• 대한한방내과학회지
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• 제25권1호
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• pp.28-45
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• 2004

Objectives : The main purpose of this study is to evaluate the effect of Injinchunggan-tang on $TNF-{\alpha}$ signal transmission system. Materials and Methods : We analyzed the following with quantitative RT-PCR method; the effect of Injinchunggan-tang on secretion of $TNF-\alpha$ mRNA/protein and stability, the effect on gene revelation that consists of signal transmission system (TRAIL, NIK, A20, TRADD, RAIDD, RIP TNFR-I, TNFR-II, TRAF1, TRAF2, FADD), the one on activation of p38, Erk1/2 MAPK and the rate of nuclear $NF-{\kappa}B/cytosolic\;NF-{\kappa}B$ in HepG2 cell. We also analyzed the inhibitory effect of Injinchunggan-tang on the apoptosis of HepG2 cell that $TNF-{\alpha}$ induces and the $NF-{\kappa}B$ restraint effected by transfection of $I{\kappa}B{\Delta}N$ through tryphan blue exclusion assay. Results : Injinchunggan-tang prohibits revelation of $TNF-{\alpha}$ mRNA in HepG2 cell and the creation of protein. However, it has no effect on the stability of $TNF-{\alpha}$ mRNA. While it did not have any effect on the generation of TRAIL, NIK, A20, TRADD, RAIDD and RIP genes, Injinchunggan-tang reduces the revelation of TNFR-I, TNFR-II, TRAF1, TRAF2 and FADD genes. It has been confirmed that Injinchunggan-tang restraints the revelation of $TNF-{\alpha}$ mRNA that is promoted by ethanol, acetaldehyde, lipopolysaccharide, in proportion to the treatment density and time. It activated $NF-{\kappa}B$ of HepG2 cell and promoted activation of $NF-{\kappa}B$ that is occurred by $TNF-{\alpha}$. It has been observed that the restraint effect against the $TNF-{\alpha}$ inducing apoptosis is lost when it is intercepted the function of $NF-{\kappa}B$ in HepG2 cell. Conclusion: It has been confirmed that Injinchunggan-tang has restraining effect against the revelation of $TNF-{\alpha}$ and mRNA that is constituent element of TNF-a signal transmission system. It also has been revealed that it restraints the activation of p38, Erk1/2 by $TNF-{\alpha}$. Through this prohibiting effect, it is inferred that it restraints signal transmission among various cells that are related to inflammation reaction. Meanwhile, Injinchunggan-tang protects liver cell from apoptosis that is caused by $TNF-{\alpha}$, by maintaining the activating function for $NF-{\kappa}B$.

• 한국전산유체공학회지
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• 제18권1호
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• pp.28-35
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• 2013

Behavior of the side force generated at high angles of attack by two ogive-cylinder bodies of revolution with nose fineness ratio of 2.3 (B1) and 3.5 (B2) and the effect of a strip placed close the nose tip of each body (B1S and B2S) are analyzed through the wind tunnel test at ReD=200,000 and a=42~60 deg. The side force generated by B1 is increased by placing a strip. The side force generated by B2 is in the starboard direction and its magnitude is higher than that of the B1S. The effect of the strips with various dimensions placed on B2 is investigated. It is found that the 4-layer strip placed on the starboard reversed the direction of the side force into port direction. It is confirmed by numerical simulations that the strip promotes the flow separation and increases the average pressure on the side where it is placed and consequently produces the side force in the corresponding direction.

• 한국산업정보학회논문지
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• 제5권2호
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• pp.22-31
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• 2000

B-ISDN 환경의 VB5.2 인터페이스는 B-BCC 프로토콜을 이용하여 액세스 망과 서비스 노드 사이에서 ATM 자원의 동적인 할당 및 해제 기능을 제공한다. 본 논문에서는 액세스 망의 도입으로 인한 연결 선정 지연을 향상시키기 위하여 VB5.2 인터페이스의 B-BCC 프로토콜을 개선시킨 B-ANCC 프로토콜과 서비스 노드에서 VS5.2 인터페이스의 연결 제어 프로토콜이 신호 프로토콜과 병렬형으로 연동하는 모델을 제안하였다. 본 논문에서 제안한 B-ANCC 프로토콜의 정확성을 확인하기 위하여 자동 도구인 SPIN을 이용하여 검증하였으며, 큐잉 모델 분석과 시뮬레이션을 통하여 B-BCC 프로토콜 기반의 순차형 연동 모델과 B-ANCC 프로토콜 기반 병렬형 연동 모델의 연결 설정 지연 및 완료비에 대한 비교, 분석을 수행하였다. 분석 결과 VB5.2 인터페이스의 연결 제어 프로토콜로 B-BCC 대신 B-ANCC를 사용하고 병렬형 연동 방식을 사용함으로써, 연결 설정 지연과 완료비 모두를 향상시킬 수 있음을 알 수 있었다.

