• Title/Summary/Keyword: $Cac_2$

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Effects of Fermentation on the Metabolic Activities of Pine Needle Juice (발효과정이 솔잎 착즙액의 항산화, alpha-Glucosidase 및 Angiotensin Converting Enzyme 저해 활성에 미치는 영향)

  • Kim, So-Yun;Lee, Hyun-Jung;Park, Jae-Hee;Kim, Rae-Young;Cheong, Hyeonsook;Park, Eunju
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.42 no.3
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    • pp.325-334
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    • 2013
  • The objective of this study was to compare the content and metabolic activities between fresh pine needle juice (PNJ) and fermented pine needle juice (FPNJ). A variety of factors were measured, including total phenolic content (TPC), antioxidant activity [DPPH radical scavenging activity (RSA), total radical-trapping antioxidant potential (TRAP), oxygen radical absorbance capacity (ORAC), cellular antioxidant capacity (CAC)], anti-genotoxic activity, ${\alpha}$-glucosidase inhibitory activity, and angiotensin converting enzyme (ACE) inhibitory activity. The TPC was $17.3{\pm}0.2$ and $4.6{\pm}0.0$ mg GAE/g in PNJ and FPNJ, respectively. The DPPH RSA, TRAP, and ORAC values increased in a dose-dependent manner for both PNJ and FPNJ, with significantly higher activities in PNJ than FPNJ. The CAC against AAPH-induced oxidative stress in HepG2 cells was protected by both PNJ and FPNJ. Pretreatment with PNJ and FPNJ in human leukocytes produced significant reductions in $H_2O_2$-induced DNA damage at a concentration of $50{\mu}g/mL$. ${\alpha}$-Glucosidase inhibitory activity was significantly higher in FPNJ than PNJ. The ACE inhibitory activity was about 87.1% and 60.0% in 1:1 diluted PNJ and FPNJ, respectively. This study suggests that the fermentation of PNJ could enhance the regulation of blood glucose metabolism and both PNJ and FPNJ might be a new potential source of natural antioxidant, anti-diabetic, and anti-hypertensive agents applicable to food.

Adaptive Call Admission Control Based on Resource Prediction by Neural Network in Mobile Wireless Environments (모바일 무선환경에서 신경망 자원예측에 의한 적응 호 수락제어)

  • Lee, Jin-Yi
    • Journal of Advanced Navigation Technology
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    • v.13 no.2
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    • pp.208-213
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    • 2009
  • This paper presents an adaptive call admission control(CAC) algorithm based on a target handoff call dropping probability in mobile wireless environments. This method uses a neural network for predicting and reserving the bandwidth demands for handoff calls and new calls. The amount of bandwidth to be reserved is adaptively adjusted by a target value of handoff call dropping probability(CDP). That is, if the handoff CDP exceeds the a target CDP value, the bandwidth to be reserved should be increased to reduce the handoff dropping probability below a target value. The proposed method is intended to prevent from increasing handoff call dropping probability when bandwidth to be reserved is not enough for handoff calls due to an uncertain prediction. Our simulations compare the handoff CDP in proposed CAC with that of an existing CAC. Results show that the proposed method sustains handoff call dropping probability below our target value.

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Functional Characterization of cAMP-Regulated Gene, CAR1, in Cryptococcus neoformans

