• Journal of Integrative Natural Science
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• v.9 no.4
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• pp.228-233
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• 2016

Cysteinyl leukotrienes are inflammatory mediators having important role in pathophysiological conditions such as asthma and allergic rhinitis. CysLT1 receptor mediates most of the disease regulatory actions of the CysLTs and it is been implicated in a number of inflammatory conditions including gastrointestinal and cardiovascular diseases. Hence in the present study, molecular docking of CysLT1 was performed with its potent and orally efficacious antagonist CP-199330 and CP-199331. The aim of this study was to compare the interaction of CP-199330 and CP-199331 with known drugs such as Zafirlukast, Pranlukast and Montelukast which had already showed clinical efficacy in the treatment of asthma. The residues such as TYR83, GLN274, LYS311 and SER313 were found to interact with both the antagonist and the known drugs. Also, we noticed the docking scores and interaction of the antagonists were comparable with the known drugs. Hence these antagonists could serve as better drugs for the treatment of allergy.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1997.03a
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• pp.81-84
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• 1997

The hot deformation behavior of SiCp/AA2024 composites reinforced with different sizes of SiCp reinforcements (1, 8, 15, 36, and 44${\mu}{\textrm}{m}$) was investigated by hot torsion tests. The hot restoration of the composites depending on the SiCp reinforcements particle size was studied from the effective stress - strain curves. Dynamic recrystallization (DRX) was occurred in the SiCp/AA2024 composites during the hot deformation at 320 - 43$0^{\circ}C$ under a strain rate of 1.0/sec. Also, the critical strain for DRX decreased with decreasing the reinforcement size of SiCp from 44 to 8${\mu}{\textrm}{m}$. The composite reinforced with SiCp of 8${\mu}{\textrm}{m}$ showed the highest flow stress (265 MPa) and the work hardening rate at 32$0^{\circ}C$ under a strain rate of 1.0/sec.

• Bulletin of the Korean Chemical Society
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• v.7 no.6
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• pp.413-421
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• 1986

Hydrocarbon solution of $Cp_2Zr(CH_3)Cl$ react rapidly with $Na_2Fe(CO)_4$ (1/2 equiv.) to yield $[Cp_2Zr(CH_3)]_2Fe(CO)_4$ and NaCl. The more soluble metal-metal bonded complex $[Cp_2ZrC_8H_{17}]_2Fe(CO)_2$ has also been prepared through the reaction of $Cp_2Zr(C_8H_{17})BF_4$ and $Na_2Fe(CO)_4 (1/2 equiv.). The complexes were characterized by IR, $^1H$ NMR, ^{13}C$ NMR, and elemental analysis. The infrared spectrum of $[Cp_2ZrR]_2Fe(CO)_4$ shows four bands, which is indicative of a cis-structure. The $^{13}C$ NMR spectrum provides evidence for the cis-structure.

• The Journal of Pediatrics of Korean Medicine
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• v.29 no.2
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• pp.1-15
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• 2015

Objectives In the theory of Korean Medicine, Cicadae Periostracum (CP) has been used to treat skin diseases such as inflammatory dermatitis, tetanus and pruritus. CP can reduce heat and disperse wind. In prior studies, anti-allergic effect and anti-inflammatory effect of CP were reported. However, there has been no report regarding the correlation of CP and allergic contact dermatitis (ACD). This study was performed to show the effects of CP in ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Methods In this experiment, the effects of CP on biological changes were measured, such as changes in ear and spleen weight, ear and dorsum skin thickness, clinical aspect on the dorsum skin and histological changes. The effect of proliferation rate of splenocytes was also investigated in vitro and vivo study. Results In results, CP application (CPA) group and CP application and administration (CPAA) group were significantly restrained in ear weight gain and increase in ear and dorsum skin thickness compared to the control group. In addition, CPA and CPAA group showed diminished erythema, desquamation, bloodstain, and marks. Also, the histological assessment showed that CP treatement diminished thickness of epidermis, hyperkeratosis, pigmentation and parakeratosis. Conclusions In conclusion, these data suggest that CP can decrease symptoms of ACD.

