• Bulletin of the Korean Chemical Society
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• 제18권3호
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• pp.305-310
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• 1997

The synthesis and characterization of the platinum heterocyclic carboxaldehyde thiosemicarbazone complexes [NC5H4CRNNC(S)NHR'PtCl] (R=H, R'=CH3(1); R=CH3, R'=CH3(2); R=CH3, R=H(3)) and diphenylphosphinophenyl carboxaldehyde thiosemicarbazone complexes [Ph2PC6H4CHNNC(S)NHRPtCl] (R=CH3(5); R=iC3H7(6); R=Ph(7)) are described. Compounds 1-3 were prepared by reaction of Pt(SEt2)2Cl2 with 2-acetylpyridine-4-alkylthiosemicarbazone in the presence of NEt3. Compounds 5-7 were prepared using Pt(SEt2)2Cl2 in toluene with diphenylphosphinophenyl carboxaldehyde alkylthiosemicarbazone. The compounds have been characterized by microanalysis, NMR (1H, 13C, 31P) spectroscopy, and single-crystal X-ray diffraction. X-ray single crystal diffraction analysis reveals that compound 5 is a mononuclear platinum compound with P,N,S-coordination mode.

• 생약학회지
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• 제53권2호
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• pp.57-63
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• 2022

Five secoiridoids (1-3, 5, 10), a iridoid (4) three flavonol glycosides (7-9) and a coumarin (6), were isolated from the flowers of Hydrangea paniculata. Their chemical structures were elucidated as kingiside (1), morroniside (2), sweroside (3), loganin (4), vogeloside (5), umbelliferone (6), quercetin-3-O-sambubioside (7), quercetin-3-O-neohesperidoside (8), kaempferol 3-O-sambubioside (9) and secologanin dimethyl acetal (10), respectively, by spectroscopic analysis. All isolated compounds 1-10 were assessed for their ability to induce C2C12 myotube hypertrophy. Among them, loganin (4) and kaempferol 3-O-sambubioside (9) increase the diameter of C2C12 myotubes. All isolated compounds 1-10 were firstly reported from the flowers of Hydrangea paniculata, and the skeletal muscle hypertrophic activity of 4 and 9 was also reported for the first time.

• Bulletin of the Korean Chemical Society
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• 제18권6호
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• pp.631-635
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• 1997

Four steroids including two novel compounds have been isolated from a sponge of the genus Tethya. All of the compounds possess a 5α,8α-epidioxy functionality as a common structural feature. Two new steroids, 1 and 2, possess a cyclopropyl ring at C-24(26) of the side chain. The structures of these compounds have been determined by combined spectroscopic methods.

• Food Science and Biotechnology
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• 제18권2호
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• pp.481-487
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• 2009

The compositional changes of wormwood (Artemisia princeps var. orientalis) essential oils were studied under 4 different storage conditions i.e., being exposed to air at 20 and $40^{\circ}C$. Sixty-four volatile compounds consisting of 24 terpene hydrocarbons, 18 alcohols, 11 ketones, 6 esters, 1 aldehyde, 2 hydrocarbons, and 2 oxides were identified on the basis of their mass spectra characteristics and retention indices in original wormwood essential oils. Identified compounds constituted 80.53% of the total peak area. Borneol (12.13%) was the most abundant compound, followed by $\alpha$-thujone (8.66%), T-cadinol (6.67%), and 1,8-cineole (6.21%) in original wormwood essential oils. Under the condition of $40^{\circ}C$ of temperature with the cap being opened for 3 min everyday respectively during 6 months of storage, the total amount of functional groups in essential oil determined by peak area percent were decreased by 79.45%, at most. The total level of monoterpene hydrocarbons decreased markedly in the aerobic condition and high temperatures. Whereas the total level of esters increased significantly. Wormwood essential oils were stored in experimental conditions, with the changes in the volatile compounds of essential oils being accelerated by high temperatures and contact with the atmosphere.

