• Korean Journal of Clinical Pharmacy
• /
• v.28 no.3
• /
• pp.204-215
• /
• 2018

Background: In this systematic review and meta-analysis, the effect of metformin on weight loss was assessed to determine whether metformin should be recommended for the prevention or treatment of weight gain in patients receiving antipsychotic medication for the treatment of schizophrenia or schizoaffective disorder. Methods: The PubMed, Embase, and Cochrane Library databases were searched for all published randomized controlled trials (RCTs) from inception to June 2018. In addition, the references of relevant articles were also examined. Using Review Manager 5, the pooled estimates of the weighted mean difference (WMD) of the changes in body weight and body mass index (BMI) and the corresponding 95 % confidence intervals (CIs) were calculated. Results: The meta-analysis included 15 RCTs. The pooled analysis showed that compared with placebo, metformin led to significant reductions in body weight (WMD: -2.09, 95% CI: -2.59, -1.60; p<0.00001) and BMI (WMD: -0.90, 95% CI: -1.08, -0.72; p<0.00001). The effect of metformin on weight loss was greater in patients receiving olanzapine than in patients receiving clozapine (body weight, WMD: -2.39, 95% CI: -3.76, -1.02; p=0.0006 for olanzapine; -1.99, 95% C: -3.47, -0.51; p=0.009 for clozapine; BMI, WMD: -1.15, 95% CI: -1.74, -0.57, p=0.0001 for olanzapine; WMD: 0.76, 95% CI: -1.23, -0.28; p=0.002 for clozapine). Conclusion: Metformin can be recommended to manage olanzapine-induced weight gain in patients with schizophrenia or schizoaffective disorder. The magnitude of the reductionss in body weight and BMI implieds that the use of metformin to attenuate olanzapine-induced weight gain can minimize the risk of coronary heart disease.

• Journal of the Korea Convergence Society
• /
• v.9 no.4
• /
• pp.313-320
• /
• 2018

This study was conducted to establish the effects of subjective body-forming perception on weight-controlling behavior and weight loss, and to suggest the need for proper information and education. Using the data from the National Health and Nutrition Examination Survey conducted in the 6th period (2013-2015), 6,238 women aged 19 and over who have a body mass index of $18.5-25kg/m^2$ were analyzed. As a result, the higher the level of education and income level, the higher they were perceived to be obese, the more they chose to lose exercise and diet in order to lose weight across the board. The weight loss effort rate was higher in the obese body type recognition group, but the body weight type was the highest in the one year body weight change group (p < .001). As a result, subjective perception of body shape affected not only weight control behavior but also weight change (p < .001). Accordingly, it is necessary to have a systematic education on healthy weight-controlling behaviors, proper body image, and healthy body type recognition.

• Journal of Nutrition and Health
• /
• v.28 no.8
• /
• pp.759-770
• /
• 1995

This study was conducted to investigate the effect of weight control by use of commercial formula diet and nutrition education on 36 obese women over a period of 6 months. During the study it motivated ways for women to control their weight and improve their health, thus analyzing variables that influence weight control. To help weight control, for the first 3 weeks, along with 1 regular mea, 2-3 liquid formula diets of 135㎉ per pack a day were provided within the 1,200-800㎉ range. For 6 months since then, all 3 meals were taken regularly and it was recommended that energy which is 500㎉ less than energy requirement be taken. To evaluate the effect of weight change by the weight control program, anthropometric measurements, biochemicl parameter, and food behavior are measured. The mean body mass index(BMI) was 30.1$\pm$3.8(25.0-43.6) and it was in the upper 5 percentile of the mean BMI of Korean women. The percent of body fat was significantly reduced from 29.1$\pm$2.4 to 26.4$\pm$2.3, showing that the weight control program induced not only a change in weight but also a change in body composition. The body circumference such as waist and hip circumference and skinfold thickness measurements of biceps, triceps, subscapular and surprailiac were reduced significantly, but the mean waist-to-hip ratio didn't change. Singnificantly improved food behavior score measured by the questionnaire indicated that the weight-contorl program induced the change of the food behavior, as well. Weight loss also induced biochemical parameters of the subject, thus total cholesterol, LDL-Cholesterol, and triglycerol which were in the high range of the normal values were reduced to 20.2%(p<0.01), 22.2%(p<0.01), 25.8%(p<0.01), repectively. HDL-cholesterol didn't change significantly, but the ratio of HDL to total cholesterol increased(p<0.01).

