• Journal of the Korean Operations Research and Management Science Society
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• v.31 no.1
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• pp.91-103
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• 2006

Given a bill of materials (BOM) tree T labeled by the breadth first search (BFS) order from node 0 to node n and a general network ${\Im}=(V,A)$, where V={1,2,...,m} is the set of production facilities and A is the set of arcs representing transportation links between any of two facilities, we assume that each node of T stands for not only a component. but also a production stage which is a possible stocking point and operates under a periodic review base-stock policy, We also assume that the random demand which can be achieved by a suitable service level only occurs at the root node 0 of T and has a normal distribution $N({\mu},{\sigma}^2)$. Then our integrated model of facility location problems and safety stock optimization problem (FLP&SSOP) is to identify both the facility locations at which partitioned subtrees of T are produced and the optimal assignment of safety stocks so that the sum of production cost, inventory holding cost, and transportation cost is minimized while meeting the pre-specified service level for the final product. In this paper, we first formulate (FLP&SSOP) as a nonlinear integer programming model and show that it can be reformulated as a 0-1 linear integer programming model with an exponential number of decision variables. We then show that the linear programming relaxation of the reformulated model has an integrality property which guarantees that it can be optimally solved by a column generation method.

• Sleep Medicine and Psychophysiology
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• v.20 no.1
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• pp.35-40
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• 2013

Objectives: The aim of this study is to evaluate the polysomnographic characteristics and prescription status of restless legs syndrome (RLS) patients in naturalistic setting. Methods: We reviewed medical record of the patients over 18 years olds who (i) satisfied the clinical RLS diagnostic criteria and (ii) had the polysomnography and got treatment related thereto. As a baseline, we evaluated the four diagnostic criteria of the International Restless Legs Syndrome Study Group (IRLSSG) and the International Restless Legs Scale (IRLS) of the subjects. Then the polysomnography and the suggested immobilization test (SIT) were conducted and, after one month of pharmacotherapy using dopamine agonist, the IRLS was evaluated again. Results: A total of 211 subjects participated in this analysis and 94 (44.5%) of them were male and the other 117 (55.5%) were female and the average age of the 211 subjects was $46.9{\pm}14.2$. Out of such 211 subjects, 136 subjects (64.5%) also had the obstructive sleep apnea (OSA), and 53 subjects (25.1%) also had the periodic limb movement disorder (PLMD). 185 subjects (87.7%) out of the 211 subjects had some other sleep disorders except RLS. The results of the polysomnography were as follows : 78.0% of sleep efficiency, 86.8 min of wake after sleep onset, and 3.4% of N3. More specifically, 12.4/h of the average apnea hypopnea index, 14.8/h of the periodic limb movement during sleep (PLMS), 41.2/h of the periodic limb movement during wake during SIT and 21.6/h of total arousal index during sleep. Out of the total subjects, 149 (70.6%) of them took the ropinirole and 47 (22.3%) of them took the pramipexole, and the average dosage of ropinirole was 0.9mg(dosage range 0.125-5 mg) while the average dosage of pramipexole was 0.5 mg (dosage range 0.125-4 mg). The dosage of the ropinirole showed a significant positive correlation with the age (r=0.25, p=0.002) and also with the IRLS (r=0.23, p=0.038). The IRLS at the baseline was 24.9 while the same was decreased down to 13.4 after one month. Conclusions: Analyzing the result of this study, a majority of clinical RLS subjects demonstrated comorbidity with some other sleep disorder such as the OSA or PLMD. 25.1% of the subjects showed a PLMD, which was less than in previous researches and the average PLMS was not very high as 14.8/h. The dosage of dopamine agonist taken was often a bit more than the amount recommended in Korea. A prospective research using a large scale controlled subjects will be necessary with respect to this topic.