• 한국음향학회지
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• 제20권5호
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• pp.76-82
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• 2001

음향특성이 균일하지 않는 생체조직은 특정의 형태 유지가 어렵기 때문에 종래의 극소형 수중청음기의 스캐닝 방법에 의한 초음파 음장 전파특성 측정이 곤란하다. 본 연구에서는 PVDF (Polyvinylidene fluoride) 압전막을 사용하여 2차원 배열 수중청음기를 제작하고, 그것에 의한 음장 측정 시스템을 구축한 후, 생체조직에 적용하였다. 중심주파수 2.25 ㎒이고 직경이 13㎜인 원형평면 트랜스듀서에 의한 실험 결과, 구축한 시스템에 의해 비교적 정밀한 음장 측정이 가능한 것을 알았으며, 그 주파수에 대해 소와 돼지의 간에서는 각각 0.7∼l.3dB/cm (평균; 1.0 dB/cm), 1.0∼l.8 dB/cm (평균; 1.6 dB/cm), 근육에서는 각각 0.9∼2.9 dB/cm (평균; 2.1dB/cm), 1.7∼3.3 dB/cm (평균: 2.5 dB/cm)의 값을 갖는 감쇠계수의 공간적 분포를 측정할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제11권3호
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• pp.482-490
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• 2001

The gene for glycoprotein B (gB2) of HSV-2-strain G was subcloned, sequenced, recombinated into the lacZ-HcNPV, expressed in insect cells, and compared with the homologous gene of other HSV-2 strains. The ORF of the gB2 gene was 2,715 bp. The overall nucleotide sequence homology of te gB2 gene compared ith that of the two previously reported HSV-2 strains appeared to be over 98%. A recombinant virus named Baculo-gB2 protein in insect cells. The recombination was confirmed by a PCR and the expression was demonstrated by radio immunoprecipitation. Insect cells infected with the Baculo-gB2 virus synthesized and processed gB2 with approximately 120 kDa in the cells, and then secreted it into the culture media, where it reacted with a nomoclonal antibody to gB2. The gB2 polypeptide contained two main hydrophobic regions (a signal sequence from 1 to 23 amino acid residues, and a membrane anchor sequence from aa 745 to 798), eight N-glycosylation sites evenly distributed, and was rich in alanine (11.2%). Antibodies to this recombinant protein that were raised in mice recognized the viral gB2 and neutralized the infectivity of the HSV-2 in vitro. There results show that the gB2 protein was successfully porduced in insect cells and could be used to raise a protective neutralizing antibody. Accordingly, this particular recombinant protein may be useful in the development of a subunit vaccine.

• 인터넷정보학회논문지
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• 제20권1호
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• pp.57-65
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• 2019

200 만명 이상의 회원을 보유하고 있는 "도매꾹" B2B 온라인 쇼핑몰인 경우70% 이상의 시장 점유율로 하루에 80만개 이상의 아이템이 판매되고 있다. 하지만, 동일하거나 유사한 물품이 서로 다른 카탈로그 엔트리에 저장 및 등록되어 있기 때문에 구매자가 아이템을 검색하는 과정에서 어려움을 느끼며 B2B 대형 쇼핑몰 관리에도 문제점이 발생하고 있다. 따라서 이에 대한 해결 방안으로 본 연구에서는 대단위 쇼핑몰 구매 정보를 기반으로 지도-학습 머신러닝 기법을 적용하여 상품에 대한 카탈로그 목록 자동 분류 및 추천 시스템을 개발하였다. 구체적으로 판매자가 자연어 형태로 물품 등록 정보를 입력하면 KoNLPy 형태소 분석 과정을 수행하였으며, Naïve Bayes 분류 방식을 응용하여 물품에 가장 적합한 카탈로그 정보를 자동으로 추천해주는 시스템을 구현하였다. 정확도가 향상된 카테고리 목록을 구축하여 결과적으로 검색 속도와 쇼핑몰 매출을 향상시키는 효과가 있었다.