• The Journal of Korean Medicine
• /
• v.45 no.1
• /
• pp.65-79
• /
• 2024

Objectives: The purpose of this study is to evaluate weight change and analyze adverse events in post-menopausal obese women with Gamitaeeumjowee-tang for weight loss. Methods: A retrospective chart review was conducted for medical records of 115 post-menopausal obese women (body mass index, BMI≥25 kg/m²) who were administered with Gamitaeeumjowee-tang for 12 weeks for the purpose of weight loss. Weight, skeletal muscle ratio and BMI changes were compared before and after the program. Adverse events were evaluated by causality, severity and system-organ classes. Results: A total of 115 patients were included in this study. The average total weight loss in post-menopausal women was 5.72±2.04kg(p<0.001) and the average weight loss rate was 8.06±2.70%(p<0.001). After the 12-week program, the body fat rate was significantly decreased(3.76±2.20%)(p<0.001) and the skeletal muscle ratio was significantly increased(2.07±1.24%)(p<0.001). There were no significant differences in weight loss, skeletal muscle ratio change and body fat rate change depending on the number of hospital visits. Insomnia was frequently reported throughout the period, and no serious adverse events were reported. Conclusions: This study showed the potential that weight management treatment with Gamitaeeumjowee-tang could be a good way to lose weight of post-menopausal obese women without serious adverse events. Continuous well designed clinical studies are needed.

• Asian-Australasian Journal of Animal Sciences
• /
• v.24 no.2
• /
• pp.279-284
• /
• 2011

The objective of this study was to evaluate the effects of storage temperature and time on the quality parameters of eggs from laying hens at peak production. A total of 576 eggs were obtained from Lohmann Light-Brown hens, which were collected 3 times when the hens were 26, 27, and 28 weeks old. The fresh eggs were collected and measured within 2 h of being laid. Samples of 48 eggs each were stored in chambers for 2, 5, or 10 d inside a refrigerator ($5^{\circ}C$), at room temperature ($21^{\circ}C$), and at a high temperature ($29^{\circ}C$). As the storage temperature and time increased, egg weight, percentage of albumen, Haugh unit (HU), and yolk color significantly (p<0.001) decreased. In addition, egg shell weight, shell percentage, and albumen weight significantly (p<0.001) decreased with storage time. Yolk weight, yolk percentage, and albumen pH significantly (p<0.001) increased with increasing storage temperature, and yolk pH significantly (p<0.001) increased with increasing storage time. When the storage temperature was increased to $29^{\circ}C$, egg weight loss dramatically increased from 1.74 to 3.67% at 5 and 10 d of storage time, respectively. With the exception of the $5^{\circ}C$ storage temperature, HU dramatically decreased according to storage time and temperature, decreasing from 91.3 to 72.63 at $21^{\circ}C$ and from 87.62 to 60.92 at $29^{\circ}C$ during 10 d of storage; however, this decline was not found at $5^{\circ}C$. A rapid increase in albumen alkalinity was observed even after just 2 d of storage regardless of the storage temperature. Interactions between storage time and temperature were significant (p<0.001) with respect to egg weight loss, egg shell weight and percentage, albumen weight and percentage, yolk weight and percentage, albumen and yolk pH, HU, and yolk color. The results of the current study indicated that eggs from laying hens at peak production had significant deterioration of internal quality with increasing storage temperature and time. The results suggest that egg weight loss, albumen pH, and HU are parameters that are greatly influenced by the storage temperature and time of eggs from hens at peak laying.

• Journal of Korean Academy of Nursing
• /
• v.40 no.5
• /
• pp.676-685
• /
• 2010