• 생약학회지
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• 제45권2호
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• pp.93-100
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• 2014

The Acer tegmentosum (3 kg) were extracted with boiled water and the freeze dried extract powder was partitioned with $CH_2Cl_2$, EtOAc, n-BuOH and $H_2O$, successively. From the EtOAc and n-BuOH fraction, six phenolic compounds were isolated through the silica gel, octadecyl silica gel and sephadex LH-20 column chromatography. On the basis of spectroscopic methods, such as $^1H$-NMR and $^{13}C$-NMR, and LC/MS, the chemical structures of the compounds as feniculin (1), avicularin (2), (+)-catechin (3), (-)-epicatechin (4), salidroside (5) and 6'-O-galloylsalidroside (6). In this study, compounds 1 and 2 have been first isolated from the A. tegmentosum. To provide insight into the effects of six compounds isolated from A. tegmentosum on inflammation, we investigated its effect on nitric oxide (NO) production in RAW 264.7 cells using lipopolysaccharide (LPS) stimulation. Compounds 1 and 6 slightly repressed NO production. Also, compounds 3 and 4 inhibited NO secretion with statistical significance. However, compounds 2 and 5 did not show any inhibitory effect on NO production.

• 한국식품영양과학회지
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• 제31권1호
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• pp.26-31
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• 2002

Pinus densiflora(2엽송) 1년생을 채취하여 가지, 잎, 새순 부분으로 구분하고, 시료병에 넣어 밀봉한 뒤, solide phase microextraction (SPME)과 dynamic headspace analysis(DHA)를 이용하여 휘발성 성분을 분리, 동정하였다. SPME와 DHA의 결과를 terpenes의 구성 성분에 따라 monoterpenes과 sesquiterpenes, oxygenated terpenes으로 나누어 조성비를 살펴보면, monoterpenes의 조성은 잎의 경우 각각 66.7%와 14.3%, 새순은 90.6%와 0.7%, 가지에서는 90.6%와 1.2%로 나타났다. Sesquiterpenes의 함량은 SPMe의 결과에서만, 잎이 25.8%, 가지 4.4%, 새순 1.5%로 나타났다. 산소를 함유하고 있는 terpenes의 함량은 새순 부위가 4.7%, 79.0%로 나타났으며, 가지 부위는 3.7%와 70.4%, 잎에서 1.0%와 50.7%를 각각 차지하였다. SPME의 결과는 이전의 용매추출을 통한 결과와 다소 비슷한 양상을 보였으며, DHA의 결과는 10$0^{\circ}C$이상의 고비점 화합물들이 나타나지 않은 반면, 5$0^{\circ}C$이하의 저비점 화합물이 15개 분리되었다.

• 생약학회지
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• 제46권1호
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• pp.6-11
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• 2015

To clarify chemical constituents of Clematis heracleifolia, isolation and structure elucidation of the underground parts of C. heracleifolia were performed. Five compounds were isolated from $CHCl_3$ and n-BuOH soluble fraction of this plant. On the basis of spectral and physico-chemical data, the structure of isolated compounds were identified as coniferyl alcohol (1), scoparone (2), (+)-lariciresinol (3), phytosterols (4), and daucosterol (5), respectively. All compounds are isolated from this plant for the first time. To evaluate anti-acetylcholinesterase activity of the isolated compounds, compounds 1, 2, 3, and 5 were tested inhibition activity against acetylcholinesterase. Among tested compounds, daucosterol (5) showed acetylcholinesterase inhibitory activity with $IC_{50}$ value of $6.1{\mu}M$.

• 한국미생물·생명공학회지
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• 제40권1호
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• pp.57-65
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• 2012

B. polyfermenticus CJ6가 생산하는 항진균 물질을 분리 정제하기 위하여 SPE, preparative HPLC, reverse phase-HPLC를 통한 정제를 시행하였다. Preparative HPLC로부터8, B, C의 3개의 항진균 활성 분획을 분리하였으며, LC/MS분석 결과 B. polyfermenticus CJ6는 2종의 iturin A($C_{14}$, $C_{15}$), 3종의 surfactin($C_{13}$, $C_{14}$, $C_{15}$), 4종의 fengycin A($C_{14}$, $C_{15}$, $C_{16}$, $C_{17}$)와 2종의 fengycin B($C_{16}$, $C_{17}$)를 생산하는 것으로 추정되었다. 분리된 항진균 활성 분획의 안정성 실험을 결과 iturin을 함유한 8번 분획은 pH, 열, 효소처리에 안정하였으나 50-$70^{\circ}C$에서 24시간 처리 시에는 항진균 활성이 다소 감소되었다. Surfactins과 fengycins을 포함하는 것으로 추정되는 B 분획은 온도에는 매우 안정하나 pH 3.0과 protease(type I) 및 ${\alpha}$-chymotrypsin 처리에 의하여 항진균활성이 감소되었다. Fengycins 만을 함유한 C 분획은 열과 pH 처리에서 모두 안정하였으나 protease(type I) 처리에 의하여 활성이 감소되었다. 항진균 활성 8번 분획은 reversephase-HPLC를 통하여 2개의 단일 피크가 분리되었으며, 아미노산 조성 분석 결과 Asx, Tyr, Gln, Pro, Ser의 분자비가 3:1:1:1:1으로서 iturin A의 아미노산 서열과 일치하는 것으로 확인되었다. 본 연구를 통하여 B. polyfermenticus CJ6는다양한 항진균 활성 lipopeptides를 생산하는 것을 알 수 있으며, 항진균 활성이 우수한 B. polyfermenticus CJ6 균주의 생물방제 및 생물보존제로서의 활용이 기대된다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 제4회 영호남학술대회 논문집
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• pp.25-30
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• 2002