• Journal of applied mathematics & informatics
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• 제31권5_6호
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• pp.669-676
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• 2013

Let $a$ and $b$ be two even integers with $2{\leq}a<b$, and let k be a nonnegative integer. Let G be a graph of order $n$ with $n{\geq}\frac{(a+b-1)(a+b-2)+bk-2}{b}$. A graph G is called an ($a,b,k$)-critical graph if after deleting any $k$ vertices of G the remaining graph of G has an [$a,b$]-factor. In this paper, it is proved that G is an ($a,b,k$)-critical graph if $${\mid}N_G(X){\mid}&gt;\frac{(a-1)n+{\mid}X{\mid}+bk-2}{a+b-1}$$ for every non-empty independent subset X of V (G), and $${\delta}(G)>\frac{(a-1)n+a+b+bk-3}{a+b-1}$$. Furthermore, it is shown that the result in this paper is best possible in some sense.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2002년도 추계학술대회
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• pp.334-341
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• 2002

본 연구는 기업간 전자상거래 수용에 영향을 주는 요인을 밝혀내고 실증적으로 분석하고자 하는데 목적이 있다. 기존 기술수용모형(TAM) 기반 연구는 수용의사결정 수준이 개인 단위에 국한되었으며, 영향요인도 인지된 혁신특성인 경우에 비해 본 연구에서는 i) 인지된 이익 ii) 조직의 준비 iii)외부 압력 등 세 관점에서 살펴보았다. 37 개 업체를 대상으로 실증 분석한 결과 인지된 이익, 조직의 준비 및 외부압력은 모두 B2B EC 수용에 영향을 미치는 것으로 밝혀졌다.

• 한국전자파학회논문지
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• 제16권2호
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• pp.139-143
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• 2005

본 논문에서는 $CMOS\;0.18\;{\mu}m $ 공정을 이용하여 MB-OFDM UWB용 RF 수신기의 광대역 LNA와 Down-mixer를 설계하였다. 광대역 LNA는 $3\~5\;GHz$의 대역에서 전력이득은 $12.8\~15dB$, 잡음지수는 2.6 dB 이하, 그리고 입력 IP3는 4 GHz에서 -8 dBm의 특성을 나타내고, 입출력 반사손실은 10 dB 이하의 특성을 보인다. Down-mixer는 3개의 채널에서 2 dB 이하의 gain flatness를 나타내고, 변환이득은 $-2.9\~0.4dB$의 특성을 나타낸다. 또한 LO의 leakage와 feedthrough는 각각 30 dB 이상의 특성을 나타내도록 설계하였다.

• 대한한의학방제학회지
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• 제9권1호
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• pp.215-230
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• 2001

The purpose of this study was to investigate the effect of Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) and its component groups on diabetes in alloxan induced diabetic rats. Sprague-Dawley male rats weighing $200{\pm}10\;gm$ were randomly assigned to one normal, one control and five experimental groups. The experimental groups was classified into to Bojungikgitang(B1 group), Soeumin bojungikgitang(B2 group), Bogihyulyak(B0 group), Siho-sengma(B1+ group) and Gwakhyang- soyeup(B2+ group). Diabetes was experimentally induced by abdomenal injection of 100 mg/kg of body weight of alloxan. Animals were sacrificed at the 6th day and 11th day of diabetic states. The results were obtained as follows: In carbohydrate metabolism, the level of glucose in control group was three-fold higher after alloxan injection than that of normal group. In B1, B2 groups the level of glucose was decreased by 39% and 43% compared with that of control group, and in component groups it was decreased by 73%, 81%, and 80% respectively. In fat metabolism, the level of triglyceride and total cholesterol in serum were lower in B1 and B2 groups with high significant difference and had similar tendency in components groups compared with that of control group. The level of HDL cholesterol on serum were increased in B1 and B2 group with significant difference. And in component group it had similar tendency compared with that of control group. In protein metabolism, the level of total protein and albumin were higher in B1 and B2 group with significant difference, and in component group also increased but with no significancy compared with control group. In kidney function, the level of creatinine group with significant difference, and other compared with control group. In liver function, the level of GOT, GPT, ${\gamma}$-GTP. ALP and bilirubin were lower in B1 and B2 group with significant difference, and in component had similar tendency compared with control group. But in the level of LDH, it was decreased with no significancy. These results indicate that Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) has strong effect on diabetes and it is useful to prevent diabetes, and in component groups the difference between B1+ and B2+ group was not significant.