Purpose: The purpose of this study was to examine the factors affecting eating attitude of female undergraduates according to BMI. Methods: A descriptive survey design with a convenience sampling was used and data collection was done using a self-report questionnaire answered by 406 female undergraduates from four universities located in Seoul, Kangwon, Gyeongsangbuk and Chungcheongnam Provinces. ANOVA, Pearson correlation coefficients, and hierarchial multiple regression were used the SPSS WIN 17.0 Program to analyze the data. Results: With respect to BMI, the students were found to be in 3 groups, whose differences in eating attitude were significant. Eating attitude had significant positive correlation with height (r=.118, p=.017), weight (r=.267, p<.000), BMI (r=.239, p<.001), and depression (r=.375, p<.001), and negative correlation with subjective well-being (r=-.153, p=.002) and body esteem (r=-.287, p<.001). In the hierarchial multiple regression analysis, college major, height, weight and religion, were controlled. Depression and body esteem regarding weight significantly predicted 40.7% of eating attitude for the underweight group and normal weight group, body esteem: weight and depression were significant predictors for 27.5% of eating attitude for the normal weight group. Body esteem: weight explained 32.6% of eating attitude for the overweight group. Conclusion: Findings of this study allow a comprehensive understanding of eating attitudes and related factors among female undergraduates in Korea. Further study with a larger random sample from various universities is necessary.

• Neonatal Medicine
• /
• v.15 no.1
• /
• pp.38-43
• /
• 2008

Purpose : The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth. Methods : Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI). Results : The mean cord serum APN was 29.2${\pm}$10.46 $\mu$g/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26${\pm}$21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI. Conclusion : APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.

• Journal of Adhesion and Interface
• /
• v.11 no.3
• /
• pp.89-99
• /
• 2010

In this paper, for polymerization of poly(vinyl acetate-co-ethylene) (VAE) by redox system using poly(vinyl alcohol) (PVOH) as emulsifier on the properties of the final emulsion, and pH changes affect the physical properties of the final emulsion was investigated. The results of the molecular weight of PVOH had a dramatic impact on the emulsion properties. The used a low molecular weight of PVOH products was obtained low viscosity and using the high molecular weight of PVOH were obtained high viscosity product. However, changing the pH of the final polymerized product properties for the PVOH obtained different results. Generally, a poly(vinyl acetate) emulsion by a high degree of polymerization and high molecular weight of PVOH was obtained high viscosity of the final emulsion. But, in VAE was lower emulsion viscosity in high pH. This is the molecular weight of the emulsion during the synthesis of PVOH is considered to be affected by degradation. The final viscosity was decreased by grafting ratio and molecular weight were decreased with increasing of pH.

• Journal of The Korean Society of Integrative Medicine
• /
• v.3 no.2
• /
• pp.73-78
• /
• 2015

Purpose: This study was conducted to investigate out the effects of power by body application of weight training that can increase vertical jump, standing long jump, and medicine ball throw that are important factors for power ability. Methods: Sixteen in normal adult were participated in this study. The subjects were divided into the upper limb weight training group(N=16), the lower limb weight training group(N=16) and they exercised during a four-week period of time, three times a week, 70 minutes each, and the each group did take part in any exercise program. To evaluate the changes in power were measured by using the vertical jump, standing long jump, and medicine ball throw. The data was analyzed with a SPSS 18.0 program. Results: The results showed that the vertical jump, standing long jump were significantly increased in the upper limb weight training group(p<.01) and medicine ball throw was significantly increased in the both group(p<.05). However, there were that showed not significantly differences in all power items between two groups after experiment(p>.05). Conclusion: It was concluded that the weight training were effective in enhancing the power ability. Also, can be considered effective the better lower limb weight training group than upper limb weight training group.

• Research in Community and Public Health Nursing
• /
• v.32 no.2
• /
• pp.140-149
• /
• 2021

Purpose: This study aimed to identify factors (biological, psychological, interpersonal, and contextual factors) associated with the weight bias internalization of the Korean girls in early adolescence. Methods: This study used a cross-sectional design. Data was collected from 233 girls aged 12~14 years with a self-reported questionnaire. With multiple regression analysis, the factors associated with the weight bias internalization of the girls in early adolescence were analyzed. Results: Of psychosocial factors, fear to fat (anti-fat attitude) (β=.43, p<.001) was associated with the weight bias internalization of the girls in early adolescence. In addition, attachment with teachers (β=-.11, p=.029) of an interpersonal factor and perceived socio-cultural pressure regarding weight control (β=.34, p<.001) of a contextual factor were associated with the weight bias internalization of the girls in early adolescence. Conclusion: For releasing the weight bias internalization of the girls in early adolescence, decreasing anti-fat attitude and socio-cultural pressure regarding weight control should be primarily required through social efforts including community and school based interventions.