• Journal of the Korean Society of Clothing and Textiles
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• v.30 no.2 s.150
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• pp.275-285
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• 2006

The purpose of this study was to examine the change of dyeing ability by K/S values, when dyed in different twisting processes and by one bath system and two bath system, to find possible ways of minimizing the color difference between cotton and polyester in composite yarn. The two types of composite yarn, which had one setting process(CP1) and two setting processes(CP2) were dyed with reactive/disperse dyes in both one bath dyeing system and two bath system. The dyeing ability according to the two different twisting processes was measured, and the values of the CP1 were higher compare to the values of CP2 in both one and two bath dyeing systems. This is because CP1 applied only one setting could shrink dyeing process at 130$^{circ}C$. This shrinkage increased the number of twists in the unit length and increased the yarn density, and this is the reason that the K/S values were measured higher than those of CP2. In wet shrinkage test, in opposition to CP2 only had 0.76$\%$ of the shrinkage rate, CP1 had 3.00$\%$ of the shrinkage rate. Also, the dyeing ability according to the two different dyeing methods was measured, and the values of CP1 and CP2 were both higher when dyed in two bath system. On the other hand, the color differences between cotton and polyester in composite yarns, were smaller for CP2 than that for CP1 and were also smaller in two bath dyeing system than in one bath dyeing system. Therefore, the ways of minimizing color difference between cotton and polyester in composite yarn are to apply enough setting in order to minimize shrinkage in dyeing process and to choose two bath dyeing system.

• Journal of Veterinary Clinics
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• v.20 no.1
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• pp.79-85
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• 2003

Dietary conjugated linoleic acid(CLA) has been shown to affect immune function. Thus, the objective of this study was to investigate the effects of CLA on the mice that treated prednisone. Mice were randomized into 6 groups and fed diet containing either 0(control, P), 0.5%(CLA1, CP1) or 1.5%(CLA2, CP2) CLA for Sweets. Before 1 week of finishing diet supplement CP1, CP2, and P group treated the prednisone by subcutaneous injection. The levels of serum immunoglobulin A, G, E, gut lumen s-IgA, MLN immunoglobulin A, body weight, mucosal protein was compared. The level of serum IgA in CLA1, CLA2, CP1, and CP2 group increased, while which of P group was decreased. The level of serum IgG in CLA 1 group increased, while which of the other group no differences. Serum IgE level showed no difference and the immunoglobulin production in MLN lymphocyte in CLA 1 group increased. The level of gut lumen s-IgA in P group showed decreased, while which of the other group showed no differences. These results support the view that CLA supplement partially enhance the cell-mediated immunity and overcome the immunosuppressive effect of prednisone.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.10
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• pp.1518-1523
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• 2003

This experiment was conducted to investigate the effect of various feeding regimens on growth performance, nutrient digestibilities, nitrogen retention, blood urea nitrogen (BUN) concentration and feed cost in young pigs weaned at 21 days of age. One hundred twenty crossbred pigs (Landrace${\times}$Large White${\times}$Duroc, average 6.8 kg BW), weaned at 21 days of age, were allotted to 5 treatments in a 5 replicates by a randomized completely block (RCB) design. Treatments were as follow: 1) 1P (1-4 weeks: CP 23% and lysine 1.60%), 2) 2P-I (1 week: CP 23% and lysine 1.60%, 2-4 weeks: CP 21% and lysine 1.45%), 3) 2P-II (1-2 weeks: CP 23% and lysine 1.60%, 3-4 weeks: CP 21% and lysine 1.45%), 4) 2P-III (1-3 weeks: CP 23% and lysine 1.60%, 4 week: CP 21% and lysine 1.45%), 5) 3P (1 week: CP 23% and lysine 1.60%, 2-3 weeks: CP 21% and lysine 1.45%, 4 week: CP 19% and lysine 1.30%). Three different diets were formulated and supplied according to phase feeding programs. Diet 1 contains 23% crude protein and 1.60% lysine, diet 2 contains 21% crude protein and 1.45% lysine and diet 3 contains 19% crude protein and 1.30 lysine, respectively. Although there was no significant difference in growth performances, there was a beneficial effect of 3 phase feeding. The ADG was higher in 3P treatment than other treatments and it was observed clearly in late period (3-4 weeks) than in early period. Also, with increase in age, growth rate of pigs in 3P treatment was higher than that in 1P treatment approximately 37% (p=0.1379). There were no significant differences among all treatments in nutrient digestibility. The concentration of BUN was higher in pigs were fed diet containing 21% crude protein and 1.45% lysine (eg, 2P-1 and 3P) than those supplied diet containing high nutrient value at 2 week. The lowest feed cost/kg weight gain of pigs showed in 3P among treatments (p<0.05) whereas, high feed cost/kg weight gain of pigs was calculated in 1P and 2P-II treatments compared with 2P-I and 2 P-II (p<0.05), because of high milk products were used in those diet.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.1
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• pp.31-38
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• 2019