• Membrane Journal
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• v.22 no.3
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• pp.171-177
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• 2012

Effect of humic acid (HA), photo-oxidation and adsorption with periodic $N_2$ back-flushing was investigated in hybrid process of ceramic ultrafiltration and photocatalyst for drinking water treatment. It was compared and investigated with the previous result at water back-flushing in viewpoints of membrane fouling resistance ($R_f$), permeate flux (J), and total permeate volume ($V_T$). As decreasing HA, $R_f$ decreased dramatically and J increased, and finally $V_T$ was the highest at HA 2 mg/L. As HA concentration increased from 2 to 10 mg/L, the membrane fouling resistance after 180 mins' operation ($R_{f,180}$) improved 0.8 times more than that of water back-flushing. Therefore, HA concentration should affect on the membrane fouling at $N_2$ back-flushing than water back-flushing. Turbidity treatment efficiencies were almost constant independent of HA concentration, but HA treatment efficiency was the maximum at HA 2 mg/L. This means that adsorption and photo-oxidation of photocatalyst beads could removed HA at HA 2 mg/L, but it was not enough at 4 mg/L. Beyond HA 6 mg/L, UF could effectively treat HA by thick cake layer on membrane surface and severe inner membrane fouling.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.12 no.3
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• pp.96-101
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• 2013

Automotive brake system is an essential element for the safety. The system is powered by the circulation of brake oil. A braker hose is used for the circulation of the oil in this system. Layout of the hose changes according to the steering and stress occur in the hose. A lot of the durability tests are performed in order to prevent serious problems such as hose bursting by the accumulation of the stress before setting an optimized hose layout on automobile. The test is conducted for the layout which is same such as set in automobile. In the test, brake hose layout shall exercise the same mode of thousands of times under the high temperature and periodic pressure condition and then the damage of the tested hose is inspected. This test, however, has a disadvantage of heavy consumption of time and money. In order to compensate for these drawbacks, the finite element method(FEM) study was performed to predict the changes in the layout of the brake hose. In this study, the FEM results and the test results were compared and the validity was verified. The radius of curvature of the FEM and test at the same positions were especially investigated for the validation. Also, this study will be used as the basis of research on the life prediction of brake hose.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.2
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• pp.184-188
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• 2001

In a summer study during May to July, involving 12 young Murrah buffalo bulls at forty months of average age, the effects of multiple shower vs single shower body cooling and vitamin A, D and E supplementation on the sexual behaviour, semen quality and freezability were investigated. The animals were divided into two groups (6 animals in each group) and housed in a half-walled shed with proper spacing, the feeding management being identical. The bulls in the control group were given a single shower at 1000 h, whereas the experimental bulls were given four showers at 10,12,14 and 16 h. In addition, the experimental bulls were given vitamin A, D and E injections at fifteen day intervals. The sexual behaviour of bulls was observed in terms of reaction time, sexual aggressiveness and ejaculatory thrust. Semen quality of all the bulls was assessed in terms of volume, mass activity, live-dead sperm and sperm concentration, sperm motility and morphology, and acrosomal abnormality. The sexual behaviour did not vary significantly between the groups, whereas semen quality differed significantly for volume, per cent live sperms, total sperms per ejaculate and total live sperm per ejaculate between groups. It can be concluded that sexual behaviour was not influenced by the thermal comfort treatment coupled with periodic vitamin A, D and E injections. But the treatments improved most of the seminal traits in the experimental group of bulls. However, benefit of treatment was not reflected in the freezability traits of the semen.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.127.1-127.1
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• 2012

The 40.8-MHz VHF coherent scatter ionospheric radar, located in South Korea (Gyeryong, $36.18^{\circ}N$, $127.14^{\circ}E$), has been operating since December 2009 to investigate ionosphere E- and F-region field-aligned irregularities (FAIs) of mid-latitude. During the observation, we found E- and F-region FAIs appeared frequently: continuous echoes during the post-sunrise period and Quasi-Periodic (QP) echoes at nighttime for E region ; strong post-sunset and pre-sunrise FAIs for F region. The characteristics of E- and F-region FAIs are presented in terms of seasonal and local time variations of occurrence during December 2009 to August 2012. In addition, to investigate the correlation with geomagnetic activity to FAIs occurrence, we compared K-index variations to local time occurrence. It is worth to note our occurrence result since long term observation over several years in the mid-latitude has not yet been carried out.

