• Korean Journal of Pharmacognosy
• /
• v.14 no.1
• /
• pp.4-4
• /
• 1983

Polygalitol, $C_6H_{12}O_5$ mp $142.5{\sim}3^{\circ}$, was isolated from the fresh leaves of Acer ginnala Max. (Aceraceae).

• Journal of Pharmaceutical Investigation
• /
• v.33 no.3
• /
• pp.229-235
• /
• 2003

The purpose of the present study was to evaluate the bioequivalence of two enalapril maleate tablets, $Renitec^{TM}$ (MSD Korea Ltd.) and $Enalace^{TM}$ (Welfide Korea Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $22.33{\pm}2.55$ year in age and $66.54{\pm}8.30$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 10 mg of enalapril maleate per tablet were orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t,\;and\;C_{max}$ untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log0.8 to log1.25$(e.g.,\;log1.02{\sim}log1.14\;and\;log1.03{\sim}log1.19\;for\;AUC_t\;and\;C_{max},\;respectively)$. The major parameters, $AUC_t,\;and\;C_{max}$, met the criteria of KDFA for bioequivalence indicating that $Enalace^{TM}$ tablet is bioequivalent to $Renitec^{TM}$ tablet.

• Journal of Pharmaceutical Investigation
• /
• v.35 no.1
• /
• pp.45-50
• /
• 2005

The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jeil Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $23.67{\pm}3.12$ year in age and $68.50{\pm}7.23$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were determined using HPLC. Pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$ and untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., $log0.94{\sim}log1.04\;and\;log0.90{\sim}log1.07\;for\;AUC_t\;and\;C_{max}$, respectively). The major parameters, $AUC_t$, and $C_{max}$, met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

• Journal of the Korean Crystal Growth and Crystal Technology
• /
• v.6 no.3
• /
• pp.439-448
• /
• 1996

The possibility of application or the transparent BK10 glass fiber/PMMA composites as a temperature-or wavelength-sensors was studied. Measurement of diameter and refractive index for glass fibers to be reinforced to PMMA as a function of drawing speed and temperature was done and the appropriate coating methods and solvent for coupling agent was researched. $T_{max%}$ value at which the maximum transmission for the composites occurs could be controlled to be in $31~50^{\circ}C$ by the processing factors such as fiber diameter, fiber vol%, molecular wt. of PMMA. Furthermore, with different wavelength other than 589.3 nm, the $T_{max%}$ value could be controlled to be in $35~55^{\circ}C$. For the sensibility of wavelength for the composites, there was not a wavelength ($\lamda_{max%}$) showing maximum transmission.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.24 no.5
• /
• pp.219-232
• /
• 2020

The slip-weakening model developed by Ohnaka and Yamashita is extended over the breakdown zone by equating the scaling relationships for the breakdown zone and the whole rupture area. For the extension, the study uses the relationship between rupture velocity and radiation efficiency, which was derived in the theory of linear elastic fracture mechanics, and the definition of f_max given in the specific barrier model proposed by Papageorgiou and Aki. The results clearly show that the extended scaling relationship is governed by the ratio of rupture velocity to S wave velocity, and the velocity ratio can be determined by the ratio of characteristic frequencies of a Fourier amplitude spectrum, which are corner frequency, f_c, and source-controlled cut-off frequency, f_max, or vice versa. The derived relationship is tested by using the characteristic frequencies extracted from previous studies of more than 130 shallow crustal events (focal depth less than 25 km, M_W 3.0~7.5) that occurred in Japan. Under the assumption of a dynamic similarity, the rupture velocity estimated from f_max/f_c and the modified integral timescale give quite similar scale-dependence of the rupture area to that given by Kanamori and Anderson. Also, the results for large earthquakes show good agreement to the values from a kinematic inversion in previous studies. The test results also indicate the unavailability of the spectral self-similarity proposed by Aki because of the scale-dependent rupture velocity and the rupture velocity-dependent f_max/f_c; however, the results do support the local similarity asserted by Ohnaka. It is also remarkable that the relationship between the rupture velocity and f_max/f_c is quite similar to Kolmogorov's hypothesis on a similarity in the theory of isotropic turbulence.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.23 no.6
• /
• pp.125-132
• /
• 2023

To NP-complete 3-SAT problem, this paper proposes a O(nm) polynomial time algorithm, where n is the number of literals and m is the total frequency of all literals in equation f. Conventionally well-known DPLLs should perform O(2^𝑙) in the worst case by performing backtracking if they fail to find a solution in a brute-force search of a branch-and-bound for the number of literals 𝑙. DPLL forms the core of the SAT Solver by substituting true(T) or false(F) for a literal so that a clause containing the least frequency literal is true(T) and removing a clause containing that literal. Contrary to DPLL, the proposed algorithm selects a literal _max𝑙 with the maximum frequency and sets $_{\max}({\mid}l{\mid},{\mid}{\bar{l}}{\mid})=1$. It then deletes 𝑙∈c_i clause in addition to ${\bar{l}}$ from ${\bar{l}}{\in}c_i$ clause. Its test results on various k-SAT problems not only show that it performs less than existing DPLL algorithm, but prove its simplicity in satisfiability verification.