  • Jung, Kwang-Woo;Maeng, Shin-Ae;Bahn, Yong-Sun
    • Mycobiology
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    • v.38 no.1
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    • pp.26-32
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    • 2010
  • The cyclic AMP (cAMP) pathway plays a major role in growth, sexual differentiation, and virulence factor synthesis of pathogenic fungi. In Cryptococcus neoformans, perturbation of the cAMP pathway, such as a deletion in the gene encoding adenylyl cyclase (CAC1), causes defects in the production of virulence factors, including capsule and melanin production, as well as mating. Previously, we performed a comparative transcriptome analysis of the Ras- and cAMP- pathway mutants, which revealed 163 potential cAMP-regulated genes (38 genes at a 2-fold cutoff). The present study characterized the role of one of the cAMP pathway-dependent genes (serotype A identification number CNAG_ 06576.2). The expression patterns were confirmed by Northern blot analysis and the gene was designated cAMP-regulated gene 1 (CAR1). Interestingly, deletion of CAR1 did not affect biosynthesis of any virulence factors and the mating process, unlike the cAMP-signaling deficient cac1$\Delta$ mutant. Furthermore, the car1$\Delta$ mutant exhibited wild-type levels of the stress-response phenotype against diverse environmental cues, indicating that Car1, albeit regulated by the cAMP-pathway, is not essential to confer a cAMP-dependent phenotype in C. neoformans.

Removal of Odor- containing Sulfur Compound, Methyl Mercaptan using Modified Activated Carbon with Various Acidic Chemicals (산으로 개질된 활성탄을 이용한 메틸 메르캅탄 악취물질 제거)

  • Kim Dae Jung;Seo Seong Gyu;Kim Sang Chai
    • Journal of Korean Society for Atmospheric Environment
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    • v.21 no.2
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    • pp.155-160
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    • 2005
  • Removal of methyl mercaptan was investigated using adsorption on virgin activated carbon (VAC) and modified activated carbons with acidic chemicals in the present work. CAC, NAC, AAC and SAC were represented as activated carbons modified with HCI, HNO$_{3}$, CH$_{3}$COOH and H$_{2}$S0$_{4}$ ,respectively The pore structures were evaluated using nitrogen isotherm. The surface properties of virgin activated carbon and modified activated carbons were characterized by EA, pH of carbon surface and acid value from Boehm titration. The modification of activated carbon with acidic chemicals resulted in a decrease in BET surface area, micropore volume and surface pH, but an increase in acid value. The order of the adsorption capacity of activated carbons was NAC>AAC>SAC>CAC>VAC, and in agreement with that of acid value of activated carbons, whereas in disagreement with that of micropore volume of activated carbons. It appeared that chemical adsorption played an important role in methyl mercaptan on modified activated carbons with acidic chemicals compared to virgin activated carbon. Modifying activated carbon with acidic chemicals enabled to significantly enhance removal of methyl mercaptan.

Development and Validation of Analytical Method for Nitroxoline in Chicken Using HPLC-PDA (HPLC-PDA를 이용한 닭고기 중 Nitroxoline 분석법 개발)

  • Cho, Yoon-Jae;Chae, Young-Sik;Kim, Jae-Eun;Kim, Jae-Young;Kang, Ilhyun;Lee, Sang-Mok;Do, Jung-Ah;Oh, Jae-Ho;Chang, Moon-Ik;Hong, Jin-Hwan
    • Korean Journal of Environmental Agriculture
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    • v.32 no.1
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    • pp.70-77
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    • 2013
  • BACKGROUND: Nitroxoline is an antibiotic agent. It is used for the treatment of the second bacterial infection by the colibacillosis, salmonellosis and viral disease of the poultry. When the nitroxoline is indiscreetly used, the problem about the abuse of the antibiotics can occur. Therefore, this study presented the residue analytical method of nitroxoline in food for the safety management of animal farming products. METHODS AND RESULTS: A simple, sensitive and specific method for nitroxoline in chicken muscle by high performance liquid chromatograph with PDA was developed. Sample extraction with acetonitrile, purification with SPE cartridge (MCX) were applied, then quantitation by HPLC with C18 column under the gradient condition with 0.1 % tetrabutylammonium hydroxide-phosphoric acid and methanol was performed. Standard calibration curve presented linearity with the correlation coefficient ($r^2$) > 0.999, analysed from 0.02 to 0.5 mg/L concentration. Limit of quantitation in chicken muscle showed 0.02 mg/kg, and average recoveries ranged from 72.9 to 88.1 % in chicken muscle. The repeatability of measurements expressed as coefficient of variation (CV %) was less than 12 % in 0.02 and 0.04 mg/kg. CONCLUSION(S): Newly developed method for nitroxoline in chicken muscle was applicable to food inspection with the acceptable level of sensitivity, repeatability and reproducibility.

