• Title/Summary/Keyword: $CCl_{4}$

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Variation of Thermal Resistance of LED Module Embedded by Thermal Via (Thermal Via 구조 LED 모듈의 열저항 변화)

  • Shin, Hyeong-Won;Lee, Hyo-Soo;Bang, Jae-Oh;Yoo, Se-Hoon;Jung, Seung-Boo;Kim, Kang-Dong
    • Journal of the Microelectronics and Packaging Society
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    • v.17 no.4
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    • pp.95-100
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    • 2010
  • LED (Light Emitting Diode) is 85% of the applied energy is converted into heat that is already well known. Lately, LED chips increasing the capacity as result delivered to increase the heat of the LED products and module that directly related to life span and degradation. Thus, in industry the high-power LED chip to control the heat generated during the course of the study and the existing aluminum, copper adhesives, and uses MLC (Metal clad laminate) structures using low-cost FR4 and copper CCL (Copper Clad Laminate) to reduce costs by changing to a study being carried out. In this study, using low-cost CCL Class, mounted 1W LED chip to analyze changes in the thermal resistance. In addition, heat dissipation in the CCL to facilitate a variety of thermal via design outside of the heat generated by the LED chip to control and facilitate the optimal structure of the heat dissipation is suggested.

Effect of Water Extract in Fruits of Omija (Schizandra chinensis Baillon) on $CCI_4$ Toxicity ($CCl_4$ 독성에 미치는 오미자 열매의 물추출물의 효과)

  • Lee, Joung-Sook;Lee, Sung-Woo
    • Journal of the Korean Society of Food Culture
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    • v.5 no.2
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    • pp.253-257
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    • 1990
  • The effect of water extract in fruits of Omija (Schizandra chinensis Ballion) on liver function in expermental liver injuries induced by $CCl_4$. The levels of GPT, GOT activities in serum were decreased apparently on the dosage of water extract in fruits of Omija correspond to raw Omija 1g compared to control group. The levels of Microsomal protein, glycogen, and pyruvate in liver and of Urea nitrogen, GPT, GOT, LDH in serum showed a trend toward restoration of normalization. No effective of levels of hepatic G6P DH activity and serum free fatty acid by water extract in fruits of Omija.

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Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXVIII) -Effect of Gamiinjinoryung-San on Hepatic Damage- (생약복합제제의 약효연구(제38보). -가미인진오령산이 실험적 간장해에 미치는 영향-)

  • Hong, Nam-Doo;Kim, Byung-Woon;Kim, Nam-Jae;Sim, Jae-Ok
    • Korean Journal of Pharmacognosy
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    • v.19 no.4
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    • pp.270-277
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    • 1988
  • Gamiinjinoryung-San is composed of eight crude drugs including Artemisiae capillaris Herba which is widely used for the treatment of acute jaundice, acute and chronic hepatitis at the Oriental hospital of Kyung-Hee Medical Center. This study was conducted to investigate the effects of water extract of Gamiinjinoryung-San on the liver function. The results obtained were as follows; the extract markedly reduced LDH and ALP activities, but slightly decreased GOT and GPT activities elevated with D-galactosamine in rat serum. The liver protective activities were shown in $CCl_4-intoxicated\;rats$. The extract prevented the prolongation of sleeping time in $CCl_4-intoxicated\;rats$. The bile flow and the biliary bile acid secretion were significantly increased in normal rats.