• Preventive Nutrition and Food Science
• /
• v.6 no.1
• /
• pp.38-42
• /
• 2001

The methanol extracts of 25 leguminous seeds in vitro were evaluated for inhibitory activities against lens aldose reductase of Sprague Dawley male rats. The responses varied with both leguminous seed and concentration used. At the concentration of 0.1 mg/mL, the methanol extracts from Amphicaraea edgeworthii, Canavalia lineata, Gylcine max var. solitae, Glycine max var. yagkong, Glycine max var. hooktae, Glycine max var. bangkong, Glycine max var. geumdu, Glycine max var. chungtae, Glycine max var. mejukong, Glycine soja, Phaseolus radiatus var. geodu, Vicia tetrasperma, Vigna angulasis, and Vigna sinensis inhibited enzyme activity by greatertha 60%. In following study, at the concentration of 0.01 mg/mL, the extracts of C. lineata and V. tetraspermahad relatively strong inhibitory activity against aldose reductase. Because of their potent inhibitory activities, the activity of each solvent fraction from C. lineata and V. tetrasperma was determined, and the potent activity was showed from chloroform and hexane fractions, respectively. {TEX}$IC_{50}${/TEX} values of C. lineata and V. tetrasperma were 0.004 and 0.006 mg/mL, respectively. As a naturally occurring therapeutic agent, leguminous seeds described could be useful for developing new agents of antidiabetic complications.

• The Korean Journal of Malacology
• /
• v.28 no.4
• /
• pp.349-359
• /
• 2012

The purpose of this study is to compare the clearance rate (CR) and intake rate (IR) of juvenile purple clam, Saxidomus purpuratus when feeding on different unialgal diet of red tide dinoflagellates (RTDs), and to know what is the most important cell characteristic of RTDs to cause the differences in feeding parameters. Experiments were performed to measure the CR and IR of juvenile S. purpuratus as a function of algal concentration when food was either the standard food, Isochrysis galbana or one of 9 RTDs. Patterns of CR with increasing algal concentration were similar among different RTDs. The highest $C_{max}$ was observed when S. purpuratus was feeding on A. affine, while the lowest on C. polykrikoides. The patterns of IR with increasing algal concentration were also similar among different RTDs. However, there were great differences in the maximum value of IR ($I_{max}$) among different RTDs. The highest $I_{max}$ was observed when S. purpuratus was feeding on A. carterae, while the lowest on G. catenatum. Some RTDs similar in size showed different $C_{max}$. Other RTDs different in size showed similar $I_{max}$. Life form of each RTD affected significantly the $I_{max}$, which was higher for single-celled RTDs than chain-forming RTDs. There were no significant differences in feeding parameters between toxic and nontoxic RTDs. Moreover, a toxic dinoflagellate, A. carterae recorded the highest $I_{max}$ among RTDs. The most important characteristic of RTD as a factor affecting the feeding rate of S. purpuratus was life form, not size or toxicity of RTD species.

• Archives of Pharmacal Research
• /
• v.18 no.4
• /
• pp.237-242
• /
• 1995

For the vioequivalence study of two ceftriaxone injection formulations ($Rocephin{\circledR}$ ; Roche, and Triaxone ; Hanmi0, the HPLC analytical method for the analysis of ceftriaxone in plasma was used. Fourteen healthy volunteers completed the study and each subject were IM in jected signle doses (1 g) of the test and the reference formulations in a two-way crossover design with an one week drug free interval between doses. Following each administration, plasma concentrations of ceftrixone were monitored over a period of 24 h. Bioequivalence parameters $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT determined from the data obtained for the two formulations were examined by analyses of variance (ANOVA) and other criteria and tests for bioequivalence. Results of ANOVA and confidence limits of test/reference ratios of $AUC_{24th}, {\;}T_{max}, {\;}C_{max}$ and MRT, and statistical tests indicated the bioequivalence of the two formulations (i.e., test/reference ratio was within $100{\pm}20%$) except for $T_{max}$ The mean of $T_{max}$ showed only 6. 9% difference from the reference but the detection limit was 22.5% which is slightly over the 20% criteria. No pharmacokinetic parameters including Ka, Kel, Vd and Cl indicated significant difference in between the two fomulations. It was concluded that the data yielded fro the two cefriaxone formulations demonstrated that they were bioequivalent.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.20 no.6
• /
• pp.484-488
• /
• 1987

The model experiments were performed in tile circular water tank on the simple cambered and the super-V otter boards attached with the slotted fowler flap at the trailing edge in order to develop more efficient shearing characteristics. The dimension of the model otter boards was varied slightly in the flap chord ratio $0.20\~0.22$ and in the area $432\~426cm^2$ in accordance with the flap angle $30\~50^{\circ}$. The maximum shearing coefficient $C_L=1.78$ and hydrodynamic efficiency $C_L/C_D=4.0$ in the superV type were higher than their efficiencies $C_L=1.75$ and $C_L/C_D=3.7$ in the simple cambered type. As the shearing forces of the otter boards with flap were increased $20\~30\%$ mere than these without flap in spite of increasing the drag and the instability. The effect of flap should be fully investigated for the application.