Physicochemical properties of a calcium aluminate cement containing nanoparticles of zinc oxide

  • Amanda Freitas da Rosa;Thuany Schmitz Amaral;Maria Eduarda Paz Dotto;Taynara Santos Goulart;Hebert Luis Rossetto;Eduardo Antunes Bortoluzzi;Cleonice da Silveira Teixeira;Lucas da Fonseca Roberti Garcia
    • Restorative Dentistry and Endodontics
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    • v.48 no.1
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    • pp.3.1-3.14
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    • 2023
  • Objectives: This study evaluated the effect of different nanoparticulated zinc oxide (nano-ZnO) and conventional-ZnO ratios on the physicochemical properties of calcium aluminate cement (CAC). Materials and Methods: The conventional-ZnO and nano-ZnO were added to the cement powder in the following proportions: G1 (20% conventional-ZnO), G2 (15% conventional-ZnO + 5% nano-ZnO), G3 (12% conventional-ZnO + 3% nano-ZnO) and G4 (10% conventional-ZnO + 5% nano-ZnO). The radiopacity (Rad), setting time (Set), dimensional change (Dc), solubility (Sol), compressive strength (Cst), and pH were evaluated. The nano-ZnO and CAC containing conventional-ZnO were also assessed using scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray spectroscopy. Radiopacity data were analyzed by the 1-way analysis of variance (ANOVA) and Bonferroni tests (p < 0.05). The data of the other properties were analyzed by the ANOVA, Tukey, and Fisher tests (p < 0.05). Results: The nano-ZnO and CAC containing conventional-ZnO powders presented particles with few impurities and nanometric and micrometric sizes, respectively. G1 had the highest Rad mean value (p < 0.05). When compared to G1, groups containing nano-ZnO had a significant reduction in the Set (p < 0.05) and lower values of Dc at 24 hours (p < 0.05). The Cst was higher for G4, with a significant difference for the other groups (p < 0.05). The Sol did not present significant differences among groups (p > 0.05). Conclusions: The addition of nano-ZnO to CAC improved its dimensional change, setting time, and compressive strength, which may be promising for the clinical performance of this cement.

Findings on Chest Low-Dose CT Images of Group Exposed to Inorganic Dusts (분진에 노출되었던 집단의 흉부 저선량 CT영상 소견)

  • Lee, Won-Jeong;Seon, Jong-Ryul;Ahn, Bong-Seon;Park, Young-Sun
    • Journal of radiological science and technology
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    • v.34 no.4
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    • pp.305-314
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    • 2011
  • The purpose of this study was to compare the findings on the chest low-dose CT (LDCT) images between the negative and positive groups for pneumoconiosis in the group exposed to inorganic dust. From May 30, 2007 to August 31, 2008, total 328 subjects were examined by a LDCT. LDCT images were read by a chest radiologist who has much experience for reading of pneumoconiosis. All subjects were classified into two groups based on digital images after consensus reading of two radiologists according to the ILO 2000 guidelines; negative group (87, 26.5%) without pneumoconiosis and positive group (241, 73.5%). Statistical analysis was performed using a SPSS 14.0. There were significant differences in age (60.9 vs. 65.0, p<0.001), and in dust expose duration (17.0 vs. 19.2, p=0.024) between two groups, but no significant difference in smoking (p=0.784). Of the 328 subjects, 13 diagnosis were extracted from 245 subjects (74.7%). Coronary artery calcification (CAC) was significantly higher in positive group than that in negative group (36.9% vs. 25.3%, p=0.049). Honeycombing showed higher frequency in positive group than in negative group (6.2% vs. 1.2%, p=0.079). Pneumoconiosis findings caused by inorganic dusts exposure showed the significant relation with CAC on LDCT images. Future studies need to prove that pneumoconiosis finding is independent risk factor for CAC using a coronary artery angiography.