• Korean Journal of Food Science and Technology
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• v.51 no.2
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• pp.176-181
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• 2019

The aim of this study was to analyze dieting practices and tendencies in 2016 using big data. The keywords related to diet were collected from the portal site Naver and analyzed through simple frequency, N-gram, keyword network, and analysis of seasonality. The results showed that exercise had the highest frequency in simple frequency analysis. However, diet menu appeared most frequently in N-gram analysis. In addition, analysis of seasonality showed that the interest of subjects in diet increased steadily from February to July and peaked in October 2016. The monthly frequency of the keyword highfat diet was highest in October, because that showed the 'Low Carbohydrate High Fat' TV program. Although diet showed a certain pattern on a yearly basis, the emergence of new trendy diets in mass media also affects the pattern of diet. Therefore, it is considered that continuous monitoring and analysis of diet is needed rather than periodic monitoring.

• Membrane Journal
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• v.18 no.1
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• pp.7-25
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• 2008

Sodium dodecyl sulfate, which was anionic surfactant, at a concentration higher than its critical micellar concentration was added to calcium solution for forming micelles. Then aggregates were formed by adsorption or binding of calcium ions on the surface of micelles, and gathering between them, and then rejected by two kinds of ceramic membranes to remove calcium ions. As result, rejection rates of calcium were higher than 99.98%. And in our experimental range the higher TMP trended to increase the resistance of membrane fouling ($R_f$), total permeate volume ($V_T$), dimensionless permeate flux ($J/J_o$) and permeate flux (J) because TMP was driving force. And we investigated effects of $N_2$-back-flushing time and filtration time, that was back-flushing period, during periodic $N_2$-back-flushing on ceramic membranes. As result, optimal BTs for NCMT-623l ($0.07{\mu}m$ pore size) and NCMT-7231 membrane ($0.10{\mu}m$) were 10 sec and 15 sec, respectively. Also, optimal FT was 5 min for both membranes, and the frequent $N_2$-back-flushing could decrease membrane fouling effectively. Then, the optimal conditions resulting from our experiments for synthetic calcium solution were applied to groundwater using as washing process of soymilk package. As result, rejection rates of calcium were higher than 99.98%.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.81-81
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• 1995

It is well known that Src Homology 2(SH2) domain in many intracellular signal transduction proteins is very important. The domain has about 100 amino acid residues and bind phosphotyrosine-containing peptide with high affinity and specificity. Lck SH2 domain is a Src-like, lymphocyte-specific tyrosine kinase. An 11-residue phosphopeptide derived from the hamster polvoma middle-T antigen, EPQp YEEIPIYL, binds with an 1 nM dissociation constant to Lck SH2 domain. And it is known that the phosphotyrosine and isoleucine residues of the peptide are tightly bound by two well-defined pockets on Lck SH2 domain's surface. To investigate the conformational changes during complexation of SH2 domain with phosphopeptide we have performed the molecular dynamics simulation for Lck SH2 domain with peptide and peptide-free form at look in aqueous solution. More than 3000 water molecules were incorporated to solvate Lck SH2 domain and peptide. Periodic boundary condition has been applied in molecular dynamics simulation. Data analysis with the results of that simulation shows that the phosphopeptide makes primary interaction with the Lck SH2 domain at six central residues, The comparison of the complexed and uncomplexed SH2 domain structures in solution has revealed only relatively small change. But the hydrophilic and hydrophobic pockets in the protein surface show the conformational changes in spite of the small structural difference between the complex and peptide-free forms.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.81.1-81.1
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• 2011

The new coherent scatter ionospheric radar has been operating at Gyerong city ($36.18^{\circ}N$, $127.14^{\circ}E$, dip lat $26.7^{\circ}N$), South Korea. This VHF radar is consisted of 24 Yagi antennas having 5 elements and observes the E- and F-region field-aligned irregularities (FAIs) in a single frequency of 40.8 MHz with a peak power of 24 kW. We present the first results of the E- and F-region FAIs over Korea by using the new VHF coherent scatter ionospheric radar. The morphological and echo characteristics are studied in terms of their echo strength, Doppler velocity and also by spectral width values. From the continuous observations from December 2009, we found ionospheric E- and F-region FAIs appeared frequently. The most interesting and striking observations for E region are occurrence of daytime E-region irregularities and strong Quasi-Periodic (QP) echoes at nighttime. And for F region, strong post-sunset and pre-sunrise FAIs appeared frequently. The VHF radar observations over Korea are discussed in the light of current understanding of mid-latitude E- and F-region FAIs.