Cheongpyesagan-tang (CP) is one of the traditional medicinal prescription to treat Taeumin (太陰人)'s disease. It has been commonly used for the treatment of stroke, arthritis, diabetes and obesity. In this study, we investigated an anti-inflammatory potential of CP water extract. We examined the effects of CP on the lipopolysarccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$). We also examined the levels of protein or mRNA of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and proinflammatory cytokines in RAW 264.7 cells. CP inhibited NO and $PGE_2$ production in a dose dependent manner and decreased the protein and mRNA expression of iNOS and COX-2. Also, CP decreased the mRNA expression of interleukin-6 (IL-6), interleukin-$1{\beta}$ (IL-$1{\beta}$), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$). These results suggest that CP has potential as anti-inflammatory therapeutic medicine.

• Journal of electromagnetic engineering and science
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• v.19 no.1
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• pp.37-41
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• 2019

A stack-ring configuration is proposed for designing a dual-band circularly polarized (CP) antenna. Each ring generates different resonant frequencies. A good CP performance at both resonant frequencies is achieved by adjusting the relative distance between the two rings. The two operating bands are separated with a small frequency ratio of 1.07. Measured results show that radiation patterns with good CP characteristics are obtained at the two resonant frequencies.

• Korean Journal of Poultry Science
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• v.36 no.1
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• pp.57-67
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• 2009

These studies were conducted to investigate the various dietary CP and ME feeding effect on productivity, blood composition and meat quality in cross bred chicks. Seven hundred twenty one day old cross bred chicks (Hanhyup Samho) were alloted to the floor pen for early starting (0~2 weeks), starting (3~5 weeks), growing (6~8 weeks), finishing period (9~10 weeks). Dietary ME and CP were 3,000, 3,100 kcal/kg, and 22% for early starting period, 19, 20, 21% for starting period, 18, 19, 20% for growing period, 17, 18, 19% for finishing period. Weight gain and feed consumption were weekly measured and feed conversion ratios were calculated. Blood and breast meat were collected at the end of experiment. Birds fed ME 3,100 kcal/kg diets improved significantly compared with others for the first two weeks (P<0.05). Feed conversion was statistically improved in CP (22)21% treatment relative to that of CP (22)20% from three to five weeks of age. No difference were found from 6 to 8 weeks of age. Weight gain and feed conversion also improved in ME 3,100 kcal/kg treatments, but feed intake decreased significantly in CP ($22{\times}21{\times}20$)19% treatment for the rest of experimental period (P<0.05). There was interaction between ME and CP for the first five weeks (P<0.05). Blood total protein showed higher in ME 3,100 kcal/kcal treatment than ME 3,000 kcal/kg (P<0.05). There were no differences in albumin, total cholesterol and glucose, but CP ($22{\times}20{\times}19$)18 treatment showed higher glucose than other treatments (P<0.05). Cooking loss, tenderness and water holding capacity were not different. However, pH was dependent on dietary ME, CP and existing the interaction between ME and CP treatments (P<0.05). As the results of this experiment, ME and CP were confirmed the 3,000 kcal/kg, 22% for the first two weeks 3,100 kcal/kg, 21% from three to five weeks of age, 3,100 kcal/kg, 18% for the growing period, 3,100 kcal/kg, 17% for the rest of period. However, further research would be required to confirm more optimum dietary nutrition for cross bred chicks.