• Title/Summary/Keyword: $15-deoxy-{\Delta}12,14-prostaglandin\

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ACTIVATION OF P38 MAP KINASE AND AP-1 DURING THE PROMOTION OF NEURITE EXTENSION OF PC-12 CELLS BY 15-DEOXY-$\Delta$12,14-PROSTAGLANDIN J2

  • Song, Y.S.;Oh. J.H.;Park, K.S.;Jung, K.M.;Lee, M.K.;Jung, H.K.;Jung, S.Y.;Hong, J.T.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.110-110
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    • 2002

  • 15-Deoxy-$\Delta$12, 14-prostaglandin J2 (15-deoxy-PGJ2), a naturally occurring ligand activates the peroxisome proliferator-activated receptor-$\gamma$(PPAR-$\gamma$). It was known to have promoting ability of nerve growth factor(NGF)-induced neurite extension. However, it is not clear yet as to what signaling pathway is involved in its promoting ability of neurite extension.(omitted)

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15-DEOXY-$\Delta$12,14-PROSTAGLANDIN J2 DECREASED ACTIVATION OF TRANSCRIPTION FACTOR NF-$\textsc{k}$B BY BETA-AMYLOID IN MUTANT PS-2 TRANSFECTED PC12 CELLS

  • Oh, Jae-Ho;Hong, Jin-Tae;Kim, Yong-Soon;Kim, Youg-Kyu;Park, Ki-Sook;Song, Chi-Won;Jung, Hai-Kwan;Park, Chang-Won;Jung, Kyung-Mi;Yang, Ki-Hwa;Chung, Soo-Youn
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.108-108
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    • 2002

  • Mutations in the presenilin genes (PS-1 and PS-2) are linked to early onset familial Alzheimer's disease(AD), but its underlying cellular mechanisms have not been clear. 15-Deoxy-Δ12, 14-prostaglandin J2 (15-deoxy-PGJ2) is know as a naturally occurring ligand of the peroxisome proliferator-activated receptor-${\gamma}$ (PPAR-${\gamma}$).(omitted)

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Influence of 17β-Estradiol on 15-Deoxy-Δ12,14 Prostaglandin J2 -Induced Apoptosis in MCF-7 and MDA-MB-231 Cells

  • Yaacob, Nik Soriani;Nasir, Rabail;Norazmi, Mohd Nor
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6761-6767
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    • 2013

  • The nuclear receptor, peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$), is expressed in various cancer cells including breast, prostate, colorectal and cervical examples. An endogenous ligand of $PPAR{\gamma}$, 15-deoxy-${\Delta}^{12,14}$ prostaglandin $J_2$ (PGJ2), is emerging as a potent anticancer agent but the exact mechanism has not been fully elucidated, especially in breast cancer. The present study compared the anticancer effects of PGJ2 on estrogen receptor alpha ($ER{\alpha}$)-positive (MCF-7) and $ER{\alpha}$-negative (MDA-MB-231) human breast cancer cells. Based on the reported signalling cross-talk between $ER{\alpha}$ and $ER{\alpha}$, the effect of the $ER{\alpha}$ ligand, $17{\beta}$-estradiol (E2) on the anticancer activities of PGJ2 in both types of cells was also explored. Here we report that PGJ2 inhibited proliferation of both MCF-7 and MDA-MB-231 cells by inducing apoptotic cell death with active involvement of mitochondria. The presence of E2 potentiated PGJ2-induced apoptosis in MCF-7, but not in MDA-MB-231 cells. The $ER{\alpha}$ antagonist, GW9662, failed to block PGJ2-induced activities but potentiated its effects in MCF-7 cells, instead. Interestingly, GW9662 also proved capable of inducing apoptotic cell death. It can be concluded that E2 enhances $ER{\alpha}$-independent anticancer effects of PGJ2 in the presence of its receptor.

  • https://doi.org/10.7314/APJCP.2013.14.11.6761 인용 PDF KSCI

Induction of Heme Oxygenase-1 By 15-Deoxy-Delta12,14-Prostaglandin J2 Is Mediated Through Activation of Transcription Factor Nrf2 in Mcf-7 Cells

  • Kim, Eun-Hee;Surh, Young-Joon
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.10b
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    • pp.180-180
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    • 2003

  • Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, is involved in the suppression of growth of several types of tumors such as liposarcoma, cancers of breast, prostate, and colon, possibly through induction of cell cycle arrest and/or apoptosis.(omitted)

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