the inverse dynamics model of the plant, which is being trained on line. The parametric model of the diesel engine is represented in a linear second-order system, with a first-order combustion part and a revolution part each at a normal operating point. The time delay in the control of the com¬bustion part is approximated to the first-order system. The tuned PID parameters are set based on the model for normal operating point. To obtain the inverse dynamics of the diesel engine system, two neural networks are used, one for inverse, the other for forward dynamics. The former is posi¬tioned across the plant to learn its inverse dynamics during operation, and the latter is placed in series with the controlled plant. Simulation results are presented to illustrate the applicability of the proposed scheme to intelligent adaptive control of diesel engines.

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Quantitative analysis of body postural stability (신체자세 안정도의 정량분석에 관한 연구)

  • Cha, E.J.;Kim, K.A.;Lee, T.S.;Lee, K.M.;Kim, N.K.;Kim, Y.H.
    • Proceedings of the KOSOMBE Conference
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    • v.1997 no.11
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    • pp.39-43
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    • 1997
  • Posturography stands or quantitative assessment of body postural stability analysis. The present study developed a balance plate system to monitor patient's center of pressure (COP) movement and to analyze its stability. An equilateral triangular shaped plate was made of duralumin and forces were measured on the three vertices of the plate using industrial load cells. Specially designed electronic circuit picked up force signals ed into data acquisition system to calculate the cartesian coordinates of COP. COP calculation error was less than 2%. The force signals enabled to compute stability measures, which consisted of a variety of clinical parameters related to postural stability. Clinical experiments were carefully designed and performed on 40 normal subjects. The results were that 1) postural stability decreased with age and 2) the best parameters were those of posture deviation measures. A customized PC-based software package was developed to apply the present technique with a great convenience to monitoring and analyzing postural stability in an accurate and quantitative way.

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A Study on Resurvey of Cadastre Business Efficiency Measurement Methods Residential Areas (지적재조사사업 주택밀집 지역 측량 방법의 효율성에 관한 연구)

  • Choe, Cho-Won;Shin, Soon-Ho
    • Journal of Cadastre & Land InformatiX
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    • v.45 no.1
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    • pp.181-191
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    • 2015
  • In the present study, the 2013 survey Uiwang pointed out how the Resurvey of Cadastre ed projects reviewed relation to the business carried GPS-RTK (Network, Single) and total station surveying (T/S) to analyze and to compare the performance of Time Measurement Accuracy urban areas Resurvey of Cadastre was to present an effective survey methods in the business district. In this study, Uiwang review survey results indicated a comprehensive evaluation of the results, which are concentrated in urban areas, the building of intelligent review of GPS-RTK surveying methods is avoided by the measurement method to establish the first principles method based on total station surveying the GPS-RTK survey to draw conclusions appropriated to take advantage of the assistance and inspection methods.