Handover Control for WCDMA Femtocell Networks

  • Chowdhury, Mostafa Zaman;Jang, Yeong-Min
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.35 no.5B
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    • pp.741-752
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    • 2010
  • The ability to seamlessly switch between the macro networks and femtocell networks is a key driver for femtocell network deployment. The handover procedures for the integrated femtocell/macrocell networks differ from the existing handovers. Some modifications of existing network and protocol architecture for the integration of femtocell networks with the existing macrocell networks are also essential. These modifications change the signal flow for handover procedures due to different 2-tier cell (macrocell and femtocell) environment. The handover between two networks should be performed with minimum signaling. A frequent and unnecessary handover is another problem for hierarchical femtocell/macrocell network environment that must be minimized. This work studies the details mobility management schemes for small and medium scale femtocell network deployment. To do that, firstly we present two different network architectures for small scale and medium scale WCDMA femtocell deployment. The details handover call flow for these two network architectures and CAC scheme to minimize the unnecessary handovers are proposed for the integrated femtocell/macrocell networks. The numerical analysis for the proposed M/M/N/N queuing scheme and the simulation results of the proposed CAC scheme demonstrate the handover call control performances for femtocell environment.

Heating Performance Evaluation of the VRF Heat Pump System with Refrigerant Heating Cycle for the Extreme Cold Region (냉매 가열식 대용량 VRF 히트펌프 사이클 설계를 통한 극한랭지 난방 성능 평가)

  • Lee, Sang-Hun;Choi, Song;Kim, Byeng-Soon;Lee, Jae-Keun;Lee, Kang-Ho
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.23 no.8
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    • pp.571-579
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    • 2011
  • Heat pump systems for commercial building with variable refrigerant flow(VRF) are expanding a market due to high energy efficiency, lower maintenance cost and easy installation comparing with the conventional heat pump with the constant refrigerant flow. In general, heat pump systems degrade the energy efficiency in the extremely low temperature regions. In this study, VRF heat pump system with refrigerant heating is experimentally investigated to overcome the low heating performance in the extremely low temperature regions. VRF heat pump system with refrigerant heating is found out the sufficient heating performance in the -25 degree temperature condition comparing with the conventional heat pump system and is obtained more than 2,500 kPa high pressure in the evaporator at low temperature.

High-velocity impact of large caliber tungsten projectiles on ordinary Portland and calcium aluminate cement based HPSFRC and SIFCON slabs -Part I: experimental investigations

  • Korucu, H.;Gulkan, P.
    • Structural Engineering and Mechanics
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    • v.40 no.5
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    • pp.595-616
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    • 2011
  • Impact experiments have been carried out on concrete slabs. The first group was traditionally manufactured, densely reinforced concrete targets, and the next were ordinary Portland and calcium aluminate cement based HPSFRC (High performance steel fiber reinforced concrete) and SIFCON (Slurry infiltrated concrete) targets. All specimens were hit by anti-armor tungsten projectiles at a muzzle velocity of over 4 Mach causing destructive perforation. In Part I of this article, production and experimental procedures are described. The first group of specimens were ordinary CEM I 42.5 R cement based targets including only dense reinforcement. In the second and third groups, specimens were produced using CEM I 42.5 R cement and Calcium Aluminate Cement (CAC40) with ordinary reinforcement and steel fibers 2 percent in volume. In the fourth group, SIFCON specimens including 12 percent of steel fibers without reinforcement were tested. A high-speed camera was used to capture impact and residual velocities of the projectile. Sample tests were performed to obtain mechanical properties of the materials. In the companion Part II of this study, numerical investigations and simulations performed will be presented. Few studies exist that examine high-velocity impact effects on CAC40 based HPSFRC targets, so this investigation gives an insight for comparison of their behavior with Portland cement based and SIFCON specimens.