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The Protective Effect of Bifidobacterium breve K-110, K-111 and B. infantis K-525 on Carbon Tetrachloride-induced Hepatotoxicity in Rats (Bifidobacterium breve K-110, K-111 및 B. infantis K-525 균주의 사염화탄소 유발 간독성 보호 효과)

  • Park, Hae-Young;Han, Myung-Joo;Choi, Eung-Chil;Kim, Dong-Hyun
    • Korean Journal of Food Science and Technology
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    • v.31 no.4
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    • pp.1096-1100
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    • 1999
  • The protective effect of Bifidobacterium breve K-110, K-111 and B. infantis K-525 on carbon tetrachloride induced hepatotoxicity in rats was investigated. Among them, B. infantis K-525 had the most potent hepatoprotective activity. It reduced serum aspartate aminotransferase and alanine aminotransferase levels to 51% and 80% of the $CCl_{4}-treated$ groups, respectively. In rat liver homogenate intoxificated with $CCl_{4}$, B. infantis K-525 inhibited in vitro as well as in vivo lipid peroxidation more than the other Bifidobacteria.

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Effect of Injinho-tang on the Liver and Hyperlipidemia (인진호탕(茵蔯蒿湯)이 손상간(損傷肝) 및 고지혈증(高脂血症)에 미치는 영향(影響))

  • Oh, Young-Sun;Cho, Chong-Kwan
    • Journal of Haehwa Medicine
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    • v.5 no.1
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    • pp.199-204
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    • 1996
  • In order to investigate the effect of Injinho-tang on liver treated with CCl4, galactosamine, thioacetamide and hyperlipidemia induced by fructose, triton wr-1339, this experiment was performed. The results are as followings. 1. Injinho-tang decreased the serum TG and TC level in normal rats. 2. Injinho-tang decreased significantly the serum TG level induced by 75% Fructose. 3. Injinho-tang depressed significantly the serum TG and TC level in hyperlipidemia induced by Triton WR-1339. 4. The silymarin-Injinhotang group decreased more significantly the serum GOT, GPT, TC, TG level in comparison to the Injinho-tang treated group in CCl4, galactosamine and thioacetamide treated mice, rats.

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Modification of C2,3,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects

  • Jeong, Byeong-Seon;Kim, Young-Choong;Lee, Eung-Seok
    • Bulletin of the Korean Chemical Society
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    • v.28 no.6
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    • pp.977-982
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    • 2007
  • For the development of novel hepatoprotective agents, C2, C3, C23 and C28 functional groups on asiatic acid were modified, and the prepared compounds were evaluated for their hepatoprotective effects. Among the prepared compounds, 9, 13 and 16 showed significant hepatoprotective activities against CCl4- and galactosamine (GaIN)-induced hepatotoxicity. Especially, compound 9 showed the most significant hepatoprotective effects against GaIN-induced hepatotoxicity (66.4% protection at 50 μM) and moderate hepatoprotective activities against CCl4-induced hepatotoxicity (20.7% protection at 50 μM).

Protective Effects of Angelica tenuissima Nakai on Hepatotoxicity by Carbon Tetrachloride in Rats (사염화탄소에 의한 간손상에 미치는 고본의 보호작용)

  • 정춘식;정기화
    • Biomolecules & Therapeutics
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    • v.10 no.4
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    • pp.211-217
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    • 2002
  • Hepatoprotective activity of methanol extract of Angelica tenuissima Nakai on the $CCl_4$-induced hepatotoxicity was investigated. To elucidate the hepatoprotective activity and free radical scavenging effect, we examined alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total protein, cholesterol, malondialdehyde (MDA) levels in serum and activities of superoxide dismutase (SOD), catalase (CAT) in hepatic tissue as compared with those of carbon tetrachloride-induced rats. The action mechanism also has been estimated by quantative analysis of cytochrome P450 (CYP), NADPH-CYP reductase for phase I metabolism and glutathion (GSH), glutathion S-transferase (GST) level for phase II metabolsim. Treatment of Angelica tenuissima methanol extract significantly lowered the levels of alanine aminotransferase and aspartate aminotransferase. In addition, the levels of cholesterol, triglyceride, MDA, CAT were decreased, and SOD was activated. This result indicates that the hepatoprotective effect of Angelica tenuissima methanol extract on the CCl4-induced hepatotoxicity would be originated from reduction of the NADPH-CYP reductase, GSH and the enhancement of the activities of GST, CYP.