The ternary semiconducting compounds of the $A_{4}BX_{6}$(A=Cd, Zn, Hg; B=Si, Sn, Ge; X=S, Se, Te) type exhibit strong fluorescence and high photosensitivity in the visible and near infrared ranges, so these are supposed to be materials applicable to photoelectrical devices. These materials were synthesized and single crystals were first grown by Nitsche, who identified the crystal structure of the single crystals. In this paper. author describe the undoped and $Co^{2+}$-doped $Zn_{4}SnSe_{6}$ single crystals were grown by the chemical transport reaction(CTR) method using iodine of $6mg/cm^{3}$ as a transport agent. For the crystal. growth, the temperature gradient of the CTR furnace was kep at $700^{\circ}C$ for the source aone and at $820^{\circ}C$ for the growth zone for 7-days. It was found from the analysis of x-ray diffraction that undoped and $Co^{2+}$-doped $Zn_{4}SnSe_{6}$ compounds have a monoclinic structure. The optical absorption spectra obtained near the fundamental absorption edge showed that these compounds have a direct energy gaps. These temperature dependence of the optical energy gap were closely investigated over the temperature range 10[K]~300[K]

• 한국식품영양과학회지
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• 제35권7호
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• pp.881-885
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• 2006

Glucose-glutamine 모델반응에서 생성물의 종류와 갈변에 의한 색의 변화를 조사하기 위하여, 가열조건을 125, 150 및 $175^{\circ}C$에서 각각 10, 20 및 30분간 가열하고 반응물의 색을 Hunter colorimeter로 측정한 후, ethyl acetate로 추출하여 GC/MS로 생성물을 분석하였다. GC/MS 분석에서 acetic acid, butanoic acid, 2-butenoic acid, di-(2-ethylhexyl) phthalate, 2,3-dihydro-3.5-dihydroxy-6-methyl-4H-pyran-4-one 및 5-hydroxymethylfurfural의 6종의 다량 생성물과 1,3-dimethylbenzene, 2-ethylhexanol, fufural, 5-methylfurfural, 2-pyrrolidinone 그리고 2,6-di(t-butly)-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one 6종의 미량 생성물이 확인되었다. 최대 생성물인 acetic acid와 미량 생성물인 2-ethylhexanol 및 2-pyrrolidinone은 온도 및 가열시간의 경과에 따라 전반적으로 증가하였으나, 그 외 9종의 화합물을은 $125^{\circ}C$부터 생성량이 증가하지만 $150^{\circ}C$ 또는 $175^{\circ}C$를 정점으로 그 이상 온도, 또는 가열시간을 증가할수록 생성량은 감소하였다. 반응생성물이 Hunter $L^*$값은 온도 및 시간의 증가에 따라 지속적으로 감소하여 암색이 반응의 최종산물에 의한 색으로 나타났으며, $a^*$ 및 $b^*$은 $125^{\circ}C$에서 낮고 $150^{\circ}C$ 또는 $175^{\circ}C$, 10분에서 최고점을 나타낸 후 온도 및 시간의 증가에 따라 감소하여 적색과 황색은 반응 중간생성물에 의한 발현이며 반응후기에는 고분자의 화합물에 고착되어 암색을 발현하는 것으로 추정되었으며, 가열조건의 변화에 따른 $a^*$ 및 $b^*$값의 변화는 앞서 언급한 9종 화합물들의 생성 변화와 유사하였다.